Article
Clinical Neurology
Susanne J. van Veluw, Konstantinos Arfanakis, Julie A. Schneider
Summary: Sporadic cerebral small vessel disease is a major cause of cognitive impairment and dementia in aging brains, characterized by brain small vessel abnormalities and frequently coexisting with Alzheimer disease changes. Ex vivo MRI is a powerful tool to bridge the gap in understanding the underlying neuropathology of MRI-detectable SVD abnormalities.
Article
Clinical Neurology
Jeremy F. Kellie, Bruce C. Campbell, Rosie Watson, Adrian J. Praeger, Girish Nair, Anand Murugasu, Christopher C. Rowe, Colin L. Masters, Steven Collins, Catriona McLean, Nawaf Yassi
Summary: Recent reports suggest the possibility of neurosurgical transmission of cerebral amyloid angiopathy (CAA), leading to intracerebral hemorrhage in young adults. However, such cases are rare in standard clinical practice.
Article
Clinical Neurology
Evangelos Pavlos Myserlis, Christopher D. Anderson, Marios K. Georgakis
Summary: Recent evidence suggests that higher CRP levels are associated with lower risk of Alzheimer disease, and this study explores whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH) caused by cerebral amyloid angiopathy. The results show that higher genetically proxied CRP levels are associated with lower odds of lobar ICH, supporting the hypothesis that high CRP levels may have a protective role in amyloid-related pathology.
Article
Neurosciences
Jonathan Graff-Radford, Timothy G. Lesnick, Michelle M. Mielke, Eleni Constantopoulos, Alejandro A. Rabinstein, Scott A. Przybelski, Prashanthi Vemuri, Hugo Botha, David T. Jones, Vijay K. Ramanan, Ronald C. Petersen, David S. Knopman, Bradley F. Boeve, Melissa E. Murray, Dennis W. Dickson, Clifford R. Jack, Kejal Kantarci, R. Ross Reichard
Summary: This study found a correlation between cerebral microbleeds (CMBs) and cerebral amyloid angiopathy (CAA) using MRI and autopsy data. The capillary and leptomeningeal/cortical CAA scores were closely associated with lobar CMBs, with the capillary component being a stronger predictor of lobar CMBs.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Erik van Zwet, Paul C. de Kruijff, Thijs W. van Harten, Ellis S. van Etten, Sanneke van Rooden, Louise van der Weerd, Mark A. van Buchem, Matthias J. P. van Osch, Steven M. Greenberg, Marianne A. A. van Walderveen, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Cortical calcifications are common in Dutch-type hereditary CAA (D-CAA) but rare in sporadic CAA. These calcifications are associated with the development of intracerebral hemorrhage (ICH) and may serve as a marker for advanced CAA. Additionally, there seems to be a link between cortical calcifications on computed tomography and the striped occipital cortex on 7T-magnetic resonance imaging.
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Jennifer S. Rabin, Emma Nichols, Renaud La Joie, Kaitlin B. Casaletto, Priya Palta, Kristen Dams-O'Connor, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie A. Schneider, Judy Pa, Adam M. Brickman
Summary: Accumulating data suggests that cerebrovascular disease contributes to the pathophysiology and progression of Alzheimer's disease. Cerebral amyloid angiopathy, characterized by the build-up of beta-amyloid in blood vessel walls, commonly co-occurs with Alzheimer's disease in the aging brain and increases the risk of dementia. This study found that cerebral amyloid angiopathy independently or interactively influences tau deposition and cognitive decline, and tau mediates the association between cerebral amyloid angiopathy and cognitive decline.
Article
Biochemistry & Molecular Biology
Jhinuk Saha, Dexter N. Dean, Shailendra Dhakal, Kelli A. Stockmal, Sarah E. Morgan, Kristy D. Dillon, Munir F. Adamo, Yona Levites, Vijayaraghavan Rangachari
Summary: Alzheimer's disease is a progressive neurodegenerative disorder affecting cognition and memory, with recent studies showing a correlation between the characteristics of Aβ42 oligomers and their effects in transgenic AD mice, with GM1Os displaying higher toxicity. These findings help to understand how oligomer conformers could elicit AD phenotypes.
