Review
Behavioral Sciences
Ngala Elvis Mbiydzenyuy, Sian Megan Joanna Hemmings, Lihle Qulu
Summary: This review article discusses the mechanisms underlying the influence of prenatal maternal stress on fetal neuroendocrine signaling, as well as the potential risks for aggressive behavior in offspring. It covers topics such as the maternal-placental-fetal interface, disruptions in the intrauterine environment, and epigenetic modifications of genes involved in aggressive behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Maria I. Cordero, Ludwig Stenz, Dominik A. Moser, Sandra Rusconi Serpa, Ariane Paoloni-Giacobino, Daniel Scott Schechter
Summary: This prospective longitudinal study explored the relationship between NR3C1 methylation in mothers with IPV-related PTSD and their toddlers, and the relationship between maternal NR3C1 methylation and child psychopathology at school age. The results showed that maternal NR3C1 methylation when children were toddlers was negatively associated with child externalizing behavior severity at school age. correlations between mothers and their children of NR3C1 methylation levels were significant only in the IPV-PTSD group. The findings suggest that maternal epigenetic signature related to glucocorticoid receptor is significantly associated with child behavior that may pose a risk for intergenerational transmission of violence and related psychopathology.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Developmental
Olivia A. Frigoletto, Amy L. Byrd, Vera Vine, Salome Vanwoerden, Maureen Zalewski, Stephanie D. Stepp
Summary: Children of parents with emotion regulation difficulties may be at greater risk for internalizing and externalizing problems, and this could be explained by maternal invalidation. This study examined the indirect effect of clinician-rated maternal emotion regulation difficulties on teacher-reported internalizing and externalizing problems through maternal invalidation. The findings suggest that mothers with emotion regulation difficulties reported more invalidation, and their children exhibited more internalizing problems and aggressive behavior in a preschool/daycare setting.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Environmental Sciences
Wei Song, Ang Li, Qian-Qian Sha, Shao-Yuan Liu, Yong Zhou, Chang-Yin Zhou, Xue Zhang, Xiao-Zhen Li, Jia-Xin Jiang, Fei Li, Chao Li, Heide Schatten, Xiang-Hong Ou, Qing-Yuan Sun
Summary: This study found that maternal exposure to 4-vinylcyclohexene diepoxide (VCD) during pregnancy significantly affects the fertility and health of mice offspring. It reduces litter size and ovarian reserve, while increasing the occurrence of microtia in F1 mice. Mechanistically, VCD inhibits meiotic prophase I progression and leads to increased expression of DNA damage markers. RAD51 and DMC1 are extensively recruited to repair DNA double strand breaks in the oocytes of VCD-exposed offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Criminology & Penology
Jennifer A. Livingston, Jared Lessard, Meghan L. Casey, Kenneth E. Leonard, Rina D. Eiden
Summary: Exposure to marital conflict has been linked to teen dating violence, especially in families affected by paternal alcoholism. Positive parenting behaviors may mitigate the effects of exposure to conflict, but a multipronged approach targeting both parental and parent-child relationships is recommended for violence prevention in high-risk families.
JOURNAL OF INTERPERSONAL VIOLENCE
(2021)
Article
Pediatrics
Franziska Koehler-Dauner, Inka Mayer, Melissa Hitzler, Alexander Karabatsiakis, Lynn Matits, Alexandra M. Bach, Katharina Rost, Joerg M. Fegert, Iris-Tatjana Kolassa, Ute Ziegenhain
Summary: The quality of maternal caregiving is crucial for a child's healthy development, and atypical maternal interaction behavior may lead to alterations in the child's stress response system. This study finds that higher levels of atypical behavior in mothers are associated with higher chronic stress levels in infants, as measured by hair cortisol concentrations.
FRONTIERS IN PEDIATRICS
(2023)
Article
Neurosciences
Pilyoung Kim, Haitao Chen, Alexander J. Dufford, Rebekah Tribble, John Gilmore, Wei Gao
Summary: Mother and infant neural and behavioral synchrony is crucial for infant development. Recent studies show that neural risk markers associated with parental psychopathology can be transmitted across generations. The current study found that functional connectivity similarity between mothers and newborns increased with infant age. Lower maternal education levels were associated with greater functional connectivity similarity.
