Review
Clinical Neurology
Silke Walter, Daniel Phillips, Brittany Wells, Robert Moon, Thomas Bertsch, Iris Q. Grunwald, Klaus Fassbender
Summary: Despite the challenges, prehospital stroke management plays a crucial role in ensuring equal access to specialized stroke care. Gender differences exist in the detection, dispatch, and delivery of stroke patients, and addressing these differences is essential for improving stroke outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kye Won Park, Eun-Jae Lee, Jun Seong Lee, Jinhoon Jeong, Nari Choi, Sungyang Jo, Mina Jung, Ja Yeon Do, Dong-Wha Kang, June-Goo Lee, Sun Ju Chung
Summary: Machine learning-based algorithms for automated rating of Parkinson's disease symptoms show very good reliability compared to ratings by nontrained human raters, providing Class II evidence in support of their feasibility.
Article
Cardiac & Cardiovascular Systems
Kathryn M. Rexrode, Tracy E. Madsen, Amy Y. X. Yu, Cheryl Carcel, Judith H. Lichtman, Eliza C. Miller
Summary: Women bear a disproportionate burden of stroke mortality and disability. Both biological sex and sociocultural gender contribute to differences in stroke risk factors, assessment, treatment, and outcomes. This review outlines the current knowledge of the impact of sex and gender on stroke, while also identifying research gaps and areas for future inquiry.
CIRCULATION RESEARCH
(2022)
Article
Biology
Matildes F. M. Sobreiro, Luisa Terroni, Valeri Delgado Guajardo, Patricia Ferreira Mattos, Claudia da Costa Leite, Edson Amaro Jr, Gisela Tinone, Dan V. Iosifescu, Renerio Fraguas
Summary: This study investigates gender-specific characteristics in the relationship between changes in depressive symptoms and changes in cognitive performance after stroke. The results suggest that women may be more vulnerable to the relationship between depressive symptoms and cognitive performance, and improvement in depression may be necessary for women's improvement in verbal fluency from the first to the fourth month after a stroke.
Article
Clinical Neurology
Jose G. Romano, Hannah Gardener, Iszet Campo-Bustillo, Yosef Khan, Sofie Tai, Nikesha Riley, Eric E. Smith, Ralph L. Sacco, Pooja Khatri, Heather M. Alger, Brian Mac Grory, Deepak Gulati, Navdeep S. Sangha, Jeffrey M. Craig, Karin E. Olds, Curtis G. Benesch, Adam G. Kelly, Scott S. Brehaut, Amit C. Kansara, Lee H. Schwamm
Summary: The study found that most patients with mild strokes had poor outcomes in the study. The primary outcome was a 90-day modified Rankin Scale score of 0 to 1, with secondary outcomes including good outcomes in the Barthel Index, Stroke Impact Scale-16, and European Quality of Life. Factors such as age, gender, race, and baseline NIHSS score were identified as predictors of worse outcomes.
Article
Cardiac & Cardiovascular Systems
Meghan Reading Turchioe, Elsayed Z. Soliman, Parag Goyal, Alexander E. Merkler, Hooman Kamel, Mary Cushman, Orysya Soroka, Ruth Masterson Creber, Monika M. Safford
Summary: This study aimed to investigate the association between atrial fibrillation (AF) and stroke symptoms among adults without a clinical history of stroke or transient ischemic attack (TIA). The results showed that stroke symptoms in the absence of a stroke diagnosis may represent subclinical cardioembolic phenomena, implying the need for further research on stroke symptom screening.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Psychology, Developmental
Brian C. Thoma, E. J. Jardas, Sophia Choukas-Bradley, Rachel H. Salk
Summary: This study examines the relationship between aspects of gender identity and mental health symptoms in transgender adolescents (TGAs). The findings suggest that higher levels of gender transition progress and gender congruence are associated with lower mental health problems. Additionally, TGAs who identify with binary identities show lower levels of transition progress and gender congruence compared to other sub-groups.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Clinical Neurology
Xiao-Min Tan, Zi-Xuan Liao, Ying-Ying Zhao, Xiao-Cui Sun, Fa-Ling Yi
Summary: This study examined the impact of longitudinal changes in depressive symptoms in middle-aged adults before and after their first stroke, as well as the influence of different ages. The results showed that middle-aged populations have a higher risk of depressive symptoms after a first stroke compared to older populations, and there is an increased severity of depressive symptoms in the two years before and after stroke.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Chantal D. Tan, Soufiane El Ouasghiri, Ulrich von Both, Enitan D. Carrol, Marieke Emonts, Michiel van Der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K. Maconochie, Federico Martinon-Torres, Ruud G. Nijman, Marko Pokorn, Irene Rivero-Calle, Maria Tsolia, Clementien L. Vermont, Werner Zenz, Dace Zavadska, Henriette A. Moll, Joany M. Zachariasse
Summary: Sex differences in presentation and management are present in previously healthy febrile children with respiratory symptoms attending European Emergency Departments. Girls are less likely to present with certain symptoms but receive more frequent antibiotic treatment. Future research should investigate whether these differences are related to clinicians' attitudes and disease severity.
