Article
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: This article provides an overview of platelet research advancements and their importance in human health and disease. It summarizes the structural and functional characteristics of platelets and focuses on platelet activation processes. Additionally, it discusses potential molecular mechanisms involving inflammation, endothelial dysfunction, and miRs. The article also presents available antiplatelet agents and drugs currently under investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Shahnam Sharif, Y. Van der Graaf, M. J. Cramer, L. J. Kapelle, G. J. de Borst, Frank L. J. Visseren, Jan Westerink
Summary: In high-risk type 2 diabetes patients, low-grade inflammation measured by hs-CRP is independently associated with vascular and all-cause mortality, but not with cardiovascular events. Chronic low-grade inflammation may be a potential target for reducing residual cardiovascular risk in type 2 diabetes patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Madeline B. Zipperer, James R. Churilla, Jessica N. Stapleton, Michael R. Richardson
Summary: This study examines the combined effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults. The findings show that low cognitive function is associated with an increased risk of all-cause mortality, regardless of CRP concentration. However, the joint effect of cognitive function and CRP on mortality risk differs between males and females.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Immunology
Michael Drozd, Mar Pujades-Rodriguez, Ann W. Morgan, Patrick J. Lillie, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Summary: Systemic inflammation assessed using C-reactive protein is common in many chronic diseases and is associated with increased long-term risk of fatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Yuting Pu, Shuangyang Li, Lingxue Wang, Bangjiang Fang, Xue Bai
Summary: The study found that serum high-sensitivity C-reactive protein is associated with the severity of neurological deficits and prognosis in patients with acute cerebral infarction, serving as an independent predictor of poor prognosis and an efficient index to discriminate certain subtypes of ACI patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Medicine, General & Internal
Ronnie Meilik, Hadas Ben-Assayag, Ahuva Meilik, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Ilana Goldiner, Shani Shenhar-Tsarfaty, Asaf Wasserman
Summary: This study found a clear association between CRP concentration at admission and 7-day mortality, with higher CRP levels indicating higher mortality rates. Additionally, CRP values obtained 24 hours after hospital admission improved diagnostic accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zhiyong Qi, Liang Hu, Jianjun Zhang, Wenlong Yang, Xin Liu, Daile Jia, Zhifeng Yao, Lin Chang, Guanxing Pan, Haoxuan Zhong, Xinping Luo, Kang Yao, Aijun Sun, Juying Qian, Zhongren Ding, Junbo Ge
Summary: PCSK9 in plasma directly enhances platelet activation and in vivo thrombosis by binding to platelet CD36 and activating downstream signaling pathways. PCSK9 inhibitors or aspirin can abolish the enhancing effects of PCSK9.
Article
Medicine, Research & Experimental
Patrizia Amadio, Benedetta Porro, Viviana Cavalca, Silvia Stella Barbieri, Sonia Eligini, Susanna Fiorelli, Alessandro Di Minno, Alessandra Gorini, Mattia Giuliani, Jose Pablo Werba, Nicola Cosentino, Paolo Olivares, Simone Barbieri, Fabrizio Veglia, Elena Tremoli, Daniela Trabattoni
Summary: This study revealed that TTS women still exhibit endothelial dysfunction even at long-term follow-up, and despite ASA treatment, they showed higher residual thromboxane formation and platelet activation levels. These findings raise questions about the use of low dose ASA in this clinical setting.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Olaitan Akinboboye, Joni S. Williams, Emma Garacci, Leonard E. Egede
Summary: This study evaluated the association between CRP levels and mortality in adults with diabetes, finding higher risk of mortality for those with very high CRP levels, smoking history, insulin use, and comorbidities like cancer or hepatitis infection. However, taking Metformin was associated with a lower risk of mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Multidisciplinary Sciences
Simcha R. Meisel, Hamuda Nashed, Randa Natour, Rami Abu Fanne, Majdi Saada, Naama Amsalem, Carmel Levin, Ofer Kobo, Aaron Frimerman, Yaniv Levi, Jameel Mohsen, Avraham Shotan, Ariel Roguin, Michael Kleiner-Shochat
Summary: The study aimed to differentiate between myopericarditis and AMI by evaluating the CRP/troponin ratio on admission, showing that myopericarditis patients had significantly higher CRP/troponin ratios compared to AMI patients.
Review
Biochemistry & Molecular Biology
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour
Summary: Diabetes mellitus is a complex metabolic disease affecting one-third of the United States population, characterized by hyperglycemia. For patients with Type 1 diabetes, C-peptide may have potential therapeutic effects on various complications.
