Article
Clinical Neurology
Paul M. Wechsler, Ava L. Liberman, Daniel Restifo, Erika L. Abramson, Babak B. Navi, Hooman Kamel, Neal S. Parikh
Summary: This study analyzed the cost-effectiveness of smoking cessation interventions in the population of stroke and transient ischemic attack survivors. The results showed that varenicline, pharmacotherapy with intensive counseling, and monetary incentives were all more effective and cost less compared to brief counseling alone in secondary stroke prevention. Overall, delivering smoking cessation therapy beyond brief counseling alone was found to be cost-effective and potentially cost-saving.
Review
Radiology, Nuclear Medicine & Medical Imaging
Xiao Wu, Mihir Khunte, Dheeraj Gandhi, Pina Sanelli, Howard P. Forman, Ajay Malhotra
Summary: This study examined published cost-effectiveness analyses on endovascular thrombectomy in acute stroke patients, revealing significant variations in methodology and highlighting the need for better standardization in future CEAs.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Paolo Candio, Mara Violato, Jose Leal, Ramon Luengo-Fernandez
Summary: Through analysis of 32 European countries, it was found that MT is more effective and cost-effective compared to standard care in the majority of countries, showing potential for significant savings in health and social care costs.
Review
Biochemistry & Molecular Biology
Dmitry Frank, Alexander Zlotnik, Matthew Boyko, Benjamin Fredrick Gruenbaum
Summary: Acute ischemic stroke is a critical condition that requires timely treatment to restart blood flow and reduce infarct volume. Recent research has focused on understanding the pathological pathways and processes of the condition and exploring drugs that can limit injury severity by manipulating molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yuesong Pan, Runqi Wangqin, Hao Li, Aoming Jin, Jiejie Li, Jinxi Lin, Xia Meng, Ying Xian, Daniel T. Laskowitz, Yongjun Wang
Summary: This study found that elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischemic stroke among patients with minor ischemic stroke or TIA. For patients with LDL-C >= 2.6 mmol/L, lipid-lowering treatment was associated with a significantly reduced risk of ischemic stroke at 3 months.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Johanna M. Ospel, Wolfgang G. Kunz, Rosalie McDonough, Wim van Zwam, Floor Pinckaers, Jeffrey L. Saver, Michael D. Hill, Andrew M. Demchuk, Tudor G. Jovin, Peter Mitchell, Bruce C. Campbell, Phil White, Keith Muir, Hamza Achit, Serge Bracard, Scott Brown, Mayank Goyal
Summary: This study aimed to investigate the clinical and economic benefit of endovascular treatment (EVT) in stroke patients with mild preexisting symptoms/disability. The results showed that EVT, in addition to best medical management, was a superior treatment strategy, resulting in cost savings and improved quality of life.
Article
Health Care Sciences & Services
Angel Estella, Miriam Perez Ruiz, Juan Jose Serrano
Summary: This study aimed to compare the combined effect and safety of tenecteplase and alteplase in ischemic stroke patients. The results showed no significant differences in successful recanalization and functional outcome between the two drugs, but tenecteplase had worse neurological results after 24 hours.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
H. T. Phan, S. L. Gall, C. L. Blizzard, N. A. Lannin, A. G. Thrift, C. S. Anderson, J. Kim, R. S. Grimley, H. C. Castley, M. F. Kilkenny, D. A. Cadilhac
Summary: This study found that women may receive stroke care less often than men, resulting in poorer health-related quality of life after stroke. Women are typically older than men, with fewer being unable to walk on admission, and having lower utility values than men, with the difference explained by age and stroke severity rather than clinical care.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Thanh N. Nguyen, Muhammad M. Qureshi, Davide Strambo, Daniel Strbian, Silja Raety, Christian Herweh, Mohamad Abdalkader, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Urs Fischer, Anh Nguyen, Joji B. Kuramatsu, David Haupenthal, Martin Koehrmann, Cornelius Deuschl, Jordi Kuehne Escola, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P. O. Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstock, Tobias Engelhorn, Piers Klein, Diogo C. Haussen, Mahmoud H. Mohammaden, Hend Abdelhamid, Lorena Souza Viana, Bruno Cunha, Isabel Fragata, Michele Romoli, Francesco Diana, Pekka Virtanen, Kimmo Lappalainen, Judith Clark, Stavros Matsoukas, Johanna T. Fifi, Sunil A. Sheth, Sergio Salazar-Marioni, Joao Pedro Marto, Joao Nuno Ramos, Milena Miszczuk, Christoph Riegler, Ashutosh P. Jadhav, Shashvat M. Desai, Volker Maus, Maximilian Kaeder, Adnan H. Siddiqui, Andre Monteiro, Hesham E. Masoud, Neil Suryadevara, Maxim Mokin, Shail Thanki, James E. Siegler, Jane Khalife, Italo Linfante, Guilherme Dabus, Negar Asdaghi, Vasu Saini, Christian H. Nolte, Eberhard Siebert, Thomas R. Meinel, Stefanos Finitsis, Markus A. Moehlenbruch, Peter A. Ringleb, Anne Berberich, Raul G. Nogueira, Uta Hanning, Lukas Meyer, Patrik Michel, Simon Nagel
Summary: This study compared the clinical outcomes of endovascular therapy (EVT) and medical management (MM) in patients with isolated posterior cerebral artery occlusion. The results showed no difference between the two groups in terms of the modified Rankin Scale and National Institutes of Health Stroke Scale at 90 days. However, the EVT group had a higher likelihood of excellent outcome and complete vision recovery, despite higher rates of symptomatic intracranial hemorrhage and mortality.
