Article
Oncology
Annekatrin Seidlitz, Bettina Beuthien-Baumann, Steffen Loeck, Christina Jentsch, Ivan Platzek, Klaus Zoephel, Annett Linge, Joerg Kotzerke, Jan Petr, Joerg van den Hoff, Joerg Steinbach, Dietmar Krex, Gabriele Schmitz-Schackert, Monique Falk, Michael Baumann, Mechthild Krause
Summary: This study reveals that in patients with glioblastoma, those without increased tracer accumulation in postoperative MET-PET have longer time to recurrence, while residual tumors detected by MRI post-surgery affect time to recurrence. Significant multivariable predictors for time to recurrence include MET accumulation in pre-RCTPET, MRI positivity, and MGMT hypermethylation.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mohammad Hazaymeh, Ronja Loeber-Handwerker, Katja Doering, Tammam Abboud, Dorothee Mielke, Veit Rohde, Vesna Malinova
Summary: Approximately 25% of glioblastomas show corpus callosum infiltration at diagnosis, which is associated with poor prognosis. The extent of corpus callosum involvement ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Maciej Harat, Maciej Blok, Izabela Miechowicz, Izabela Wiatrowska, Karolina Makarewicz, Bogdan Malkowski
Summary: This study evaluated the safety and efficacy of simultaneous integrated boost (SIB) planned using dual FET-PET for postoperative GBM treatment. The results showed that SIB with dual FET-PET improved survival outcomes, but there was a risk of radiation necrosis.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Weir-Chiang You, Hsu-Dung Lee, Hung-Chuan Pan, Hung-Chieh Chen
Summary: This study aimed to evaluate the effectiveness of combining re-irradiation and bevacizumab in treating patients with recurrent glioblastoma multiforme (GBM) resistant to bevacizumab monotherapy. The results showed that the group receiving re-irradiation had higher survival rates and longer median survival time than the group receiving no re-irradiation. The target volume of re-irradiation was identified as a significant factor for overall survival time after re-irradiation.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xu Yang, Yan Zhang, Zhiwei Xue, Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Guowei Liu, Wenjie Li, Xiaofei Liu, Xingang Li, Mingzhi Han, Jian Wang
Summary: This study found an increased expression of TRIM56 in glioblastoma, which promoted glioma progression by stabilizing cIAP1 through deubiquitination. The interaction between TRIM56 and cIAP1 may play a key role in glioma development. Additionally, TRIM56 could serve as a potential therapeutic molecular target and prognostic indicator for glioblastoma patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Parveen Kumar, Vivek Verma, Dheeraj Mohania, Surbhi Gupta, Avneet K. Babbar, Bhawna Rathi, Rakesh S. Dhanda, Manisha Yadav
Summary: The study revealed that RUNX1T1 is mutated in different cancers and associated with poor overall survival in glioma patients, possibly affecting glioma growth and development through HIF1α regulation. Experimental results showed that downregulation of RUNX1T1 may lead to degradation of HIF1α, reducing proliferation and invasiveness of glioblastoma cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shuai Wang, Jingheng Wu, Wujun Zhao, Miaomiao Li, Shaoyi Li
Summary: CEBPB and P4HA2 are upregulated in IDH1 wt gliomas and associated with poor prognosis. CEBPE promotes proliferation and TMZ resistance by inducing P4HA2 expression in glioma cells.
