Article
Physiology
Alexander D. Cohen, Amritpal S. Jagra, Nicholas J. Visser, Baolian Yang, Brice Fernandez, Suchandrima Banerjee, Yang Wang
Summary: The study compared an advanced multiband multi-echo (MBME) with an existing multiband single-echo (MB) sequence to evaluate BH activation and CVR mapping. The results indicate that rCVR for MBME scans was significantly higher than for MB scans, but in areas of high susceptibility-induced signal dropout, MBME rCVR was significantly lower than MB rCVR.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Kai Chen, Hang Yang, Heming Zhang, Chun Meng, Benjamin Becker, Bharat Biswal
Summary: This study examined brain activation in response to breath-holding tasks with different respiratory rates and found systematic differences in activation intensity. Fast breathing resulted in the greatest increase in activation intensity, followed by self-paced and slow breathing. The findings suggest that using a variable respiratory rate in breath-holding tasks allows for more flexibility in measuring cerebrovascular reactivity.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Keerthana Deepti Karunakaran, Katherine Ji, Donna Y. Chen, Nancy D. Chiaravalloti, Haijing Niu, Tara L. Alvarez, Bharat B. Biswal
Summary: This study examined the relationship between age and cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) in 45 young healthy adult participants aged 18-41 years. Results showed a negative relationship between hemodynamic measures in the sensorimotor cortex during breath holding and age, as well as increased positive coactivation between medial sensorimotor regions and other brain areas with age. The reliability of fNIRS in measuring CVR was found to be low to fair/good, but the hemodynamic responses to breath holding were consistent across sessions.
Article
Medicine, General & Internal
Jack Quach, Olga Theou, Judith Godin, Kenneth Rockwood, Dustin Scott Kehler
Summary: The study investigated the combined burden of frailty and poor cardiovascular health on mortality risk by sex and age, finding that the impact varies with age in males but remains constant in females. Older males with at least mild frailty and intermediate cardiovascular health or worse had a higher risk of all-cause and CVD-related mortality. Adding frailty assessment to evaluations of cardiovascular health may help identify individuals at higher risk of mortality.
Article
Respiratory System
Carolina Ciumas, Mayara Bolay, Romain Bouet, Sylvain Rheims, Danielle Ibarrola, Johnson P. Hampson, Samden D. Lhatoo, Philippe Ryvlin
Summary: Using fMRI, a study found that voluntary breath-holding can trigger neural responses in the respiratory centers and control centers in the brainstem. This method may serve as a biomarker for investigating disorders of central control of breathing in individual patients. Group analysis showed activation of most respiratory centers during breath-holding, with a significant relationship to the drop in SpO(2). Individual analysis revealed activations in cortical/subcortical and brainstem structures related to respiratory control in 19 out of 21 subjects.
Article
Immunology
Sara Sanz-Rojo, Rodrigo Jimenez-Garcia, Ana Lopez-de-Andres, Javier de Miguel-Diez, Napoleon Perez-Farinos, Jose J. Zamorano-Leon
Summary: This study utilized data from the 2020 European Health Survey for Spain to analyze influenza vaccination uptake among individuals aged >65 years, healthcare workers, and those with high-risk chronic medical conditions. The results showed that uptake rates remain below desirable levels and have not significantly improved since 2017. Factors such as female sex, older age, being born in Spain, self-reported respiratory or cardiovascular diseases, diabetes, cancer, and being a healthcare worker were associated with higher vaccination uptake.
Review
Health Care Sciences & Services
Chase Kelley, Jonathan Vander Molen, Jennifer Choi, Sahar Bhai, Katelyn Martin, Cole Cochran, Prasanth Puthanveetil
Summary: Glucocorticoids play an important role in the cardiovascular system, regulating growth, development, and providing anti-inflammatory protection, but excessive or long-term use can have negative effects on the heart.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Seyed Hamid Borsi, Gholamreza Goudarzi, Gholamreza Sarizadeh, Maryam Dastoorpoor, Sahar Geravandi, Habib Allah Shahriyari, Zahra Akhlagh Mohammadi, Mohammad Javad Mohammadi
Summary: The presence of criteria air pollutants in the ambient air poses a serious threat to public health. This study evaluated the health outcomes of cardiovascular mortalities, hospital admissions with cardiovascular disease, and hospital admissions for respiratory disease due to exposure to these pollutants. The results showed that increased levels of particle matter, ozone, nitrogen dioxide, and sulfide dioxide were associated with higher morbidity and mortality rates. Thus, these findings are of great importance in improving public health.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Jose Antonio Pico-Monllor, Beatriz Ruzafa-Costas, Eva Nunez-Delegido, Pedro Sanchez-Pellicer, Javier Peris-Berraco, Vicente Navarro-Lopez
Summary: Studies have shown that certain probiotic strains can be used to prevent and improve respiratory tract infections. A combination of various probiotics can effectively strengthen the immune system of the healthy working population and reduce symptoms of upper respiratory tract infections.
