Article
Oncology
Richard Choo, David W. Hillman, Cecilia Mitchell, Thomas Daniels, Carlos Vargas, Jean Claude Rwigema, Kimberly Corbin, Sameer Keole, Sujay Vora, Kenneth Merrell, Bradley Stish, Thomas Pisansky, Brian J. Davis, Adam Amundson, William Wong
Summary: The purpose of this study was to evaluate the late gastrointestinal (GI) and genitourinary (GU) toxicity of moderately hypofractionated intensity-modulated proton therapy (IMPT) targeting the prostate and pelvic lymph nodes. The results showed that moderately hypofractionated IMPT was generally well tolerated with minimal toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Kiyonao Nakamura, Yoshiki Norihisa, Itaru Ikeda, Haruo Inokuchi, Rihito Aizawa, Toshiyuki Kamoto, Tomomi Kamba, Takahiro Inoue, Toshinari Yamasaki, Shusuke Akamatsu, Takashi Kobayashi, Osamu Ogawa, Takashi Mizowaki
Summary: This study evaluates the outcomes of whole-pelvic simultaneous integrated boost intensity-modulated radiation therapy combined with androgen deprivation therapy in pelvic node-positive prostate cancer. The results show that the treatment can be safely administered and has low rates of biochemical relapse. Additionally, the International Society of Urological Pathology grade group 5 and post-treatment detectable nadir PSA levels are associated with worse survival and progression of castration resistance.
Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Melline G. M. Schilham, Patrik Zamecnik, Bastiaan M. Prive, Bas Israel, Mark Rijpkema, Tom Scheenen, Jelle O. Barentsz, James Nagarajah, Martin Gotthardt
Summary: Accurate assessment of lymph node metastases in prostate cancer patients is crucial. PSMA PET/CT and nano-MRI are imaging modalities with high potential for identifying LN metastases. This study compared the results of these modalities, finding that nano-MRI detected more suspicious LNs, especially smaller ones, across all anatomical regions of the pelvis. It suggests that nano-MRI could complement PSMA PET/CT in imaging PCa patients, but further investigation is needed.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O'Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Alain P. Algazi, Patrick Ha, Matthew H. Spitzer
Summary: CD8+ T cell responses in lymph nodes play a critical role in anti-tumor immunity in human head and neck squamous cell carcinomas. These responses are associated with specific T cells in circulation and provide important insights for immune-based therapies in cancer.
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Haoliang Lin, Dongyan Wang, Hui Li, Chuling Wu, Fengqian Zhang, Zhongqiu Lin, Tingting Yao
Summary: This study investigated the survival, treatment pattern, and treatment outcome of patients with cervical cancer metastasized to lymph nodes beyond the pelvis. The results showed that patients with distant lymphatic metastasis had better survival compared to those with pelvic organ invasion or distant organ metastasis. The prognosis of these patients was significantly affected by local tumor burden and local treatment. Adequate and aggressive local radiotherapy, such as image-guided brachytherapy, may lead to better outcomes for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sota Nakahara, Takayuki Ohguri, Sho Kakinouchi, Hirohide Itamura, Takahiro Morisaki, Subaru Tani, Katuya Yahara, Naohiro Fujimoto
Summary: This study retrospectively analyzed the efficacy and toxicity of adding regional hyperthermia to intensity-modulated radiotherapy (IMRT) plus neoadjuvant androgen deprivation therapy (ADT) for high-risk localized prostate carcinoma. The results showed that adding hyperthermia improved clinical relapse-free survival and higher thermal dose predicted improved biochemical disease-free survival.