Article
Clinical Neurology
Qi Li, Maria Clara Zanon Zotin, Andrew D. Warren, Yuan Ma, Edip Gurol, Joshua N. Goldstein, Steven M. Greenberg, Andreas Charidimou, Nicolas Raposo, Anand Viswanathan
Summary: This study found that cSAH detected in 40.5% of patients with acute lobar ICH related to CAA on CT is associated with an increased risk of recurrent ICH. cSAH may be used as a marker to stratify the risk of ICH in patients with CAA.
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Neurosciences
Claire Muller
Summary: Recently, there has been increased recognition of iatrogenic cerebral amyloid angiopathy (iCAA) cases globally. This case study examines the clinicoradiological features of a probable iCAA case in Australia, with extensive history documentation and MRI data spanning two decades. The study highlights the aggressive course and early disease manifestations of iCAA, providing insights for the more commonly seen sporadic cases.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Konark Malhotra, Aikaterini Theodorou, Aristeidis H. Katsanos, Christina Zompola, Ashkan Shoamanesh, Efstathios Boviatsis, George P. Paraskevas, Martha Spilioti, Charlotte Cordonnier, David J. Werring, Andrei Alexandrov, Georgios Tsivgoulis
Summary: Limited data exist regarding the prevalence of clinical and neuroimaging manifestations among patients diagnosed with cerebral amyloid angiopathy (CAA). In this study, a systematic review and meta-analysis were conducted, revealing that approximately half of CAA patients have cerebral microbleeds, cortical superficial siderosis, mild cognitive impairment, dementia, intracerebral hemorrhage (ICH), or transient focal neurological episodes. Cortical superficial siderosis was the only neuroimaging marker associated with higher odds of ICH recurrence.
Review
Clinical Neurology
Konark Malhotra, Christina Zompola, Aikaterini Theodorou, Aristeidis H. Katsanos, Ashkan Shoamanesh, Himanshu Gupta, Simon Beshara, Nitin Goyal, Jason Chang, Ashis H. Tayal, Efstathios Boviatsis, Konstantinos Voumvourakis, Charlotte Cordonnier, David J. Werring, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: Among patients with spontaneous intracerebral hemorrhage, approximately 1 in 4 cases have undetermined etiology, leading to a relatively high short-term mortality rate. Cerebral amyloid angiopathy accounts for the largest hemorrhage volume, while hypertensive arteriopathy and undetermined ICH have smaller volumes.
Review
Clinical Neurology
Sarah N. N. Ohashi, Jonathan H. H. DeLong, Mariel G. G. Kozberg, David J. J. Mazur-Hart, Susanne J. J. van Veluw, Nabil J. J. Alkayed, Lauren H. H. Sansing
Summary: Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral hemorrhage and subarachnoid hemorrhage. Inflammatory immune responses play a crucial role in the pathophysiology of these types of stroke, both affecting tissue recovery and injury. Understanding these processes can lead to the development of effective therapeutic strategies.
Article
Transplantation
Roel Bijkerk, Marije H. Kallenberg, Laurien E. Zijlstra, Bernard M. van den Berg, Jeroen de Bresser, Sebastiaan Hammer, Esther E. Bron, Hakim Achterberg, Mark A. van Buchem, Noeleen C. Berkhout-Byrne, Willem Jan W. Bos, Diana van Heemst, Ton J. Rabelink, Anton Jan van Zonneveld, Marjolijn van Buren, Simon Mooijaart
Summary: This study focused on the association between levels of angiopoietin and cognitive impairment in ESRD patients, revealing an unfavorable angiogenic profile in these patients and identifying certain miRNAs associated with different cognitive domains. These novel angiogenic markers may help to identify cognitive decline in older ESRD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Emma A. Koemans, Sabine Voigt, Ingeborg Rasing, Thijs W. van Harten, Wilmar M. T. Jolink, Floris H. B. M. Schreuder, Erik W. van Zwet, Mark A. van Buchem, Matthias J. P. van Osch, Gisela M. Terwindt, Catharina J. M. Klijn, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: This study investigated the frequency of cerebellar superficial siderosis and its relation to hemorrhagic magnetic resonance imaging markers in patients with cerebral amyloid angiopathy (CAA). The study found that cerebellar superficial siderosis may be a novel marker for CAA.
