Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Mark Etherton, Kathleen Donahue, Carissa Tuozzo, Marco Nardin, Anne-Katrin Giese, Ona Wu, Vince D. Calhoun, Christian Grefkes, Natalia S. Rost
Summary: This study aimed to explore the whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation to stroke severity. The research identified differences in dynamic connectivity configurations between patients with different levels of stroke severity and highlighted the importance of dynamic connectivity involving default mode network components for recovery in the first 3 months poststroke.
HUMAN BRAIN MAPPING
(2021)
Review
Cell Biology
Claudia Alia, Daniele Cangi, Verediana Massa, Marco Salluzzo, Livia Vignozzi, Matteo Caleo, Cristina Spalletti
Summary: Ischemic damage in brain tissue leads to plastic changes in cell-to-cell interactions, influencing a wide range of molecular and structural interactions. Understanding and manipulating these intercellular connections is crucial for post-stroke neurorehabilitation.
Article
Neurosciences
Emily R. Olafson, Keith W. Jamison, Elizabeth M. Sweeney, Hesheng Liu, Danhong Wang, Joel E. Bruss, Aaron D. Boes, Amy Kuceyeski
Summary: Motor recovery after ischemic stroke is dependent on the brain's ability to compensate for damaged tissue through functional reorganization. Research has shown that regions in the cerebellar/subcortical networks undergo the most frequent functional reorganization, and that areas with more disruption due to stroke experience more remapping over time. Additionally, greater motor impairment at baseline correlates with more extensive early subacute functional reorganization, leading to better motor recovery at 6 months.
Review
Clinical Neurology
Jessica M. Cassidy, Jasper Mark, Steven C. Cramer
Summary: Stroke is a major cause of disability, and predicting post-stroke recovery is challenging. Neuroimaging-based biomarkers, particularly those measuring structural and functional connectivity of the brain, have shown potential in predicting motor recovery after stroke. This review explores the use of functional neural network connectivity measurements obtained from various imaging techniques in describing and predicting post-stroke behavioral status and recovery. The authors argue for the importance of implementing a causal inference framework in stroke research to move from association to causation.
Article
Multidisciplinary Sciences
Noor Sajid, Emma Holmes, Thomas M. Hope, Zafeirios Fountas, Cathy J. Price, Karl J. Friston
Summary: Functional recovery after brain damage varies depending on factors such as lesion site and extent. Recovery can occur by engaging residual components or utilizing intact neural structures, with different types of lesions having different effects.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Jack Jiaqi Zhang, Dalinda Isabel Sanchez Vidana, Jackie Ngai-Man Chan, Edward S. K. Hui, Kui Kai Lau, Xin Wang, Benson W. M. Lau, Kenneth N. K. Fong
Summary: This study aimed to review potential biomarkers that can predict poststroke functional recovery. Neurophysiological measurements, neuroimaging, and a wide variety of molecules have been used as prognostic biomarkers. Future studies may incorporate a combination of multiple biomarkers and develop algorithms using data mining methods to predict the recovery potential of patients after stroke more accurately.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huachen Huang, Mengxuan Shi, Caiyun Qi, Qi Tian, Handong Li, Mingming Liu, Minshu Li, Qiang Liu
Summary: S1PR modulation improves neurogenesis and functional recovery following brain ischemia by increasing the number of type A cells and promoting the proliferation of DCX+ cells.
