Article
Endocrinology & Metabolism
Danilo A. Moraes, Ricardo B. Machado, Michael Koban, Gloria E. Hoffman, Deborah Suchecki
Summary: This study compared the stress responses of animals exposed to different stressors to those of animals subjected to paradoxical sleep deprivation (PSD). The results showed that the pituitary-adrenal response to PSD was similar to that induced by psychological stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Da-Hye Kim, Yoo-Kyung Lee, Sung-Dae Lee, Sang-Ho Kim, Kyung-Woo Lee
Summary: This study investigated the impact of a 42-day heat stress on laying hens, focusing on physiological parameters and behaviors. Results showed that high temperature exposure increased rectal temperature, heart rate, body-surface temperature, and H/L ratio, while also elevating plasma CORT and yolk CORT levels. Laying hens in high-temperature conditions exhibited specific behaviors such as panting and wing elevation. The study suggested that rectal and body-surface temperature, heart rate, and behavior can serve as reliable indicators for assessing the stress status of laying hens under prolonged heat stress.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Behavioral Sciences
Anna U. Odland, Rune Sandahl, Jesper T. Andreasen
Summary: Stressful life events can have complex effects on cognitive flexibility, and it is possible to improve cognitive flexibility by altering sensitivity to negative feedback.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: The study findings demonstrate that microglial activation modulates the secretion of several hormones to varying degrees during sepsis, and this process is associated with inflammatory mediators produced both centrally and peripherally.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Tristan J. Philippe, Lexia Bao, Maya E. Koblanski, Victor Viau
Summary: This study found that male and female rats showed region-specific changes in 5-HT 1A receptor function after repeated restraint, which may be explained by changes in receptor availability.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zainab Ahmed, Ahmed Tokhi, Mehreen Arif, Naeem Ur Rehman, Vahid Sheibani, Khalid Rauf, Robert D. E. Sewell
Summary: This study investigated the acute effects of fraxetin in a chronic unpredictable stress (CUS) paradigm. The results demonstrated that fraxetin decreased depression-like behavior and anxiety, improved memory deficits, and restored altered neurochemical levels. These findings suggest a potential application of fraxetin in managing anxiety and depression. However, further research is needed to explore the chronic effects of fraxetin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Rebecca B. Kann, Russell D. Romeo
Summary: The hormonal stress response changes significantly during puberty, with higher resting levels of ACTH and POMC in the pituitary and higher corticosterone concentrations in the adrenals of pre-pubertal rats compared to adults.
NEUROBIOLOGY OF STRESS
(2022)
Article
Multidisciplinary Sciences
Janja Novak, Ivana Jaric, Marianna Rosso, Reto Rufener, Chadi Touma, Hanno Wuerbel
Summary: This study aimed to assess the effects of different handling methods on behavioral and physiological stress measures in laboratory mice during routine husbandry. The results indicate that routine tail handling can affect behavioral measures of anxiety, but may not be a significant source of chronic husbandry stress. The study also highlights strain-dependent responses to handling methods.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Jessy Le Du-Carree, Rania Boukhari, Jerome Cachot, Joelle Cabon, Lenaig Louboutin, Thierry Morin, Morgane Danion
Summary: The study investigated the impact of glyphosate and its co-formulants on an F2 generation issued from exposed generations F0 and F1. It was found that glyphosate induces developmental toxicity and increases viral susceptibility. Further investigations are required to study the specific mechanisms of transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
J. M. Viveros-Paredes, A. M. Puebla-Perez, O. Gutierrez-Coronado, A. M. Macias-Lamas, G. Hernandez-Flores, P. C. Ortiz-Lazareno, A. Bravo-Cuellar, M. M. Villasenor-Garcia
Summary: Capsaicin treatment enhances immune response, rescues stress-induced splenocyte apoptosis, modulates Th1 and Th2 cytokines while decreasing TGF-01, reduces corticosterone production, attenuates corticosterone-induced immunosuppression, and directly modulates cellular immunomodulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Zhen Yao, Bei-Xuan Zhang, Hui Chen, Xiao-Wei Jiang, Wei-Min Qu, Zhi-Li Huang
Summary: Elevated glucocorticoid levels triggered by stress potentially contribute to sleep disturbances in stress-induced depression. However, the effects of the major glucocorticoid corticosterone (CORT) on sleep in rodents remain unclear. In this study, acute or chronic administration of CORT in mice resulted in rapid promotion of wakefulness, suppression of REM and NREM sleep, and altered EEG activity. Prolonged CORT exposure led to excessive wakefulness and REM sleep, decreased NREM sleep, and persistent sleep changes even after drug withdrawal. The observed sleep alterations were associated with elevated plasma CORT levels and depressive phenotypes. These findings provide insight into the neural link between insomnia and depression.
