Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Wegen, Lutz van Heek, Philipp Linde, Karina Claus, Dennis Akuamoa-Boateng, Christian Baues, Shachi Jenny Sharma, Klaus Schomaecker, Thomas Fischer, Katrin Sabine Roth, Jens Peter Klussmann, Simone Marnitz, Alexander Drzezga, Carsten Kobe
Summary: This study compares the use of [(68) Ga]Ga-FAPI-46 PET/CT and [F-18]F-FDG PET/CT in improving target volume definition and radiotherapy planning for head and neck cancers. The results demonstrate the usefulness of [(68) Ga]Ga-FAPI-46 PET/CT in detecting tumor lesions in these patients.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuvnik Trada, Paul Keall, Michael Jameson, Daniel Moses, Peter Lin, Phillip Chlap, Lois Holloway, Myo Min, Dion Forstner, Allan Fowler, Mark T. Lee
Summary: Combining DWI MRI and FDG-PET/CT for measuring tumor changes during radiotherapy can predict treatment response in mucosal head and neck carcinoma. Evaluating ADC mean and MTV together improves the accuracy of predicting local recurrence.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Yangmeihui Song, Fang Liu, Weiwei Ruan, Fan Hu, Muhsin H. Younis, Zairong Gao, Jie Ming, Tao Huang, Weibo Cai, Xiaoli Lan
Summary: PET/MR technology, combining MRI and PET capabilities, shows potential in achieving high diagnostic performance for refractory malignancies in DTC patients. Compared to PET/CT, PET/MR demonstrates better detection rates and sensitivity in assessing recurrent DTC lesions and lymph node metastases, providing more precise diagnostic information without additional ionizing radiation. Further studies and economic analysis are needed for scaling-up prospective applications.
Article
Otorhinolaryngology
Brendan C. Stack, Fenghai Duan, Rathan M. Subramaniam, Justin Romanoff, JoRean D. Sicks, Twyla Bartel, Chien Chen, Val J. Lowe
Summary: FDG-PET/CT is effective for assessing neck nodal disease. This study reports the risks and patterns of nodal disease based on primary site and nodal level, with oral cavity (level I), pharynx (level II), and larynx (level VI) being the levels at greatest risk for nodal disease in cN0.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ludwig Opalinski, Sandra Schmitz, Pascal Van Eeckhout, Philippe d'Abadie, Olivier Gheysens
Summary: A 54-year-old man with a history of tonsillar squamous cell carcinoma and seropositive rheumatoid arthritis presented with right cervical pain and dysphagia. Imaging showed a necrotic lesion connected to the hyoid bone. Surgical resection revealed a necrotizing granuloma consistent with a rheumatoid nodule.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
C. Pisani, L. Vigna, F. Mastroleo, G. Loi, V Amisano, L. Masini, L. Deantonio, P. Aluffi Valletti, G. Sacchetti, M. Krengli
Summary: The study analyzed the pattern of failure in head and neck squamous cell carcinoma patients treated with definitive radio-chemotherapy in relation to pre-treatment [F-18] FDG-PET/CT uptake. The research findings suggest that tumor recurrence in high-dose volume may be a potential indicator for local relapse prevention by intensifying the dose on these volumes.
RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gwenaelle Creff, Franck Jegoux, Xavier Palard, Adrien Depeursinge, Ronan Abgral, Remi Marianowski, Jean-Christophe Leclere, Thomas Eugene, Olivier Malard, Renaud De Crevoisier, Anne Devillers, Joel Castelli
Summary: This study confirmed the association of nodal MTV and maximal tumor-node distance with the risk of DMFS, as well as a higher risk of death. These prognostic factors can guide individualized treatment.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dominic Raphael Schwaninger, Martin Hullner, Dominique Bichsel, Barbara Giacomelli-Hiestand, Nicole Selina Stutzmann, Panagiotis Balermpas, Silvio Valdec, Bernd Stadlinger
Summary: This study aimed to compare oral and maxillo-mandibular inflammatory foci on standard oral radiographs with FDG-PET/CT data and discuss whether FDG-PET/CT can support oral care specialists when performing oral focus examinations.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Malek Z. O. Hassan, Ahmed Tawakol, Ying Wang, Raza M. Alvi, Magid Awadalla, Maeve Jones-O'Connor, Rula B. Bakar, Dahlia Banerji, Adam Rokicki, Lili Zhang, Connor P. Mulligan, Michael T. Osborne, Azmaeen Zarif, Basma Hammad, Annie W. Chan, Lori J. Wirth, Erica T. Warner, Roger K. Pitman, Katrina A. Armstrong, Daniel Addison, Tomas G. Neilan
Summary: The mechanisms linking chronic stress and higher mortality in individuals with cancer are not fully understood. This retrospective cohort study found that higher stress-associated neural activity in individuals with head and neck cancer was associated with poorer survival. Future research should investigate strategies to reduce this neural activity and improve cancer survival.
