Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nicholas Dietz, Ahmad Alhourani, Scott A. Wylie, Jessica L. McDonnell, Fenna T. Phibbs, Benoit M. Dawant, William J. Rodriguez, Elise B. Bradley, Joseph S. Neimat, Nelleke C. van Wouwe
Summary: Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Globus Pallidus (GPi) in Parkinson's disease (PD) patients have similar effects on inhibitory control processes.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Junhuai Zhang, Jiayu Li, Fang Chen, Xingzhi Liu, Chun Jiang, Xinghua Hu, Lin Ma, Zhongye Xu
Summary: Both STN and GPi-DBS were equally effective in improving motor dysfunction in patients with APD. However, STN-DBS showed superiority in reducing medication usage, while GPi-DBS may lead to less dyskinesia and improved activities of daily living. Further studies comparing adverse events and quality of life between these two targets are needed.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Review
Clinical Neurology
Stephen Tisch, Kishore Raj Kumar
Summary: GPi DBS is an effective intervention for refractory dystonia, with factors such as disease duration and subtype influencing outcomes. Other factors affecting variability in results include body distribution, pattern of dystonia, and DBS-related factors. Different monogenic forms of dystonia may respond differently to DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Neurosciences
Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Summary: The Forel field has potential for the treatment of cervical dystonia, Parkinson's disease, and dystonia. Recent studies have shown promising results for the efficacy of FF-DBS in treating dystonia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hong Tian, Bo Zhang, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Liang Wang
Summary: DBS of the posterior GPi may lead to better clinical outcomes in treating primary Meige syndrome, and higher GPi neuronal activity, particularly in the ventral part, can be utilized as a biomarker to guide DBS electrode implantation during surgery.
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Chun-Hwei Tai, Sheng-Che Chou, Chin-Hsien Lin, Wang-Tso Lee, Ruey-Meei Wu, Sheng-Hong Tseng
Summary: Patients with isolated dystonia, either monogenic or idiopathic, tend to respond better to GPi DBS compared to those with acquired dystonia. Selection of patients based on dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial for achieving better long-term outcomes.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Kantharuby Tambirajoo, Luciano Furlanetti, Michael Samuel, Keyoumars Ashkan
Summary: Adult-onset dystonic syndromes presenting with dystonic opisthotonus are rare, and often refractory to medical management. In this study, three patients showed rapid and sustained clinical improvement of symptoms following GPi-DBS, with the ability to resume daily activities and reintegrate into society. Thorough investigation and tailored management are necessary for this highly disabling condition with varying etiologies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yijie Lai, Naying He, Hongjiang Wei, Lifu Deng, Haiyan Zhou, Jun Li, Marcus Kaiser, Chencheng Zhang, Dianyou Li, Bomin Sun
Summary: This study investigated patient-specific functional connectivity related to globus pallidus internus (GPi) deep brain stimulation (DBS) outcome in Parkinson disease (PD) and established connectivity models for outcome prediction. The results showed that patient-specific functional connectivity seeding from the VTA-GPi intersection could help in GPi DBS outcome prediction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biology
Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto, Yasushi Takagi
Summary: The study assessed the outcomes of 12 patients with TD who underwent GPi DBS, with an average BFMDRS improvement rate of 75.6% at 1 month postoperatively and 78.0% in the long term. Two patients responded poorly to DBS, which was attributed to longer duration from TD onset to surgery and older age at surgery.
