Article
Immunology
Francois Marceau, Eric Petitclerc
Summary: The newly approved drug avacopan by the FDA is an orally bioavailable treatment for the rare disease ANCA-associated vasculitis, targeting inflammation-induced small vessel vasculitis by inhibiting the effects of C5a on vascular tissues through C5aR1 blockade.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Liu Ouyang, Xiaoyan Su, Wenxin Li, Liangqiu Tang, Mengbi Zhang, Yongjun Zhu, Changming Xie, Puhua Zhang, Jie Chen, Hui Huang
Summary: The study found that decreased levels of leukocyte DNA N-6-methyladenine in patients with chronic kidney disease can lead to aggravated vascular calcification, while overexpression of ALKBH1 can exacerbate this process. By activating BMP2 transcription and subsequently inducing osteogenic reprogramming of VSMCs, VC progression is promoted. Therefore, targeting ALKBH1 may be a therapeutic method to reduce the burden of vascular calcification in CKD.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cardiac & Cardiovascular Systems
Shuangshuang Wang, Siwang Hu
Summary: Vascular calcification is a common pathological change in many chronic diseases, but the exact mechanism of its pathogenesis is unclear. Sirtuins may play a protective role in VC and restoring their activity could be an effective treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Kostina, Arseniy Lobov, Daria Semenova, Artem Kiselev, Polina Klausen, Anna Malashicheva
Summary: Despite significant progress in bone tissue regeneration, the early mechanisms of osteogenic differentiation remain poorly understood. Various cells can undergo osteogenic transformation, with Notch signaling playing a key role in this process. Research demonstrates differences in the ability of different cell types to undergo Notch-dependent osteogenic differentiation.
Article
Medicine, Research & Experimental
Wenxin Li, Weijing Feng, Xiaoyan Su, Dongling Luo, Zhibing Li, Yongqiao Zhou, Yongjun Zhu, Mengbi Zhang, Jie Chen, Baohua Liu, Hui Huang
Summary: SIRT6 is downregulated in CKD patients and plays a protective role in preventing VC by suppressing the osteogenic transdifferentiation of VSMCs.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Bai, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Lanmei Li, Yaling Bai, Jinsheng Xu
Summary: This study found that KAP1 is significantly upregulated in VSMCs and promotes osteoblast differentiation through activation of the ERK signaling pathway. Therefore, KAP1 may serve as a potential diagnostic and therapeutic target for vascular calcification.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Urology & Nephrology
Annette Bruchfeld, Hasan Magin, Patrick Nachman, Samir Parikh, Richard Lafayette, Antonia Potarca, Shichang Miao, Pirow Bekker
Summary: This study evaluated the safety and efficacy of avacopan in IgAN patients with persistent proteinuria despite maximally tolerated drug therapy. Results showed numerical improvement in proteinuria in three out of seven patients with a 50% improvement. Longer treatment duration may be needed for maximal benefit.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Qihong Yu, Jin-Xin Liu, Xichuan Zheng, Xueke Yan, Peng Zhao, Chuanzheng Yin, Wei Li, Zifang Song
Summary: This study reveals the significant role of Sox9 in mediating autophagy-dependent vSMC phenotypic modulation and the development of TA. Inhibition of Sox9 expression can attenuate neointimal formation, providing a potential therapeutic approach for vascular pathologies.
Article
Multidisciplinary Sciences
Junhao Yin, Zhanglong Zheng, Xiaoli Zeng, Yijie Zhao, Zexin Ai, Miao Yu, Yang'ou Wu, Jirui Jiang, Jia Li, Shengjiao Li
Summary: The study revealed that lncRNA Malat1 plays a critical role in maintaining the osteogenic potential of aging BMSCs by sponging miR-129-5p. This suggests that Malat1 and miR-129-5p play important roles in regulating the osteogenic ability of BMSCs.