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert J. O'Shea, Chris Rookyard, Sam Withey, Gary J. R. Cook, Sophia Tsoka, Vicky Goh
Summary: Radiomic models offer potential for improving the assessment of oesophageal adenocarcinoma through quantitative medical image analysis. However, the selection and generalizability of these models remain challenges. Although radiomic models show promise in predicting and distinguishing clinical features of oesophageal adenocarcinoma, further improvements in sensitivity and generalizability are needed. Future research should prioritize the prospective validation of proposed models to facilitate their clinical translation.
INSIGHTS INTO IMAGING
(2022)
Article
Endocrinology & Metabolism
Sarah Boughdad, Ann O'Connor, Gary J. Cook, Lucy Pike, Steve Connor, Rupert Obholzer, Victoria Warbey
Summary: FDG PET-CT demonstrates good clinical performance in detecting head and neck paragangliomas (HNPGLs), especially in pre-therapeutic assessment. Regardless of SDHx mutation status, a high SUVmax is associated with more clinical events.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Clelia Di Carlo, Maika di Benedetto, Lisa Vicenzi, Sara Costantini, Francesca Cucciarelli, Francesco Fenu, Eleonora Arena, Cristina Mariucci, Maria Montisci, Valeria Panni, Fabiola Patani, Marco Valenti, Andrea Palucci, Luca Burroni, Giovanna Mantello
Summary: Radiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy is the standard treatment for anal cancer. Intensity Modulated Radiotherapy (IMRT) allows precise tumor treatment with reduced damage to surrounding tissues. The study found that 18FDG-PET/CT has a significant impact on staging and target volume delineation in anal cancer patients, leading to clinical stage variation in 14% of cases. More research is needed to further define the role of 18FDG-PET/CT in target volume delineation for anal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yaqun Jiang, Bing Wen, Chongjiao Li, Yueli Tian, Zhiwei Xiao, Kui Xu, Diankui Xing, Zili Yu, Jing Huang, Jun Jia, Yong He
Summary: This study compares the performance of Ga-68-FAPI-04 and F-18-FDG PET/CT in the staging and detection of recurrences in head and neck squamous cell carcinoma (HNSCC). The results showed that Ga-68-FAPI-04 PET/CT outperformed F-18-FDG PET/CT in evaluating preoperative N staging and detecting distant metastasis. It also showed potential in clinical management and monitoring treatment response.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Otorhinolaryngology
Thomas M. Stadler, Gregoire B. Morand, Niels J. Rupp, Martin W. Hullner, Martina A. Broglie
Summary: This retrospective study on head and neck carcinoma patients found that FDG-PET-CT/MRI led to significant changes in pretherapeutic N classification, with a 18.7% cumulative incidence of distant metastases and second primaries detected.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Hsi-Huei Lu, Nan-Tsing Chiu, Mu-Hung Tsai
Summary: Early post-treatment F-18-FDG PET/CT can be used to predict radiation-induced hypothyroidism (RIHT) in head and neck cancer patients. The thyroid functioning volume and abnormal F-18-FDG uptake on PET/CT can be early indicators for predicting RIHT.
