Article
Medicine, General & Internal
Sara Torresan, Gaia Zussino, Francesco Cortiula, Alessandro Follador, Gianpiero Fasola, Rossano Girometti, Lorenzo Cereser
Summary: We report a case of radiation recall pneumonitis followed by immune-checkpoint inhibitor-induced pneumonitis in a patient with non-small cell lung cancer. This case emphasizes the importance of considering radiation recall pneumonitis in the differential diagnosis of lung consolidation during immunotherapy and suggests that it may anticipate more extensive immune-checkpoint inhibitor-induced pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kuan-Heng Lin, Chen-Xiong Hsu, Shan-Ying Wang, Greta S. P. Mok, Chiu-Han Chang, Hui-Ju Tien, Pei-Wei Shueng, Tung-Hsin Wu
Summary: This study developed a volume-based algorithm (VBA) to predict lung V-5 and optimize lung dose in treatment planning. The predicted lung V-5 was positively correlated with actual lung V-5, while a decrease in arc angle led to a decrease in lung dose and an increase in heart dose.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bing Li, Xiaoli Zheng, Jiang Zhang, Saikit Lam, Wei Guo, Yunhan Wang, Sunan Cui, Xinzhi Teng, Yuanpeng Zhang, Zongrui Ma, Ta Zhou, Zhaoyang Lou, Lingguang Meng, Hong Ge, Jing Cai
Summary: The study evaluates the effectiveness of features obtained from proposed incremental-dose-interval-based lung subregion segmentation for predicting grade >= 2 acute radiation pneumonitis (ARP) in lung cancer patients. Results show that features from lung subregions outperform those from the whole lung in predicting ARP, especially when using dosiomics or combined radiomics-dosiomics features. This improved model performance could enhance clinical management and patient quality of life.
Article
Oncology
Anqi Zhang, Fuyuan Yang, Lei Gao, Xiaoyan Shi, Jiyuan Yang
Summary: Radiation pneumonitis is a common and serious complication of thoracic radiotherapy, and the use of immune checkpoint inhibitors in the treatment of non-small cell lung cancer may increase the risk of immune-related adverse events. This paper reviews the occurrence of radiation pneumonitis, immune pneumonitis, and combined treatment and provides the latest research results.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Junichi Soh, Seiichiro Sugimoto, Kei Namba, Akihiro Miura, Toshio Shiotani, Haruchika Yamamoto, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Kuniaki Katsui, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Shinichi Toyooka
Summary: Trimodality therapy is a common treatment option for locally advanced non-small cell lung cancer (LA-NSCLC) patients. Chronic lung injury (CLI) is a frequent complication after such treatment, often leading to cavity formation and chronic infections requiring surgical intervention. Further research on appropriate management for CLI post-trimodality therapy is needed.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Yongmei Liu, Weili Wang, Kevin Shiue, Huan Yao, Alberto Cerra-Franco, Ronald H. Shapiro, Ke Colin Huang, Douglas Vile, Mark Langer, Gordon Watson, Greg Bartlett, Huisi Ai, Francis Sheski, Jian-Yue Jin, Rich Zellars, Pingfu Fu, Tim Lautenschlaeger, Feng-Ming (Spring) Kong
Summary: This study investigated risk factors for radiation pneumonitis (RP) in NSCLC patients undergoing SBRT, finding that factors such as respiratory comorbidity history, previous thoracic radiation, and right lung location were significantly associated with RP2. A model combining clinical and dosimetric factors showed high predictive accuracy, suggesting that limiting mean lung dose can reduce lung toxicity risk.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingshu Meng, Yan Li, Chao Wan, Yajie Sun, Xiaomeng Dai, Jing Huang, Yan Hu, Yanan Gao, Bian Wu, Zhanjie Zhang, Ke Jiang, Shuangbing Xu, Jonathan F. Lovell, Yu Hu, Gang Wu, Honglin Jin, Kunyu Yang
Summary: The study highlights the importance of targeting senescence-like characteristics in cancer-associated fibroblasts to enhance radiosensitivity of non-small cell lung cancer cells, as well as alleviate radiation-induced pulmonary fibrosis.
Article
Oncology
Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takacs-Szabo, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bogsted, Tine McCulloch, Jens Brondum Frokjaer, Ursula Gerda Falkmer, Oluf Dimitri Roe
Summary: This study aimed to evaluate the utility of a novel radiation-induced lung injury (RILI) grading scale (RGS) for predicting radiation pneumonitis (RP) after thoracic radiation therapy. Results showed that patients with RGS grades 2-3 had a significantly higher risk for developing RP, and RGS demonstrated good specificity in predicting symptomatic RP.
RADIATION ONCOLOGY
(2021)
Article
Immunology
Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Morten Lindberg, Bente Halvorsen, Pal Aukrust, Aslaug Helland, Thor Ueland
Summary: This study found that T cell activation and exhaustion markers sCD25 and sTIM-3 are enhanced in NSCLC patients developing radiation pneumonitis (RP) and are associated with poor survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qingtao Qiu, Ligang Xing, Yu Wang, Alei Feng, Qiang Wen
Summary: This study aims to differentiate between immune checkpoint inhibitor-related pneumonitis (CIP) and radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) through pretreatment CT radiomics and clinical or radiological parameters. The radiomics signature and nomogram model showed good performance in distinguishing between CIP and RP. The addition of bilateral changes and sharp border improved the classification performance and could enhance clinical decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Daisuke Kawahara, Nobuki Imano, Riku Nishioka, Yasushi Nagata
Summary: This study proposes a prediction model using a convolutional neural network (CNN) model with image cropping to predict the severity of radiation pneumonitis (RP) in non-small-cell lung cancer (NSCLC) patients after radiotherapy. The CNN model uses 3D computed tomography (CT) images, cropped in different regions, as input data to classify patients into RP grade < 2 or RP grade >= 2. The performance of the model is evaluated using sensitivity, specificity, accuracy, and area under the curve (AUC) measures, with the nLung boolean AND 20 Gy method achieving the highest accuracy, specificity, sensitivity, and AUC.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Article
Oncology
Donald A. Muller, Sunil W. Dutta, Eric Aliotta, Jason C. Sanders, Krishni Wijesooriya, William T. Watkins, James M. Larner
Summary: Lung stereotactic body radiotherapy (SBRT) is effective for inoperable non-small-cell lung cancer, but multicourse lung SBRT has not been extensively studied. This study found that composite lung V-5 and timing of the second course of SBRT may be related to the development of radiation pneumonitis.
CLINICAL LUNG CANCER
(2021)
Article
Medicine, General & Internal
Bae Kwon Jeong, Jin Hyun Kim, Myeong Hee Jung, Ki Mun Kang, Yun Hee Lee
Summary: Analysis of cytokine profiles showed that changes in IL-6, G-CSF, and IFN-gamma levels at 3 weeks after the initiation of radiotherapy could identify patients predisposed to severe RP. Further investigation is needed to understand the mechanism of cytokine variation in relation to RP severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon, Toshiaki Takahashi
Summary: ILAs were found to be a predictive factor for radiation pneumonitis in patients with LS-SCLC treated with chemoradiotherapy. Patients with LS-SCLC and ILAs who were treated with chemoradiotherapy had both the possibility of long-term survival and risk of radiation pneumonitis.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Matthew R. McFarlane, Kimberly A. Hochstedler, Anna M. Laucis, Yilun Sun, Aulina Chowdhury, Martha M. Matuszak, James Hayman, Derek Bergsma, Thomas Boike, Larry Kestin, Benjamin Movsas, Inga Grills, Michael Dominello, Robert T. Dess, Caitlin Schonewolf, Daniel E. Spratt, Lori Pierce, Peter Paximadis, Shruti Jolly, Matthew Schipper
Summary: This study analyzed pneumonitis risk after radiation therapy for lung cancer using a large, prospective dataset. Comorbidity burden, smoking status, and dosimetric parameters were incorporated in an integrated risk model to guide clinicians in assessing pneumonitis risk in individual patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)