Article
Clinical Neurology
David X. Zhao, Emma Gootee, Michelle C. Johansen
Summary: The study found an association between atrial cardiopathy and the presence of cerebral microbleeds in ischemic stroke patients, but not with the number of microbleeds.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Melissa J. Visser, Joseph Yuan-Mou Yang, Fernando Calamante, Michael Kean, Christopher L. Adamson, Gagan Sharma, Vicki Anderson, Bruce C. V. Campbell, Mark T. Mackay
Summary: This study demonstrated the feasibility of rapidly assessing perfusion-diffusion mismatch in childhood AIS using automated software and identified some children with favorable mismatch profiles. The results suggest potential therapeutic benefit of RAPID use beyond the standard 4.5 hours window for thrombolysis. Further research is needed to determine the utility of perfusion-based imaging for guiding clinical decision making, whether adult thresholds need modification in childhood AIS, and the impact of time-delay and cause on mismatch characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastien Verclytte, Robin Gnanih, Stephane Verdun, Thorsten Feiweier, Bryan Clifford, Khalid Ambarki, Marta Pasquini, Juliette Ding
Summary: The study aimed to compare the performance of AI-enhanced ultrafast MRI protocol with the reference protocol in the management of AIS. The results showed that the AI-enhanced ultrafast MRI protocol allowed for effective detection and characterization of AIS and differential diagnoses in less than 2 minutes.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
XiaoQing Cheng, XiaoQin Su, JiaQian Shi, QuanHui Liu, ChangSheng Zhou, Zheng Dong, Wei Xing, HaiTao Lu, ChengWei Pan, XiuLi Li, YiZhou Yu, LongJiang Zhang, GuangMing Lu
Summary: The study compared the performance of a deep learning-based automatic software tool (eDWI-ASPECTS) with neuroradiologists' evaluation in assessing acute stroke, focusing on 10 ASPECTS regions. Overall, eDWI-ASPECTS demonstrated strong positive correlation and excellent agreement with manual raters, but discrepancies were found in certain individual ASPECTS regions, likely due to uncertain scoring rules and midline shift interference.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-Quan Xu, Yue Chu, Guang-Chen Shen, Gao Ma, Shan-Shan Lu, Sheng Liu, Hai-Bin Shi, Fei-Yun Wu
Summary: This study assessed the prognostic value of post-treatment DWI ASPECTS in predicting the clinical outcome of AIS patients after EVT, and found that both DWI ASPECTS and infarction volume were independent predictors of good clinical outcome, with high accuracy.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Peisen Zhang, Yicheng Feng, Lichong Zhu, Kunyao Xu, Qiuhong Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang Shi, Gang Chen, Zhe Shi, Meng Qin, Yi Hou, Mingyuan Gao
Summary: Ischemic stroke is a major threat to global health. Thrombolysis is the primary treatment for acute ischemic stroke, but it may cause bleeding and secondary damage. Accurately assessing collateral circulation and predicting the risk of thrombolytic hemorrhage are essential for treatment decisions and prognosis. This study reports a dual-targeted magnetic resonance imaging nanoprobe that can visualize cerebral collateral circulation and ischemic inflammation.
Article
Clinical Neurology
Hongli Fan, Pan Su, Doris Da May Lin, Emily B. Goldberg, Alexandra Walker, Richard Leigh, Argye E. Hillis, Hanzhang Lu
Summary: Magnetic resonance fingerprinting (MRF) arterial spin labeling (ASL) allows simultaneous estimation of cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T-1 map, and may provide a new approach for quantitative hemodynamic and structural imaging in ischemic stroke, aiding in the detection of hemodynamic and structural damage, as well as in predicting neurological deficits and disability in patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengping Lin, Ziyu Meng, Tianyao Wang, Rong Guo, Yibo Zhao, Yudu Li, Bin Bo, Yue Guan, Jun Liu, Hong Zhou, Xin Yu, David J. Lin, Zhi-Pei Liang, Parashkev Nachev, Yao Li
Summary: This study aimed to assess the temporal dynamics of neurometabolites and their value in predicting early vs. late hyperacute stroke. NAA and creatine were significantly lower in subacute stroke compared to acute stroke. NAA was lower in late hyperacute patients and inversely correlated with time from symptom onset. Combining NAA, creatine, and choline signals improved discrimination.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Clinical Neurology
Nadinda A. M. van der Ende, Sven P. R. Luijten, Leo Kluijtmans, Alida A. Postma, Sandra A. Cornelissen, Antonius M. G. van Hattem, Geert J. Nijeholt, Reinoud P. H. Bokkers, Lars Thomassen, Ulrike Waje-Andreassen, Nicola Logallo, Serge Bracard, Benjamin Gory, Bob Roozenbeek, Diederik W. J. Dippel, Aad van der Lugt
Summary: This study assessed the interobserver agreement on the presence and types of intracranial hemorrhage (ICH) in patients treated with reperfusion therapy using magnetic resonance imaging. The results showed that the presence of any ICH can be reliably scored on magnetic resonance imaging, and there is substantial agreement on the types of ICH according to the Heidelberg Bleeding Classification.
