Article
Computer Science, Interdisciplinary Applications
Yang Yao, Shuran Zhou, Jordi Alastruey, Liling Hao, Stephen E. Greenwald, Yuelan Zhang, Lin Xu, Lisheng Xu, Yudong Yao
Summary: This study aims to identify pulse wave features for a more accurate estimation of carotid-femoral pulse wave velocity (cfPWV) from a single radial pulse wave measurement. The results show that the amplitude ratio of the diastolic peak to the notch of the radial pulse waveform is correlated with cfPWV and this correlation may not be dependent on wave reflection.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Peripheral Vascular Disease
Sae Young Jae, Kevin S. Heffernan, Hyun Jeong Kim, Setor K. Kunutsor, Bo Fernhall, Sudhir Kurl, Jari A. Laukkanen
Summary: High pulse wave velocity (PWV) and low socioeconomic status (SES) are independently associated with increased risk of stroke. Elevated PWV is a risk factor for stroke regardless of SES.
JOURNAL OF HYPERTENSION
(2022)
Article
Neurosciences
Wenting Guo, Jiali Xu, Linqing Ma, Jin Ma, Sijie Li, Changhong Ren, Longfei Wu, Chuanjie Wu, Chuanhui Li, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study aimed to investigate the impact of different administration routes of a low dose of tirofiban on AIS patients with successful recanalization post EVT. The results showed that a low dose of tirofiban was safe for AIS patients who achieved successful recanalization with EVT, but only IA + IV tirofiban improved clinical outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Peripheral Vascular Disease
Tiantian Sang, Naqiang Lv, Aimin Dang, Nan Cheng, Wei Zhang
Summary: baPWV is independently associated with an increased risk of cardiovascular events, cardiovascular mortality, and all-cause mortality in ASCVD patients, regardless of various factors such as age, hypertension, and follow-up duration.
HYPERTENSION RESEARCH
(2021)
Article
Chemistry, Analytical
Flora Antali, Daniel Kulin, Konrad Istvan Lucz, Balazs Szabo, Laszlo Szucs, Sandor Kulin, Zsuzsanna Miklos
Summary: The study evaluated the PRV analysis module of a digital arterial PPG-based telemedical system and found good agreement between PRV and HRV parameters in healthy individuals and diabetic patients.
Review
Clinical Neurology
Yajing Chen, Yuxia Ma, Jiangxia Qin, Xiaoqin Wei, Yiyi Yang, Yue Yuan, Fanghong Yan, Xiaoning Huo, Lin Han
Summary: This study systematically reviewed the association between blood pressure variability and prognosis in acute stroke patients. The results showed that higher systolic blood pressure variability is associated with a higher risk of poor outcome among acute stroke patients without thrombolysis, including function disability, mortality, early neurological deterioration, and stroke recurrence. Higher diastolic blood pressure variability is associated with a higher risk of mortality and functional disability.
JOURNAL OF NEUROLOGY
(2023)
Review
Chemistry, Analytical
Shiyun Li, Can Zhang, Zhirui Xu, Lihua Liang, Ye Tian, Long Li, Huaping Wu, Sheng Zhong
Summary: This paper evaluates the developments and future research trends in the field of cuffless blood pressure monitoring using bibliometric analysis. It identifies machine learning technologies as widely applied in blood pressure monitoring and suggests improving accuracy and achieving portability and miniaturization as future goals.
