Concise Review: The Piwi-piRNA Axis: Pivotal Beyond Transposon Silencing

Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

(2012) Doron Lipson et al.   NATURE MEDICINE

KIF5B-RET fusions in lung adenocarcinoma

(2012) Takashi Kohno et al.   NATURE MEDICINE

Hiwi Mediated Tumorigenesis Is Associated with DNA Hypermethylation

(2012) Sara Siddiqi et al.   PLoS One

Piwil2 Suppresses P53 by Inducing Phosphorylation of Signal Transducer and Activator of Transcription 3 in Tumor Cells

(2012) Yilu Lu et al.   PLoS One

Identification of piRNAs in Hela cells by massive parallel sequencing

(2011) Yilu Lu et al.   BMB Reports

piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

(2011) Jia Cheng et al.   CANCER LETTERS

Expression of HIWI in Human Hepatocellular Carcinoma

(2011) Jianxia Jiang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells

(2011) Jia Cheng et al.   CLINICA CHIMICA ACTA

Gatekeepers for Piwi–piRNA complexes to enter the nucleus

(2011) Hirotsugu Ishizu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

(2011) Hsin-Yi Huang et al.   EMBO JOURNAL

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line

(2011) S. H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separation of stem cell maintenance and transposon silencing functions of Piwi protein

(2011) M. S. Klenov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double Take on Piwi Protein/piRNA Complex Structure

(2011) Harald Schwalbe   STRUCTURE

Somatic and germline expression of piwi during development and regeneration in the marine polychaete annelid Capitella teleta

(2011) Vincent C Giani et al.   EvoDevo

Distributions of Transposable Elements Reveal Hazardous Zones in Mammalian Introns

(2011) Ying Zhang et al.   PLoS Computational Biology

Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells

(2010) Qiuling Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical significance of Hiwi gene expression in gliomas

(2010) Guan Sun et al.   BRAIN RESEARCH

Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate

(2010) Yuval Rinkevich et al.   DEVELOPMENTAL BIOLOGY

Somatic stem cells express Piwi and Vasa genes in an adult ctenophore: Ancient association of “germline genes” with stemness

(2010) Alexandre Alié et al.   DEVELOPMENTAL BIOLOGY

Piwi expression in archeocytes and choanocytes in demosponges: insights into the stem cell system in demosponges

(2010) Noriko Funayama et al.   EVOLUTION & DEVELOPMENT

How does the Royal Family of Tudor rule the PIWI-interacting RNA pathway?

(2010) M. C. Siomi et al.   GENES & DEVELOPMENT

The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells

(2010) Hongying Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells

(2010) F. Cichocki et al.   JOURNAL OF IMMUNOLOGY

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells

(2009) Li-jing Yang et al.   ACTA PHARMACOLOGICA SINICA

The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect

(2009) Travis Thomson et al.   Annual Review of Cell and Developmental Biology

The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters

(2009) Carla Klattenhoff et al.   CELL

The TDRD9-MIWI2 Complex Is Essential for piRNA-Mediated Retrotransposon Silencing in the Mouse Male Germline

(2009) Masanobu Shoji et al.   DEVELOPMENTAL CELL

Whole body regeneration in a colonial ascidian,Botrylloides violaceus

(2009) Federico D. Brown et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein

(2009) James S. Parker et al.   MOLECULAR CELL

A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

(2009) Kuniaki Saito et al.   NATURE

Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability

(2009) Yohei Kirino et al.   NATURE CELL BIOLOGY

Cancer Stem Cells in Solid Tumors: An Overview

(2009) Catherine Adell O'Brien et al.   SEMINARS IN RADIATION ONCOLOGY

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

(2009) Alexei A. Aravin et al.   PLoS Genetics

The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death

(2008) L F Grochola et al.   BRITISH JOURNAL OF CANCER

Small RNA guides for de novo DNA methylation in mammalian germ cells

(2008) A. A. Aravin et al.   GENES & DEVELOPMENT

MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation

(2008) Yingdee Unhavaithaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone

(2008) Celso Silva et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing

(2008) J. Brennecke et al.   SCIENCE

Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells

(2008) Kevin V. Morris et al.   PLoS Genetics

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY