Review
Neurosciences
Mohammad Uzair, Muhammad Arshad, Turki Abualait, Zeyad T. Al-Harbi, Talal M. Al-Harbi, Reem Bunyan Fahad, Abida Arshad, Woo Kyoung Yoo, Shahid Bashir
Summary: Stroke is a physiological disorder involving interruption of cerebral blood flow, leading to neuronal death and functional impairment. Rehabilitation of functional capabilities is the goal of stroke therapy. Recent studies have shown that combining d-amphetamine with rehabilitative training has beneficial effects on neuronal activation and motor function in a rodent stroke model. This review aims to examine the therapeutic effects of this combination therapy and magnetic field stimulation on stroke recovery.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Cell Biology
Andreas Rogalewski, Wolf-Ruediger Schaebitz
Summary: Stroke recovery processes involve restoration and compensation of lost or acquired functions. The translation of results from animal models to human situation is hindered by various factors, including genetic and anatomical differences, as well as differences in clinical function and behavior. The design of clinical trials also varies widely, making it difficult to compare and draw conclusions. Developing a recovery enhancing therapy for chronic stroke patients is a major unmet need in stroke research.
NEURAL REGENERATION RESEARCH
(2022)
Review
Behavioral Sciences
Kate Y. O'Malley, Carl L. Hart, Sharon Casey, Luke A. Downey
Summary: The relationship between amphetamine use and aggressive or violent behavior remains unclear. A review of laboratory data in humans suggests that acute doses of amphetamine or methamphetamine did not increase aggression according to traditional laboratory measures.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Philipp J. Koch, Chang-Hyun Park, Gabriel Girard, Elena Beanato, Philip Egger, Giorgia Giulia Evangelista, Jungsoo Lee, Maximilian J. Wessel, Takuya Morishita, Giacomo Koch, Jean-Philippe Thiran, Adrian G. Guggisberg, Charlotte Rosso, Yun-Hee Kim, Friedhelm C. Hummel
Summary: Stroke patients vary in outcomes, with some showing natural recovery proportional to initial impairment. Predicting individual recovery potential through structural connectome analysis, especially in severely impaired patients, allows for personalized neuro-rehabilitation decisions. Understanding neuronal network mechanisms underlying recovery is crucial for predicting and facilitating stroke rehabilitation.
Article
Medicine, General & Internal
Cecilia Brannmark, Sofia Klasson, Tara M. Stanne, Hans Samuelsson, Margit Alt Murphy, Katharina S. Sunnerhagen, N. David Aberg, Oscar Jalnefjord, Isabella Bjorkman-Burtscher, Katarina Jood, Turgut Tatlisumak, Christina Jern
Summary: This study aims to explore the trajectories of recovery and biomarkers after stroke by evaluating stroke patients using various methods. A total of 500 first-ever stroke patients from the stroke unit at the Sahlgrenska University Hospital in Sweden are involved in the study. The evaluation includes clinical assessments, neuroimaging, and blood sample analysis, and the study also records clinical variables that may influence recovery outcomes. The results of this study will provide novel data on stroke recovery and biomarkers.
Article
Clinical Neurology
Stephen M. Wilson, Jillian L. Entrup, Sarah M. Schneck, Caitlin F. Onuscheck, Deborah F. Levy, Maysaa Rahman, Emma Willey, Marianne Casilio, Melodie Yen, Alexandra C. Brito, Wayneho Kam, L. Taylor Davis, Michael de Riesthal, Howard S. Kirshner
Summary: Most individuals with aphasia after stroke recover to some extent in the first year, and the recovery process is partially dependent on lesion location and extent. This study aims to provide a comprehensive description of patterns of recovery from aphasia in the first year after stroke. It found that lesion location and extent, as well as different language domains, have an impact on aphasia recovery.
Article
Biology
George A. Mashour, Ben J. A. Palanca, Mathias Basner, Duan Li, Wei Wang, Stefanie Blain-Moraes, Nan Lin, Kaitlyn Maier, Maxwell Muench, Vijay Tarnal, Giancarlo Vanini, E. Andrew Ochroch, Rosemary Hogg, Marlon Schwartz, Hannah Maybrier, Randall Hardie, Ellen Janke, Goodarz Golmirzaie, Paul Picton, Andrew R. McKinstry-Wu, Michael S. Avidan, Max B. Kelz
Summary: Studying the recovery process of consciousness from unconsciousness in healthy individuals undergoing anesthesia showed that cognitive functions recover over time, with executive function returning first, contrary to initial hypotheses. Early involvement of the prefrontal cortex in recovery is consistent with the global neuronal workspace theory.
Article
Clinical Neurology
James D. Stefaniak, Fatemeh Geranmayeh, Matthew A. Lambon Ralph
Summary: The recovery of language abilities in aphasia patients is heterogeneous and multidimensional, with different components of language showing distinct recovery trajectories. These components rely on different neural regions, suggesting that treatment strategies should be personalized based on individual language profiles to be effective.