Article
Biochemistry & Molecular Biology
Chiara Greggi, Ida Cariati, Federica Onorato, Riccardo Iundusi, Manuel Scimeca, Umberto Tarantino
Summary: The study revealed that PTX3 plays a role in osteogenic differentiation and possesses osteoinductive capacity, making it a potential biomarker and therapeutic agent for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Silvia Fittipaldi, Sabrina Valente, Daniela Pollutri, Francesca Ricci, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: The study reveals that End-MT serves as a crucial link between inflammation and vascular calcification. Moreover, miR-30a-5p and miR-30d can regulate both the End-MT and osteogenic processes, with an impact on key genes like SLUG, VIMENTIN, and RUNX-2.
Article
Pharmacology & Pharmacy
Ayna Emanuelli Alves Barreto, Victor Gustavo Balera Brito, Mariana Sousa Patrocinio, Beatriz Babeto Ballassoni, Sabrina Cruz Tfaile Frasnelli, Sandra Helena Penha Oliveira
Summary: The beta-adrenergic receptors play a significant role in osteoblastic differentiation of bone marrow mesenchymal stem cells, with ADRB1 potentially suppressing the effects of ADRB2 on the cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinfu Qian, Wu Luo, Chengyi Dai, Jun Wang, Xinfu Guan, Chunpeng Zou, Nipon Chattipakorn, Gaojun Wu, Weijian Huang, Guang Liang
Summary: Studies show that MD2 plays a crucial role in Ang II-induced vascular inflammation and EndMT, suggesting that MD2 could be targeted to mitigate inflammatory cardiovascular and EndMT-associated diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Oncology
Nikolaos T. Skenteris, Till Seime, Anna Witasp, Eva Karlof, Grzegorz B. Wasilewski, Marina A. Heuschkel, Armand M. G. Jaminon, Loureen Oduor, Robert Dzhanaev, Malin Kronqvist, Mariette Lengquist, Frederique E. C. M. Peeters, Magnus Soderberg, Rebecka Hultgren, Joy Roy, Lars Maegdefessel, Hildur Arnardottir, Eva Bengtsson, Isabel Goncalves, Thomas Quertermous, Claudia Goettsch, Peter Stenvinkel, Leon J. Schurgers, Ljubica Matic
Summary: Recent studies have found a correlation between plasma and tissue levels of osteomodulin (OMD) and cardiovascular calcification, suggesting the potential of OMD as a clinical biomarker. OMD was found to be present in calcified cardiovascular tissues and was induced by pro-inflammatory and pro-osteogenic stimuli. Furthermore, the presence of OMD in the extracellular environment attenuated smooth muscle cell (SMC) calcification.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Polina Klauzen, Daria Semenova, Daria Kostina, Vladimir Uspenskiy, Anna Malashicheva
Summary: Research has found that there are significant differences between stenotic aortic valve interstitial cells and normal cells under osteogenic stimulation, and the purinergic signaling of stenotic cells is impaired, suggesting its potential as a target for anti-calcification therapy.
Article
Surgery
Sarah Dehne, Christian Heck, Julia Sander, Katrin Meisenbacher, Christoph Arens, Christian Niklas, Dorothea Kronsteiner, Evangelos Giannitsis, Dittmar Boeckler, Markus A. Weigand, Jan Larmann
Summary: This study aimed to evaluate the association between peri-operative aspirin resistance and adverse cardiovascular outcomes in vascular surgery patients. Peri-operative aspirin resistance was found to be common in vascular or endovascular surgery patients, but it was not associated with any adverse cardiovascular outcomes in patients who continued using aspirin throughout the peri-operative period.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Editorial Material
Physiology
Henrike Janssen, Nana Maria Wagner, L. Christian Napp, Jan Larmann
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Thomas M. Pausch, Magdalena Holze, Bodil Gesslein, Inga Rossion, Franziska von Eisenhart Rothe, Martin Wagner, Anja Sander, Solveig Tenckhoff, Marc Bartel, Jan Larmann, Pascal Probst, Frank Pianka, Thilo Hackert, Rosa Klotz
Summary: Pancreatic resections are important surgeries for treating various diseases, but postoperative pancreatic fistula (POPF) remains a common and serious complication. The SmartPAN indicator is a medical device that can detect pancreatic leakage during surgery, potentially guiding effective closure and mitigating POPF development.
