Journal
STATISTICS IN MEDICINE
Volume 29, Issue 30, Pages 3203-3210Publisher
WILEY-BLACKWELL
DOI: 10.1002/sim.3981
Keywords
cross-over trial; missing data; parallel group trial; infertility; Mantel-Haenszel
Categories
Funding
- British Council
- Boehringer Ingelheim
Ask authors/readers for more resources
The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examples of trials in infertility. An approach that may be used to compare designs via simulation is explained briefly. It is concluded that provided that cross-over trials in infertility are regarded as parallel group trials with extra information rather than as cross-over trials with missing information, their use may be more promising than that has previously been concluded. Copyright (C) 2010 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available