Article
Oncology
Li C. Cheung, Paul S. Albert, Shrutikona Das, Richard J. Cook
Summary: In the settings we examined, we found that misspecifying a time-inhomogenous semi-Markov process as a time-homogeneous Markov process resulted in biased estimates of the mean sojourn times. When screen-detection of the intermediate disease leads to more frequent future screening assessments, there was minimal bias induced compared to when screen-detection of the intermediate disease leads to less frequent screening.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Tao Hou, Weichao Dan, Tianjie Liu, Bo Liu, Yi Wei, Chenyang Yue, Taotao Que, Yuzeshi Lei, Zixi Wang, Jin Zeng, Yizeng Fan, Lei Li
Summary: This study reveals that the deubiquitinating enzyme OTUD5 activates the mTOR signaling pathway to promote bladder cancer progression. OTUD5 stabilizes the function of RNF186, a RING-type E3 ligase, leading to the degradation of sestrin2, an inhibitor of the mTOR signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Zhengnan Huang, Yilin Yan, Zhen Zhu, Jiakuan Liu, Xiao He, Sumiya Dalangood, Meiqian Li, Mingyue Tan, Jinming Cai, Pengfei Tang, Ruimin Huang, Bing Shen, Jun Yan
Summary: CBX7 is frequently downregulated in urinary bladder cancer due to promoter hypermethylation, leading to poor prognosis. Its ectopic expression suppresses UBC cell aggressiveness and tumor development by downregulating AKR1B10 and inactivating ERK signaling, providing a potential therapeutic target against UBC.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Ningshu Lin, Luyan Chen, Yunni Zhang, Yi Yang, Lei Zhang, Lei Chen, Peng Zhang, Huiming Su, Min Yin
Summary: KIF4A overexpression is associated with bladder cancer and activation of immunocytes. High expression of KIF4A is correlated with decreased CD8(+) tumor-infiltrating lymphocytes and worse prognosis in patients. KIF4A promotes tumor growth, especially in immune-competent mice.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Katerina-Marina Pilala, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Petros Barbarigos, Panagiotis Levis, Georgios Kotronopoulos, Konstantinos Stravodimos, Andreas Scorilas, Margaritis Avgeris
Summary: Bladder cancer (BlCa) is characterized by heterogeneous molecular landscape and lacks personalized treatment. In this study, we investigated the epigenetic regulation of the miR-143/145 cluster in BlCa. We found that the methylation of MIR145 core promoter was associated with disease progression and poor survival in BlCa patients. Combining MIR145 core promoter methylation with established disease markers improved risk stratification and prediction of treatment outcome. Our findings highlight the importance of personalized risk stratification and management in BlCa.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cell Biology
Ganping Wang, Yarong Dai, Kang Li, Maosheng Cheng, Gan Xiong, Xiaochen Wang, Shuang Chen, Zhi Chen, Jianwen Chen, Xiuyun Xu, Rong-song Ling, Liang Peng, Demeng Chen
Summary: The study demonstrates that Mettl3-mediated m(6)A modification is crucial for the activation of TEK-VEGF-A-mediated tumor progression and angiogenesis in bladder cancer. Experimental results using transgenic mouse models and bladder cancer stem cell populations showed that depletion of Mettl3 inhibits tumor oncogenesis and progression in bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria I. Aroca-Siendones, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Michela Verbeni, Javier Arnedo, Julia Escudero-Feliu, Maria Garcia-Costela, Adelina Garcia-Robles, Angel Carazo, Josefa Leon
Summary: Low expression of PER2 and BMAL1 is associated with metastasis at the time of CRC diagnosis, high expression of CRY1 is an independent prognostic factor for metastasis development, and high expression of NR1D2 is an independent prognostic factor for local recurrence development. Patients with low BMAL1 expression and high CRY1 expression show lower overall survival and disease-free survival at five years.