Article
Clinical Neurology
Destiny M. B. Printz Pereira, Damion J. Grasso, Colin A. Hodgkinson, Kimberly J. McCarthy, Lauren S. Wakschlag, Margaret J. Briggs-Gowan
Summary: This study investigated the role of the FKBP5 gene in moderating the relationship between maternal PTS and child symptoms, finding that maternal PTS can predict increased symptoms in children carrying the minor T-allele of the FKBP5 gene. The results suggest that the gene x environment interaction involving FKBP5 and child trauma exposure may extend to other environmental perturbations.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Arielle R. Strzelewicz, Haley A. Vecchiarelli, Alejandro N. Rondon-Ortiz, Anthony Raneri, Matthew N. Hill, Amanda C. Kentner
Summary: Exposure to adverse childhood experiences can increase the risk for psychiatric disorders and cardiovascular diseases. This study used animal models to investigate the impact of early life stress on maternal care quality and offspring behavior, revealing that multiple early adverse events can have interactive impacts, emphasizing the importance of modeling complex interactions among stressors during development.
HORMONES AND BEHAVIOR
(2021)
Article
Psychology, Clinical
Stefanie E. Mayer, Joanna Guan, Jue Lin, Elissa Hamlat, Jordan E. Parker, Kristy Brownell, Candice Price, Mahasin Mujahid, A. Janet Tomiyama, George M. Slavich, Barbara A. Laraia, Elissa S. Epel
Summary: This study found that maternal stressors during pregnancy were associated with child telomere length, but this effect was only present in children of White mothers and not Black mothers. Furthermore, only financial stressors were related to child telomere length.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Marion I. van den Heuvel, Catherine Monk, Cassandra L. Hendrix, Jasmine Hect, Seonjoo Lee, Tianshu Feng, Moriah E. Thomason
Summary: This study found that maternal experiences of childhood maltreatment are associated with fetal brain development, particularly in the left hemisphere. The findings suggest that the intergenerational transmission of trauma may occur prior to birth.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Erin E. Dunning, Brae Anne McArthur, Lyn Y. Abramson, Lauren B. Alloy
Summary: The mechanisms behind the relationship between maternal depression and offspring psychopathology may involve the transmission of cognitive vulnerabilities, rather than a direct influence on symptoms. This suggests a potential link between maternal depression and offspring internalizing psychopathology through the transmission of cognitive vulnerabilities.
JOURNAL OF YOUTH AND ADOLESCENCE
(2021)
Article
Immunology
Clare McCormack, Vincenzo Lauriola, Tianshu Feng, Seonjoo Lee, Marisa Spann, Anika Mitchell, Frances Champagne, Catherine Monk
Summary: Inflammatory processes may be a mechanism through which early adversity is biologically embedded and leads to poorer health outcomes, with pregnancy being a pathway for intergenerational transmission of adversity. Research indicates that factors such as mood, diet, BMI, and social support may moderate the association between childhood trauma history and inflammation in adulthood, with limited studies examining these associations among pregnant women.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Multidisciplinary Sciences
Aya Osman, Simone Zuffa, Gemma Walton, Elizabeth Fagbodun, Panos Zanos, Polymnia Georgiou, Ian Kitchen, Jonathan Swann, Alexis Bailey
Summary: The study found that continued consumption of milk containing A1 beta-casein after weaning can lead to increased stress-induced immobility in rats, along with an increase in specific bacteria groups in the intestines, changes in brain receptors, and alterations in urinary biochemical profiles. These results suggest that milk containing A1 beta-casein may affect mood through a gut-brain axis mechanism.
