Reflections on meta-analyses involving trials stopped early for benefit: Is there a problem and if so, what is it?

Bias and Trials Stopped Early for Benefit

(2010) Steven Goodman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Stopping Randomized Trials Early for Benefit and Estimation of Treatment EffectsSystematic Review and Meta-regression Analysis

(2010) Dirk Bassler   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The experts debate: Perioperative beta-blockade for noncardiac surgery--proven safe or not?

(2009) D. POLDERMANS et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Stopping trials for efficacy: an almost unbiased view

(2009) Steven N Goodman   Clinical Trials

Perioperative β blockers in patients having non-cardiac surgery: a meta-analysis

(2008) Sripal Bangalore et al.   LANCET

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial

(2008)   LANCET

What is “quality of evidence” and why is it important to clinicians?

(2008) Gordon H Guyatt et al.   BMJ-British Medical Journal

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

(2008) Gordon H Guyatt et al.   BMJ-British Medical Journal

Systematic reviews are not biased by results from trials stopped early for benefit

(2007) Steven N. Goodman   JOURNAL OF CLINICAL EPIDEMIOLOGY