Article
Multidisciplinary Sciences
Joonghee Kim, Sang Jun Park, Sangbum Choi, Won-woo Seo, Yeon Joo Lee
Summary: This study found that the long-term risk of pneumonia significantly increases after a new acute coronary syndrome (ACS) event. It is important to consider this when planning post-discharge care and preventive vaccination strategies for patients with ACS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Eunyoung Emily Lee, Kyoung-Ho Song, Woochang Hwang, Sin Young Ham, Hyeonju Jeong, Jeong-Han Kim, Hong Sang Oh, Yu Min Kang, Eun Bong Lee, Nam Joong Kim, Bum Sik Chin, Jin Kyun Park
Summary: The study identified three distinct patterns of inflammatory immune response to COVID-19, with hyper-inflammatory immune responses associated with severe disease and worse outcomes. Targeting the hyper-inflammatory response may improve the clinical outcome of COVID-19.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Ylenia Pastorello, Roxana O. Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevin
Summary: Circulating C-reactive protein (pCRP) concentrations significantly increase during acute and chronic infection and disease, playing a role in complement fixation. It is now known that pCRP dissociates into the monomeric form (mCRP) when exposed to activated immune cells or damaged tissue, becoming biologically active. Studies have shown that mCRP is distributed within the brain tissue of individuals with neuroinflammatory disease and has been linked to neurovascular dysfunction, blood brain barrier compromise, and increased risk of dementia. Future therapeutic options aim to inhibit pCRP-LPC mediated dissociation and prevent associated damage.
Article
Physiology
Jiaofeng Huang, Mingfang Wang, Yinlian Wu, Rahul Kumar, Su Lin
Summary: This study confirms that hs-CRP is an independent predictive factor of poor prognosis in patients with MAFLD, with hs-CRP level greater than 0.5 mg/dl being associated with increased risk of all-cause mortality, cardiovascular mortality, and malignant neoplasms related mortality.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Health Care Sciences & Services
Jessamy Bagenal, Kapil Sahnan, Saran Shantikumar
JOURNAL OF PATIENT SAFETY
(2016)
Article
Health Care Sciences & Services
Rhona Johnston, Olalekan Uthman, Ewen Cummins, Christine Clar, Pamela Royle, Jill Colquitt, Bee Kang Tan, Andrew Clegg, Saran Shantikumar, Rachel Court, J. Paul O'Hare, David McGrane, Tim Holt, Norman Waugh
HEALTH TECHNOLOGY ASSESSMENT
(2017)
Article
Biotechnology & Applied Microbiology
Cristina Beltrami, Marie Besnier, Saran Shantikumar, Andrew I. U. Shearn, Cha Rajakaruna, Abas Laftah, Fausto Sessa, Gaia Spinetti, Enrico Petretto, Gianni D. Angelini, Costanza Emanueli
Review
Multidisciplinary Sciences
Rupert W. Major, Mark R. I. Cheng, Robert A. Grant, Saran Shantikumar, Gang Xu, Issaam Oozeerally, Nigel J. Brunskill, Laura J. Gray
Article
Medicine, Research & Experimental
Marie Besnier, Saran Shantikumar, Maryam Anwar, Parul Dixit, Aranzazu Chamorro-Jorganes, Walid Sweaad, Graciela Sala-Newby, Paolo Madeddu, Anita C. Thomas, Lynsey Howard, Sobia Mushtaq, Enrico Petretto, Andrea Caporali, Costanza Emanueli
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Clinical Neurology
Kate Hill, Allan House, Peter Knapp, Carrie Wardhaugh, John Bamford, Andy Vail
Meeting Abstract
Primary Health Care
Stephanie Soyombo, Harpal Aujla, Rhian Stanbrook, David Capewell, Mary Shantikumar, Daniel Todkill, Saran Shantikumar
BRITISH JOURNAL OF GENERAL PRACTICE
(2019)
Article
Environmental Sciences
Pietro Ferrara, Saran Shantikumar, Vitor Cabral Verissimo, Rafael Ruiz-Montero, Cristina Masuet-Aumatell, Josep Maria Ramon-Torrell, Karen Buckley, Vitor Hugo Cabral Verissimo, Daniela Costa, Viola Del Prete, Pietro Ferrara, Damir Ivankovic, Vasco Ricoca Freire Duarte Peixoto, Paula Peremiquel-Trillas, Mariana Perez Duque, Rafael Ruiz-Montero, Saran Shantikumar, Robin Thomas, Dorja Vocanec
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Primary Health Care
Hannah Reichel, Rhian Stanbrook, Hans Johnson, William Proto, Mary Shantikumar, Pooja Bakhshi, Sarah Hillman, Dan Todkill, Saran Shantikumar
Summary: The study investigated the impact of NHS England guidance on primary care prescriptions of simple analgesia, finding a 4.4% reduction in prescribing rates following publication. There was also a correlation between higher practice-level prescribing rates and more deprived areas.