Article
Neurosciences
Yu-Fen Lin, Kao Chin Chen, Yen Kuang Yang, Ya-Hsin Hsiao
Summary: CRMP5 expression in the hippocampus was increased in stress-susceptible mice compared to control and stress-resilient mice, with a negative correlation between CRMP5 levels and social interaction ratio. Lowering hippocampal CRMP5 levels improved social interactions in stress-susceptible mice, while overexpression of CRMP5 induced social avoidance behaviors. Furthermore, increased CRMP5 expression also elevated serum corticosterone concentrations in stress-susceptible and CRMP5-treated mice. These findings shed light on how CRMP5 may contribute to susceptibility to social stress and suggest potential therapeutic targets for stress disorders in humans.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephen C. Lenzi, Lee Cossell, Benjamin Grainger, Sarah F. Olesen, Tiago Branco, Troy W. Margrie
Summary: The study investigates the behavioral responses of animals to threats, particularly focusing on escape behaviors in laboratory mice. Results show that mice can rapidly learn to distinguish between threatening and non-threatening stimuli, exhibiting a learned suppression of escape behavior. This adaptive control of decision-making is influenced by recent threat history and serves as a useful model for understanding the neurophysiological mechanisms underlying experience-dependent decision-making.
Article
Psychology, Biological
Christopher M. Olsen, Breanna L. Glaeser, Aniko Szabo, Hershel Raff, Carol A. Everson
Summary: Sleep restriction during abstinence did not significantly affect opioid seeking, while specific phenotypes and sex were associated with drug seeking behavior.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Brady L. Weber, Marissa M. Nicodemus, Allianna K. Hite, Isabella R. Spalding, Jasmin N. Beaver, Lauren R. Scrimshaw, Sarah K. Kassis, Julie M. Reichert, Matthew T. Ford, Cameron N. Russell, Elayna M. Hallal, T. Lee Gilman
Summary: Certain life stressors can have lasting physiological and behavioral effects by causing significant shifts in monoamine neurotransmitters. Reduced PMAT function enhances the responsiveness to stressors in mice, and male heterozygotes exhibit malleable fear behaviors after prior stressor or sham stress exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
Antonio Armario, Javier Labad, Roser Nadal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Endocrinology & Metabolism
Roser Nadal, Marina Gabriel-Salazar, Maria Sanchis-Olle, Humberto Gagliano, Xavier Belda, Antonio Armario
Summary: Through experiments on rats, it was found that the neuroendocrine response of individuals to different stressors is more dependent on the similarity in intensity rather than other characteristics, showing correlations between stressors of similar intensity. Therefore, it is difficult to predict the response to another stressor greatly differing in intensity based on the response to a particular stressor.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
A. Florido, E. R. Velasco, C. M. Soto-Faguas, A. Gomez-Gomez, L. Perez-Caballero, P. Molina, R. Nadal, O. J. Pozo, C. A. Saura, R. Andero
Summary: Memory formation is crucial for brain function, and understanding the mechanisms behind it helps in understanding neural processes. The Tac2 pathway in the central amygdala plays a key role in fear memory consolidation, with opposite effects observed in male and female mice.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Antonio Armario
Summary: The forced swim test is a commonly used method for evaluating antidepressant treatments and depression-like states in rodents, but its theoretical and predictive validity have been questioned. The test mainly assesses coping strategies in an inescapable situation, and proper interpretation of the behavior depends on its relationship with other behavioral traits.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Behavioral Sciences
Ximena Goldberg, Carme Espelt, Daniel Porta-Casteras, Diego Palao, Roser Nadal, Antonio Armario
Summary: Chronic stress can lead to alterations in the stress-response system, impacting the development of non-communicable diseases. Survivors of intimate partner violence may be particularly vulnerable to the effects of prolonged threat exposure.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Maria Sanchis-Oll, Laura Sanchez-Benito, Silvia Fuentes, Humberto Gagliano, Xavier Belda, Patricia Molina, Javier Carrasco, Roser Nadal, Antonio Armario
Summary: Differences in behavioral and physiological characteristics between rat and mouse strains can explain discrepancies in research results. LongEvans (LE) rats show higher levels of ACTH and corticosterone, as well as a stronger HPA responsiveness to stressors. They exhibit hyperactive behavior in novel environments and are prone to passive-like behavior.