Article
Oncology
Jaap C. Reijneveld, Abigirl Machingura, Corneel Coens, Martin J. B. Taphoorn, Walter Taal, Paul M. Clement, Ahmed Idbaih, Filip Y. F. Vos, Martin Klein, Wolfgang Wick, Paul J. Mulholland, Joanne Lewis, Vassilis Golfinopoulos, Irina Ghislain, Andrew Bottomley, Martin J. van den Bent, EORTC Brain Tumor Grp
Summary: In an international study, the addition of bevacizumab to temozolomide did not significantly improve or negatively affect health-related quality of life (HRQoL) in patients with non1p/19q co-deleted WHO grade 2 or 3 gliomas. The study assessed HRQoL using several scales and found no clinically significant differences between the treatment arms.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Cell Biology
Xia Hong, Jingjing Zhang, Jianmin Zou, Jiecai Ouyang, Boan Xiao, Peng Wang, Xiaobin Peng
Summary: This study identified COL6A2 as a potential biomarker related to glioma stem cells and chemotherapy resistance, suggesting its potential use in treatment.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Junhui Liu, Lun Gao, Xiaonan Zhu, Rongxin Geng, Xiang Tao, Haitao Xu, Zhibiao Chen
Summary: The study revealed that GSDMD expression was upregulated in glioma, significantly associated with WHO grade IV, IDH 1/2 wild-type, and mesenchymal subtypes, as well as shorter overall survival. GSDMD may participate in regulating macrophage infiltration and polarization, serving as a prognostic biomarker and TMZ-treatment response marker in glioma.
Article
Oncology
Deheng Li, Liangdong Li, Xin Chen, Wentao Yang, Yiqun Cao
Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Multidisciplinary Sciences
Sang-Soo Choi, Haeyoun Choi, In-Cheol Baek, Soon A. Park, Jae-Sung Park, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn
Summary: This case-control study evaluated the association between HLA polymorphism and the risk of glioblastoma development in Koreans. Findings suggest that certain HLA types may affect the development of glioblastoma in Koreans. Further research with larger sample sizes is needed to confirm the role of HLA polymorphisms in the pathogenesis of glioblastoma.
Article
Medical Laboratory Technology
Elena Porcu, Francesca Maule, Lorenzo Manfreda, Elena Mariotto, Silvia Bresolin, Alice Cani, Roberta Bortolozzi, Alessandro Della Puppa, Diana Corallo, Giampietro Viola, Elena Rampazzo, Luca Persano
Summary: We found that ANXA2 is a key mediator of the pro-oncogenic features of GBM tumors, involved in stemness, proliferation and invasion, thus affecting patient prognosis. Using the QUADrATiC bioinformatic tool, we identified Homoharringtonine (HHT) as a potent inhibitor of GBM cell motility and proliferation. HHT inhibits a transcriptional program involved in cell migration and invasion by impairing PDGFRα-dependent signaling through STAT3 and RhoA axes. This suggests that HHT could be an effective treatment option for GBM by targeting its hallmarks.
TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Songya Li, Jiayi Li, Yani Fan, Tao Huang, Yanfen Zhou, Runze Qiu, Qi Zhang, Hongwei Fan
Summary: The combination of formononetin and calycosin enhances the sensitivity of malignant glioma to temozolomide. The mechanisms involved include metabolic pathway regulation and inhibition of specific targets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemical Research Methods
Rasmus Krempel, Pranav Kulkarni, Annie Yim, Ulrich Lang, Bianca Habermann, Peter Frommolt
BMC BIOINFORMATICS
(2018)
Article
Biochemistry & Molecular Biology
Daniela Welcker, Manaswita Jain, Safiya Khurshid, Mladen Jokic, Martin Hoehne, Anna Schmitt, Peter Frommolt, Carien M. Niessen, Judith Spiro, Thorsten Persigehl, Maike Wittersheim, Reinhard Buettner, Maurizio Fanciulli, Bernhard Schermer, Hans Christian Reinhardt, Thomas Benzing, Katja Hoepker