Article
Oncology
Guang-Li Zhu, Xiao-Min Zhang, Kai-Bin Yang, Ling-Long Tang, Jun Ma
Summary: This study investigated the metastatic patterns of level II-V lymph nodes in nasopharyngeal carcinoma (NPC) patients using vertebrae as anatomical landmarks. It was found that the metastasis rate gradually decreased from higher vertebral levels to lower levels. The study suggests that the clinical target volume in radiotherapy can be reduced to two vertebral levels below the metastatic level II-V nodes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Xieraili Wumener, Yarong Zhang, Zhenguo Wang, Maoqun Zhang, Zihan Zang, Bin Huang, Ming Liu, Shengyun Huang, Yong Huang, Peng Wang, Ying Liang, Tao Sun
Summary: This study evaluates the diagnostic value of quantitative metabolic parameters derived from dynamic F-18-FDG PET/CT in differentiating metastatic and non-metastatic lymph nodes in lung cancer patients. The results suggest that parameters such as K-1, k(2), K-i, and K-i/K-1 show promising results for differentiation of metastatic and non-metastatic lymph nodes with high uptake.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Corrado Tinterri, Giuseppe Canavese, Wolfgang Gatzemeier, Erika Barbieri, Alberto Bottini, Andrea Sagona, Giulia Caraceni, Alberto Testori, Simone Di Maria Grimaldi, Carla Dani, Luca Boni, Paolo Bruzzi, Bethania Fernandes, Marta Scorsetti, Alberto Zambelli, Damiano Gentile, SINODAR ONE Collaborative Grp
Summary: For patients with T1-2 breast cancer and 1-2 macrometastatic sentinel lymph nodes, breast-conserving surgery, sentinel lymph node biopsy only, and adjuvant therapy showed similar survival rates and recurrence rates compared to axillary lymph node dissection. Mastectomy patients who underwent sentinel lymph node biopsy alone also had comparable outcomes without the need for axillary lymph node dissection.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Yu Murakami, Takashi Soyano, Takuyo Kozuka, Masaru Ushijima, Yuuki Koizumi, Hikaru Miyauchi, Masahiro Kaneko, Masahiro Nakano, Tatsuya Kamima, Takeo Hashimoto, Yasuo Yoshioka, Masahiko Oguchi
Summary: A dosiomics-based prediction model for biochemical recurrence (BCR) in prostate cancer patients was developed, with dosiomic features significantly associated with BCR. Combining dosiomic features with clinical variables improved performance, suggesting the potential for integrating dosiomics into clinical workflows.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Engineering, Biomedical
Jiayuan Peng, Yuanhua Chen, Jun Zhao, Jiazhou Wang, Xiang Xia, Bin Cai, Thomas R. Mazur, Ji Zhu, Zhen Zhang, Weigang Hu
Summary: The study developed an efficient and automatic approach, AGAP, that fully automated the IMRT planning process in rectal cancer radiotherapy. It reduced the dependence on planner experience and maintained comparable plan quality with P-auto plans.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Jiangrui Liu, Yibin Su, Xing Liu, Jinfu Zhuang, Yuanfeng Yang, Guoxian Guan
Summary: D3 or CME surgery is common for colon cancer metastasis treatment. Clinical misuse of lymph node dissection brings burdens to patients. Detailed guidance for T3 and T4 stage right colon cancer patients is needed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Daria Klusa, Fabian Lohaus, Giulia Furesi, Martina Rauner, Martina Benesova, Mechthild Krause, Ina Kurth, Claudia Peitzsch
Summary: Radiotherapy and surgery are effective treatments for localized prostate cancer, but once the cancer spreads, the survival rate drops dramatically. Understanding the biological characteristics of PCa metastasis is crucial, and modern imaging technologies can improve early detection of metastases. Unmet clinical needs include biomarkers for targeted radiotherapy and diagnosing minimal residual disease. Monitoring circulating tumor cells during radiotherapy may provide insights into metastatic spread and treatment resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Bas Israel, Jos Immerzeel, Marloes van der Leest, Gerjon Hannink, Patrik Zamecnik, Joyce Bomers, Ivo G. Schoots, Jean-Paul Van Basten, Frans Debruyne, Inge van Oort, Michiel Sedelaar, Jelle Barentsz
Summary: The study evaluated the outcomes of pre-biopsy MRI pathways in biopsy-naive men with suspicion of prostate cancer in routine clinical practice. The results showed that pre-biopsy MRI can be used as a decision tool without compromising cancer detection rates and with a higher biopsy avoidance rate. There were comparable cancer detection and complication rates between TR- and TP-MRDB.
Letter
Dermatology
C. Chello, S. Ciardo, J. Chester, M. Guanti, F. Farnetani, S. Guida, A. Sticchi, P. Giacobazzi, B. Meduri, F. Lohr, G. Pellacani, M. Manfredini
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Urology & Nephrology
Cristina Masini, Cinzia Iotti, Ugo De Giorgi, Roberto Salvatore Bellia, Sebastiano Buti, Francesco Salaroli, Ilaria Zampiva, Renzo Mazzarotto, Claudia Mucciarini, Maria Giuseppa Vitale, Alessio Bruni, Frank Lohr, Giuseppe Procopio, Orazio Caffo, Franco Nole, Franco Morelli, Susanne Baier, Consuelo Buttigliero, Patrizia Ciammella, Giorgia Timon, Emanuela Fantinel, Gabriele Carlinfante, Annalisa Berselli, Carmine Pinto
Summary: This study evaluated the efficacy and safety of stereotactic body radiotherapy (SBRT) in combination with nivolumab in second- and third-line metastatic renal cell carcinoma (mRCC) patients. The results showed that the combination treatment did not provide additional clinical benefits but was safe and showed a good response in the irradiated lesions.