Article
Medicine, General & Internal
Anastasia Murtha-Lemekhova, Juri Fuchs, Miriam Teroerde, Heike Rau, Otto R. Frey, Daniel Hornuss, Adrian Billeter, Rosa Klotz, Ute Chiriac, Jan Larmann, Markus A. Weigand, Pascal Probst, Katrin Hoffmann
Summary: The RESISTAAS I study aims to investigate the impact of redosing antibiotic prophylaxis in major abdominal surgery, including postoperative infections, patient pathogens, and economic outcomes. The study will be conducted in accordance with the guidelines of the Medical Ethics Review Board of Heidelberg University, and the results are planned to be disseminated in a peer-reviewed journal.
Article
Immunology
Judith Schenz, Katharina Rump, Benedikt Hermann Siegler, Inga Hemmerling, Tim Rahmel, Jan N. Thon, Hartmuth Nowak, Dania Fischer, Anna Hafner, Lucas Tichy, Katharina Bomans, Manja Meggendorfer, Bjoern Koos, Thilo von Groote, Alexander Zarbock, Mascha O. Fiedler, Johanna Zemva, Jan Larmann, Uta Merle, Michael Adamzik, Carsten Mueller-Tidow, Torsten Haferlach, Florian Leuschner, Markus A. Weigand
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) increases the risk of hospitalization for COVID-19 patients and affects their immune response. Therefore, the CHIP status can serve as a biomarker for risk stratification and early treatment guidance for COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Sarah Dehne, Carlo Riede, Rosa Klotz, Anja Sander, Manuel Feisst, Uta Merle, Markus Mieth, Mohammad Golriz, Arianeb Mehrabi, Markus W. Buechler, Markus A. Weigand, Jan Larmann
Summary: The use of prothrombin complex concentrates (PCC) and fibrinogen concentrate during liver transplantation surgery is associated with an increased risk of thrombotic complications, including hepatic artery thrombosis, portal vein thrombosis, and inferior vena cava thrombosis. These treatments are also linked to adverse outcomes such as increased 30-day mortality, graft failure, intraoperative blood loss, and prolonged hospitalization.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Giovanna A. Lurati Buse, Eckhard Mauermann, Daniela Ionescu, Wojciech Szczeklik, Stefan De Hert, Miodrag Filipovic, Beatrice Beck-Schimmer, Savino Spadaro, Purificacion Matute, Daniel Bolliger, Sanem Cakar Turhan, Judith van Waes, Filipa Lagarto, Kassiani Theodoraki, Anil Gupta, Hans-Joerg Gillmann, Luca Guzzetti, Katarzyna Kotfis, Hinnerk Wulf, Jan Larmann, Dan Corneci, Frederique Chammartin-Basnet, Simon J. Howell
Summary: This study aimed to investigate the predictive value of self-reported functional capacity for major adverse cardiovascular events (MACEs) after noncardiac surgery. The results showed that self-reported functional capacity was associated with MACEs, but did not improve the accuracy of prediction.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, Research & Experimental
B. Muessle, J. Kirchberg, N. Buck, O. Radulova-Mauersberger, D. Stange, T. Richter, B. Mueller-Stich, R. Klotz, J. Larmann, S. Korn, A. Klimova, X. Graehlert, E. Trips, J. Weitz, T. Welsch
Summary: This study is a randomized trial evaluating the early removal of postoperative drains after robot-assisted minimally invasive oesophagectomy (RAMIE). Evidence is lacking about feasibility, associated pain, recovery, and morbidity. The study involves 72 patients undergoing RAMIE, with random allocation into two groups.
