Review
Biochemistry & Molecular Biology
Irit Gottfried, Nofar Schottlender, Uri Ashery
Summary: Hyperbaric oxygen treatment (HBOT) is an effective therapy for various clinical situations, including carbon monoxide intoxication, incurable diabetes or radiation-injury wounds, and smoke inhalation. It has also been used to improve cognition, neuro-wellness, and quality of life following brain trauma and stroke in recent years.
Article
Biochemistry & Molecular Biology
Jelena Nesovic Ostojic, Milan Ivanov, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Sanjin Kovacevic, Predrag Brkic, Maja Zivotic, Una Jovana Vajic, Djurdjica Jovovic, Rada Jeremic, Senka Ljubojevic-Holzer, Zoran Miloradovic
Summary: This study evaluated the effects of HBO preconditioning in an experimental model of AKI and found that HBO preconditioning upregulated HO-1 and Bcl-2 protein expression, improved renal function, and had protective effects in both Wistar and SHR rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vivian Doerr, Ryan N. Montalvo, Branden L. Nguyen, Franccesco P. Boeno, Michael D. Sunshine, Victoria E. Bindi, David D. Fuller, Ashley J. Smuder
Summary: DOX chemotherapy can lead to cardiorespiratory dysfunction, while HBO therapy may increase muscle antioxidant expression. However, HBO therapy is not sufficient to prevent DOX-induced cardiorespiratory dysfunction.
Review
Biochemistry & Molecular Biology
Samantha Schimmel, Bassel El Sayed, Gavin Lockard, Jonah Gordon, Isabella Young, Francesco D'Egidio, Jea Young Lee, Thomas Rodriguez, Cesar V. Borlongan
Summary: Traumatic brain injury (TBI) can lead to altered brain functions and is a major public health concern. Hyperbaric oxygen therapy (HBOT) has shown promising therapeutic potential in TBI by increasing brain oxygenation levels and reducing inflammation and secondary injury. However, the mechanisms underlying the effects of HBOT on TBI are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Jiuhong You, Xinxin Chen, Mei Zhou, Hui Ma, Qiaoling Liu, Cheng Huang
Summary: Acute high-altitude diseases, including AMS, HACE, and HAPE, are potentially lethal for altitude climbers. HBO preconditioning has been proposed as a safe and effective preventive method for these diseases. The mechanisms of HBO preconditioning may involve protection of the blood-brain barrier, inhibition of inflammatory responses, induction of hypoxia-inducible factor, and increase in antioxidant activity. However, the optimal protocol needs further exploration and more large-scale studies are needed.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Morgan Caplan, Thibault Duburcq, Anne-Sophie Moreau, Julien Poissy, Saad Nseir, Erika Parmentier-Decrucq
Summary: This study aimed to assess the relationship between hyperbaric oxygen therapy (HBOT) and ventilator-acquired pneumonia (VAP). It was found that factors such as immunosuppression, duration of mechanical ventilation, length of stay, reintubation, intra-hospital transport, and use of paralytic agents were significantly associated with the occurrence of VAP, while HBOT was not identified as an additional risk factor for VAP within the studied group. Further research is needed to fully understand the impact of HBOT on VAP and physiological microbiome.
Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jingshu Tang, Yuying Kang, Longjian Huang, Xinhong Feng, Lei Wu, Ying Peng
Summary: The study revealed that Hemocoagulase Agkistrodon (HCA) has neuroprotective effects in experimental traumatic brain injury (TBI), improving neurological deficits, reducing brain edema and hemorrhage, lowering proinflammatory cytokines while increasing anti-inflammatory cytokine levels, and diminishing BBB disruption by regulating tight junction proteins. These findings suggest the therapeutic potential of HCA in acute TBI to mitigate neuropathological damage.
