Review
Clinical Neurology
Alonso Zea Vera, Andrea L. Gropman
Summary: Refractory movement disorders in inborn errors of metabolism can significantly affect quality of life and may lead to life-threatening complications. Surgical techniques, such as deep brain stimulation and lesioning, are an additional treatment option. However, the application and benefits of these procedures in neurometabolic conditions are not well understood, posing challenges for selecting surgical candidates and counseling patients preoperatively.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Jakov Tiefenbach, Hugh H. H. Chan, Andre G. G. Machado, Kenneth B. B. Baker
Summary: This article provides a comprehensive review of the current scientific evidence on the use of invasive neurostimulation for the treatment of deficits associated with traumatic brain injury (TBI). The study highlights the promising potential of neurostimulation in improving cognitive and motor functions, relieving symptoms and supporting emotional adjustment in TBI patients. However, the current literature is limited and further research is needed to identify optimal stimulation targets and paradigms, as well as to explore the impact of biological variables on treatment outcomes.
Article
Clinical Neurology
Nathaniel D. Sisterson, April A. Carlson, Ueli Rutishauser, Adam N. Mamelak, Mitchell Flagg, Nader Pouratian, Yousef Salimpour, William S. Anderson, R. Mark Richardson
Summary: Through analyzing data from 367 DBS surgeries, the study found that conducting ECoG research during surgery did not significantly increase complication rates, providing confirmation of the safety of such procedures.
Review
Clinical Neurology
Mitch R. Paro, Michal Dyrda, Srinath Ramanan, Grant Wadman, Stacey -Ann Burke, Isabella Cipollone, Cory Bosworth, Sarah Zurek, Patrick B. Senatus
Summary: This systematic review summarizes the case studies of deep brain stimulation (DBS) for poststroke movement disorders. The results suggest that DBS may be an effective and safe option for improving function in patients with movement disorders after a stroke, even years after the initial event.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Josue M. Avecillas-Chasin, Christopher R. Honey, Manraj K. S. Heran, Marie T. Krueger
Summary: In patients with essential tremor whose tremor had progressed and no longer responded well to standard deep brain stimulation, directional deep brain stimulation (dDBS) provided better tremor control. The involvement of both the cerebellothalamic and pallidofugal pathways obtained with dDBS is associated with additional improvement over standard deep brain stimulation.
JOURNAL OF NEUROSURGERY
(2022)
Review
Psychiatry
Sarah Babette Hageman, Geeske van Rooijen, Isidoor O. Bergfeld, Frederike Schirmbeck, Pelle de Koning, P. Rick Schuurman, Damiaan Denys
Summary: This meta-analysis demonstrates equal efficacy of ABL and DBS in treating refractory OCD. Therefore, the choice of intervention should depend on factors such as the risk of developing impulsivity, patient preferences, and experiences of the psychiatrist and neurosurgeon. Future research should provide more insight on the differences between ABL and DBS to enable personalized treatment decisions.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano
Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Danika L. Paulo, Graham W. Johnson, Derek J. Doss, Jackson H. Allen, Hernan F. J. Gonzalez, Robert Shults, Rui Li, Tyler J. Ball, Sarah K. Bick, Travis J. Hassell, Pierre-Francois D'Haese, Peter E. Konrad, Benoit M. Dawant, Saramati Narasimhan, Dario J. Englot
Summary: This study aims to demonstrate the value of intraoperative neurophysiological testing paired with image-based data in optimizing final electrode positioning in deep brain stimulation surgery. The results show that this approach can lead to improved patient outcomes.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Han Yan, Lior M. Elkaim, Flavia Venetucci Gouveia, Joelene F. Huber, Jurgen Germann, Aaron Loh, Juan Carlos Benedetti-Isaac, Paresh K. Doshi, Cristina V. Torres, David J. Segar, Gavin J. B. Elias, Alexandre Boutet, G. Rees Cosgrove, Alfonso Fasano, Andres M. Lozano, Abhaya V. Kulkarni, George M. Ibrahim
Summary: Individuals with autism spectrum disorder (ASD) may exhibit extreme behaviors that are difficult to control through medication or behavioral interventions. Deep brain stimulation (DBS) is a surgical alternative that modulates brain circuits. This study provides a comprehensive overview of the evidence for the use of DBS in treating extreme behaviors associated with ASD, identifying key circuits common to DBS targets through network mapping.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Tao Xue, Houyou Fan, Shujun Chen, Zijian Guo, Huizhi Wang, Chunlei Han, Anchao Yang, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study comprehensively investigated the changes in probable rapid eye movement sleep behavior disorder (pRBD) symptoms after subthalamic nucleus-deep brain stimulation (STN-DBS) in Parkinson's disease patients. The results showed that prefrontal connections were associated with improved symptoms, while sensorimotor connectivity was associated with deterioration.
