Article
Multidisciplinary Sciences
Martin Connock, Peter Auguste, Jean-Francois Obadia, Lazaros Andronis, Xavier Armoiry
Summary: When updated clinical trial data becomes available, reassessing the cost-effectiveness of technologies may modify estimates and influence decision-making. In this study, the impact of updated trial outcomes on the cost-effectiveness of percutaneous mitral repair (PR) for secondary mitral regurgitation was investigated. The updated trial data showed an increase in mortality in the intervention arm between two and three years follow-up, leading to a higher incremental cost-effectiveness ratio compared to previous estimates.
Article
Energy & Fuels
Lizhong Xiao, Xining Li, Quanyuan Jiang, Guangchao Geng
Summary: This paper investigates the problem of inaccurate state-of-charge (SoC) estimation in battery energy storage systems (BESS) and proposes an online refining method based on historical operating data to improve the accuracy. Through analyzing historical time-series data, SoC reference points are determined and the maximum available capacity of charge or discharge is further calculated. The refined SoC estimation is obtained by enhanced coulomb counting method. Experimental results validate the effectiveness of the proposed approach in providing more accurate SoC estimation.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Engineering, Industrial
Jin Gang Lee, Hyun-Soo Lee, Moonseo Park, JoonOh Seo
Summary: This study proposes an enhanced ANN-based cost estimating model that incorporates artificial neural networks, ensemble modeling, and a factor analysis approach to improve the accuracy and stability of conceptual cost estimates with limited project data quantity.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2022)
Editorial Material
Hematology
Hedwig M. Blommestein, Sonja Zweegman
Summary: In this study, the first-line treatment with daratumumab in combination with different drugs was found to increase quality adjusted life years (QALYs) and reduce treatment costs compared to delaying daratumumab treatment and using it as a second-line therapy with carfilzomib and dexamethasone.
Article
Computer Science, Interdisciplinary Applications
Tuomas Vaisanen, Olle Jarv, Tuuli Toivonen, Tuomo Hiippala
Summary: This article examines language use in Helsinki Metropolitan Area to better understand the spatio-temporal patterns of linguistic diversity. The study combines various data sources and methods to analyze the influence of physical and socio-economic environment on linguistic diversity. The findings provide insights for urban planning and understanding urban diversity.
COMPUTERS ENVIRONMENT AND URBAN SYSTEMS
(2022)
Article
Immunology
Ariel Nikas, Hasan Ahmed, Veronika I. Zarnitsyna
Summary: Understanding the reasons behind the waning of vaccine-induced protection is crucial for the fields of immunology and public health. Heterogeneities in susceptibility and vaccine response among populations can lead to changes in measured vaccine effectiveness (mVE) over time, even without pathogen evolution or actual waning of immune responses. Agent-based models, using epidemiological and immunological data, demonstrate the impact of these heterogeneities on mVE. The models show that heterogeneity in underlying susceptibility accelerates apparent waning, whereas heterogeneity in vaccine response slows it down.
Article
Oncology
Tima Mohammadi, Daphne P. Guh, Alexander C. T. Tam, Reka E. Pataky, Peter C. Black, Alan So, Larry D. Lynd, Wei Zhang, Annalijn I. Conklin
Summary: In this study, a modeling framework was constructed to evaluate the cost-effectiveness of using a new risk assessment tool (RAT) for biopsy decision-making in men with gray zone prostate-specific antigen (PSA) levels. The RAT based on an existing biomarker's characteristics was found to be a dominant strategy, resulting in cost savings and improved quality-adjusted life years (QALY) compared to the current standard of care (SOC). The findings suggest that implementing a more accurate RAT for biopsy guidance can be cost-effective.
Article
Orthopedics
Andrew J. Schoenfeld, Gordon P. Bensen, Justin A. Blucher, Marco L. Ferrone, Tracy A. Balboni, Joseph H. Schwab, Mitchel B. Harris, Jeffrey N. Katz, Elena Losina
Summary: This study compared the cost-effectiveness of surgical and non-surgical treatments for spinal metastases, showing that the value of surgery varies depending on the patient population. Surgical intervention was found to be cost-effective for patients presenting with nonambulatory status due to acute neurologic compromise, but not for those who were ambulatory at presentation.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Medicine, General & Internal
Dan Su, Bin Wu, Lizheng Shi
Summary: Cost-effectiveness evaluation of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma from the US payer perspective showed that the treatment is unlikely to be cost-effective compared with sorafenib. Lowering the prices of atezolizumab and bevacizumab may enhance cost-effectiveness, and tailoring treatments based on individual patient factors could also improve economic outcomes.