Article
Multidisciplinary Sciences
A. Schrader, G. Crispatzu, S. Oberbeck, P. Mayer, S. Putzer, J. von Jan, E. Vasyutina, K. Warner, N. Weit, N. Pflug, T. Braun, E. I. Andersson, B. Yadav, A. Riabinska, B. Maurer, M. S. Ventura Ferreira, F. Beier, J. Altmueller, M. Lanasa, C. D. Herling, T. Haferlach, S. Stilgenbauer, G. Hopfinger, M. Peifer, T. H. Bruemmendorf, P. Nuernberg, K. S. J. Elenitoba-Johnson, S. Zha, M. Hallek, R. Moriggl, H. C. Reinhardt, M. -H. Stern, S. Mustjoki, S. Newrzela, P. Frommolt, M. Herling
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Orom, Joerg Heeren, Matthias Blueher, Martin Bilban, Jan-Wilhelm Kornfeld
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Alexander Quaas, Carina Heydt, Florian Gebauer, Hakan Alakus, Heike Loeser, Reinhard Buettner, Axel Hillmer, Christiane Bruns, Sabine Merkelbach-Bruse, Thomas Zander, Peter Frommolt
TRANSLATIONAL ONCOLOGY
(2019)
Article
Cell Biology
Sarah Fischer, Ramesh Rijal, Peter Frommolt, Prerana Wagle, Roman Konertz, Jan Faix, Susanne Wissling, Ludwig Eichinger
Article
Biotechnology & Applied Microbiology
Paul Klemm, Peter Frommolt, Jan-Wilhelm Kornfeld
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Cell & Tissue Engineering
Magdalena Laugsch, Michaela Bartusel, Rizwan Rehimi, Hafiza Alirzayeva, Agathi Karaolidou, Giuliano Crispatzu, Peter Zentis, Milos Nikolic, Tore Bleckwehl, Petros Kolovos, Wilfred F. J. van Ijcken, Tomo Saric, Katrin Koehler, Peter Frommolt, Katherine Lachlan, Julia Baptista, Alvaro Rada-Iglesias
Article
Multidisciplinary Sciences
Marija Herholz, Estela Cepeda, Linda Baumann, Alexandra Kukat, Johannes Hermeling, Sarah Maciej, Karolina Szczepanowska, Victor Pavlenko, Peter Frommolt, Aleksandra Trifunovic
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Rainer W. J. Kaiser, Michael Ignarski, Eric L. Van Nostrand, Christian K. Frese, Manaswita Jain, Sadrija Cukoski, Heide Heinen, Melanie Schaechter, Lisa Seufert, Konstantin Bunte, Peter Frommolt, Patrick Keller, Mark Helm, Katrin Bohl, Martin Hoehne, Bernhard Schermer, Thomas Benzing, Katja Hoepker, Christoph Dieterich, Gene W. Yeo, Roman-Ulrich Mueller, Francesca Fabretti
SCIENTIFIC REPORTS
(2019)
Letter
Dermatology
P. Moinzadeh, P. Frommolt, M. Franitza, M. R. Toliat, K. Becker, P. Nuernberg, S. I. Nihtyanova, M. Ahrazoglu, D. Belz, N. Hunzelmann, D. Abraham, V. H. Ong, L. Mouthon, R. Hesselstrand, C. P. Denton, T. Krieg
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Multidisciplinary Sciences
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjork Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Buening, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Troeder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
NATURE COMMUNICATIONS
(2020)
Article
Endocrinology & Metabolism
A. L. Ostermann, C. M. Wunderlich, L. Schneiders, M. C. Vogt, M. A. Woeste, B. F. Belgardt, C. M. Niessen, B. Martiny, A. C. Schauss, P. Frommolt, A. Nikolaev, N. Hoevelmeyer, R. C. Sears, P. J. Koch, D. Guenzel, J. C. Bruening, F. T. Wunderlich
Meeting Abstract
Biochemistry & Molecular Biology
M. Laugsch, M. Bartsuel, R. Rehimi, H. Alirzayeva, A. Karaolidou, G. Crispatzu, P. Zentis, M. Nikolic, T. Bleckwehl, P. Kolovos, W. F. J. van Ijcken, T. Saric, K. Koehler, P. Frommolt, C. Schaaf, K. Lachlan, J. Baptista, A. Rada-Iglesias
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Cell & Tissue Engineering
Sara Cruz-Molina, Patricia Respuela, Christina Tebartz, Petros Kolovos, Milos Nikolic, Raquel Fueyo, Wilfred F. J. van Ijcken, Frank Grosveld, Peter Frommolt, Hisham Bazzi, Alvaro Rada-Iglesias