Article
Biochemistry & Molecular Biology
Arleta Drozd, Dariusz Kotlega, Krzysztof Dmytrow, Malgorzata Szczuko
Summary: The main aim of this study was to investigate the impact of cigarette smoking on selected derivatives of arachidonic acid, linoleic acid, DHA, and EPA, which may serve as markers for post-stroke inflammation. The eicosanoid profile was compared between smokers and non-smokers, both with and without gender division. The results revealed that non-smokers had higher levels of the linolenic acid derivative (LA) 9S HODE than smokers. However, when the results were further divided by gender, it was found that non-smoking women had higher levels of this derivative compared to smoking women, while no difference was observed in the group of men. Similarly, the level of the arachidonic acid metabolite LTX A4 differed only in the group of women. Moreover, a number of statistically significant correlations were identified between the analyzed groups, with smokers showing fewer correlations compared to non-smokers. This study highlights the importance of smoking cessation in reducing inflammation mediated by lipid mediators in both genders.
Article
Geriatrics & Gerontology
Yuqing Wang, Fengjuan Jiao, Huancheng Zheng, Qingsheng Kong, Ran Li, Xiaojie Zhang, Li Yan, Yanlei Hao, Yili Wu
Summary: The study found that leukocyte telomere length (LTL) is differently associated with risk factors in male and female stroke patients, with lack of exercise and LDL levels in males, and dyssomnia and diabetes in females. This suggests that gender differences should be considered when utilizing LTL as an index for stroke risk and prognosis, as well as in developing intervention strategies for stroke prevention and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Pernille Pape, Alice Herrlin Jensen, Ove Bergdal, Tina Norgaard Munch, Soren Steemann Rudolph, Lars Simon Rasmussen
Summary: This study evaluated the time to brain CT scan in patients with acute severe neurological symptoms and found that the time exceeded 30 minutes for some patients, particularly in children. The 30-day mortality rate was 21.3% for adults and 43.9% for elders, with no deaths in children within 30 days.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Done Indira Priya, Rajeswari Aghoram, Sunil K. Narayan
Summary: The study found that young stroke survivors frequently experience neuropsychiatric symptoms, with depression being the most common. Presence of multiple infarcts on imaging was associated with self-reported depression and presence of any neuropsychiatric symptom.
NEUROLOGICAL SCIENCES
(2021)
Article
Psychology, Clinical
F. Maccallum, M. Lundorff, M. Johannsen, I. Farver-Vestergaard, M. O'Connor
Summary: The study identified many similarities and few differences in terms of prolonged grief symptoms between males and females. Findings suggest that future studies should examine alternate sources of variation in grief outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Roman Koposov, Andrew Stickley, Denis Sukhodolsky, Vladislav Ruchkin
Summary: Previous research has shown that anger and aggression may be higher in adolescents with bulimia nervosa. However, little is known about the link between bulimia symptoms and anger/aggression in adolescents in the general population. This study aimed to explore this association and determine the role of gender.
Article
Rheumatology
Julia F. Simard, Marios Rossides, Elizabeth V. Arkema, Elisabet Svenungsson, Anna-Karin Wikstrom, Murray A. Mittleman, Jane E. Salmon
Summary: This study investigated the association between hypertensive disorders of pregnancy (HDPs) and cardiovascular disease risk in pregnant women, especially those with systemic lupus erythematosus (SLE). The results showed that women with SLE had a higher prevalence of HDPs, and HDPs were significantly associated with cardiovascular outcomes and incident hypertension.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yuichiro Yano, Yan Gao, Dayna A. Johnson, Mercedes Carnethon, Adolfo Correa, Murray A. Mittleman, Mario Sims, Elizabeth Mostofsky, James G. Wilson, Susan Redline
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Critical Care Medicine
Andrew J. Synn, Wenyuan Li, Gary M. Hunninghake, George R. Washko, Raul San Jose Estepar, George T. O'Connor, Cyrus A. Kholdani, Robert W. Hallowell, Alexander A. Bankier, Murray A. Mittleman, Mary B. Rice
Summary: In a community-based sample, lower pulmonary vascular volumes on CT were associated with increased odds of ILA, ILA progression, and restrictive pattern on spirometry. This suggests that more severe vascular pruning on CT may be an indicator of early pulmonary vasculopathy associated with interstitial lung disease.
Letter
Critical Care Medicine
Andrew J. Synn, Wenyuan Li, Raul San Jose Estepar, George R. Washko, George T. O'Connor, Connie W. Tsao, Murray A. Mittleman, Mary B. Rice
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Surgery
Brandon McGuinness, Akash Goel, Fadi Elias, Theodore Rapanos, Murray A. Mittleman, Karim S. Ladha
Summary: This study focused on the perioperative risks of cannabis use disorder (CUD) in vascular surgery patients, revealing that CUD patients had a higher incidence of perioperative myocardial infarction and stroke, but a lower incidence of sepsis. Further investigation in prospective cohorts is warranted to confirm these findings.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Yongmei Huang, Marianthi-Anna Kioumourtzoglou, Murray A. Mittleman, Zev Ross, Michelle A. Williams, Alexander M. Friedman, Joel Schwartz, Ronald J. Wapner, Cande Ananth
Summary: The study found that exposure to high concentrations of PM2.5 in the third trimester and to nitrogen dioxide in the first trimester is associated with an increased risk of placental abruption. Simultaneous exposure to high levels of PM2.5 and nitrogen dioxide also increases the likelihood of abruption.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Kobina K. Hagan, Wenyuan Li, Elizabeth Mostofsky, Suzanne M. Bertisch, Angeliki Vgontzas, Catherine Buettner, Murray A. Mittleman
Summary: Regular moderate to vigorous exercise at least three times per week is associated with fewer headache days per month in adults with episodic migraines, especially among those using prophylactic medications. However, exercise does not appear to affect headache intensity or duration.