NEUROBIOLOGY OF STRESS
(2021)
Article
Psychiatry
Marta Llorens, Maria Barba, Jordi Torralbas, Roser Nadal, Antonio Armario, Humberto Gagliano, Maria Betriu, Lara Urraca, Susana Pujol, Itziar Montalvo, Rebeca Gracia, Olga Gimenez-Palop, Diego Palao, Montserrat Pamias, Javier Labad
Summary: The study found that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD, and childhood maltreatment and sex exert distinct moderating effects depending on the symptom type.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Maria Sanchis-Olle, Xavier Belda, Humberto Gagliano, Joan Visa, Roser Nadal, Antonio Armario
Summary: A single exposure to some stressors can have long-term consequences similar to those seen in post-traumatic stress disorder (PTSD), but the findings are often controversial. The single prolonged stress (SPS) model, which involves exposure to different stressors in a sequence, has been widely accepted as an animal model for PTSD. However, there is inconsistent evidence, particularly regarding the effect on the hypothalamic-pituitary-adrenal (HPA) axis, and it is unclear whether SPS is distinct from models using a single severe stressor. In this study, we compared the behavioral and neuroendocrine (HPA) effects of immobilization on boards (IMO) with a SPS-like model (SPSi) in male rats. Both procedures had similar effects on food intake, body weight, and sensitization of the HPA response to a novel environment. There were also similarities in the reduction of activity/exploration in a hole-board, although SPSi had a greater impact of sudden noise compared to IMO. Neither IMO nor SPSi significantly affected contextual fear conditioning acquisition, but there was a trend towards impaired fear extinction compared to controls. Additional stressors in the SPSi did not interfere with HPA adaptation to IMO. Overall, there were only modest differences between IMO and SPSi in terms of neuroendocrine and behavioral effects, highlighting the need for further studies comparing different PTSD models.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Behavioral Sciences
Patricia Molina, Raul Andero, Antonio Armario
Summary: This article discusses the use of restricted movement as a model for inducing stress in laboratory animals, which is widely used in stress-related disorder research. Despite the various methods available, few studies directly compare the differential impact of these protocols. Additionally, there is a lack of standardized language distinguishing between restraint and immobilization terms in the literature. This review provides evidence of physiological differences in the impact of distinct restraint and immobilization procedures in rats and mice, highlighting the need for standardized language and further systematic studies to determine the best methodology for specific research objectives.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Jose Antonio Monreal, Neus Salvat-Pujol, Alexandre Gonzalez-Rodriguez, Mikel Urretavizcaya, Jose Manuel Crespo, Roser Nadal, Aida de Arriba-Arnau, Clara Massaneda, Diego Palao, Jose Manuel Menchon, Javier Labad, Virginia Soria
Summary: The aim of this study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. The study found that female sex was associated with an increased cortisol awakening response and a more flattened diurnal cortisol slope. However, a negative significant interaction between harm avoidance and female sex was found. Regarding the cortisol suppression ratio, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Meeting Abstract
Clinical Neurology
Patricia Molina, Xavier Belda, Silvia Fuentes, Humberto Gagliano, Roser Nadal, Raul Andero, Antonio Armario
JOURNAL OF NEURAL TRANSMISSION
(2021)
Review
Substance Abuse
Elena Diaz-Miranda, Roser Nadal, Antonio Armario, Javier Labad
Summary: The systematic review aimed to explore the relationship between prenatal alcohol exposure (PAE) and hypothalamic-pituitary-adrenal (HPA) axis functioning in humans. Results showed that PAE has long-term consequences on HPA axis activity, with infants/toddlers exhibiting a blunted response to painful stressors and children/adolescents experiencing altered cortisol circadian rhythm. The findings support the programming effects of alcohol on the HPA stress system.
CURRENT ADDICTION REPORTS
(2021)
Article
Cell & Tissue Engineering
Ana Belen Alvarez-Palomo, Jordi Requena-Osete, Raul Delgado-Morales, Victoria Moreno-Manzano, Carme Grau-Bove, Agueda M. Tejera, Manel Juan Otero, Carme Barrot, Irene Santos-Barriopedro, Alejandro Vaquero, Jovita Mezquita-Pla, Sebastian Moran, Carlos Hobeich Naya, Iris Garcia-Martinez, Francisco Vidal Perez, Maria A. Blasco, Manel Esteller, Michael J. Edel
Summary: The study demonstrates that utilizing synthetic mRNA transfection of CYCLIN D1 during reprogramming repairs DNA and significantly improves the genetic stability of human iPSC. This method reduces various genetic instabilities, decreases DNA damage, promotes correct protein expression, and reduces single-nucleotide polymorphism changes per chromosome.