Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: Treating brainstem cavernous malformations with microsurgery or radiosurgery has shown to be effective in reducing the rehemorrhage rate. The neurosurgery cohort had lower incidence of symptomatic intracranial hemorrhage, while the radiosurgery cohort had lower incidence of persistent focal neurological deficit.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Laurel Rauschenbach, Alejandro N. Santos, Thiemo F. Dinger, Marvin Darkwah Oppong, Yan Li, Stephan Tippelt, Christian Dohna-Schwake, Boerge Schmidt, Ramazan Jabbarli, Karsten H. Wrede, Ulrich Sure, Philipp Dammann
Summary: The purpose of this study was to investigate the functional outcome following surgical resection of cerebral cavernous malformations (CCM) in pediatric patients. The study found that complete resection of the lesion achieved favorable functional outcomes for the majority of patients, depending on lesion localization. However, brainstem localization was identified as a predictor of postoperative deterioration. The study suggests that surgery for CCM remnants may be safe and favorable based on minor evidence.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
You-Cong Chen, Chieh-Chih Tsai, Shih-Jen Chen, Hsiu-Mei Wu, Huai-Che Yang, Ching-Jen Chen, Yong -Sin Hu, Chung -Jung Lin, Wan-Yuo Guo, David Hung -Chi Pan, Wen-Yuh Chung, Cheng-Chia Lee
Summary: The objective of this study was to evaluate the safety and efficacy of single-session Gamma Knife radiosurgery (GKRS) for orbital cavernous hemangiomas (OCHs). The results of this study demonstrate that GKRS is a safe and effective treatment for OCHs, with significant improvements in visual acuity and visual field deficits, as well as tumor regression, observed over long-term follow-up. No adverse radiation effects were observed.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Ruyi Yang, Xinjun Wang, Ziqiang Xv, Puxue Zhao, Junwu Li, Quan An, Shan Huang
Summary: This study retrospectively evaluated the effectiveness and safety of staged GKRS treatment for giant CSHs, and the results showed that staged GKRS is an effective method for treating giant CSHs with a remarkably low incidence of adverse effects.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Hsien-Chung Chen, Chaur-Jong Hu, David Hung-Chi Pan
Summary: Although surgical excision is the conventional treatment for orbital cavernous hemangioma (OCH), gamma knife radiosurgery (GKRS) can be a safe and effective alternative, with favorable clinical outcomes and substantial tumor volume reduction. This retrospective study included four OCH patients treated with single-session GKRS between 2014 and 2020, showing significant improvement in visual acuity and tumor shrinkage after treatment.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Clinical Neurology
Joshua S. Catapano, Kavelin Rumalla, Visish M. Srinivasan, Peter M. Lawrence, Kristen Larson Keil, Michael T. Lawton
Summary: This study proposes a novel taxonomy for midbrain cavernous malformations based on clinical presentation and anatomical location. Different subtypes of midbrain BSCMs were identified and associated with distinct neurological symptoms and surgical approaches. The proposed taxonomy can enhance diagnostic acumen, improve surgical planning, and optimize patient outcomes.
JOURNAL OF NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Yu Duan, Renling Mao, Xuanfeng Qin, Yujun Liao, Jian Li, Gong Chen
Summary: Surgery is a main treatment for symptomatic intramedullary spinal cavernous hemangioma (ISCH), with microsurgical resection being safe and effective. Emergency rescue surgery (ERS) is effective for deteriorative patients in improving long-term spinal cord function, while lesions at the lumbosacral segment are a poor prognostic factor for functional recovery.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Philipp Dammann, Annika Herten, Alejandro N. Santos, Laurel Rauschenbach, Bixia Chen, Marvin Darkwah Oppong, Boerge Schmidt, Michael Forsting, Christoph Kleinschnitz, Ulrich Sure
Summary: This study assessed outcomes after surgery for brainstem cavernous malformations (BSCMs) and found that patients' health-related quality of life (HRQOL) was impaired post-surgery, especially in those with unfavorable functional outcomes. Psychological impairment was more significant in unfavorable outcome patients, while minimal in those with favorable outcomes. Symptoms related to brainstem and cranial nerves had a notable impact on HRQOL.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Susanna M. Zuurbier, Charlotte R. Hickman, Leon A. Rinkel, Rebecca Berg, Ulrich Sure, Rustam Al-Shahi Salman
Summary: This study suggests that the use of beta-blockers may be associated with a lower risk of intracranial hemorrhage or persistent/progressive focal neurological deficit, while the use of statin drugs may be associated with a slightly lower risk.