Article
Rheumatology
Jina Yeo, Ju Yeon Kim, Mi Hyeon Kim, Jun Won Park, Jin Kyun Park, Eun Bong Lee
Summary: This study evaluated the clinical utility and reliability of the breath-holding test (BHT) in assessing cardiopulmonary function in patients with SSc. The results showed that BHT had significant correlations with the Borg dyspnea scale, SHAQ, and pulmonary parameters, suggesting that it may be a useful surrogate marker of pulmonary capacity in SSc patients.
Review
Neurosciences
Andrew E. Beaudin, Patrick J. Hanly, Jill K. Raneri, Magdy Younes, Matiram Pun, Todd J. Anderson, Marc J. Poulin
Summary: Exposure to intermittent hypoxia (IH) is believed to increase the risk of cerebrovascular and cardiovascular disease, but sleep accompanied by IH does not significantly alter vascular responses to hypoxia and hypercapnia in healthy young individuals. However, IH sleep does lead to an increased heart rate response to hypoxia upon waking.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Environmental Sciences
Cheng-Yu Tsai, Chien-Ling Su, Yuan-Hung Wang, Sheng-Ming Wu, Wen-Te Liu, Wen-Hua Hsu, Arnab Majumdar, Marc Stettler, Kuan-Yuan Chen, Ya-Ting Lee, Chaur-Jong Hu, Kang-Yun Lee, Ben-Jei Tsuang, Chien-Hua Tseng
Summary: Long-term exposure to air pollution can lead to cardiovascular disease, metabolic syndrome, and chronic respiratory disease. A study in Taiwan evaluated the impact of air pollution exposure at different life stages and found that exposure after 40 years of age may increase the risk of metabolic syndrome, hypertension, diabetes, and cardiovascular disease. Models considering lifetime exposure showed higher precision, accuracy, and F1 scores than models incorporating only late-stage exposures.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biology
Kamen A. Tsvetanov, Richard N. A. Henson, James B. Rowe
Summary: Accurate identification of brain function is necessary for understanding cognitive ageing, and fMRI is a common tool used for this purpose. However, studies on vascular ageing factors are limited, and current approaches focus on dissociating neuronal and vascular components of BOLD-fMRI. Emerging evidence suggests that vascular mechanisms in the brain have complex interactions that influence neuronal function.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Respiratory System
Jose Luis Izquierdo, Carlos Almonacid, Yolanda Gonzalez, Carlos Del Rio-Bermudez, Julio Ancochea, Remedios Cardenas, Sara Lumbreras, Joan B. Soriano
Summary: The study analyzed clinical data of 71,182 asthma patients and found that those with COVID-19 were older, predominantly female, and had higher prevalence of comorbidities. The use of inhaled corticosteroids and biologics in asthma patients may have a protective effect against severe COVID-19 infection.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Audrey Paulin, Hasanga D. Manikpurage, Jean-Pierre Despres, Sebastien Theriault, Benoit J. Arsenault
Summary: The impact of BMI on ASCVD risk in metabolically healthy individuals is uncertain, but lifestyle and cardiometabolic risk factors strongly predict ASCVD incidence. Assessing lifestyle and cardiometabolic risk factors, as well as body fat distribution, can help identify individuals at high ASCVD risk regardless of body weight.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Josip Katic, Ante Anic, Toni Breskovic, Zrinka Jurisic
Summary: The study showed that higher and targeted lesion size index on different segments of pulmonary veins during ablation could lead to better clinical outcomes for paroxysmal atrial fibrillation without harmful effects.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Jan Elaine Soriano, Rinaldo Romac, Jordan W. Squair, Otto F. Barak, Zoe K. Sarafis, Amanda H. X. Lee, Geoff B. Coombs, Bita Vaseghi, Christopher Grant, Rebecca Charbonneau, Tanja Mijacika, Andrei Krassioukov, Philip N. Ainslie, Kelly A. Larkin-Kaiser, Aaron A. Phillips, Zeljko Dujic
Summary: The study investigated the cardiorespiratory response of individuals with cervical SCI to passive leg cycling. The results showed that passive cycling increased cardiovascular activity and improved endothelial function in people with cervical SCI, suggesting it as a beneficial exercise intervention for the cardiovascular and respiratory systems in this population.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David B. MacLeod, Philip N. Ainslie, Zeljko Dujic
Summary: In this study, it was found that prolonged apnea duration during voluntary asphyxia leads to increased cerebral blood flow and blood-brain barrier permeability. The study highlights the critical role of hypoxemia and hypercapnia in BBB disruption.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Martin, Marina Fowler, Toni Breskovic, Alexandre Ouss, Lukas Dekker, Sing-Chien Yap, Rohit Bhagwandien, Elizabeth M. Albrecht, Nele Cielen, Elizabeth Richards, Binh C. Tran, Nigel Lever, Ante Anic
Summary: This study evaluated the long-term safety and efficacy of a novel cryoballoon in treating paroxysmal atrial fibrillation (PAF). The results showed that the cryoballoon demonstrated good acute isolation outcomes, with most patients remaining free of arrhythmia during follow-up, although some patients experienced phrenic nerve injury.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Sport Sciences
Tyler Kelly, Alexander Patrician, Mohini Bryant-Ekstrand, Courtney Brown, Christopher Gasho, Hannah G. Caldwell, Rachel N. Lord, Tony Dawkins, Aimee Drane, Michael Stembridge, Tanja Dragun, Otto Barak, Boris Spajic, Ivan Drvis, Joseph W. Duke, Glen E. Foster, Philip N. Ainslie, Zeljko Dujic, Andrew T. Lovering
Summary: The prevalence of patent foramen ovale is significantly higher in apnea divers, potentially due to the pulmonary arterial hypertension during diving and effects of bubbles in the heart.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Multidisciplinary Sciences
Jan Elaine Soriano, Jordan W. Squair, Jacquelyn J. Cragg, Jennifer Thompson, Rafael Sanguinetti, Bita Vaseghi, Carolyn A. Emery, Christopher Grant, Rebecca Charbonneau, Kelly A. Larkin-Kaiser, Aaron A. Phillips, Zeljko Dujic
Summary: This study found that individuals with spinal cord injury have lower levels of physical activity compared to the general population. This knowledge is important for directing future research and allocating healthcare resources.