Review
Multidisciplinary Sciences
B. Cristoffer Sakshaug, Evelina Folkesson, Tonje Husby Haukaas, Torkild Visnes, Asmund Flobak
Summary: This article presents a systematic review of studies on the performance of patient-derived organoids in predicting the effect of anti-cancer therapies in colorectal cancer. The review shows that patient-derived organoids have a high predictive value for treatment outcomes in chemotherapy, targeted drugs, and radiation therapy for colorectal cancer.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Dexin Chen, Meiting Fu, Liangjie Chi, Liyan Lin, Jiaxin Cheng, Weisong Xue, Chenyan Long, Wei Jiang, Xiaoyu Dong, Jian Sui, Dajia Lin, Jianping Lu, Shuangmu Zhuo, Side Liu, Guoxin Li, Gang Chen, Jun Yan
Summary: In this study, a pathomics signature (PSGC) derived from multiple features of haematoxylin and eosin-stained slides is proposed as an independent predictor of prognosis for gastric cancer patients. The PSGC, when combined with the TNM staging system, significantly improves the accuracy of predicting prognosis. Additionally, satisfactory chemotherapy benefits are observed in patients with a low PSGC, suggesting its potential usefulness as a predictive indicator for decision-making regarding adjuvant chemotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Vikram Venkatraghavan, Elisabeth J. Vinke, Esther E. Bron, Wiro J. Niessen, M. Arfan Ikram, Stefan Klein, Meike W. Vernooij
Summary: This study investigated the predictive utility of disease timelines constructed in a case-controlled setting for pre-symptomatic Alzheimer's disease in a population-based cohort. By using co-init DEBM, APOE-specific disease timelines were estimated from structural MRI biomarkers, with promising results in distinguishing AD subjects from controls and predicting disease progression in both case-controlled and population-based cohorts.
Article
Medicine, General & Internal
Antonella Cormio, Gian Maria Busetto, Clara Musicco, Francesca Sanguedolce, Beppe Calo, Marco Chirico, Ugo Giovanni Falagario, Giuseppe Carrieri, Claudia Piccoli, Luigi Cormio
Summary: The study found that Mfn2 and ClpP proteins were overexpressed in bladder cancer compared to non-lesional bladder tissue, with Mfn2 expression predicting disease progression.
Article
Multidisciplinary Sciences
Aseel Shomar, Omri Barak, Naama Brenner
Summary: This article proposes a framework of learning theory to explain the complexities of drug resistance and metastasis in cancer. The learning process at the single-cell level is driven by stress and involves trial-and-error exploration to diminish stress. At the population level, the tissue is viewed as a network of exploring agents that communicate with each other, maintaining health by restraining cancer formation.
Article
Computer Science, Information Systems
Zhaohong Sun, Zhoujian Sun, Wei Dong, Jinlong Shi, Zhengxing Huang
Summary: A novel Variational Hawkes Process (VHP) model is proposed for predictive analysis of disease progression, capturing irregular visit intensity in medical trajectories and integrating it into a Variational Auto-Encoder for future state prediction. The model significantly outperforms existing baselines, offering practical insights for disease progression management and applications.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Computer Science, Hardware & Architecture
Lechang Yang, Chenxing Wang, Chunyan Ling, Min Xie
Summary: This article proposes a survival signature-based reliability framework for an imprecise multistate system (IMSS) to address the challenges of reliability evaluation for complex systems with imprecise parameters. The framework defines the survival signature and calculates the multistate survival functions based on the combination of states of composing elements. A simulation method is developed for probability estimation when imprecision is involved. An approximate Bayesian computation method with a Jensen-Shannon divergence-based kernel is developed to perform stochastic model updating and calibrate imprecise parameters. The proposed framework is validated with a numerical case of a typical bridge system and a real application example.