Article
Oncology
Leonie Rabe, Frederik Wenz, Michael Ehmann, Frank Lohr, Ralf Dieter Hofheinz, Daniel Buergy
Summary: This study evaluated the usage of radiotherapy in trial protocols for anti-cancer drugs approved by the US FDA, finding that over 90% of newly approved anti-cancer drugs lack publicly available data on drug/radiotherapy interactions.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Antonella Iudicello, Stefano Boschi, Pietro Ghedini, Frank Lohr, Stefano Panareo
Summary: [Ga-68]Ga-PSMA-11 PET/CT plays a pivotal role in the diagnosis and staging of prostate cancer due to its higher sensitivity and detection rate. Optimizing the radiochemical yield of the radiopharmaceutical is important for clinical activity planning and optimization. The presence of metal ion contaminants in the peptide precursor during radiometallation of PSMA-11 can decrease the radiochemical yield of [Ga-68]Ga-PSMA-11 due to competition with gallium-68.
Article
Oncology
Lena Kaestner, Yasser Abo-Madyan, Lena Huber, Manon Spaniol, Kerstin Siebenlist, Marie-Kristin Sacks, Michael Ehmann, Florian Stieler, Sven Clausen, Frank Lohr, Jens Fleckenstein, Judit Boda-Heggemann
ADVANCES IN RADIATION ONCOLOGY
(2022)
Review
Oncology
Alessia Di Rito, Francesco Fiorica, Roberta Carbonara, Francesca Di Pressa, Federica Bertolini, Francesco Mannavola, Frank Lohr, Angela Sardaro, Elisa D'Angelo
Summary: Oral cavity carcinoma (OCC) is a common malignant tumor with high risk of recurrence. The efficacy of postoperative chemotherapy in addition to radiotherapy (POCRT) for OCC with minor risk factors is controversial. A systematic review and meta-analysis were conducted, revealing that POCRT showed improved overall survival (OS) but inconclusive disease-free survival (DFS) and local-recurrence-free survival (LRFS). Further analysis is warranted.
Article
Chemistry, Multidisciplinary
Hannes Berg, Maria A. Wirtz Martin, Nadide Altincekic, Islam Alshamleh, Jasleen Kaur Bains, Julius Blechar, Betul Ceylan, Vanessa de Jesus, Karthikeyan Dhamotharan, Christin Fuks, Santosh L. Gande, Bruno Hargittay, Katharina F. Hohmann, Marie T. Hutchison, Sophie Marianne Korn, Robin Krishnathas, Felicitas Kutz, Verena Linhard, Tobias Matzel, Nathalie Meiser, Anna Niesteruk, Dennis J. Pyper, Linda Schulte, Sven Trucks, Kamal Azzaoui, Marcel J. J. Blommers, Yojana Gadiya, Reagon Karki, Andrea Zaliani, Philip Gribbon, Marcius da Silva Almeida, Cristiane Dinis Anobom, Anna L. Bula, Matthias Butikofer, Icaro Putinhon Caruso, Isabella Caterina Felli, Andrea T. Da Poian, Gisele Cardoso de Amorim, Nikolaos K. Fourkiotis, Angelo Gallo, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Bing Hao, Vilius Kurauskas, Lauriane Lecoq, Yunfeng Li, Nathane Cunha Mebus-Antunes, Miguel Mompean, Thais Cristtina Neves-Martins, Marti Ninot-Pedrosa, Anderson S. Pinheiro, Letizia Pontoriero, Yulia Pustovalova, Roland Riek, Angus J. Robertson, Marie Jose Abi Saad, Miguel A. Trevino, Aikaterini C. Tsika, Fabio C. L. Almeida, Ad Bax, Katherine Henzler-Wildman, Jeffrey C. Hoch, Kristaps Jaudzems, Douglas Laurents, Julien Orts, Roberta Pierattelli, Georgios A. Spyroulias, Elke Duchardt-Ferner, Jan Ferner, Boris Furtig, Martin Hengesbach, Frank Lohr, Nusrat Qureshi, Christian Richter, Krishna Saxena, Andreas Schlundt, Sridhar Sreeramulu, Anna Wacker, Julia E. Weigand, Julia Wirmer-Bartoschek, Jens Wohnert, Harald Schwalbe
Summary: This study explores novel drug design against SARS-CoV-2 through NMR screening and computational mapping. They identified multiple molecules that bind to SARS-CoV-2 proteins and studied their structural and chemical properties, providing new insights for drug development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, General & Internal