Article
Medicine, General & Internal
Thilo von Groote, Melanie Meersch, Stefano Romagnoli, Marlies Ostermann, Javier Ripolles-Melchor, Antoine Guillaume Schneider, Wim Vandenberghe, Celine Monard, Silvia De Rosa, Lucia Cattin, Tim Rahmel, Michael Adamzik, Diego Parise, Angel Candela-Toha, Jan Gerrit Haaker, Ulrich Goebel, Alice Bernard, Nuttha Lumlertgul, Paula Fernandez-Valdes-Bango, Irene Romero Bhathal, A. Suarez-de-la-Rica, Jan Larmann, Gianluca Villa, Savino Spadaro, Hinnerk Wulf, Christian Arndt, Christian Putensen, Raquel Garcia-Alvarez, Timo Brandenburger, Antonio Siniscalchi, Richard Ellerkmann, Florian Espeter, Christian Porschen, Mahan Sadjadi, Khaschayar Saadat-Gilani, Raphael Weiss, Joachim Gerss, John Kellum, Alexander Zarbock
Summary: The BigpAK-2 trial aims to verify the effectiveness of the KDIGO guideline-based bundle in reducing the incidence and severity of AKI after surgery. It will recruit 1302 high-risk patients undergoing major surgery and randomize them into either a standard of care or the KDIGO-based AKI care bundle. The primary endpoint is the incidence of moderate or severe AKI within 72 hours after surgery.
Article
Anesthesiology
Mareike Kulzer, Markus A. Weigand, Wojciech Pepke, Jan Larmann
Summary: In the past 20 years, there has been a significant increase in spine surgeries worldwide due to advancements in surgical techniques and perioperative patient care. This has allowed for a wider range of procedures, from minimally invasive to complex surgeries involving multiple segments of the spinal column, which require meticulous perioperative management and high blood loss. This article outlines the key aspects of preoperative, intraoperative, and postoperative care in spinal surgery, as well as specific considerations such as airway management in cervical spine instability and the use of intraoperative neuromonitoring.
Article
Anesthesiology
Christian Niklas, Tobias Holle, Martin Dugas, Markus A. Weigand, Jan Larmann
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Kummer, M. Zaradzki, K. Stefan, M. A. Weigand, J. Larmann
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Oncology
Rosa Klotz, Maximilian Joos, Anja Tremmel, Christopher Buesch, Phillip Knebel, Jan Larmann
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Review
Anesthesiology
S. Dehne, M. Monnard, M. A. Weigand, J. Larmann
Summary: Elderly patients are more likely to experience perioperative cardiac complications, with a risk of cardiovascular and cerebrovascular complications up to 13% depending on patient population and comorbidities. Screening high-risk patients and implementing optimal co-morbid therapy and anesthesia procedures can reduce the incidence of perioperative cardiac complications.
ANASTHESIOLOGIE & INTENSIVMEDIZIN
(2022)
Article
Medicine, General & Internal
Melanie Meersch, Raphael Weiss, Mira Kuellmar, Lars Bergmann, Astrid Thompson, Leonore Griep, Desiree Kusmierz, Annika Buchholz, Alexander Wolf, Hartmuth Nowak, Tim Rahmel, Michael Adamzik, Jan Gerrit Haaker, Carina Goettker, Matthias Gruendel, Andre Hemping-Bovenkerk, Ulrich Goebel, Julius Braumann, Irawan Wisudanto, Manuel Wenk, Darius Flores-Bergmann, Andreas Boehmer, Sebastian Cleophas, Andreas Hohn, Anne Houben, Richard K. Ellerkmann, Jan Larmann, Julia Sander, Markus A. Weigand, Nicolas Eick, Sebastian Ziemann, Eike Bormann, Joachim Gerss, Daniel Sessler, Carola Wempe, Christina Massoth, Alexander Zarbock
Summary: This study aimed to investigate the effect of handovers of anesthesia care on postoperative complications and mortality. The results showed no significant difference in the composite primary outcome of mortality, readmission, or serious postoperative complications within 30 days between patients who received handover of anesthesia care and those who did not, among adults undergoing extended surgical procedures.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
