Article
Cell Biology
Orlando Arguello-Miranda, Ashley J. Marchand, Taylor Kennedy, Marielle A. X. Russo, Jungsik Noh
Summary: Cellular quiescence is a nonproliferative state that allows cell survival under stress and during development. This study investigates the stress pathways associated with high-Cdk1 quiescent states triggered by starvation in Saccharomyces cerevisiae. It is found that both low- and high-Cdk1 quiescent states involve stress-associated processes, but differ in the nuclear accumulation of stress transcription factors. The decision between low- or high-Cdk1 quiescence is controlled by cell cycle-independent accumulation of Xbp1.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ya He, Maohong Luo, Shan Lei, Zhirui Zeng, Tengxiang Chen, Yingmin Wu, Dongyan Wang, Long Wang, Lu Wang
Summary: Luteoloside has exhibited anti-inflammatory, antiviral, and antitumor properties. Its effect on neuroblastoma cells was investigated in this study. Luteoloside inhibited the proliferation of neuroblastoma cells by activating the p38 MAPK pathway, indicating its potential as an anticancer drug for treating neuroblastoma.
Article
Pharmacology & Pharmacy
Jiayan Liu, Tao Mi, Zhaoxia Zhang, Liming Jin, Maoxian Li, Chenghao Zhanghuang, Mujie Li, Jinkui Wang, Xin Wu, Zhaoying Wang, Xiaojun Tan, Zhang Wang, Dawei He
Summary: Malignant rhabdoid tumor of the kidney (MRTK) has a poor prognosis and is unresponsive to radiotherapy and chemotherapy. In this study, BKM120 was identified as a potential therapeutic agent for MRTK by inhibiting the PI3K/Akt signaling pathway to induce cell apoptosis and cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effects of BKM120 on MRTK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ajay Kumar, Sandeep Kaur, Kritika Pandit, Varinder Kaur, Sharad Thakur, Satwinderjeet Kaur
Summary: The study found that the Obea fraction extracted from O. bracteata exhibits strong antioxidant properties and cytotoxicity, showing significant antiproliferative activity against human osteosarcoma MG-63, human neuroblastoma IMR-32, and human lung cancer A549 cell lines. Antioxidant and cytotoxic potential were attributed to the presence of catechin, kaempferol, onosmin A, and epicatechin in the Obea fraction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Majid Rasool Kamli, Jamal S. M. Sabir, Maqsood Ahmad Malik, Aijaz Ahmad
Summary: This study investigated the antifungal effect of human beta defensin-1 (hBD-1) and its mechanism of action in Candida glabrata. The results showed that hBD-1 exhibited antifungal activity against C. glabrata and induced oxidative stress and cell cycle arrest. This suggests that hBD-1 has the potential to be developed as an antifungal drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Xiaoyan Zhang, Wei Zhou, Yang Liu, Linyu Jin, Jiawei Huo, Yang Yang, Shumu Li, Haijun Ma, Jiao Li, Mingming Zhen, Jie Li, Chunru Wang
Summary: Functional fullerene derivatives have shown inhibitory effects on tumor progress and metastasis by regulating tumor microenvironment, but the molecular mechanisms remain unknown. This study demonstrates that nanosize aminated fullerene can activate autophagic flux, induce G0/G1 cell cycle arrest, and inhibit tumor growth by promoting the expression of cathepsin D. This work reveals the anti-tumor activity of aminated fullerene, elucidates the molecular mechanism, and provides a new strategy for antineoplastic drug development.
Article
Biochemistry & Molecular Biology
Won Lee, Su-Rak Eo, Ju-Hye Choi, Yu-Mi Kim, Myeong-Hyun Nam, Young-Kwon Seo
Summary: The study showed that medium-magnitude sonic vibration can impact the osteogenic differentiation of human dental pulp stem cells by altering cell activity and gene expression levels at specific frequencies. Vibration at certain frequencies can induce changes in cell morphology and gene expression, leading to enhanced cell differentiation and extracellular matrix production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jiayu Chen, Rui Wang, Ying Li, Chunhe Li, Tao Liu, Yi Xin, Yiling Li, Dianbao Zhang
Summary: Ginkgolic acid (GA) inhibits the proliferation and migration of hepatocellular carcinoma (HCC) cells by inducing G0/G1 cell cycle arrest through activation of p38 MAPK, making it a potential candidate for HCC treatment.
Article
Environmental Sciences
Huan Liu, Huidan Deng, Zhijie Jian, Hengmin Cui, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao, Yanqiu Zhu
Summary: The study demonstrates that high copper exposure leads to hepatocellular G0/G1 cell-cycle arrest in mice by suppressing the Ras/PI3K/Akt signaling pathway and reducing the levels of CDK2/4 and cyclin E/D, essential for the G1-S transition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin, Liangcheng Zheng
Summary: ZNF674-AS1 expression is decreased in NSCLC compared to normal tissues, and its downregulation is significantly correlated with advanced TNM stage and decreased overall survival of NSCLC patients. ZNF674-AS1 inhibits NSCLC cell proliferation, colony formation, and tumorigenesis, accompanied by G0/G1 cell cycle arrest, through upregulation of p21 and downregulation of miR-423-3p. This study suggests the therapeutic potential of ZNF674-AS1 in NSCLC treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Developmental Biology
Chengyu Li, Zhaojun Liu, Gang Wu, Ziyu Zang, Jia-Qing Zhang, Xiaoxuan Li, Jingli Tao, Ming Shen, Honglin Liu
Summary: This study found that cell cycle arrest at G0/G1 phase under hypoxic conditions is associated with FOXO signaling, with FOXO1 inhibiting follicle granulosa cell cycle transition through TP53INP1. The findings provide potential avenues for clinical treatment of human infertility due to impaired follicular development.
Article
Cell Biology
Yun Ha Hur, Shi Feng, Kristin F. Wilson, Richard A. Cerione, Marc A. Antonyak
Summary: Exposure of embryonic stem cells to extracellular vesicles derived from ESCs helps maintain their stem cell properties, preventing differentiation and preserving the ability to generate chimeric mice. These effects are mediated by fibronectin bound to the surfaces of EVs, which interact with ESC-associated integrins and activate FAK effectively.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Ying Gao, Sarah L. Miles, Piyali Dasgupta, Gary O. Rankin, Stephen Cutler, Yi Charlie Chen
Summary: Trichodermin effectively inhibits the proliferation of ovarian cancer cells by inducing G0/G1 cell cycle arrest, mainly targeting c-Myc. Its anti-tumor activity was also validated in animal experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yong-Li Zhang, Gui-Lin Chen, Ye Liu, Xiao-Cui Zhuang, Ming-Quan Guo
Summary: The study demonstrated that the extract of Warburgia ugandensis Sprague (WUD) exhibited significant anti-proliferative effects on A549 cells by increasing intracellular ROS levels and subsequently modulating cell proliferation and G(0)/G(1) cell cycle progression.
Article
Oncology
Mustafa Karabicici, Sena Alptekin, Zeynep Firtina Karagonlar, Esra Erdal
Summary: Therapeutic induction of senescence may increase cancer stem cell phenotype, leading to increased tumor aggressiveness and disease recurrence. In liver cancer cells, doxorubicin can induce cellular senescence, increase stem cell gene expression, and cause a shift in stem cell characteristics.
MOLECULAR ONCOLOGY
(2021)