Article
Clinical Neurology
Bart A. A. Franx, Annette Van der Toorn, Caroline Van Heijningen, Denis Vivien, Thomas Bonnard, Rick M. Dijkhuizen
Summary: Molecular MRI can detect vascular inflammation after acute ischemic stroke, providing complementary information for treatment decision-making. In the study, it was found that VCAM-1 expression significantly increased at 6 hours post-recanalization and declined after 24 hours, but remained elevated in lesion borderzones.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin-hao Lyu, Sen-hao Zhang, Xue-yang Wang, Zhi-hua Meng, Xiao-yan Wu, Wen Chen, Guo-hua Wang, Qing-liang Niu, Xin Li, Yi-tong Bian, Dan Han, Wei-ting Guo, Shuai Yang, Meng-ting Wei, Ting-yang Zhang, Qi Duan, Cao-hui Duan, Xiang-bing Bian, Cheng-lin Tian, Xin Lou
Summary: This study aimed to investigate the prognostic value of fluid-attenuated inversion recovery vessel hyperintensity (FVH) in patients with acute ischemic stroke (AIS) receiving medical therapy. The presence of FVH, along with larger infarct volume and higher FVH grade, was found to predict poor long-term functional outcomes in patients with large vessel stenosis (LVS).
EUROPEAN RADIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yan Cheng, Airong Cheng, Yanlong Jia, Lin Yang, Yan Ning, Liang Xu, Yazhi Zhong, Zerui Zhuang, Jitian Guan, Xiaolei Zhang, Yan Lin, Teng Zhou, Xiusong Fan, Jianwu Li, Peng Liu, Gen Yan, Renhua Wu
Summary: The study developed a pH-sensitive theranostic nanoplatform for the precise delivery of rapamycin to ischemic brain tissues, enhancing therapeutic accuracy and enabling multimodal imaging for drug distribution monitoring. The nanoparticles showed good stability and biocompatibility, with the potential for neuroprotection in rats with transient middle cerebral artery occlusion (tMCAO). This pH-sensitive multifunctional nanoplatform could be a promising solution for the accurate in vivo imaging and treatment of acute ischemic stroke and other diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Clinical Neurology
Hao Wang, Yi Sun, Jie Zhu, Yuzhong Zhuang, Bin Song
Summary: The study aimed to investigate the role of DWI-based radiomics in predicting 1-year ischemic stroke recurrence. The results showed that the radiomics-based model provided better predictive performance, and the model that combined clinical and radiomic characteristics performed the best.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Robin Lemmens
Summary: With the introduction of imaging-based treatment selection beyond the traditional time window, the efficacy of acute ischemic stroke treatment has been expanded. Different mismatch concepts have been adopted in clinical practice to select patients for treatment in extended and unknown time windows.