Article
Oncology
T. Gambichler, C. Finis, N. Abu Rached, C. H. Scheel, J. C. Becker, K. Lang, H. U. Kafferlein, T. Bruning, N. Abolmaali, L. Susok
Summary: The study investigated the protein expression of DNA mismatch repair (MMR) proteins in patients with cutaneous melanoma (CM) receiving immune checkpoint inhibitor (ICI) therapy. Immunohistochemistry was performed on tumor tissue of 50 patients, and reduced MMR protein expression was observed in 16% of patients. Baseline neutrophil/lymphocyte ratio and reduced intratumoral MMR protein expression were significantly associated with favorable treatment response. However, further validation is required in larger patient cohorts.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Sebastian Zschaeck, Julian Weingaertner, Elia Lombardo, Sebastian Marschner, Marina Hajiyianni, Marcus Beck, Daniel Zips, Yimin Li, Qin Lin, Holger Amthauer, Esther G. C. Troost, Joerg van den Hoff, Volker Budach, Joerg Kotzerke, Konstantinos Ferentinos, Efstratios Karagiannis, David Kaul, Vincent Gregoire, Adrien Holzgreve, Nathalie L. Albert, Pavel Nikulin, Michael Bachmann, Klaus Kopka, Mechthild Krause, Michael Baumann, Joanna Kazmierska, Paulina Cegla, Witold Cholewinski, Iosif Strouthos, Klaus Zoephel, Ewa Majchrzak, Guillaume Landry, Claus Belka, Carmen Stromberger, Frank Hofheinz
Summary: The study evaluates the prognostic and potentially predictive value of FDG-PET in head and neck squamous cell carcinomas. The results show that FDG-PET parameters have considerable prognostic value and potential predictive value in subgroups of patients, especially regarding treatment de-intensification and organ-preservation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Volker Arndt, Daniela Doege, Stefan Froehling, Peter Albers, Hana Alguel, Ralf Bargou, Carsten Bokemeyer, Martin Bornhaeuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Bruemmendorf, Hartmut Doehner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann
Summary: The capacities of German Comprehensive Cancer Centers (CCCs) in various aspects of oncology care were significantly affected during the first 2 years of the COVID-19 pandemic. Follow-up, psycho-oncologic care, and tumor surgery were particularly impacted, along with other areas of multidisciplinary oncological care. This study highlights the importance of developing strategies to prevent similar limitations in the future.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Marie-Catherine Vozenin, Andreas Schuller, Marie Dutreix, Karen Kirkby, Michael Baumann, Rob P. Coppes, David Thwaites
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Daria Klusa, Fabian Lohaus, Andre Franken, Marian Baumbach, Monica Cojoc, Paul Dowling, Annett Linge, Anne Offermann, Steffen Loeck, Dejan Husman, Mahdi Rivandi, Bernhard Polzer, Vera Freytag, Tobias Lange, Hans Neubauer, Michael Kuecken, Sven Perner, Tobias Hoelscher, Anna Dubrovska, Mechthild Krause, Ina Kurth, Michael Baumann, Claudia Peitzsch
Summary: We investigated the circulating tumor cells (CTCs) of patients with metastatic prostate cancer, and found that the number of CTCs is associated with the time of biochemical progression after radiotherapy. Specifically, the expression of CXCR4 and CCL2 is related to cellular radiosensitivity, tumorigenicity, and stem-like potential.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Oncology
Birgitte Vrou Offersen, Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dieter Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W. M. Lee, Steffen Loeck, David I. Thwaites, Albert J. van der Kogel, Uulke van der Heide, Vincenzo Valentini, Jens Overgaard, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Sebastian Starke, Alexander Zwanenburg, Karoline Leger, Klaus Zoephel, Joerg Kotzerke, Mechthild Krause, Michael Baumann, Esther G. C. Troost, Steffen Loeck
Summary: This study investigates the predictive ability of machine learning-based radiomics models using imaging data obtained during the course of treatment. Features were extracted from pre-treatment CT and FDG-PET images, as well as images obtained two and three weeks after the start of radiochemotherapy. Models comprised of combined features from both modalities and multiple timepoints were evaluated. The results show that predictive model performance is improved when features from in-treatment imaging are used.
