Journal
CANCER RESEARCH AND TREATMENT
Volume 47, Issue 4, Pages 823-833Publisher
KOREAN CANCER ASSOCIATION
DOI: 10.4143/crt.2014.074
Keywords
Apurinic/apyrimidinic endonuclease 1/redox factor-1; Urinary bladder neoplasms; Biological markers; Enzyme linked immunosorbent assay
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Funding
- National Research Foundation of Korea (NRF) - Korean government (MEST) [2011-0006231]
- INNOPOLIS Foundation - Korean government [M2013DD001]
- Ministry of Science, ICT & Future Planning, Republic of Korea [M2013DD001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2007-0054932] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Purpose Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. Materials and Methods Serum APE1/Ref-1 levels were determined using enzyme linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1. Results Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548 0.333 ng/100 pL [n=511 for bladder cancer vs. 1.547 0.319 ng/100 pL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence. Conclusion Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
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