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Medicine, General & Internal
Jessica Mooney, Roger Yau, Haseeb Moiz, Farah Kidy, Andrew Evans, Sarah Hillman, Dan Todkill, Saran Shantikumar
Summary: This study investigated the correlation between socioeconomic deprivation and the rate of prescribing of individual pharmaceutical drugs and drug classes in primary care in England. The results revealed novel associations between prescribing and deprivation, with some drugs showing higher prescribing rates in more deprived areas and others in more affluent areas. Further research is needed to identify the underlying reasons for these associations and develop appropriate interventions to address healthcare inequality.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Joao Brainer Clares de Andrade, Jay P. Mohr, Felipe Brito Timbo, Camila Rodrigues Nepomuceno, Joao Vitor da Silva Moreira, Isabelle da Costa Goes Timbo, Fabricio Oliveira Lima, Gisele Sampaio Silva, John Bamford
Summary: The study described the development and validation of a computer-based algorithm based on OCSP classification, showing that the algorithm significantly improved the accuracy and score rates of correct classification by neurology residents through a randomized trial.
EUROPEAN STROKE JOURNAL
(2021)
Article
Medicine, General & Internal
Matthew J. Tanti, Melissa J. Maguire, Daniel J. Warren, John Bamford
Summary: AMACR deficiency is a rare peroxisomal disorder that causes pristanic acid accumulation. We presented a case of a female patient in her seventies who experienced dysphasia, headache, and sensory disturbance, along with unusual brain changes seen on MRI. After eight years, she developed a febrile encephalopathy with hemispheric dysfunction, focal convulsive seizures, and coma. Whole genome sequencing finally revealed the diagnosis of AMACR deficiency, with highly elevated pristanic acid levels.
Article
Clinical Neurology
Joanna M. Wardlaw, Lisa J. Woodhouse, Iris I. Mhlanga, Katherine Oatey, Anna K. Heye, John Bamford, Vera Cvoro, Fergus N. Doubal, Timothy England, Ahamad Hassan, Alan Montgomery, John T. O'Brien, Christine Roffe, Nikola Sprigg, David J. Werring, Philip M. Bath
Summary: The study tested the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke. The results showed that ISMN and cilostazol reduced recurrent stroke, dependence, and cognitive impairment, and improved quality of life, with no safety concerns. These agents could prevent other adverse outcomes in cerebral small vessel disease (cSVD) and should be tested in large phase 3 trials.
Article
Clinical Neurology
R. Al-Shahi Salman, C. Keerie, J. Stephen, S. Lewis, M. S. Dennis, D. E. Newby, J. M. Wardlaw, G. Y. H. Lip, P. M. White, C. Baigent, D. Lasserson, C. Oliver, A. Party-Jones, F. O'Mahony, S. Amoils, J. Bamford, J. Armitage, J. Emberson, G. Lowe, G. Rinkel, K. Innes, K. Adamczuk, L. Dinsmore, J. Dreyer, G. Milne, A. Walker, A. Hutchison, C. Williams, R. Fraser, R. Anderson, K. Covil, K. Stewart, J. Rees, J. Norrie, P. Hall, A. Bullen, A. Stoddart, T. J. Moullaali, J. Palmer, L. Dinsrnore, E. Sakka, J. Perthen
Summary: The study aimed to investigate whether survivors of intracranial hemorrhage with atrial fibrillation should start oral anticoagulation, and the results showed that starting oral anticoagulation was not superior to avoiding it. There were more serious adverse events during the trial, raising questions about the benefits of oral anticoagulation for this patient population.
Article
Public, Environmental & Occupational Health
Alex Bhattacharya, Saran Shantikumar, Damon Beaufoy, Adrian Allman, Deborah Fenelon, Karen Reynolds, Andrea Normington, Musarrat Afza, Dan Todkill
EPIDEMIOLOGY AND INFECTION
(2020)