Article
Health Care Sciences & Services
Michael Pignone, Brennan Lanier, Nicole Kluz, Victoria Valencia, Patrick Chang, Todd Olmstead
Summary: The study investigated the impact and cost-effectiveness of a mailed FIT screening program for colorectal cancer, finding it to be an effective and cost-effective strategy, particularly for vulnerable patients.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Johan Lyth, Emma Svennberg, Lars Bernfort, Mattias Aronsson, Viveka Frykman, Faris Al-Khalili, Leif Friberg, Marten Rosenqvist, Johan Engdahl, Lars-Ake Levin
Summary: This study aimed to evaluate the cost-effectiveness of population-based screening for atrial fibrillation (AF) using clinical outcomes. The analysis showed that the screening intervention group had higher gained life years and gained quality-adjusted life years at a lower cost.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Melike Yildirim, Bradley N. Gaynes, Pinar Keskinocak, Brian W. Pence, Julie Swann
Summary: The study aimed to determine the cost-effectiveness of depression screening schedules, showing that routine screening is cost-effective for all age groups of females and young, middle-aged males.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Statistics & Probability
Chenghao Chu, Bingming Yi
Summary: In clinical trials, incorporating historical data to evaluate the treatment effect of experimental drugs is challenging due to potential bias and error rate inflation. A proposed dynamic historical borrowing method adjusts borrowing based on the similarity of historical and current data, showing reduced bias and improved power compared to existing methods. This approach allows better control of Type-1 error rate inflation while maximizing the use of historical data.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
(2021)
Article
Chemistry, Analytical
John Byabazaire, Gregory M. P. O'Hare, Rem Collier, Declan Delaney
Summary: Timely data quality assessment is crucial for the development of IoT-based applications, but it poses a challenge due to varying data quality requirements for different applications. This paper proposes a novel approach that integrates fusion methods into end-to-end data quality assessment to address this challenge and cater to diverse data quality needs within a single data pipeline.
Article
Oncology
Harry Hill, Ben Kearns, Nora Pashayan, Cristina Roadevin, Peter Sasieni, Judith Offman, Stephen Duffy
Summary: Risk-stratified breast cancer screening has the potential to be beneficial for women at the population level, but the net health benefit will depend on the particular risk-based strategy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Benedicte Delcoigne, Niels Hagenbuch, Maria E. C. Schelin, Agus Salim, Linda S. Lindstrom, Jonas Bergh, Kamila Czene, Marie Reilly
STATISTICAL METHODS IN MEDICAL RESEARCH
(2018)
Article
Mathematical & Computational Biology
Agus Salim, Benedicte Delcoigne, Krystyn Villaflores, Woon-Puay Koh, Jian-Min Yuan, Rob M. van Dam, Marie Reilly
STATISTICS IN MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Xuling Chang, Agus Salim, Rajkumar Dorajoo, Yi Han, Chiea-Chuen Khor, Rob M. van Dam, Jian-Min Yuan, Woon-Puay Koh, Jianjun Liu, Daniel Y. T. Goh, Xu Wang, Yik-Ying Teo, Yechiel Friedlander, Chew-Kiat Heng
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Catherine Itsiopoulos, Teagan Kucianski, Hannah L. Mayr, William J. van Gaal, Miguel Angel Martinez-Gonzalez, Hassan Vally, Michael Kingsley, Antigone Kouris-Blazos, Jessica Radcliffe, Leonie Segal, Laima Brazionis, Agus Salim, Audrey C. Tierney, Kerin O'Dea, Andrew Wilson, Colleen J. Thomas
AMERICAN HEART JOURNAL
(2018)
Article
Environmental Sciences