IEEE TRANSACTIONS ON RELIABILITY
(2023)
Article
Immunology
Yanping Hu, Jiuzhou Zhao, Yihang Shen, Chengjuan Zhang, Qingxin Xia, Guoqiang Zhang, Bo Wang, Bing Wei, Rentao Yu, Jie Ma, Yongjun Guo
Summary: The study found that CD8 + CD279+ cells are an independent prognostic factor for DFS in CRC patients, with high levels of CD8 + CD279+ cells associated with better DFS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Nigel Bundred, Nuria Porta, Adrian Murray Brunt, Angela Cramer, Andrew Hanby, Abeer M. Shaaban, Emad A. Rakha, Anne Armstrong, Ramsey Cutress, David Dodwell, Marie A. Emson, Abigail Evans, Sue M. Hartup, Kieran Horgan, Sarah E. Miller, Stuart A. McIntosh, James P. Morden, Jay Naik, Sankaran Narayanan, Jane Ooi, Anthony Skene, David A. Cameron, Judith M. Bliss
Summary: The EPHOS-B trial aimed to investigate the impact of perioperative anti-HER2 therapy on proliferation and apoptosis in HER2-positive breast cancer. The results showed that early response after short-term dual anti-HER2 therapy can identify cancers dependent on the HER2 pathway and provide a strategy for risk-adapted individualized treatment de-escalation.
CLINICAL CANCER RESEARCH
(2022)
Article
Health Care Sciences & Services
Marta Bofill Roig, Guadalupe Gomez Melis
Summary: The study introduces a class of statistics for testing the equality of proportions and survival functions, which are non-parametric and do not rely on specific assumptions. The proposed statistics are evaluated through simulation studies and clinical trials, demonstrating their performance in small sample sizes.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Meeting Abstract
Oncology
Nigel Bundred, Nuria Porta, Adrian Murray Brunt, Angela Cramer, Andrew Hanby, Abeer Shaaban, Emad Rakha, Anne Armstrong, Ramsey Cutress, David Dodwell, Marie Emson, Abigail Evans, Sue Hartup, Kieran Horgan, Stuart McIntosh, Jay Naik, Samkaran Narayanan, Jane Oii, Anthony Skene, David Cameron, Judith Bliss
Article
Environmental Sciences
Laura E. Beane Freeman, Manolis Kogevinas, Kenneth P. Cantor, Cristina M. Villanueva, Ludmila Prokunina-Olsson, Oscar Florez-Vargas, Jonine D. Figueroa, Mary H. Ward, Stella Koutros, Dalsu Baris, Montserrat Garcia-Closas, Molly Schwenn, Allison Johnson, Consol Serra, Adonina Tardon, Reina Garcia-Closas, Alfredo Carrato, Nuria Malats, Margaret R. Karagas, Nathaniel Rothman, Debra T. Silverman
Summary: This study investigated the combined effect on bladder cancer risk contributed by TTHMs, bladder cancer susceptibility variants identified through genome-wide association studies, and variants in several candidate genes. The results showed that rs907611 at 11p15.5 exhibited the strongest associations in the highest exposure category in both studies, with evidence of interaction.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Urology & Nephrology
Emma Hall, Syed A. Hussain, Nuria Porta, Rebecca Lewis, Malcolm Crundwell, Peter Jenkins, Christine Rawlings, Jean Tremlett, Thiagarajan Sreenivasan, Jan Wallace, Isabel Syndikus, Denise Sheehan, Anna Lydon, Robert Huddart, Nicholas James
Summary: This study provides long-term follow-up results on the efficacy of radiotherapy with or without chemotherapy for patients with muscle-invasive bladder cancer (MIBC). The findings confirm the benefit of adding fluorouracil and mitomycin C to radiotherapy, with improved locoregional control and invasive locoregional control. The benefit of adding chemotherapy to radiotherapy was maintained over a 10-year period.
Meeting Abstract
Oncology
T. A. D. Smith, C. M. West, B. Lane, J. Irlam-Jones, E. More, H. Mistry, P. J. Hoskin, S. A. Hussain, E. Hall, N. Porta, R. A. Huddart, N. D. James, A. Choudhury
ANNALS OF ONCOLOGY
(2022)
Review
Health Care Sciences & Services
Harry Parr, Emma Hall, Nuria Porta
Summary: This study reviews the joint model strategies that have been applied to predict the association between time-dependent PSA trajectories and time-to-event outcomes in localized prostate cancer. The results show that dynamic prediction models enable real-time prediction of individual patient prognosis and utilize all available longitudinal information, making them superior to traditional baseline-only prediction models.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Oncology
L. Philipps, N. Porta, N. James, R. Huddart, S. Hafeez, L. Ballas, E. Hall
Summary: This study analyzed the differences in health-related quality of life (HRQoL) and toxicity between male and female patients with muscle-invasive bladder cancer who received radiotherapy with or without chemotherapy. The results revealed that female patients reported worse treatment-related toxicity in the post-treatment years 2 and 3 compared to males.