Article
Clinical Neurology
Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M. Ratajska, Dawn Bowers, Robert S. Eisinger, Leonardo Almeida, Kelly D. Foote, Michael S. Okun, Adolfo Ramirez-Zamora
Summary: Globus pallidus internus deep brain stimulation in Parkinson's disease patients showed sustained long-term benefits in tremor scores, motor complications, but gradual worsening in HRQoL and cardinal motor symptoms other than tremor in the long term. Benefits in tremor and dyskinesia are expected to be most persistent following bilateral GPi DBS implantation.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Riaan van Coller, Anne-Fleur van Rootselaar, Clara Schutte, C. H. van der Meyden
PARKINSONISM & RELATED DISORDERS
(2017)
Review
Clinical Neurology
Nafisa Cassimjee, Riaan van Coller, Pieter Slabbert, Lizelle Fletcher, Janardan Vaidyanathan
Article
Genetics & Heredity
Nicola du Toit, Riaan van Coller, David G. Anderson, Jonathan Carr, Soraya Bardien
Letter
Clinical Neurology
Riaan van Coller, Soraya Bardien, Annika Neethling, Jonathan Can, Clara Schutte
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Multidisciplinary Sciences
Mark A. Corbett, Thessa Kroes, Liana Veneziano, Mark F. Bennett, Rahel Florian, Amy L. Schneider, Antonietta Coppola, Laura Licchetta, Silvana Franceschetti, Antonio Suppa, Aaron Wenger, Davide Mei, Manuela Pendziwiat, Sabine Kaya, Massimo Delledonne, Rachel Straussberg, Luciano Xumerle, Brigid Regan, Douglas Crompton, Anne-Fleur van Rootselaar, Anthony Correll, Rachael Catford, Francesca Bisulli, Shreyasee Chakraborty, Sara Baldassari, Paolo Tinuper, Kirston Barton, Shaun Carswell, Martin Smith, Alfredo Berardelli, Renee Carroll, Alison Gardner, Kathryn L. Friend, Ilan Blatt, Michele Iacomino, Carlo Di Bonaventura, Salvatore Striano, Julien Buratti, Boris Keren, Caroline Nava, Sylvie Forlani, Gabrielle Rudolf, Edouard Hirsch, Eric Leguern, Pierre Labauge, Simona Balestrini, Josemir W. Sander, Zaid Afawi, Ingo Helbig, Hiroyuki Ishiura, Shoji Tsuji, Sanjay M. Sisodiya, Giorgio Casari, Lynette G. Sadleir, Riaan van Coller, Marina A. J. Tijssen, Karl Martin Klein, Arn M. J. M. van den Maagdenberg, Federico Zara, Renzo Guerrini, Samuel F. Berkovic, Tommaso Pippucci, Laura Canafoglia, Melanie Bahlo, Pasquale Striano, Ingrid E. Scheffer, Francesco Brancati, Christel Depienne, Jozef Gecz
NATURE COMMUNICATIONS
(2019)
Article
Geriatrics & Gerontology
Amokelani C. Mahungu, David G. Anderson, Anastasia C. Rossouw, Riaan van Coller, Jonathan A. Carr, Owen A. Ross, Soraya Bardien
NEUROBIOLOGY OF AGING
(2020)
Review
Neurosciences
Devina Chetty, Shameemah Abrahams, Riaan van Coller, Jonathan Carr, Colin Kenyon, Soraya Bardien
Summary: Parkinson's disease is characterized by the aggregation of alpha-synuclein, leading to pathology in both the brain and gastrointestinal tracts. This review discusses the spread of alpha-synuclein pathology along the gut-brain axis and proposes curcumin as a potential candidate for preventing the spread of pathology. Potential dietary supplementation with curcumin may offer a novel approach to complement existing PD treatment strategies.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
R. Van Coller, C-M Schutte, E. Lubbe, B. Ngele
Summary: This study investigated the outcome of pallidal deep-brain stimulation surgery in black African patients with childhood-onset generalised dystonia caused by TOR1A mutations. The results showed positive outcomes with significant improvement in UDRS scores post-surgery.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Christina Fevga, Christelle Tesson, Ana Carreras Mascaro, Thomas Courtin, Riaan van Coller, Salma Sakka, Federico Ferraro, Nouha Farhat, Soraya Bardien, Mariem Damak, Jonathan Carr, Melanie Ferrien, Valerie Boumeester, Jasmijn Hundscheid, Nicola Grillenzoni, Irini A. Kessissoglou, Demy J. S. Kuipers, Marialuisa Quadri, Jean-Christophe Corvol, Chokri Mhiri, Bassem A. Hassan, Guido J. Breedveld, Suzanne Lesage, Wim Mandemakers, Alexis Brice, Vincenzo Bonifati
Summary: This study identified variants in the PTPA gene associated with early-onset parkinsonism and intellectual disability. These variants lead to impaired activation of the PP2A complex, resulting in neurodegeneration. The Drosophila model further confirmed this mechanism.
Article
Medicine, General & Internal
D. G. Anderson, R. van Coller, J. Carr
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2017)
Letter
Clinical Neurology
Maria Fiorella Contarino, Riaan van Coller, Arne Mosch, Niels A. van der Gaag, Carel F. Hoffmann
Article
Medicine, General & Internal
C-M Schutte, C. H. van der Meyden, L. van Niekerk, M. Kakaza, R. van Coller, V. Ueckermann, N. M. Oosthuizen
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2016)
Article
Medicine, General & Internal
C-M Schutte, T. Townsend, R. Van Coller, S. Olorunju
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2013)