Vincenzo Livio Malavasi, Jacopo Francesco Imberti, Alberto Tosetti, Giulio Francesco Romiti, Marco Vitolo, Massimo Zecchin, Ercole Mazzeo, De Marco Giuseppina, Frank Lohr, Teresa Lopez-Fernandez, Giuseppe Boriani
Summary: The prevalence of radiotherapy-induced CIEDs malfunctions ranges from 4% to 20%. The use of neutron-producing energies and more complex devices (ICD/CRT-D) are associated with a higher risk of device malfunction, while the radiation dose at CIED does not significantly impact the risk unless higher doses (>10 Gy) are used.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Alessio Bruni, Federica Bertolini, Elisa D'Angelo, Giorgia Guaitoli, Jessica Imbrescia, Anna Cappelli, Gabriele Guidi, Alessandro Stefani, Massimo Dominici, Frank Lohr
Summary: Locally advanced non-small-cell lung cancer poses challenges in treatment choice and outcomes. Different treatments such as chemo-radiotherapy followed by immunotherapy or surgery followed by adjuvant therapies may yield similar results. We present a case of successful treatment for mediastinal nodal recurrence after thoracic surgery using sequential chemo-radiotherapy-immunotherapy. The patient also received stereotactic ablative radiotherapy for a single brain lesion. Comprehensive clinical data are needed to determine the role of combining systemic and local treatments in managing relapse after chemo-radiotherapy and immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
G. M. Mistretta, F. Itta, P. Ceroni, M. V. Gutierrez, N. Maffei, F. Campanaro, A. Bernabei, F. Marino, F. Lohr, G. Guidi
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
C. Dreher, P. Wojtal, H. Oppitz, L. Kaestner, K. Siebenlist, M. Eckl, D. Buergy, J. Fleckenstein, F. Lohr, M. Ehmann, J. Boda-Heggemann
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulio Francolini, Barbara Alicja Jereczek-Fossa, Vanessa Di Cataldo, Gabriele Simontacchi, Giulia Marvaso, Sara Gandini, Federica Corso, Lucia Pia Ciccone, Maria Alessia Zerella, Piercarlo Gentile, Federico Bianciardi, Sara Allegretta, Beatrice Detti, Isacco Desideri, Rolando Maria D'Angelillo, Laura Masi, Gianluca Ingrosso, Mario Di Staso, Ercole Mazzeo, Fabio Trippa, Frank Lohr, Alessio Bruni, Lorenzo Livi
Summary: This study compared the outcomes of salvage radiation therapy (SRT) with curative intent and stereotactic radiotherapy (SSRT) for macroscopic prostate recurrence after radical prostatectomy. The results showed no significant differences in terms of biochemical recurrence-free survival and progression-free survival between the two treatment groups. The matched cohort analysis revealed lower rates of toxicity for patients undergoing SSRT.
Meeting Abstract
Oncology
L. Nicosia, D. Franceschini, F. Perrone Congedi, F. Casamassima, M. A. Gerardi, M. Perna, V. Scotti, A. Fodor, R. Mazzola, M. Rigo, A. Iurato, F. Pasqualetti, G. Gadducci, S. Chiesa, R. M. Niespolo, A. Bruni, L. Frassinelli, P. Borghetti, A. Di Marzo, A. Ravasio, B. De Bari, M. Sepulcri, D. Aiello, G. Mortellaro, C. Sangalli, M. Franceschini, G. Montesi, F. M. Aquilanti, R. Valdagni, I. Fazio, L. Corti, L. Vavassori, E. Maranzano, S. M. Magrini, F. Lohr, S. Arcangeli, V. Valentini, F. Paiar, S. Ramella, N. G. Di Muzio, L. Livi, B. A. Jereczek-Fossa, M. F. Osti, M. Scorsetti, F. Alongi
RADIOTHERAPY AND ONCOLOGY
(2021)
Meeting Abstract
Oncology
G. R. Sarria, C. Dreher, G. Miebach, C. Henkenberens, S. Stera, P. Wojtal, D. Krug, H. Oppitz, F. A. Giordano, J. J. Schaefer, F. Lohr, J. Dunst, O. Blanck, J. Boda-Heggemann
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)