Nuclear Akt2 Opposes Limbal Keratinocyte Stem Cell Self-Renewal by Repressing a FOXO-mTORC1 Signaling Pathway

Sestrins at the crossroad between stress and aging

(2016) Jun Hee Lee et al.   Aging-US

Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation

(2012) Amar M. Singh et al.   Cell Stem Cell

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Concise Review: Limbal Stem Cell Deficiency, Dysfunction, and Distress

(2012) Sajjad Ahmad   Stem Cells Translational Medicine

Interplay between FOXO, TOR, and Akt

(2011) Nissim Hay   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An eye to treating blindness

(2010) Elena Ezhkova et al.   NATURE

Location of corneal epithelial stem cells

(2010) Tung-Tien Sun et al.   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration

(2010) Paolo Rama et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modelling the Response of FOXO Transcription Factors to Multiple Post-Translational Modifications Made by Ageing-Related Signalling Pathways

(2010) Graham R. Smith et al.   PLoS One

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

(2009) Rogerio M. Castilho et al.   Cell Stem Cell

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

(2009) Keisuke Ito et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

In sickness and in health: Corneal epithelial stem cell biology, pathology and therapy

(2009) M. Notara et al.   EXPERIMENTAL EYE RESEARCH

Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress

(2009) Shi-Yan Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

(2009) Hitoshi Niwa et al.   NATURE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

(2009) Hasan Korkaya et al.   PLOS BIOLOGY

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

(2008) Y. Rebecca Chin et al.   CELLULAR SIGNALLING

Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression

(2008) Sara Cabodi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epithelial stem cells in corneal regeneration and epidermal gene therapy

(2008) G Pellegrini et al.   JOURNAL OF PATHOLOGY

Oligopotent stem cells are distributed throughout the mammalian ocular surface

(2008) François Majo et al.   NATURE

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells

(2008) Takahiro Nakamura et al.   STEM CELLS