Article
Multidisciplinary Sciences
Cecilia Nunez, Jennifer K. Hoots, Scott T. Schepers, Michael Bower, Harriet de Wit, Margaret C. Wardle
Summary: Many mental health disorders are characterized by impaired ability to exert effort for rewards, with dopamine implicated in this process. However, the effects of other neurotransmitter systems like opioids and acetylcholine have received less attention. Two separate studies tested the acute effects of naltrexone and nicotine on effort-based decision-making in healthy adults, but neither drug affected willingness to exert effort for monetary rewards. Although the drugs had significant effects on mood and behavior, they did not alter effort-based decision-making.
Article
Clinical Neurology
Meiling Huang, Shaohang Xu, Mingchao Zhou, Jiao Luo, Fubing Zha, Linlin Shan, Qingqing Yang, Baojin Zhou, Yulong Wang
Summary: This study conducted lipidomic analyses on plasma metabolic features in stroke patients and healthy individuals, identifying potential lipid markers related to long-term functional recovery in stroke patients. The results suggest that lysophosphatidylcholines (LPC) may play a positive role in patient rehabilitation through an anti-inflammatory mechanism. Appropriate management or intervention for lipid levels is expected to lead to better clinical outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Melissa D. Stockbridge, Zafer Keser, Lisa D. Bunker, Argye E. Hillis
Summary: This study retrospectively examined the impact of cholinergic, GABAergic, and dopaminergic medications on language recovery after stroke. The results suggest that these medications do not significantly impede post-stroke language recovery.
Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Mark Etherton, Kathleen Donahue, Carissa Tuozzo, Marco Nardin, Anne-Katrin Giese, Ona Wu, Vince D. Calhoun, Christian Grefkes, Natalia S. Rost
Summary: This study aimed to explore the whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation to stroke severity. The research identified differences in dynamic connectivity configurations between patients with different levels of stroke severity and highlighted the importance of dynamic connectivity involving default mode network components for recovery in the first 3 months poststroke.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
James F. Cavanagh, Sarah L. Olguin, Jo A. Talledo, Juliana E. Kotz, Benjamin Z. Roberts, John A. Nungaray, Joyce Sprock, David Gregg, Savita G. Bhakta, Gregory A. Light, Neal R. Swerdlow, Jared W. Young, Jonathan L. Brigman
Summary: The development of pro-cognitive therapeutics for psychiatric disorders has been hindered by translational failures. This study identifies a cross-species translational marker of reward processing and explores the impact of d-amphetamine on this marker in humans and mice. The findings suggest the role of dopamine in reward sensitivity and provide a pharmacologically valid biomarker for future research.
PSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Daniel S. Marin-Medina, Paula A. Arenas-Vargas, Juan C. Arias-Botero, Manuela Gomez-Vasquez, Manuel F. Jaramillo-Lopez, Jorge M. Gaspar-Toro
Summary: After a stroke, neural plasticity mechanisms can be activated for significant recovery. Rehabilitation therapies aim to restore tissue and reorganize neural connections. New technologies such as brain-computer interfaces, robot-assisted and virtual reality therapies, brain stimulation, and cell therapies have emerged as promising options for better functional outcomes.
NEUROLOGICAL SCIENCES
(2023)
Article
Biology
Jeff Goldsmith, Tomoko Kitago, Angel Garcia de la Garza, Robinson Kundert, Andreas Luft, Cathy Stinear, Winston D. Byblow, Gert Kwakkel, John W. Krakauer
Summary: The proportional recovery rule (PRR) is a statistically relevant model for stroke recovery. This article describes methods for assessing associations between baseline and changes, and provides support for the PRR compared to alternative models.
Editorial Material
Medicine, General & Internal
Larry B. Goldstein
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Review
Clinical Neurology
Narayanaswamy Venketasubramanian, Craig Anderson, Hakan Ay, Selma Aybek, Waleed Brinjikji, Gabriel R. de Freitas, Oscar H. Del Brutto, Klaus Fassbender, Miki Fujimura, Larry B. Goldstein, Roman L. Haberl, Graeme J. Hankey, Wolf-Dieter Heiss, Isabel Lestro Henriques, Carlos S. Kase, Jong S. Kim, Masatoshi Koga, Yoshihiro Kokubo, Satoshi Kuroda, Kiwon Lee, Tsong-Hai Lee, David S. Liebeskind, Gregory Y. H. Lip, Stephen Meairs, Roman Medvedev, Man Mohan Mehndiratta, Jay P. Mohr, Masao Nagayama, Leonardo Pantoni, Panagiotis Papanagiotou, Guillermo Parrilla, Daniele Pastori, Sarah T. Pendlebury, Luther Creed Pettigrew, Pushpendra N. Renjen, Tatjana Rundek, Ulf Schminke, Yukito Shinohara, Wai Kwong Tang, Kazunori Toyoda, Katja E. Wartenberg, Mohammad Wasay, Michael G. Hennerici
Summary: The COVID-19 pandemic has posed challenges for stroke management, with clinicians facing various etiologies for stroke compounded by unique complications associated with the virus. Strict infection control measures and continuous medical care are essential throughout the patient care journey.
CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Greg A. Jicha, Erin L. Abner, Steven E. Arnold, Maria C. Carrillo, Hiroko H. Dodge, Steven D. Edland, Keith N. Fargo, Howard H. Feldman, Larry B. Goldstein, James Hendrix, Ruth Peters, Julie M. Robillard, Lon S. Schneider, Jodi R. Titiner, Christopher J. Weber
Summary: Consensus guidance has been developed for the development and conduct of high-quality Alzheimer's disease clinical trials, covering aspects such as scientific justification, trial registration, conflict of interest disclosure, and defined trial population. This guidance aims to assist in protocol development and may also support the education of potential trial participants and the public on appropriate clinical trial participation decisions.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Letter
Clinical Neurology
Zhu Cenjing, Phoebe M. Tran, Rachel P. Dreyer, Larry B. Goldstein, Judith H. Lichtman
Article
Neurosciences
Dana L. Ionel, Fred O. Odago, Andre N. Ene, Jessica D. Lee, William N. O'Connor, Larry B. Goldstein, L. Creed Pettigrew
Summary: In this case report, we describe a patient with Williams-Beuren syndrome who experienced sudden neurological deterioration following a cardiac ablative procedure. Williams-Beuren syndrome is a rare genetic disorder with distinctive clinical features. Chromosomal microdeletion leads to various neurological and cardiac complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Tanya N. Turan, Osama O. Zaidat, Gary S. Gronseth, Marc Chimowitz, Antonio Culebras, Anthony J. Furlan, Larry B. Goldstein, Nestor R. Gonzalez, Julius G. Latorre, Steven R. Messe, Thanh N. Nguyen, Rajbeer S. Sangha, Michael J. Schneck, Aneesh B. Singhal, Lawrence R. Wechsler, Alejandro A. Rabinstein, Mary Dolan O'Brien, Heather Silsbee, Jeffrey J. Fletcher
Summary: This study reviewed treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). The major recommendations include prescribing aspirin and clopidogrel for long-term prevention of stroke, recommending high-intensity statin therapy, maintaining target blood pressure levels, engaging in regular physical activity, and treating other modifiable vascular risk factors. The study also advises against certain procedures such as angioplasty and stenting for stroke prevention in moderate or severe sICAS patients.
Article
Clinical Neurology
Daniel Albjerg Rudolph, Stine Munk Hald, Luis Alberto Garcia Rodriguez, Soren Moller, Jesper Hallas, Larry B. Goldstein, David Gaist
Summary: The study demonstrates an association between long-term statin use and a lower risk of intracerebral hemorrhage.
Editorial Material
Clinical Neurology
Larry B. Goldstein
Article
Cardiac & Cardiovascular Systems
Phoebe M. Tran, Lam T. Tran, Cenjing Zhu, Tiffany Chang, Inna P. Powers, Larry B. Goldstein, Judith H. Lichtman
Summary: Poststroke antihypertensive use is comparable in rural and urban stroke survivors with a reported history of hypertension, but there is a trend for increased use among urban residents.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Erica C. Leifheit, Yun Wang, Larry B. Goldstein, Judith H. Lichtman
Summary: Data on trends in recurrent stroke in the US are limited, but this study found an overall decrease in recurrent ischemic strokes from 2001 to 2017. However, there were geographic areas with persistently higher recurrence rates.
Article
Clinical Neurology
Phoebe M. M. Tran, Joshua L. L. Warren, Erica C. C. Leifheit, Larry B. B. Goldstein, Judith H. H. Lichtman
Summary: Long-term exposure to air pollutants is associated with increased risk of hospital readmission within 30 days after stroke, regardless of hospital performance category. The study assessed the relationship between exposure to carbon monoxide, nitrogen dioxide, ozone, particulate matter 2.5, and sulfur dioxide and 30-day all-cause hospital readmission in elderly stroke patients. Despite being below national limits, long-term exposure to air pollutants still increased the risk of readmission.
Article
Biochemistry & Molecular Biology
Deepak Kotiya, Noah Leibold, Nirmal Verma, Gregory A. Jicha, Larry B. Goldstein, Florin Despa
Summary: Amylin-A beta co-aggregation plays a significant role in Alzheimer's disease (AD), but its mechanisms are not fully understood. In this study, a new ELISA method was developed to detect amylin-A beta hetero-oligomers in brain tissue and blood. The results showed that this assay is sensitive to circulating amylin-A beta hetero-oligomers in the blood and may contribute to understanding and treating the development of AD.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
