Article
Chemistry, Multidisciplinary
Guanghao Wu, Zhenya Liu, Changwen Mu, Da Song, Jiaxin Wang, Xiangxi Meng, Ziyuan Li, Hong Qing, Yuping Dong, Hai-Yan Xie, Dai-Wen Pang
Summary: Hybrid cells that fused MSCs with platelets and loaded with LPA-QDs were fabricated for efficient ICH therapy. These cells not only inherited the capabilities of both platelets and MSCs but also exhibited enhanced proliferation. The treatment process can be tracked by near-infrared II fluorescence imaging.
Review
Biochemistry & Molecular Biology
Eva Giralt-Steinhauer, Joan Jimenez-Balado, Isabel Fernandez-Perez, Lucia Rey Alvarez, Ana Rodriguez-Campello, Angel Ois, Elisa Cuadrado-Godia, Jordi Jimenez-Conde, Jaume Roquer
Summary: This review summarizes the advances in genetics and epigenetics of intracerebral hemorrhage (ICH), shedding light on the understanding of ICH pathophysiology and the potential for developing therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Biochemistry & Molecular Biology
Ekaterina Vasilevskaya, Aleksandr Makarenko, Galina Tolmacheva, Irina Chernukha, Anastasiya Kibitkina, Liliya Fedulova
Summary: The study conducted a comprehensive short-term study on the development of cerebrovascular disorders in rats with an intracerebral hematoma model. The overall lethality of the model was 43.7% and it reflects the main diagnostic criteria for acute disorders of cerebral circulation.
Article
Clinical Neurology
Felix Lehmann, Lorena M. Schenk, Joshua D. Bernstock, Christian Bode, Valeri Borger, Florian A. Gessler, Erdem Gueresir, Motaz Hamed, Anna-Laura Potthoff, Christian Putensen, Matthias Schneider, Julian Zimmermann, Hartmut Vatter, Patrick Schuss, Alexis Hadjiathanasiou
Summary: The study revealed that the ratio of red blood cell distribution width to platelet count (RPR) may serve as an independent inflammatory marker for prognostic assessment in deep-seated intracerebral hemorrhage (ICH), and is associated with 90-day mortality.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi
Summary: The study validates revised definitions of hematoma expansion incorporating intraventricular hemorrhage expansion for predicting poor outcome, outperforming conventional definitions even after accounting for care limitations.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Biochemistry & Molecular Biology
Dominic Robles, De-Huang Guo, Noah Watson, Diana Asante, Sangeetha Sukumari-Ramesh
Summary: Stroke is a common disease that often leads to brain injury and mortality, with intracerebral hemorrhage (ICH) being the most severe subtype. However, the effect of aging on ICH pathophysiology is not well studied, and there is no effective treatment for ICH. Recent studies have shown that circulating microRNAs can be potential diagnostic and prognostic biomarkers in various conditions, but their functions in ICH are not well understood. This study aims to identify potential blood biomarkers for acute ICH in the elderly by analyzing dysregulated microRNAs in aged mice.
Article
Biochemistry & Molecular Biology
Minshu Li, Xiuping Li, Dan Wang, Xiaolin Gao, Shiyao Li, Xiaojing Cheng, Yiming Shen, Shenghui Li, Qiang Jia, Qiang Liu
Summary: Inhibition of exosome release exacerbates neuroinflammation and ICH injury by increasing leukocyte infiltration into the brain and barrier disruption. However, exosomes extracted from the ICH brain can reduce ICH injury in recipient mice, showing potential neuroprotective effects. Further investigation into the impact of exosomes released from the ICH brain on the immune system is warranted.
Article
Pharmacology & Pharmacy
Lining Duan, Ying Zhang, Yuna Yang, Shiyu Su, Ligui Zhou, Po-Chieh Lo, Jiaying Cai, Yiqi Qiao, Min Li, Shuiqing Huang, Hong Wang, Yousheng Mo, Qi Wang
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability rates, where ferroptosis plays a dominant role in its pathogenesis. Baicalin, a main active ingredient of Chinese herbal medicine, exhibits neuroprotective effects against ICH-induced brain injury by inhibiting ferroptosis and shows potential as a therapeutic drug for ICH treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Laurent Puy, Adrian R. R. Parry-Jones, Else Charlotte Sandset, Dar Dowlatshahi, Wendy Ziai, Charlotte Cordonnier
Summary: Intracerebral haemorrhage (ICH) is a serious condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. It is a major cause of stroke-related mortality and dependency, with limited treatment options available. This Primer provides a comprehensive overview of the epidemiology, pathophysiology, diagnosis, and treatment of ICH, highlighting the importance of prevention and management of haematoma expansion and long-term vascular risk.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Clinical Neurology
Maximilian Spruegel, Joji B. Kuramatsu, Stefan T. Gerner, Jochen A. Sembill, Dominik Madzar, Caroline Reindl, Tobias Bobinger, Tamara Mueller, Philip Hoelter, Hannes Luecking, Tobias Engelhorn, Hagen B. Huttner
Summary: This study examined the impact of age on bleeding characteristics and clinical outcomes in different types of intracerebral hemorrhage. Results showed that elderly patients had worse functional outcomes at three months, with oral anticoagulant patients having larger baseline hemorrhage volumes and hematoma enlargement compared to non-OAC patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Jatinder S. Minhas, Tom J. Moullaali, Gabriel J. E. Rinkel, Craig S. Anderson
Summary: Blood pressure is an important factor in managing intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage. However, there are controversies surrounding the management of blood pressure for these conditions. Current research involves analyzing patient data to determine the strength and direction of blood pressure changes and provide recommendations for clinical practice and future research.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tsz-Kit Chow, Ka-Lun Chiu, Chun-Ho Chan, Wai-Han Ma
Summary: This study described the changes in cerebral glucose metabolism after acute intracranial hemorrhage, which may be helpful for future research to optimize patient care.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Jiayan Wang, Tianyou Wang, Mei Fang, Zexu Wang, Wei Xu, Bang Teng, Qijuan Yuan, Xin Hu
Summary: This review comprehensively discusses the pathology, available therapeutic drugs, and nanotechnology applied in treating intracerebral hemorrhage (ICH), aiming to provide novel and efficient strategies for ICH therapy in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Linxin Li, Santosh B. Murthy
Summary: This article reviews the cardiovascular complications after ICH, including ischemic and hemorrhagic events, and highlights potential secondary stroke and venous thrombotic prevention strategies. The article also discusses the epidemiology and risk factors associated with these complications and their impact on ICH outcomes.