JOURNAL OF NEUROSURGERY
(2023)
Article
Neurosciences
Patrick Fricke, Robert Nickl, Maria Breun, Jens Volkmann, Dalal Kirsch, R. -I. Ernestus, Frank Steigerwald, Cordula Matthies
Summary: This study focused on the feasibility, difficulties, and complications of implanting D-leads for deep brain stimulation. It compared the surgical parameters, complications, and challenges of precise positioning between D-leads and conventional ring electrodes.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Article
Clinical Neurology
Luigi G. Remore, Mahmoud Omidbeigi, Evangelia Tsolaki, Ausaf A. Bari
Summary: Deep brain stimulation (DBS) has been studied for decades for the treatment of drug-resistant epilepsy (DRE). Recent approval by CE and FDA for DBS targeting the anterior nucleus of the thalamus (ANT) highlights its effectiveness in focal-onset DRE. However, the low contrast definition among thalamic nuclei on current MRI sequences makes targeting difficult. Another thalamic nucleus receiving attention is the centromedian nucleus (CM), but its targeting is still based on indirect stereotactic coordinates.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
Andre A. Wakim, Natasha A. Sioda, James J. Zhou, Margaret Lambert, Virgilio Gerald H. Evidente, Francisco A. Ponce
Summary: This study compares the outcomes of direct and indirect targeting of the ventral intermediate nucleus of the thalamus (VIM) for deep brain stimulation (DBS) in patients with essential tremor. The results showed that direct targeting led to electrodes placed more laterally and anteriorly, lower stimulation amplitude, and greater improvement in Quality of Life in Essential Tremor Questionnaire hobby score. The direct targeting group had more symptomatic hemorrhages, but all patients recovered without intervention.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Ben Shofty, Ron Gadot, Ashwin Viswanathan, Nicole R. Provenza, Eric A. Storch, Sarah A. McKay, Matthew S. Meyers, Alyssa G. Hertz, Michelle Avendano-Ortega, Wayne K. Goodman, Sameer A. Sheth
Summary: Deep brain stimulation (DBS) is an accepted therapy for severe, treatment-refractory obsessive-compulsive disorder (trOCD). Various studies have suggested that the optimal target location within the anterior limb of the internal capsule may lie in the vicinity of the anterior commissure (AC), either just anterior to the AC above the ventral striatum (VS), or just posterior to the AC above the bed nucleus of the stria terminalis (BNST). In this study, the authors describe their practice of planning trajectories to both the VS and BNST and using awake intraoperative valence testing to individualize permanent target selection.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Joachim Runge, Johanna M. Nagel, Luisa Cassini Ascencao, Christian Blahak, Thomas M. Kinfe, Christoph Schrader, Marc E. Wolf, Assel Saryyeva, Joachim K. Krauss
Summary: This study investigated the impact of a transventricular trajectory compared to a transcerebral approach on the occurrence of symptomatic and asymptomatic hemorrhage after deep brain stimulation (DBS) electrode placement. The results showed that transventricular approaches can be safely performed when precautions like using a guiding cannula are applied.
OPERATIVE NEUROSURGERY
(2022)