Article
Oncology
L. Philipps, N. Porta, N. James, S. Hafeez, E. Hall
Summary: This study aims to evaluate the correlation between patient-reported outcomes (PROs) and clinician-reported outcomes (CROs) in bladder cancer follow-up post-radiotherapy. The results show that the correlation between PROs and CROs is generally poor, and PROs appear to be more sensitive, with higher grade events reported.
Article
Oncology
Harry Parr, Nuria Porta, Alison C. Tree, David Dearnaley, Emma Hall
Summary: The study assessed moderately hypofractionated radiation therapy in localized prostate cancer and used longitudinal PSA measurements to predict patient prognosis. A joint statistical model was developed to evaluate biochemical or clinical recurrence risk, considering repeated PSA values and baseline prognostic factors. The results demonstrated the importance of dynamically updated PSA information in improving prognostication and guiding follow-up and treatment management options.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Michael J. Dubec, David L. Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Christina Hague, Cynthia L. Eccles, Peter J. Hoskin, Robert G. Bristow, Julian C. Matthews, Marcel van Herk, Ananya Choudhury, Geoff J. M. Parker, Andrew McPartlin, James P. B. O'Connor
Summary: The study aimed to develop oxygen-enhanced MRI (OE-MRI) in head and neck cancer patients and translate the technique onto an MR Linac system. The results showed that OE-MRI was feasible and had good repeatability, and it has the potential to guide future clinical trials of biology guided adaptive radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Alvaro H. Ingles Garces, Nuria Porta, Trevor A. Graham, Udai Banerji
Summary: The evolution of drug-resistant cell subpopulations leads to treatment failure in cancer. Preclinical evidence suggests the possibility of influencing the response to subsequent treatments by modeling clonal evolution and collateral sensitivity. New therapy strategies and clinical trial designs are needed to steer cancer evolution. The competition between different subsets of drug-sensitive and resistant clones for nutrients/blood supply indicates the potential use of treatment paradigms based on cell-cell competition. This requires different clinical trial designs from the conventional practice and the integration of next-generation sequencing to improve the assessment of clinical response/resistance and exploit evolution.
CANCER TREATMENT REVIEWS
(2023)
Correction
Oncology
Alvaro H. Ingles Garces, Nuria Porta, Trevor A. Graham, Udai Banerji
CANCER TREATMENT REVIEWS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sam Keaveney, Alina Dragan, Mihaela Rata, Matthew Blackledge, Erica Scurr, Jessica M. Winfield, Joshua Shur, Dow-Mu Koh, Nuria Porta, Antonio Candito, Alexander King, Winston Rennie, Suchi Gaba, Priya Suresh, Paul Malcolm, Amy Davis, Anjumara Nilak, Aarti Shah, Sanjay Gandhi, Mauro Albrizio, Arnold Drury, Guy Pratt, Gordon Cook, Sadie Roberts, Matthew Jenner, Sarah Brown, Martin Kaiser, Christina Messiou
Summary: The study evaluated image quality in a multi-center prospective trial using MY-RADS guidelines, finding that the overall image quality was generally good, with issues mostly stemming from low quality diffusion-weighted imaging. Correlation between radiological and quantitative scoring was significant, and repeatability was generally good. The signal to noise ratio in diffusion-weighted imaging was identified as a significant predictor of examination quality.
INSIGHTS INTO IMAGING
(2023)
Article
Health Care Sciences & Services
Denis Horgan, Jasmina Koeva-Balabanova, Ettore Capoluongo, Beata Jagielska, Ivana Cattaneo, Marta Kozaric, Birute Tumiene, Jean-Paul El Ahl, Jonathan A. Lal, Dipak Kalra, Nuria Malats
Summary: The current delicate balance of funding rare disease research and development in Europe is facing new threats from forthcoming policy changes, which may reduce incentives and disrupt the flow of innovative treatments.