BRAIN RESEARCH BULLETIN
(2021)
Article
Clinical Neurology
Qiqi Huo, Wenshuo Dong, Yu Gao, Yi Zhang, Xuehua Liu, Lu Yang, Ding Nan, Jing Yang
Summary: This study found that blood and urinary concentrations of beta 2-microglobulin were significantly increased in patients with brain injury. The concentrations of beta 2-microglobulin were correlated with the degree of consciousness and cognitive function. These findings suggest that the changes in beta 2-microglobulin may serve as clinical monitoring indices for evaluating the disturbance of consciousness and cognitive degree in patients, and provide a basis for early prognosis assessment.
Article
Clinical Neurology
Fang Liang, Nan Kang, Pinpin Li, Xuehua Liu, Ge Li, Jing Yang
Summary: This study investigated the effect of HBOT on promoting the shift of M1 towards M2 phenotype after TBI, showing an increase in M2 biomarkers expression and decrease in M1 biomarkers expression in the early stage post-TBI.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell Biology
Manuela Zinni, Julien Pansiot, Pierre-Louis Leger, Marina El Kamouh, Olivier Baud
Summary: Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are common brain injuries with a complex pathogenesis involving alterations of the cerebrovascular system, cell death, and inflammation. Preclinical data suggest that sildenafil may have a neuroprotective effect on both adult and neonatal brain injuries.
Article
Integrative & Complementary Medicine
Jeetprakash Barot, Bhagawati Saxena
Summary: The study demonstrates the neuroprotective effects of eugenol in a rat model of TBI, improving impaired locomotor function and short-term memory caused by trauma. Pretreatment with eugenol also alleviates histopathological, neurochemical, and behavioral consequences of the injury.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Medicine, General & Internal
Zhiguo Liu, Xirui Wang, Zhiyou Wu, Gangfeng Yin, Haibin Chu, Pengyue Zhao
Summary: This study compares the cognitive outcomes of normobaric hyperoxia (NBH) and hyperbaric oxygen therapy (HBOT) in mild traumatic brain injury (TBI) patients. It found that both NBH and HBOT can improve cognitive outcome and reduce brain injury, with HBOT showing better results.
Article
Health Care Sciences & Services
Hung-Chen Wang, Pei-Ming Wang, Yu-Tsai Lin, Nai-Wen Tsai, Yun-Ru Lai, Chia-Te Kung, Chih-Min Su, Cheng-Hsien Lu
Summary: The study showed that HBOT can improve the serum oxidative stress in TBI patients, with markers potentially becoming part of clinical evaluation and treatment. Further large-scale studies may be needed to confirm these findings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
P. Brancaccio, S. Anzilotti, O. Cuomo, A. Vinciguerra, M. Campanile, A. Herchuelz, S. Amoroso, L. Annunziato, G. Pignataro
Summary: Researchers are studying endogenous neuroprotective strategies to identify alternative interventions for neonatal hypoxic-ischemic encephalopathy. They found that hypoxic preconditioning can promote neurogenesis and provide neuroprotection by regulating ionic homeostasis.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Katarzyna Stepien, Robert P. Ostrowski, Ewa Matyja
Article
Clinical Neurology
Adnan I. Qureshi, Muhammad A. Saleem, Vikram Jadhav, Shawn S. Wallery, Faisal Raja
JOURNAL OF NEUROIMAGING
(2018)
Article
Oncology
Emanuela Pucko, Ewa Matyja, Miroslawa Koronkiewicz, Robert P. Ostrowski, Zygmunt Kazimierczuk
ANTICANCER RESEARCH
(2018)
Article
Neurosciences
Robert P. Ostrowski, John H. Zhang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Editorial Material
Clinical Neurology
Tao Wang, Jichang Luo, Xue Wang, Kun Yang, Vikram Jadhav, Peng Gao, Yan Ma, Na Zhao, Liqun Jiao
Review
Nanoscience & Nanotechnology
Vikram Jadhav, Arun Bhagare, Ismat H. Ali, Akshay Dhayagude, Dnyaneshwar Lokhande, Jayraj Aher, Mohammed Jameel, Mycal Dutta
Summary: Biosynthesis of nanomaterials, as an environmentally friendly method, has many advantages and serves as a bridge for interdisciplinary research. Using extracts from the Moringa oleifera plant, metal and metal oxide nanomaterials can be synthesized with potential applications.
