The Transition from Stem Cell to Progenitor Spermatogonia and Male Fertility Requires the SHP2 Protein Tyrosine Phosphatase

Age-Dependent Germline Mosaicism of the Most Common Noonan Syndrome Mutation Shows the Signature of Germline Selection

(2013) Song-Ro Yoon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Tyrosine Phosphatase SHP2 Regulates Sertoli Cell Junction Complexes1

(2013) Pawan Puri et al.   BIOLOGY OF REPRODUCTION

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation

(2012) K. Ishii et al.   DEVELOPMENT

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

(2012) Shannon J. Gallagher et al.   DEVELOPMENTAL BIOLOGY

The In Vivo Response of Stem and Other Undifferentiated Spermatogonia to the Reversible Inhibition of Glial Cell Line-Derived Neurotrophic Factor Signaling in the Adult

(2012) Joseph Savitt et al.   STEM CELLS

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

(2011) H. H. Zhu et al.   BLOOD

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

(2011) G. Chan et al.   BLOOD

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney

(2011) Regina Willecke et al.   DEVELOPMENTAL BIOLOGY

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

(2011) Meredith J. Goertz et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

(2010) T. J. Bauler et al.   Disease Models & Mechanisms

Protein-tyrosine Phosphatase SHP2 Contributes to GDNF Neurotrophic Activity through Direct Binding to Phospho-Tyr687in the RET Receptor Tyrosine Kinase

(2010) Maurice Perrinjaquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Requirement of the Protein TyrosinePhosphatase Shp2 in Establishing the Neuronal Fatein Early Retinal Development

(2010) Z. Cai et al.   JOURNAL OF NEUROSCIENCE

Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic  -cells

(2009) S. S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark

Effects of ETV5 (Ets Variant Gene 5) on Testis and Body Growth, Time Course of Spermatogonial Stem Cell Loss, and Fertility in Mice1

(2007) Heather N. Schlesser et al.   BIOLOGY OF REPRODUCTION

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING

Gdnf Upregulates c-Fos Transcription via the Ras/Erk1/2 Pathway to Promote Mouse Spermatogonial Stem Cell Proliferation

(2007) Zuping He et al.   STEM CELLS