Article
Geriatrics & Gerontology
Tamas Oroszi, Eva Geerts, Sietse F. de Boer, Regien G. Schoemaker, Eddy A. van der Zee, Csaba Nyakas
Summary: Research has shown that whole body vibration (WBV) has positive effects on memory, anxiety-related behavior, and motor performance in aged animals. This alternative form of exercise has similar benefits to active physical exercise on the musculoskeletal and central nervous systems. WBV can be considered as a useful option for individuals who are unable to engage in active physical exercise due to physical or mental issues.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Biological
Clara S. Costa, Andre W. C. Oliveira, Alexander Easton, Marilia Barros
Summary: A stressful experience can affect information storage and memory retrieval in rodents, but conflicting results have called for further investigation. This study explores the effects of stress on memory in nonhuman primates and finds that the timing of stress plays a crucial role in its impact. Specifically, stress induced before encoding impairs memory, while stress before retrieval enhances familiarity preference. Negative discrimination ratios can serve as a measure of memory in the novel object recognition task, and a change in strategy does not necessarily indicate memory failure.
BEHAVIOURAL PROCESSES
(2022)
Article
Biochemical Research Methods
Ana Paula de Castro Araujo, Jalles Dantas de Lucena, Davi Carvalho Drieskens, Livia Rodrigues Neves, Karen Cristina Pugliane, Hindiael Aeraf Belchior, Rochele Castelo-Branco, Flavio Freitas Barbosa
Summary: The study introduces a new object recognition memory task for rats with multiple trials, evaluating temporal and spatial memory capabilities, where shorter protocols were found to be more efficient. It is the first task to simultaneously assess temporal and spatial aspects of episodic-like memory in rats.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Behavioral Sciences
Antonis Asiminas, Stephanie A. Lyon, Rosamund F. Langston, Emma R. Wood
Summary: This study investigated the ontogeny of episodic-like memory and its components in three rat strains using four spontaneous short-term object exploration tasks. Results showed that short term memory for objects was present early in life, while object-context memory developed during the fifth week, and object-place and object-place-context memories developed around the seventh week. These findings suggest different developmental trajectories of recognition memory in rats depending on the content and complexity of associations, highlighting the utility of spontaneous object exploration tasks for assessing memory system ontogeny.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Martina Canatelli-Mallat, Priscila Chiavellini, Marianne Lehmann, Rodolfo Gustavo Goya, Gustavo Ramon Morel
Summary: Ageing is associated with impaired recognition memory. This study aimed to evaluate the ability of female rats at different ages to retain long-term recognition memory. The results showed that spatial discrimination capacity could be affected earlier than feature discrimination capacity. Furthermore, neurogenesis depletion in the Dentate Gyrus and microglial disruption in the perirhinal cortex were associated with memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Skyler Younger, Sydney Boutros, Francesca Cargnin, Shin Jeon, Jae W. Lee, Soo-Kyung Lee, Jacob Raber
Summary: FOXG1 syndrome is a rare and devastating neurodevelopmental disorder characterized by various symptoms. Mouse models with Foxg1 gene mutation displayed phenotypes similar to symptoms of human FS individuals, including anxiety, cognitive impairments, and fear memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Multidisciplinary
Stefanie Klatt, Nicholas J. Smeeton
Summary: The study found that working memory capacity plays an important role in selective visual attention, with individuals having higher capacity performing better in the task. Additionally, visual stimuli located along the same meridian were perceived more accurately compared to stimuli located along different meridians.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Qinbo Qiao, Caroline Mairlot, Daniel Bendor
Summary: Our brain's capacity for memory storage is vast but finite, and it selects what to remember and forget through a process of memory triage. Recent salient memories are prioritized for consolidation, while less salient memories are eventually forgotten. A new task has been designed to measure memory capacity and prioritization.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
Summary: The hippocampal formation is vulnerable to normal aging, and Long-Evans rats serve as a valuable model to study aging. This study found individual differences in spatial navigation and episodic-like memory abilities in aged rats, similar to age-related cognitive decline observed in humans. These findings suggest that aged Long-Evans rats can be used to explore the changes in cognitive function during aging.
Article
Neurosciences
Justin J. Botterill, K. Yaragudri Vinod, Kathleen J. Gerencer, Catia M. Teixeira, John J. LaFrancois, Helen E. Scharfman
Summary: The dentate gyrus (DG) of the hippocampus plays a crucial role in cognition and behavior, with mossy cells (MCs) potentially regulating anxiety-like behaviors and cognitive performance in specific ways. Manipulations of MCs can bidirectionally influence behaviors by activating or inhibiting MCs. Sex-specific effects were observed in some behaviors, with females showing more pronounced effects than males.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Nader Nikbakht, Mathew E. Diamond
Summary: Recent studies have shown that rats still possess visual form discrimination capacity under red light, contradicting the assumption of red-light blindness in dichromats. It is advised that investigations on rodent functions without visual input should not assume red-light blindness.
Article
Behavioral Sciences
Nikolaos Pitsikas, Elli Zoupa, Achille Gravanis
Summary: This study aimed to investigate whether the synthetic microneurotrophin BNN27 can attenuate cognition deficits induced by anesthetic ketamine. Object recognition and object location tests were used, and the results showed that BNN27 counteracted the memory deficits caused by ketamine, without affecting motility.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Dominika Radostova, Daniela Kuncicka, Branislav Krajcovic, Lukas Hejtmanek, Tomas Petrasek, Jan Svoboda, Ales Stuchlik, Hana Brozka
Summary: We designed a behavioral task called OTTER to study the incidental formation of associations between temporally discontinuous stimuli in rats. The rats were habituated to two similar contexts and then experienced a sequence of acoustic cue and aversive stimulus in one of the contexts. The recall test showed that 59% of the rats responded to the cue by escaping to a different context. The OTTER task provides a flexible tool to study memory acquired incidentally after a single experience, which may be essential for episodic memory formation.
Article
Multidisciplinary Sciences
Anuck Sawangjit, Maximilian Harkotte, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
Summary: Memory consolidation is promoted by both sleep and wakefulness, but their effects on hippocampal and nonhippocampal representations differ. Sleep consolidation involves event-context binding, while wake consolidation tends to strengthen context-independent representations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)