JOURNAL OF NANOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Robert P. Ostrowski, Emanuela B. Pucko
Summary: Studies have shown that glioma cells rely on intermediate levels of reactive oxygen and nitrogen species for growth and invasion, but utilizing oxidative and nitrosative stress for therapeutic effects remains a challenging area of research. Selective induction of oxidative/nitrosative stress in glioma cells is a therapeutic challenge that requires further investigation.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Vikram Jadhav, Arun Bhagare, Shadma Wahab, Dnyaneshwar Lokhande, Chandraprabha Vaidya, Akshay Dhayagude, Mohammad Khalid, Jayraj Aher, Amine Mezni, Mycal Dutta
Summary: Calcium oxide nanoparticles (CaO NPs) have unique catalytic and biological properties, making them highly applicable in material science, environmental science, and medicinal science. Using a biological method to synthesize CaO NPs can reduce the use of hazardous chemicals and be cost-effective and ecologically profitable. This study investigated the production of CaO NPs using Moringa oleifera plant leaves aqueous extract and demonstrated their antimicrobial activities.
JOURNAL OF NANOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Payal Walunj, Arpita Roy, Vikram Jadhav, Pragati Athare, Akshay Dhaygude, Jayraj Aher, Jari S. S. Algethami, Dnyaneshwar Lokhande, Mohammed S. S. Alqahtani, Arun Bhagare, Saad Alghamdi, Lienda Bashier Eltayeb, Issa Saad Al-Moraya, Krishna Kumar Yadav, Yongtae Ahn, Byong-Hun Jeon
Summary: This study investigates the applications of zinc oxide nanoparticles in medicinal and photocatalytic degradation of dyes. Polyol-mediated ZnO NPs were successfully synthesized using the non-aqueous-based reflux method and characterized using various techniques. The results reveal that these nanoparticles have good crystallinity and exhibit photocatalytic and antimicrobial properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Yogeshwar Baste, Vikram Jadhav, Arpita Roy, Saad Alghamdi, Mohamed Abbas, Jari S. Algethami, Mazen Almehmadi, Mamdouh Allahyani, Devvret Verma, Krishna Kumar Yadav, Byong-Hun Jeon, Hyun-Kyung Park
Summary: The synthesis of silver-incorporated copper oxide nanomaterials (Ag@CuO NMs) using a polyol-mediated refluxing method is discussed in this study. The photocatalytic activity of these nanomaterials, specifically their ability to degrade methylene blue (MB) dye, is investigated. Results show that the NMs with 5% weight of silver exhibited the highest degradation activity against MB dye, indicating their potential for wastewater purification.
Letter
Anesthesiology
Adnan I. Qureshi, Asad Ahrar, Vikram Jadhav, Shawn S. Wallery
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2018)
Meeting Abstract
Clinical Neurology
P. Gao, Q. Yang, Y. Wang, Y. Chen, Y. Ma, V. Jadhav, L. Jiao
CEREBROVASCULAR DISEASES
(2017)
Article
Medicine, General & Internal
Robert P. Ostrowski, Katarzyna Stepien, Emanuela Pucko, Ewa Matyja
ARCHIVES OF MEDICAL SCIENCE
(2017)
Meeting Abstract
Clinical Neurology
Sushrut Dharmadhikari, Vikram Jadhav, Abhishek Fnu, Andrew Xavier
Review
Medicine, Research & Experimental
Robert P. Ostrowski, Katarzyna Stepien, Emanuela Pucko, Ewa Matyja
MEDICAL GAS RESEARCH
(2016)