Article
Oncology
Bouchra Tawk, Katrin Rein, Christian Schwager, Maximilian Knoll, Ute Wirkner, Juliane Hoerner-Rieber, Jakob Liermann, Ina Kurth, Panagiotis Balermpas, Claus Roedel, Annett Linge, Steffen Loeck, Fabian Lohaus, Ingeborg Tinhofer, Mechtild Krause, Martin Stuschke, Anca Ligia Grosu, Daniel Zips, Stephanie E. Combs, Claus Belka, Albrecht Stenzinger, Christel Herold-Mende, Michael Baumann, Peter Schirmacher, Jurgen Debus, Amir Abdollahi
Summary: This study suggests that the DNA methylation landscape of tumor cells may indicate epigenetic changes caused by chronic tumor hypoxia. The researchers developed a tumor hypoxia classifier (Hypoxia-M) based on DNA methylation profiles, which showed independent prognostic effects in patients with head and neck squamous cell carcinoma (HNSCC). These findings underscore the importance of DNA methylation-based classifiers as biomarkers of tumor hypoxia.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Michael Baumann, Julio Celis, Ulrik Ringborg, Manuel Heitor, Anton Berns, Tit Albreht, Jeliazko Arabadjiev, Michael Boutros, Mario Brandenburg, Helena Canhao, Fatima Carneiro, Christine Chomienne, Francesco De Lorenzo, Alexander M. M. Eggermont, Angel Font, Elena Garralda, Margarida Goulart, Rui Henrique, Mark Lawler, Lena Maier-Hein, Francoise Meunier, Simon Oberst, Pedro Oliveira, Maria Papatriantafyllou, Joachim Schuez, Eric Solary, Alfonso Valencia, Rosalia Vargas, Elisabete Weiderpass, Nils Wilking
Summary: European cancer research stakeholders gathered in Heidelberg, Germany, for the 5(th) Gago conference on European Cancer Policy in October 2022. The meeting focused on the current state of cancer research and care policy in Europe, identifying gaps in existing programs and proposing priorities for the future through the Heidelberg Manifesto for cancer research. The discussions in the meeting covered various aspects of cancer research, including infrastructure, digitalization, and collaboration, with an emphasis on implementation and sustainability.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Chiara Valentini, Nadja Ebert, Lydia Koi, Manuel Pfeifer, Steffen Loeck, Christoph Erdmann, Mechthild Krause, Michael Baumann
Summary: This study aimed to compare the efficacy of fractionated radiotherapy versus radiochemotherapy with cisplatin in HPV-positive and negative human head and neck squamous cell carcinoma xenografts. The results showed that RCT significantly increased local tumor control in two out of three HPV-positive tumor models and one HPV-negative tumor model. In the pooled group of all HPV-positive tumors, RCT substantially enhanced local tumor control, while this effect was not observed in HPV-negative tumors.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Lydia Koi, Verena Bitto, Corina Weise, Lisa Moebius, Annett Linge, Steffen Loeck, Ala Yaromina, Maria Jose Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause, Michael Baumann
Summary: Combining nimorazole with radiochemotherapy can improve local tumor control in some patients with head and neck squamous cell carcinoma, especially those with hypoxic tumors. In addition, molecular biomarkers have been identified for targeted therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Biographical-Item
Multidisciplinary Sciences
Michael Baumann, Magnus von Knebel Doeberitz
Review
Oncology
David A. Jaffray, Felicia Knaul, Michael Baumann, Mary Gospodarowicz
Summary: The pace of technological innovation has made radiotherapy one of the most technologically intense disciplines in medicine. However, global barriers hinder access to this effective treatment. Efforts are being made in the radiation oncology community to align individualized therapy with global access needs.
Article
Oncology
F. Raschke, K. Witzmann, A. Seidlitz, T. Wesemann, C. Jentsch, I. Platzek, J. van den Hoff, J. Kotzerke, B. Beuthien-Baumann, M. Baumann, J. Linn, M. Krause, E. G. C. Troost
Summary: This study measured the atrophy of subcortical structures including the hippocampus, amygdala, thalamus, putamen, pallidum, and caudate nucleus in glioma patients before and after radiotherapy using MRI. The results showed significant atrophy in the hippocampus, amygdala, thalamus, putamen, and pallidum after radiotherapy, with the hippocampus having the highest atrophy rate. The findings suggest that these structures should be further investigated in relation to neurocognitive decline after radiotherapy.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Tobias Hoelscher, Michael Baumann, Joerg Kotzerke, Klaus Zoephel, Frank Paulsen, Arndt-Christian Mueller, Daniel Zips, Lydia Koi, Christian Thomas, Steffen Lock, Mechthild Krause, Manfred Wirth, Fabian Lohaus
Summary: This study suggests that local ablative radiotherapy (aRT) is safe and effective for patients with oligometastatic prostate cancer, and one in five patients had no recurrent prostate-specific antigen after 3 years. This may be an option to avoid systemic therapy in selected patients.
EUROPEAN UROLOGY ONCOLOGY
(2022)