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Bossoni, Ingrid Hegeman-Kleinn, Sjoerd G. van Duinen, Marjolein Bulk, Lena H. P. Vroegindeweij, Janneke G. Langendonk, Lydiane Hirschler, Andrew Webb, Louise Van der Weerd
Summary: The off-resonance saturation method was effective in detecting iron in gray matter structures in postmortem brain tissue, with iron concentrations obtained via this method shown to be in agreement with existing literature. This method can be used to study diseases characterized by brain iron accumulation and complement other iron-sensitive parametric methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Rheumatology
Francesca Inglese, Myriam G. Jaarsma-Coes, Gerda M. Steup-Beekman, Rory Monahan, Tom Huizinga, Mark A. van Buchem, Itamar Ronen, Jeroen de Bresser
Summary: Patients with neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) showed higher white matter hyperintensity (WMH) volume and more complex WMH shape compared to non-NPSLE patients, with the inflammatory phenotype exhibiting more significant findings.
Article
Clinical Neurology
Sigurdur Sigurdsson, Thor Aspelund, Olafur Kjartansson, Elias Gudmundsson, Palmi Jonsson, Mark A. van Buchem, Vilmundur Gudnason, Lenore J. Launer
Summary: This study found that the risk factors for different types of brain infarcts vary depending on the location in the brain. Small vessel disease risk factors such as hypertension and diabetes were associated with subcortical infarcts, while atherosclerotic/coronary processes were associated with cortical infarcts, and a mixed profile of factors was associated with cerebellar infarcts. Assessing risk factors based on the location of asymptomatic infarcts detected on magnetic resonance imaging may help improve preventive therapeutic approaches for stroke.
Article
Neurosciences
Francesca Inglese, Minseon Kim, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Mark A. van Buchem, Jeroen de Bresser, Dae-Shik Kim, Itamar Ronen
Summary: Self-supervised contrastive learning algorithms can be used to distinguish between NPSLE and non-NPSLE patients in SLE. This study found that common brain changes in NPSLE patients include tissue loss, local atrophy, and periventricular white matter lesions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Andreas Charidimou, Gregoire Boulouis, Matthew P. Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, Francois Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jager, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martinez-Saez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A. Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A. Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M. Wardlaw, Andrew Warren, Frank A. Wollenweber, Marialuisa Zedde, Mark A. van Buchem, M. Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E. Smith, David J. Werring, Steven M. Greenberg
Summary: This study aimed to update and validate the Boston criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The results showed that the Boston criteria version 2.0 had superior accuracy in terms of sensitivity and specificity, and incorporated new MRI markers.
Article
Neurosciences
Thijs W. van Harten, Anne Heijmans, Sanneke van Rooden, Marieke J. H. Wermer, Matthias J. P. van Osch, Hugo J. Kuijf, Susanne J. van Veluw, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Marianne A. A. van Walderveen
Summary: This study found no differences in DMV parameters between Dutch-type hereditary CAA mutation carriers and controls, and no associations between DMV parameters and MRI markers associated with D-CAA. Therefore, DMVs may not play a role in the pathogenesis of MRI markers associated with CAA.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neuroimaging
Jasmin A. Keller, Ilse M. J. Kant, Arjen J. C. Slooter, Simone J. T. van Montfort, Mark A. van Buchem, Matthias J. P. van Osch, Jeroen Hendrikse, Jeroen de Bresser
Summary: This study investigated the association between cardiovascular risk factors and WMH markers in non-demented older adults. The results showed that hypertension was associated with irregular WMH shape, while diabetes was associated with WMH volume. Different cardiovascular risk factors may lead to different WMH MRI phenotypes.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Clinical Neurology
R. Van Dort, I. Rasing, E. Koemans, S. Voigt, K. Kaushik, R. Van der Zwet, M. Schipper, T. Van Harten, E. Van Etten, M. Verbeek, M. Van Buchem, S. Van Rooden, J. Van der Grond, E. Van Zwet, M. Van Walderveen, M. Van Osch, G. Terwindt, M. Wermer
INTERNATIONAL JOURNAL OF STROKE
(2022)
Meeting Abstract
Clinical Neurology
S. Voigt, E. Koemans, I. Rasing, K. Kaushik, T. Van Harten, E. Van Etten, M. Van Buchem, F. Baas, M. Verbeek, C. Klijn, M. Van Osch, A. Van Es, M. Van Walderveen, G. Terwindt, L. Van der Weerd, M. Wermer
INTERNATIONAL JOURNAL OF STROKE
(2021)