Nugroho Harry Susanto, Ann-Marie Malby Schoos, Marie Standl, Adrian J. Lowe, Shyamali C. Dharmage, Cecilie Svanes, Agus Salim, Andrea von Berg, Irina Lehmann, Morten Arendt Rasmussen, Matthias Werchan, Karl-Christian Bergmann, Caroline Lodge, Michael J. Abramson, Joachim Heinrich, Hans Bisgaard, Bircan Erbas
ENVIRONMENT INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P. Mintoff, Franco Caramia, Roberto Salgado, David J. Byrne, Zhi L. Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J. Luen, Catherine Poliness, Sophie S. Nightingale, Anita S. Skandarajah, David E. Gyorki, Chantel M. Thornton, Paul A. Beavis, Stephen B. Fox, Kathleen Cuningham, Phillip K. Darcy, Terence P. Speed, Laura K. Mackay, Paul J. Neeson, Sherene Loi
Article
Biochemical Research Methods
Luqman Hakim Abdul Hadi, Quy Xiao Xuan Lin, Tri Tran Minh, Marie Loh, Hong Kiat Ng, Agus Salim, Richie Soong, Touati Benoukraf
BMC BIOINFORMATICS
(2018)
Correction
Biochemistry & Molecular Biology
Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P. Mintoff, Franco Caramia, Roberto Salgado, David J. Byrne, Zhi L. Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J. Luen, Catherine Poliness, Sophie S. Nightingale, Anita S. Skandarajah, David E. Gyorki, Chantel M. Thornton, Paul A. Beavis, Stephen B. Fox, Phillip K. Darcy, Terence P. Speed, Laura K. Mackay, Paul J. Neeson, Sherene Loi
Article
Endocrinology & Metabolism
Julian W. Sacre, Elizabeth Holmes-Truscott, Agus Salim, Kaarin J. Anstey, Grant R. Drummond, Rachel R. Huxley, Dianna J. Magliano, Peter van Wijngaarden, Paul Z. Zimmet, Jane Speight, Jonathan E. Shaw
Summary: The study found that the COVID-19 pandemic and lockdown measures significantly impacted the quality of life, behavioral risk factors, and healthcare utilization of adults with type 2 diabetes. However, anxiety and depressive symptoms remained relatively stable.
Article
Nutrition & Dietetics
Christian J. Brakenridge, Genevieve N. Healy, Parneet Sethi, Alison Carver, John Bellettiere, Agus Salim, Sebastien F. M. Chastin, Neville Owen, David W. Dunstan
Summary: The study found that reducing sitting time and increasing standing, especially replacing it with stepping, can improve glycemic control in middle-aged and older adults, particularly those at higher risk of type 2 diabetes.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Biochemistry & Molecular Biology
Agus Salim, Ramyar Molania, Jianan Wang, Alysha De Livera, Rachel Thijssen, Terence P. Speed
Summary: Normalization of single cell RNA-seq data is challenging and the performance of different methods varies greatly between datasets. We propose RUV-III-NB, a method that can remove unwanted variation from both cell embedding and gene-level counts, considering potential association with biology. The method performs consistently and is not sensitive to the number of contributing factors.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Hematology
Huimin Cao, Shalin H. Naik, Daniela Amann-Zalcenstein, Peter Hickey, Agus Salim, Benjamin Cao, Susan K. Nilsson, M. Cristina Keightley, Graham J. Lieschke
Summary: This study identifies the crucial role of the ZBTB11 transcription factor in definitive hematopoiesis. Deletion of ZBTB11 in mice leads to embryonic death and hematopoietic failure. Loss of ZBTB11 results in overspecification of hematopoietic stem cells, loss of stemness, impaired differentiation, and cell cycle regulation. This study highlights the cell-intrinsic requirement of ZBTB11 in maintaining a pool of maturation-capable HSCs and progenitor cells.
Review
Cardiac & Cardiovascular Systems
Elizabeth L. Potter, Ingrid Hopper, Jonathan Sen, Agus Salim, Thomas H. Marwick
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2019)
Article
Psychology, Clinical
Amy J. Morgan, Ronald M. Rapee, Agus Salim, Jordana K. Bayer
Article
Biochemical Research Methods
Malathi S. I. Dona, Luke A. Prendergast, Suresh Mathivanan, Shivakumar Keerthikumar, Agus Salim