Article
Neurosciences
Bibiana Torok, Anna Fodor, Sandor Zsebok, Eszter Sipos, Dora Zelena
Summary: The study found that vasopressin-deficient pups showed reduced maternal separation-induced ultrasonic vocalization (MS-USV) and adrenocorticotropin levels, even with unchanged corticosterone levels. V1bRs play a key role in regulating adrenocorticotropin (ACTH), but a combination of V1aR and V1bR antagonists may also be beneficial through other mechanisms, reducing the possibility of side effects. In contrast, antagonizing the V2Rs may be stressful due to an imbalance in saltwater homeostasis.
Article
Endocrinology & Metabolism
Danilo A. Moraes, Ricardo B. Machado, Michael Koban, Gloria E. Hoffman, Deborah Suchecki
Summary: This study compared the stress responses of animals exposed to different stressors to those of animals subjected to paradoxical sleep deprivation (PSD). The results showed that the pituitary-adrenal response to PSD was similar to that induced by psychological stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychology, Biological
Gabriela Garcia-Laguna, Maria Fernanda Gerena-Cruz, Angel Yobany Sanchez, Jeison Monroy-Gomez, Zulma Duenas
Summary: This study suggests that maternal separation may increase the risk of breast tumors in rats, particularly when exposed to DMBA. Rats treated with DMBA showed significantly lower body weight gain, while the MS group exhibited more preneoplastic changes and breast carcinogenesis.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Fatemeh Sadat Zolfaghari, Fardad Pirri, Evan Gauvin, Maghsoud Peeri, Shayan Amiri
Summary: This study shows that exercise and FLX treatment during adolescence can alleviate depressive and anxiety-like symptoms induced by maternal separation stress in adult male rats, while treadmill exercise has anxiolytic effects but fails to produce antidepressant-like effects.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Behavioral Sciences
Livea Dornela Godoy, Norberto Garcia-Cairasco
Summary: The WAR strain showed higher plasma corticosterone concentration in neonate pups and altered maternal behavior in dams under stressful events. This strain could be an interesting model to study vulnerability to epilepsy and its associated neuropsychiatric comorbidities.
EPILEPSY & BEHAVIOR
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaohui Zhang, Xueying Wang, James Ayala, Yuliang Liu, Junhui An, Donghui Wang, Zhigang Cai, Rong Hou, Mingyue Zhang
Summary: The research aimed to evaluate the possible adverse effects of the traditional parenting mode on the gut microbiota of captive giant pandas, and the results showed that early and frequent maternal separation did not change the diversity indices of the gut microbes, but it increased certain bacteria abundance and stress-related fecal metabolites in the intestinal tract of giant pandas in adulthood, which affected protein digestion and absorption functions and disturbed short-chain fatty acids metabolism.
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: The study findings demonstrate that microglial activation modulates the secretion of several hormones to varying degrees during sepsis, and this process is associated with inflammatory mediators produced both centrally and peripherally.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sophida Phuthong, Cynthia Guadalupe Reyes-Hernandez, Pilar Rodriguez-Rodriguez, David Ramiro-Cortijo, Marta Gil-Ortega, Raquel Gonzalez-Blazquez, M. Carmen Gonzalez, Angel Luis Lopez de Pablo, Silvia M. Arribas
Summary: Fetal undernutrition has a significant impact on cardiometabolic diseases, with males showing higher susceptibility. The study revealed that male fetuses demonstrate poorer adaptation to undernutrition, associated with oxidative imbalance, reduced vascularization, and glucocorticoid barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Rebecca B. Kann, Russell D. Romeo
Summary: The hormonal stress response changes significantly during puberty, with higher resting levels of ACTH and POMC in the pituitary and higher corticosterone concentrations in the adrenals of pre-pubertal rats compared to adults.
NEUROBIOLOGY OF STRESS
(2022)
Article
Biology
Sameera Abuaish, Sophia G. Lavergne, Benjamin Hing, Sophie St-Cyr, Richard L. Spinieli, Rudy Boonstra, Patrick O. McGowan
Summary: This study investigated the effects of prenatal predator odour exposure on offspring CBG levels and Cort dynamics in mice. The results showed that male offspring exposed to POE had higher CBG levels and lower Free Cort levels, suggesting an adaptive response to a high predator risk environment.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biology
Ivana Schoepf, Sarena Olson, Ignacio T. Moore, Frances Bonier
Summary: Hosts with long coevolutionary history with parasites often assume negligible fitness costs of chronic infection. However, experimental manipulation of infections reveals effects of parasites on hosts during reproduction. In this study, the authors found that reducing haemosporidian infections in red-winged blackbirds resulted in significant benefits to mothers and their offspring.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Viviane C. Ceschim, Paula Sumaran, Andrea A. Borges, Carlos Eduardo N. Girardi, Deborah Suchecki
Summary: Social behaviour impairment is a characteristic of emotional disorders, resulting in increased avoidance of social contact. The study investigated the long-term effects of maternal deprivation (DEP) at postnatal days 3 (DEP3) or 11 (DEP11) on anxiety-like behaviour in rats, focusing on neurobiological outcomes. The results suggest that DEP during certain developmental phases does not alter social investigation, but leads to distinct neurobiological changes.