Article
Behavioral Sciences
E. T. Cox Lippard, T. M. Jarrett, M. S. McMurray, P. S. Zeskind, K. A. Garber, C. R. Zoghby, K. Glaze, W. Tate, J. M. Johns
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Neurosciences
Matthew Stephen McMurray, Leslie Renee Amodeo, Jamie Donahey Roitman
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Neurosciences
Brittany R. Howell, Matthew S. McMurray, Dora B. Guzman, Govind Nair, Yundi Shi, Kai M. McCormack, Xiaoping Hu, Martin A. Styner, Mar M. Sanchez
SOCIAL NEUROSCIENCE
(2017)
Article
Neurosciences
L. R. Amodeo, M. S. Mcmurray, J. D. Roitman
Article
Multidisciplinary Sciences
Emily V. Ho, Stephanie J. Klenotich, Matthew S. McMurray, Stephanie C. Dulawa
Article
Behavioral Sciences
Shannon M. Thompson, Amber N. Simmons, Matthew S. McMurray
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Amanda C. Welch, Jie Zhang, Jinrui Lyu, Matthew S. McMurray, Jonathan A. Javitch, Christoph Kellendonk, Stephanie C. Dulawa
Summary: D2R-OENAc alters glucose metabolism in both sexes but drives robust weight loss only in females during scheduled fasting, implicating metabolic mechanisms in this sexually dimorphic effect.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Biological
Danielle N. Tapp, Hannah L. Zerkle, Matthew S. McMurray
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2020)
Article
Behavioral Sciences
Danielle N. Tapp, Mitchell D. Singstock, Meredith S. Gottliebson, Matthew S. McMurray
HORMONES AND BEHAVIOR
(2020)
Article
Psychology, Experimental
Max Teaford, William Berg, Vincent A. Billock, Matthew S. McMurray, Robin Thomas, L. James Smart
Summary: The rubber hand illusion is a perceptual illusion where people feel a hand-shaped object is part of their body. This study explores the relationship between muscle activity and experiencing the illusion, and finds that muscle fatigue is positively associated with proprioceptive drift when the stimulation is synchronous or visual movement only.
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2023)
Article
Behavioral Sciences
Brianna F. Roberts, Alexia L. Zylko, Courtney E. Waters, Jessica D. Crowder, William J. Gibbons Jr, Abhishek K. Sen, J. Andrew Jones, Matthew S. McMurray
Summary: This study investigated the effects of psilocybin on decision-making and motivation in rats. The results showed that psilocybin did not affect decision-making and motivation, but it did cause head twitch responses. Therefore, the study suggests that psilocybin may not impair or improve decision-making and motivation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Alexandra M. Adams, Nicholas A. Anas, Abhishek K. Sen, Jordan D. Hinegardner-Hendricks, Philip J. O'Dell, William J. Gibbons, Jessica E. Flower, Matthew S. McMurray, J. Andrew Jones
Summary: Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has increased significantly. In this study, a novel E. coli platform was developed for the production of norbaeocystin, an intermediate compound in the psilocybin pathway. In vivo measurements showed that psilocybin had a dose response, while norbaeocystin did not elicit any pharmacological response, suggesting a weak affinity of norbaeocystin and its metabolites for the serotonin 2A receptor. This research provides a mechanism to source norbaeocystin for future studies and supports the safety of cell broth as a drug delivery vehicle.
METABOLIC ENGINEERING COMMUNICATIONS
(2022)
Review
Psychology, Clinical
Max Teaford, Matthew S. McMurray, Vincent Billock, Madison Filipkowski, L. James Smart
Summary: Individuals with anorexia nervosa show abnormalities in multisensory integration, reduced discrimination ability for complex haptic and tactile stimuli, and decreased sensitivity to nociceptive stimuli, indicating potential avenues for future research.
JOURNAL OF EXPERIMENTAL PSYCHOPATHOLOGY
(2021)
Article
Neurosciences
Matthew S. McMurray, Sineadh M. Conway, Jamie D. Roitman
Article
Behavioral Sciences
Leslie R. Amodeo, Eliza Jacobs-Brichford, Matthew S. McMurray, Jamie D. Roitman
BEHAVIOURAL BRAIN RESEARCH
(2017)