Article
Computer Science, Interdisciplinary Applications
Rachel Smith, Liam Murphy, Christopher G. Pretty, Thomas Desaive, Geoffrey M. Shaw, J. Geoffrey Chase
Summary: This study tested a dynamically identified tube-load model for accurately estimating stroke volume during hemodynamic instability. Results showed reasonable agreement and performance in estimating stroke volume in pigs, both during long-term state-change and short-term dynamic events.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Review
Nutrition & Dietetics
Arnav Mehta, Lorenzo De Paola, Tiberiu A. Pana, Ben Carter, Roy L. Soiza, Mohannad W. Kafri, John F. Potter, Mamas A. Mamas, Phyo K. Myint
Summary: This study systematically reviewed several prospective cohort studies and found that the nutritional status of stroke patients is associated with their outcomes. Underweight and low serum albumin levels increase the risk of death, while overweight and obesity reduce the risk of death.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gilles Soulat, Kelly Jarvis, Ashitha Pathrose, Alireza Vali, Michael Scott, Amer A. Syed, Menhel Kinno, Shyam Prabhakaran, Jeremy D. Collins, Michael Markl
Summary: The study showed that RASI therapy after cryptogenic stroke can reduce blood flow reversal and aortic stiffness. Compared to the RASI group, there were no significant changes in aortic PWV and FRF in the non-RASI group.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Peng Zhang, Xiu-Li Yan, Yang Qu, Zhen-Ni Guo, Yi Yang
Summary: In stroke patients, obesity and overweight were found to be associated with longer survival time, while underweight was linked to shorter survival time. In acute ischemic stroke patients, only obesity showed a positive association with longer survival compared to normal weight, with underweight showing a negative association with shorter survival.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Chemistry, Analytical
Lukas Matera, Pavol Sajgalik, Vratislav Fabian, Yegor Mikhailov, David Zemanek, Bruce D. Johnson
Summary: Czech physiologist Penaz developed a non-invasive method for continuous arterial waveform detection and beat-to-beat analysis using a finger mounted BP cuff. The study validated the signal analysis acquired by a novel brachial occlusion-cuff principle and showed a positive correlation between brachial pulse waves measured by the new device and Finapres. The proposed parameter, Occlusion Cuff Index (OCCI), has potential as an index for describing changes during beat-to-beat cardiac cycles.
Article
Clinical Neurology
Sauson Soldozy, Kaan Yagmurlu, Pedro Norat, Mazin Elsarrag, John Costello, Faraz Farzad, Jennifer D. Sokolowski, Khadijeh A. Sharifi, Turki Elarjani, Joshua Burks, Petr Tvrdik, Mark E. Shaffrey, Min S. Park, Robert M. Starke, Errol Gordon, M. Yashar S. Kalani
Summary: This study systematically reviewed the usefulness of serum biomarkers in predicting long-term outcome after ischemic stroke (IS). The analysis identified C-reactive protein, albumin, copeptin, and D-dimer to be significantly associated with long-term outcome. These serum biomarkers, combined with imaging biomarkers and used in artificial intelligence algorithms, can provide refined predictive outcomes.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Zhengbao Zhu, Daoxia Guo, Kaixin Zhang, Pinni Yang, Yiming Jia, Mengyao Shi, Yanbo Peng, Jing Chen, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: Plasma osteoprotegerin is associated with poor prognosis of ischemic stroke. High levels of plasma osteoprotegerin are associated with increased risk of death and major disability. Genetically determined high plasma osteoprotegerin is associated with an increased risk of primary outcome.
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim
Summary: Background and objective: This study aimed to investigate whether statin therapy is associated with a reduced risk of stroke in patients with moyamoya disease (MMD), a chronic and progressive cerebrovascular disease. The results showed that statin therapy was significantly associated with a reduced risk of stroke and all-cause mortality in MMD patients.
STROKE AND VASCULAR NEUROLOGY
(2023)
Letter
Clinical Neurology
Kijeong Lee, HyungWoo Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Joonsang Yoo, Sunghee Cho, Ji Hoe Heo
Article
Clinical Neurology
JoonNyung Heo, Hyungwoo Lee, Il Hyung Lee, Hyo Suk Nam, Young Dae Kim
Summary: This study investigated the stroke outcomes in patients with left atrial or left atrial appendage thrombus. The results showed that patients with LA/LAA thrombus had a poorer functional outcome after 3 months, which was associated with relevant arterial occlusion and prolonged hospital stay.
Editorial Material
Medicine, General & Internal
Hyo Suk Nam, Byung Moon Kim
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Harin Kim, Dong-Min Shin, Jae-Hoon Lee, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Summary: This study compared various nutritional and inflammatory indicators and found that P-CONUT may be a better prognostic indicator for patients with colorectal cancer, compared to inflammatory markers such as neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Da-Hye Son, Hye Sun Lee, So-Young Seol, Yong-Jae Lee, Jun-Hyuk Lee
Summary: Oxidative stress is a new risk factor for chronic kidney disease (CKD). The study aimed to verify the relationship between the overall oxidative balance represented by the oxidative balance score (OBS) and the incidence of CKD. Data from 5795 participants without CKD were analyzed, and a dose-response association between the OBS and incident CKD was found in both men and women. The results suggest that a healthy diet and lifestyle that increase the OBS may help prevent CKD in both genders.
