4.5 Article

A spatio-temporal absorbing state model for disease and syndromic surveillance

Journal

STATISTICS IN MEDICINE
Volume 31, Issue 19, Pages 2123-2136

Publisher

WILEY
DOI: 10.1002/sim.5350

Keywords

conditional autoregressive model; hierarchical model; hidden Markov model; influenza

Funding

  1. NSF [DMS-0914906, DMS-0914903, DMS-0914603, DMS-0914921, DMS-0112069]
  2. National Security Agency [H98230-11-1-0208]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Mathematical Sciences [1106435] Funding Source: National Science Foundation
  5. Division Of Mathematical Sciences
  6. Direct For Mathematical & Physical Scien [0914603, 0914906] Funding Source: National Science Foundation

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Reliable surveillance models are an important tool in public health because they aid in mitigating disease outbreaks, identify where and when disease outbreaks occur, and predict future occurrences. Although many statistical models have been devised for surveillance purposes, none are able to simultaneously achieve the important practical goals of good sensitivity and specificity, proper use of covariate information, inclusion of spatio-temporal dynamics, and transparent support to decision-makers. In an effort to achieve these goals, this paper proposes a spatio-temporal conditional autoregressive hidden Markov model with an absorbing state. The model performs well in both a large simulation study and in an application to influenza/pneumonia fatality data. Copyright (C) 2012 John Wiley & Sons, Ltd.

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