Article
Clinical Neurology
Angeliki Vgontzas, Wenyuan Li, Elizabeth Mostofsky, Murray A. Mittleman, Suzanne M. Bertisch
Summary: In patients with episodic migraine, poor sleep quality was associated with a higher rate of headache recurrence over the next 6 weeks, especially among those with coexisting moderate to high stress levels.
Article
Environmental Sciences
Jessica A. Montresor-Lopez, Stephanie R. Reading, Jeffrey D. Yanosky, Murray A. Mittleman, Ronny A. Bell, Tessa L. Crume, Dana Dabelea, Lawrence Dolan, Ralph B. D'Agostino, Santica M. Marcovina, Catherine Pihoker, Kristi Reynolds, Elaine Urbina, Angela D. Liese, Lesliam Quiros-Alcala, J. Carson Smith, P. Jacob Bueno de Mesquita, Robin C. Puett
Summary: In a study investigating the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score among youth with type 1 diabetes, no consistent relationships were observed. However, associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
ENVIRONMENTAL RESEARCH
(2021)
Letter
Hematology
Matthew Moll, Rebecca L. Zon, Katelyn W. Sylvester, Jessica Rimsans, Evan C. Chen, Auyon J. Ghosh, Eric Abston, Andy Kim, Henry Rutherford, Xhoi Mitre, Aaron Hakim, Nathan T. Connell, Elisabeth Battinelli, Laura E. Fredenburgh, Rebecca M. Baron, Brian D. Hobbs, Michael H. Cho, Murray A. Mittleman, Ann E. Woolley, Jean M. Connors
THROMBOSIS RESEARCH
(2021)
Article
Environmental Sciences
Joel D. Schwartz, Ma'ayan Yitshak-Sade, Antonella Zanobetti, Qian Di, Weeberb J. Requia, Francesca Dominici, Murray A. Mittleman
Summary: This study demonstrates that the long-term exposure to PM2.5 is associated with an increased mortality rate, while the effects of O3 and NO2 are more complicated. The impact of PM2.5 is more significant among Black individuals.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Clinical Neurology
Angeliki Vgontzas, Elizabeth Mostofsky, Kobina Hagan, Michael Rueschman, Murray A. Mittleman, Suzanne M. Bertisch
Summary: The study found that napping may be an uncommonly used behavioral strategy for prolonged migraine attacks and does not contribute to nightly sleep disturbance. Future studies are needed to examine the acute analgesic effects of daytime napping in patients with migraine.
Article
Cardiac & Cardiovascular Systems
Andrew J. Synn, Constance De Margerie-Mellon, Sun Young Jeong, Farbod N. Rahaghi, Iny Jhun, George R. Washko, Raul San Jose Estepar, Alexander A. Bankier, Murray A. Mittleman, Paul A. VanderLaan, Mary B. Rice
Summary: This study found that more severe CT-based vascular pruning was associated with greater histologic arterial remodeling, suggesting that CT imaging may be a non-invasive indicator of pulmonary vascular pathology.
PULMONARY CIRCULATION
(2021)
Review
Surgery
Ali Hage, Fadi Hage, Hussein Al-Amodi, Suruchi Gupta, Stefania I. Papatheodorou, Robert Hawkins, Gorav Ailawadi, Murray A. Mittleman, Michael W. A. Chu
Summary: In elderly patients, minimally invasive mitral valve surgery was associated with lower postoperative complications, reduced blood transfusion, shorter ICU and hospital stay, but longer cross-clamp and bypass times compared to conventional sternotomy.
INNOVATIONS-TECHNOLOGY AND TECHNIQUES IN CARDIOTHORACIC AND VASCULAR SURGERY
(2021)
Article
Environmental Sciences
Andrew J. Synn, Katerina L. Byanova, Wenyuan Li, Diane R. Gold, Qian Di, Itai Kloog, Joel Schwartz, Raul San Jose Estepar, George R. Washko, George T. O'Connor, Murray A. Mittleman, Mary B. Rice
Summary: The study found that higher exposure to O-3 was associated with lower small pulmonary vessel volumes in community-dwelling adults in the northeastern United States, while 1-year EC exposure and proximity to roads were weakly correlated with small vessel volumes. PM2.5 was not significantly associated with small vascular volumes.
ENVIRONMENTAL EPIDEMIOLOGY
(2021)