HORMONES AND BEHAVIOR
(2021)
Article
Psychiatry
Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong Li
Summary: The study evaluated depression behavior in female adult SD rats by combining early maternal separation (MS) and adolescent chronic unpredictable mild stress (CUMS). Rats in the MS+CUMS group showed more severe depression-like and anxiety-like behaviors compared to the MS group, possibly due to impaired synaptic plasticity. Additionally, fewer neurons and downregulated synaptic protein expressions were observed in the hippocampus of rats in the MS+CUMS group.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Daniela R. C. Foscolo, Paulo M. A. Lima, Gisele Rodovalho, Candido C. Coimbra
Summary: This study examined the impact of early maternal separation (MS) on activating stress-responsive areas in the brain of adult rats. The results showed that the MS group had a greater increase in c-Fos immunoreactive (c-Fos-ir) neurons in multiple brain regions in response to physical or psychological stressors. This suggests that early life adversity can induce reprogramming in the brain response to stress in adulthood.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Roberto Ruiz-Gonzalez, Naima Lajud, Aldo Rafael Tejeda-Martinez, Mario Eduardo Flores-Soto, Juan Jose Valdez-Alarcon, Luis A. Tellez, Angelica Roque
Summary: Maternal separation in rats causes neuroendocrine, behavioral, and metabolic alterations related to gut dysbiosis. Antibiotic-induced microbiota depletion mimics the behavioral consequences of maternal separation and can partially prevent metabolic imbalance. These findings suggest that gut dysbiosis may be involved in the mechanisms underlying the long-term consequences of early life stress.
Review
Psychology, Biological
D. A. Revillo, E. Cotella, M. G. Paglini, C. Arias
PHYSIOLOGY & BEHAVIOR
(2015)
Meeting Abstract
Endocrinology & Metabolism
Evelin M. Cotella, Rachel L. Morano, Aynara C. Wulsin, Susan E. Martelle, James P. Herman
PSYCHONEUROENDOCRINOLOGY
(2017)
Article
Neurosciences
Evelin M. Cotella, Ivan Mestres Lascano, Gloria M. Levin, Marta M. Suarez
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2009)
Article
Behavioral Sciences
Evelin M. Cotella, Patricia E. Durando, Marta M. Suarez
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2014)
Article
Clinical Neurology
Evelin M. Cotella, Antonela Scarponi Gomez, Paige Lemen, Carrie Chen, Guillermo Fernandez, Christian Hansen, James P. Herman, Maria Gabriela Paglini
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Biology
Jessie R. Scheimann, Rachel D. Moloney, Parinaz Mahbod, Rachel L. Moreno, Maureen Fitzgerald, Olivia Hoskins, Benjamin A. Packard, Evelin M. Cotella, Yueh-Chiang Hu, James P. Herman
Article
Endocrinology & Metabolism
Evelin M. Cotella, Rachel L. Morano, Aynara C. Wulsin, Susan M. Martelle, Paige Lemen, Maureen Fitzgerald, Benjamin A. Packard, Rachel D. Moloney, James P. Herman
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Behavioral Sciences
Susan E. Martelle, Evelin M. Cotella, Nawshaba Nawreen, Carrie Chen, Benjamin A. Packard, Maureen Fitzgerald, James P. Herman
Summary: PACAP is highly expressed in putative pyramidal neurons in the infralimbic cortex of rats, while PAC1 is enriched in interneurons. Infusion of PACAP into the IL alters stress responses, increases anxiety-like behavior, and enhances fear memory retention in rodents.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Biology
L. Sofia Gonzalez, Austen A. Fisher, Shane P. D'Souza, Evelin M. Cotella, Richard A. Lang, J. Elliott Robinson
Summary: The mesolimbic dopamine system plays a role in attention, appetitive behavior, and reward processing. Dopaminergic signaling in the ventral striatum/nucleus accumbens has been studied for its role in behavioral reinforcement, reward prediction error encoding, and motivational salience. This study reveals that dopamine release in the lateral NAc encodes changes in environmental luminance rather than visual stimulus threat level.
Article
Behavioral Sciences
James P. Herman, Nawshaba Nawreen, Marissa A. Smail, Evelin M. Cotella
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Meeting Abstract
Substance Abuse
S. E. Martelle, S. C. Woodburn, R. D. Moloney, E. M. Cotella, P. Lemen, B. A. Packard, J. P. Herman
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)