JOURNAL OF NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Ozge Yagcioglu Yassa, Saime Fusun Domac, Gulay Kenangil
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2020)
Article
Neurosciences
Ozge Yagcioglu Yassa, Gulay Kenangil, Ayse Destina Yalcin
Summary: This study discussed a rare case of a 25-year-old male with adult-onset SSPE presenting with tonic seizures accompanying myoclonic seizures. The patient was treated with clonazepam and an isoprinosine regimen. Adult-onset SSPE with tonic seizures is rare and recognizing this type of motor seizures is crucial for patient management.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Gulay Kenangil, Mehmet Demir, Esma Tur, Fusun Domac
Summary: This study investigated the relationship between alexithymia, cognition, and depression in patients with Parkinson's disease (PD). The results showed that alexithymia is common in PD patients and is associated with cognitive impairment and depression.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Isil Ezgi Eryilmaz, Sevda Erer, Mehmet Zarifoglu, Unal Egeli, Ece Karakus, Beste Yurdacan, Gulsah Cecener, Berrin Tunca, Beril Colakoglu, Ayse Bora Tokcaer, Esen Saka, Meltem Demirkiran, Cenk Akbostanci, Okan Dogu, Hakan Kaleagasi, Gulay Kenangil, Raif Cakmur, Bulent Elibol
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Letter
Clinical Neurology
Gulay Ozgen Kenangil, Buse Cagla Ari, Cagan Guler, Mustafa Kemal Demir
ACTA NEUROLOGICA BELGICA
(2021)
Correction
Clinical Neurology
Gulay Ozgen Kenangil, Buse Cagla Ari, Cagan Guler, Mustafa Kemal Demir
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Buse Cagla Ari, Esma Kobak Tur, Fusun Mayda Domac, Gulay Ozgen Kenangil
Summary: This study aimed to assess the association between lower UA concentrations and PD risk, investigate its relationship with patients' demographic and clinical data, and determine the compatibility of previous studies with the Turkish-sampled population. The study found a correlation between low UA concentrations and PD, but UA is not a strong indicator for predicting PD risk.
IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Figen Yavlal, Rahsan Inan, Gulay Kenangil
Summary: The study found that patients with OSAS had higher EDW values compared to the control group, indicating that EDW can be an important diagnostic tool for the early diagnosis of atherosclerosis risk in OSAS patients.
JOURNAL OF TURKISH SLEEP MEDICINE-TURK UYKU TIBBI DERGISI
(2022)
Article
Clinical Neurology
Eda Turk Arisoy, Fusun Mayda Domac, Sakir Gica, Mustafa Ulker, Gulay Ozgen Kenangil
Summary: This study aimed to determine the relationship between severity of obstructive sleep apnea syndrome (OSAS) and cognitive functions, and to investigate the effect of continuous positive airway pressure (CPAP) treatment on cognitive functions. The results showed that disease severity negatively affected long-term logical memory, sustained attention, and verbal fluency, and significant improvement was observed in all cognitive areas with CPAP treatment.
IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Buse Cagla Ari, Fusun Mayda Domac, Gulay Ozgen Kenangil, Nergis Imamova, Aysegul Cinar Kuskucu
Summary: This study aimed to investigate the relationship between the polymorphisms of ADORA2A gene and levodopa-induced dyskinesias (LID) in Turkish patients with Parkinson's disease (PD). The results showed that the alleles of ADORA2A gene may not be related to LID in patients with PD.
Article
Clinical Neurology
Sevda Erer, Isil Ezgi Eryilmaz, Dilara Kamer Colak, Unal Egeli, Gulsah Cecener, Berrin Tunca, Ece Karakus, Beril Colakoglu, Ayse Bora Tokcaer, Esen Saka, Meltem Demirkiran, Cenk Akbostanci, Mehmet Zarifoglu, Okan Dogu, Hakan Kaleagasi, Gulay Kenangil, Raif Cakmur, Bulent Elibol
Summary: This study evaluated the association between the functional single nucleotide polymorphism rs1611115 in the DBH gene and early-onset Parkinson's disease (EOPD) in the Turkish population, finding no significant differences in genotypic and allelic frequencies between EOPD patients and healthy controls. Further studies are needed to determine the role of dopamine metabolism-related genetic variants in EOPD susceptibility in the Turkish population.
TURKISH JOURNAL OF NEUROLOGY
(2021)
Meeting Abstract
Clinical Neurology
G. Kenangil, M. Demir, E. Kobak Tur, F. Mayda Domac
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Neurosciences
Buse Cagla Ari, Fusun Mayda Domac, Gulay Ozgen Kenangil
Meeting Abstract
Clinical Neurology
G. Kenangil, M. Demir, E. Tur, F. Domac
MOVEMENT DISORDERS
(2020)
Article
Medicine, General & Internal
Murat Gultekin, Cagri Ulukan, Sabiha Tezcan, Okan Dogu, Hasmet Hanagasi, Basar Bilgic, Ayse Bora Tokcaer, Raif Cakmur, Bulent Elibol, Meral Mirza, Dilek Ince Gunal, Cigdem Sevda Erer Ozbek, Gulay Kenangil, Ozge Yilmaz Kusbeci, Muhittin Cenk Akbostanci
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)