Article
Multidisciplinary Sciences
Miribi Rho, Sei Hyun Chun, Eunjung Lee, Hye Sun Lee, Jung Hyun Yoon, Vivian Youngjean Park, Kyunghwa Han, Jin Young Kwak
Summary: This study assessed the performance of a deep convolutional neural network (CNN) in discriminating malignant and benign thyroid nodules under 10mm in size, and compared its diagnostic performance with that of radiologists. The CNN, trained using ultrasound images, showed better diagnostic and categorization performance than the radiologists, especially for nodules under 5mm.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Doyoun Kim, Jae-Hoon Lee, Eun-Suk Cho, Su-Jin Shin, Hye Sun Lee, Hwa-Hee Koh, Kang Young Lee, Jeonghyun Kang
Summary: Combining preoperative and postoperative ALBI scores is an independent prognostic factor for the overall survival of patients with colorectal cancer (CRC), and it shows superior predictive power compared to using preoperative or postoperative scores alone.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Public, Environmental & Occupational Health
Joonsang Yoo, Joo Youn Shin, Jimin Jeon, Jinkwon Kim
Summary: This study evaluated the association between statin therapy and the risk of cardiovascular events in patients with retinal vein occlusion (RVO). The study found that statin treatment was associated with a lower risk of cardiovascular events in newly diagnosed RVO patients. Furthermore, longer statin treatment after RVO was associated with a further reduction in cardiovascular risk.
EPIDEMIOLOGY AND HEALTH
(2023)
Article
Multidisciplinary Sciences
Yoonkyung Chang, Jimin Jeon, Tae-Jin Song, Jinkwon Kim
Summary: This study found a significant positive association between TG/HDL ratio and the risk of developing severe complications in COVID-19-infected patients, providing valuable insight into the potential prognostic role of TG/HDL ratio in COVID-19.
Article
Clinical Neurology
JoonNyung Heo, Hyungwoo Lee, Young Seog, Sungeun Kim, Jang-Hyun Baek, Hyungjong Park, Kwon-Duk Seo, Gyu Sik Kim, Han-Jin Cho, Minyoul Baik, Joonsang Yoo, Jinkwon Kim, Jun Lee, Yoonkyung Chang, Tae-Jin Song, Jung Hwa Seo, Seong Hwan Ahn, Heow Won Lee, Il Kwon, Eunjeong Park, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam
Summary: In this study, machine learning models were developed and validated to diagnose ischemic stroke patients with cancer using histopathologic images of thrombi. The models showed high accuracy in classifying patients into cancer group and other determined cause group. The models accurately predicted the presence of occult cancer in patients with high probabilities.
Article
Medicine, General & Internal
Chul Hwan Park, Juyeon Yang, Hye Sun Lee, Tae Hoon Kim, Lucy Youngmin Eun
Summary: This study evaluated the clinical and radiological manifestations of teenagers with chest pain after COVID-19 mRNA vaccination. Among the 61 patients, only 3.3% were diagnosed with confirmed myocarditis, while myocardial abnormalities were observed in 39.3% of patients on CMR. Female sex and older age were associated with these abnormalities. The findings suggest that myocarditis is uncommon, but myocardial abnormalities may occur frequently in teenagers after COVID-19 vaccination.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kyungchul Song, Juyeon Yang, Hye Sun Lee, Su Jin Kim, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
Summary: This study aimed to investigate the prevalences of obesity, abdominal obesity, and NAFLD among children and adolescents during the COVID-19 outbreak. The results showed that the prevalences of abdominal obesity and NAFLD increased among obese Korean children and adolescents, as well as in rural areas. These findings highlight the importance of monitoring abdominal obesity and NAFLD among children, particularly obese young children and individuals in rural areas, during the COVID-19 pandemic.
YONSEI MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Soyoung Kim, Jae-Hoon Lee, Eun Jung Park, Hye Sun Lee, Seung Hyuk Baik, Tae Joo Jeon, Kang Young Lee, Young Hoon Ryu, Jeonghyun Kang
Summary: This study investigated the feasibility of using preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/ computed tomography (CT) radiomics with machine learning to predict microsatellite instability (MSI) status in colorectal cancer (CRC) patients. A predictive model incorporating PET radiomic features, called rad_score, was established and evaluated for its ability to predict MSI status. The rad_score showed similar predictive performance in both the training and test sets, and it was found to be an independent predictor of MSI status in CRC. Furthermore, the rad_score outperformed conventional PET parameters in predicting MSI status.
YONSEI MEDICAL JOURNAL
(2023)