SCIENTIFIC REPORTS
(2022)
Correction
Cardiac & Cardiovascular Systems
Sing-Chien Yap, Ante Anic, Toni Breskovic, Annika Haas, Rohit E. Bhagwandien, Zrinka Jurisic, Tamas Szili-Torok, Armin Luik
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sing-Chien Yap, Ante Anic, Toni Breskovic, Annika Haas, Rohit E. Bhagwandien, Zrinka Jurisic, Tamas Szili-Torok, Armin Luik
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zoe K. Sarafis, Jordan W. Squair, Otto F. Barak, Geoff B. Coombs, Jan Elaine Soriano, Kelly A. Larkin-Kaiser, Amanda H. X. Lee, Alex Hansen, Maro Vodopic, Rinaldo Romac, Christopher Grant, Rebecca Charbonneau, Tanja Mijacika, Andrei V. Krassioukov, Philip N. Ainslie, Zeljko Dujic, Aaron A. Phillips
Summary: Cervical spinal cord injury (SCI) leads to impaired common carotid artery (CCA) responsiveness and increases the risk of cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Marko Kumric, Goran Dujic, Josip Vrdoljak, Karla Svagusa, Tina Ticinovic Kurir, Daniela Supe-Domic, Zeljko Dujic, Josko Bozic
Summary: This study found that a 5-week administration of CBD can reduce blood pressure in hypertensive patients, and this antihypertensive effect may be explained by CBD's interaction with the sympatho-chromaffin system.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Ante Anic, Thomas Phlips, Toni Breskovic, Pieter Koopman, Steven Girouard, Vikramaditya Mediratta, Zrinka Jurisic, Ivan Sikiric, Lucija Lisica, Johan Vijgen
Summary: The study demonstrates that pulsed field ablation using the CENTAURI System with three commercial ablation catheters can achieve effective pulmonary vein isolation and has a favorable safety profile, providing a feasible treatment option for atrial fibrillation.
Article
Biology
Josip Kedzo, Sanja Lovric Kojundzic, Maja Marinovic Guic, Leida Tandara, Toni Breskovic, Zrinka Jurisic
Summary: This study aimed to determine the association of persistent AF with brain perfusion and cognition. The results showed that there was no significant difference in brain perfusion between AF patients and control subjects. However, restoration of sinus rhythm was associated with significantly improved brain perfusion.
Article
Cardiac & Cardiovascular Systems
Josip Katic, Zrinka Jurisic, Marko Kumric, Josip A. Borovac, Ante Anic, Toni Breskovic, Daniela Supe-Domic, Josko Bozic
Summary: The autonomic nervous system plays a crucial role in initiating and maintaining atrial fibrillation (AF), and catestatin regulates cardiovascular systems and reduces excessive sympathetic nervous system activity. This study found that serum catestatin concentrations were higher in AF patients compared to controls, and greater severity of AF was associated with higher catestatin levels. Additionally, higher CHA2DS2-VASc scores and NT-proBNP levels were also associated with higher catestatin concentrations. Furthermore, AF duration was negatively correlated with serum catestatin levels. These findings suggest the potential role of catestatin in the pathophysiology of AF.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Meeting Abstract
Peripheral Vascular Disease
Vinicius Garcia, Andrew Park, Noah DeSouza, Jared Greiner, Otto Barak, Tanja Mijacika, Zeljko Dujic, Philip Ainslie, Christopher DeSouza
Meeting Abstract
Sport Sciences
Damian M. Bailey, Anthony Bain, Ryan Hoiland, Otto Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David MacLeod, Philip Ainslie, Zeljko Dujic
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)