Review
Clinical Neurology
Neal S. Parikh, Elora Basu, Mu Ji Hwang, Russel Rosenblatt, Lisa B. Vanwagner, Hana I. Lim, Santosh B. Murthy, Hooman Kamel
Summary: Chronic liver disease (CLD) is a prevalent condition that includes subclinical liver disease which may have an impact on stroke risk, mechanisms, and outcomes. However, there is limited synthesis of data and guidance on the relationship between CLD and stroke. Therefore, a multidisciplinary review is necessary to evaluate the correlation between CLD and stroke and provide treatment considerations.
Article
Clinical Neurology
Yan Zhang, Jianliang Wang, Zhaoxi Ma, Guihua Mu, Da Liang, Yifan Li, Xiaoyan Qian, Luyuan Zhang, Fang Shen, Lei Zhang, Jie Yu, Yang Liu
Summary: In this study, the efficacy and safety of early low-dose tirofiban treatment in AIS patients with early neurological deterioration after IVT were evaluated. The results showed that tirofiban treatment improved functional recovery and reduced neurological deficits without increasing the risk of hemorrhagic complications.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Puhr-Westerheide, Matthias F. Froelich, Olga Solyanik, Eva Gresser, Paul Reidler, Matthias P. Fabritius, Matthias Klein, Konstantin Dimitriadis, Jens Ricke, Clemens C. Cyran, Wolfgang G. Kunz, Philipp M. Kazmierczak
Summary: The study found that supplemental short-protocol MRI in emergency patients is cost-effective for the detection of minor strokes, enabling timely secondary prophylaxis and resulting in higher cumulative QALYs.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shalika Bohingamu Mudiyanselage, Jo Stevens, Julian Toscano, Mark A. Kotowicz, Christopher L. Steinfort, Robyn Hayles, Jennifer J. Watts
Summary: The study evaluates the cost-effectiveness of a personalised telehealth intervention for managing chronic diseases in the long term. The pilot study compared the costs and effectiveness of telehealth monitoring with usual care and found that the intervention resulted in a significant improvement in health-related quality of life at an additional cost per patient. The study suggests that offering the program to a larger population may be necessary to achieve cost-effectiveness.
Article
Orthopedics
Andrew J. Schoenfeld, Gordon P. Bensen, Justin A. Blucher, Marco L. Ferrone, Tracy A. Balboni, Joseph H. Schwab, Mitchel B. Harris, Jeffrey N. Katz, Elena Losina
Summary: This study compared the cost-effectiveness of surgical and non-surgical treatments for spinal metastases, showing that the value of surgery varies depending on the patient population. Surgical intervention was found to be cost-effective for patients presenting with nonambulatory status due to acute neurologic compromise, but not for those who were ambulatory at presentation.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Medicine, General & Internal
Doris Sau-Fung Yu, Polly Wai-Chi Li, Shirley Xue Li, Robert D. Smith, Sunny Chiu-Sun Yue, Bryan P. Y. Yan
Summary: This randomized clinical trial demonstrates that an empowerment-based self-care education program can significantly improve self-care and symptom perception in patients with heart failure. It also reduces the risk of emergency department visits and hospital admissions. The program also shows positive effects on improving patients' knowledge and confidence and is cost-effective.