Article
Rehabilitation
Kent P. Simmonds, Zhehui Luo, Mathew Reeves
Summary: The study showed significant racial/ethnic disparities in poststroke function, with Black and Hispanic patients having lower FIM scores compared to White patients. These disparities varied by stroke subtype, with the most prominent differences observed between Black and White patients. Age was a major confounding factor for Black-White disparities, especially for patients with hemorrhagic stroke.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Plant Sciences
Yuan Zhang, Ling Shen, Jian Xie, Lu Li, Wen Xi, Bin Li, Ying Bai, Honghong Yao, Shenyang Zhang, Bing Han
Summary: This study assessed the efficiency of Pushen capsule in treating ischemic stroke and identified its potential therapeutic targets and active ingredients. The results showed that Pushen reduced infarct volume, improved the blood-brain barrier, and promoted functional restoration in stroke model mice. Key active ingredients in Pushen, including tricin, quercetin, luteolin, kaempferol, and physcion, were found to regulate the expression of genes in the cAMP signaling pathway through binding with the transcription factor c-Myc. Pushen also improved gut microbiota dysbiosis and reduced inosine levels, leading to reduced Adora2a expression in the brain.
Article
Engineering, Environmental
Xiaoyu Ma, Fuhai Gao, Wei Su, Yuanyuan Ran, Tuerhong Bilalijiang, Yerasel Tuolhen, Guiqin Tian, Lin Ye, Zengguo Feng, Jianing Xi, Zongjian Liu
Summary: A precursor solution loaded with BDNF and VEGF is injected into the brain cavity of a stroke mouse induced by the photothrombotic method to form a multifunctional hydrogel. BDNF and VEGF are sustainably released from the hydrogel, promoting angiogenesis and neuroplasticity. The hydrogel also modulates microglial polarization and enhances motor recovery in stroke mice.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemical Research Methods
Gloria Cecchini, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Curzio Checcucci, Emilia Conti, Ihusan Adam, Duccio Fanelli, Roberto Livi, Francesco Saverio Pavone, Thomas Kreuz
Summary: This study explores new spatiotemporal propagation indicators to track neural correlates of motor deficits and functional recovery following stroke. Combining motor training and pharmacological intervention leads to new propagation patterns that are faster and smoother than pre-stroke patterns, suggesting potential for more targeted post-stroke therapies.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Clinical Neurology
Isabella Stuckart, Timo Siepmann, Christian Hartmann, Lars-Peder Pallesen, Annahita Sedghi, Jessica Barlinn, Heinz Reichmann, Volker Puetz, Kristian Barlinn
Summary: In acute ischemic stroke patients, early treatment with sertraline may contribute to improved functional recovery. Patients in the sertraline group showed worse neurological scores at baseline, but had a higher rate of favorable functional outcomes at 3 months and lower incidence of incident depression compared to the control group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan
Summary: The study found that minocycline can promote microglial phenotype shift, reduce brain infarct volume, protect neurons from injury, and improve neurological functional recovery after AIS.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Luke R. Lemmerman, Maria H. H. Balch, Jordan T. Moore, Diego Alzate-Correa, Maria A. Rincon-Benavides, Ana Salazar-Puerta, Surya Gnyawali, Hallie N. Harris, William Lawrence, Lilibeth Ortega-Pineda, Lauren Wilch, Ian B. Risser, Aidan J. Maxwell, Silvia Duarte-Sanmiguel, Daniel Dodd, Gina P. Guio-Vega, Dana M. McTigue, W. David Arnold, Shahid M. Nimjee, Chandan K. Sen, Savita Khanna, Cameron Rink, Natalia Higuita-Castro, Daniel Gallego-Perez
Summary: Intracranial delivery of EFF-nanotransfected fibroblasts resulted in a dose-dependent increase in perfusion 14 days post injection. Mice treated with EFF-nanotransfected fibroblasts showed around 70% infarct resolution and up to 90% motor recovery. Immunohistological analysis confirmed increased vascularity, neuronal cellularity, and reduced glial scar formation in response to treatment with EFF-nanotransfected fibroblasts, suggesting a promising strategy for ischemic stroke treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Muyul Park, Yejin Cho, Dae Hyun Kim, Hyun Seok Choi, Dong-Hyun Kim, Deog Young Kim
Summary: MWI was used to monitor myelin content changes during rehabilitation in stroke patients, showing significant changes in MWF in the CST. Robot-assisted rehabilitation resulted in a significantly larger MWF change compared to conventional rehabilitation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