Article
Neurosciences
Manjul Tripathi, Raghav Singla, Renu Madan, Aman Batish, Chirag K. Ahuja, Manoj K. Tewari, Sandeep Mohindra, Ninad R. Patil, Sushant Dutta, Rajeev Chauhan
Summary: Cavernous sinus hemangioma (CSH) are difficult to excise due to their location, propensity for bleeding and complex relationship with neurovascular structures. This study presents the first report of fractionated gamma knife radiosurgery (GKRS) for giant CSH, showing significant clinical improvement and tumor volume reduction in a short period. Hypofractionated GKRS may be considered an effective and safe alternative for treating these challenging lesions.
Review
Cardiac & Cardiovascular Systems
Daniel A. Snellings, Courtney C. Hong, Aileen A. Ren, Miguel A. Lopez-Ramirez, Romuald Girard, Abhinav Srinath, Douglas A. Marchuk, Mark H. Ginsberg, Issam A. Awad, Mark L. Kahn
Summary: Cerebral cavernous malformations are a common cause of central nervous system hemorrhage and stroke, and significant progress has been made in understanding the pathogenesis of this vascular disease over the past 20 years. New knowledge includes genetic and molecular causes of the disease, environmental influences on disease pathogenesis, and drivers of disease endpoints. These insights are the result of integrated research spanning human clinical studies, human genetic studies, studies in genetic models, and basic molecular and cellular studies.
CIRCULATION RESEARCH
(2021)
Review
Neurosciences
Sandeep Mishra, Akshay Ganesh Kumar, Kanwaljeet Garg, Manoj Phalak, Manjul Tripathi, Deepak Agrawal, Manmohan Singh, Shashank Sharad Kale
Summary: This study conducted a meta-analysis to assess the effects and complications of stereotactic radiosurgery (SRS) in treating cavernous sinus haemangiomas (CSHs), and compared it to surgical excision. The results showed that SRS is a safe and effective option, with over 50% reduction in tumor volume for the majority of patients.
Review
Surgery
George Fotakopoulos, Hugo Andrade-Barazarte, Juri Kivelev, Mardjono Tjahjadi, Felix Goehre, Juha Hernesniemi
Summary: This study conducted a systematic review and meta-analysis on the therapeutic strategies for brainstem cavernous malformations. The findings suggest that there is no superiority between microsurgical resection and stereotactic radiosurgery in terms of mortality, rebleeding rate, and permanent neurological deficits.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Nathan Beucler, Sebastien Boissonneau, Aurelia Ruf, Stephane Fuentes, Romain Carron, Henry Dufour
Summary: This study reviewed the proportion of CBS caused by bleeding episode arising from brainstem cavernous malformation reported in the literature. Hemorrhagic BCM accounted for approximately 7% of CBS cases. Microsurgical excision may be indicated after the second bleeding episode.
Article
Ophthalmology
Tianming Jian, Fengyuan Sun, Tong Wu, Liang Zhao, Xiaoming Huang, Lina Wang, Yanjin He, Dongrun Tang
Summary: Severe vision impairment after surgery for primary orbital tumors in the muscle cone is associated with tumor location in the orbital apex, severe optic nerve displacement, and intraoperative tight adhesion. The incidence of PSVI in intraconal tumors is 7.3%, with NLP occurring in 1.8% of cases.