Review
Nutrition & Dietetics
Amit Zamir, Tavor Ben-Zeev, Jay R. Hoffman
Summary: This review focuses on the impact of manipulating energy and nutrient intake on circulating concentrations of testosterone and the potential mechanisms governing these changes. The importance of understanding how changes in macronutrient and micronutrient intake can influence the androgen response is emphasized.
Article
Obstetrics & Gynecology
M. Peigne, V Simon, P. Pigny, N. E. H. Mimouni, C. Martin, D. Dewailly, S. Catteau-Jonard, P. Giacobini
Summary: This study investigated the changes in serum concentration of total and cleaved anti-Muullerian hormone (AMH) molecular forms and androgens in women with and without PCOS before and throughout pregnancy. The results showed that women with PCOS had higher levels of total and cleaved AMH compared to controls from preconception to the third trimester of pregnancy, and higher levels of testosterone and androstenedione during pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Mega O. Oyovwi, Benneth Ben-Azu, Tesi P. Edesiri, Emojevwe Victor, Rume A. Rotu, Queen E. B. Ozegbe, Eze K. Nwangwa, Vivian Atuadu, Olusegun G. Adebayo
Summary: The study found that kolaviron can alleviate busulfan-induced episodic memory deficit and dysfunction in the male reproductive system in rats through neurochemical modulation and increasing testicular androgenic hormones/enzymes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Sarah Collet, Noor Gieles, Chantal M. Wiepjes, Annemieke C. Heijboer, Tim Reyns, Tom Fiers, Bruno Lapauw, Martin den Heijer, Guy T'Sjoen
Summary: The study found that testosterone levels in transgender women remain stable after initiating feminizing hormone therapy. Adrenal androgens decrease in the first year of hormone therapy and remain unchanged after gonadectomy. The correlation with clinical symptoms still needs to be elucidated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ali Abbara, Maya Al-Memar, Maria Phylactou, Elisabeth Daniels, Bijal Patel, Pei C. Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Tia Hunjan, Ewa Pacuszka, Lisa Yang, Paul Bech, Tricia Tan, Alexander N. Comninos, Tom W. Kelsey, Christopher Kyriacou, Hanine Fourie, Tom Bourne, Waljit S. Dhillo
Summary: Our study aimed to evaluate the changes in circulating kisspeptin levels in women with antenatal complications. The results showed that third-trimester kisspeptin levels were higher in women with hypertensive disorders of pregnancy (HDP) but lower in those with fetal growth restriction (FGR). We found that the odds of HDP increased by 30% and the odds of FGR decreased by 28% for every 1 nmol/L increase in plasma kisspeptin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Rebeca Chavez-Genaro, Agustina Toledo, Karina Hernandez, Gabriel Anesetti
Summary: Fetal or neonatal androgen exposure can have long-lasting detrimental effects on uterine development, including altered glandular development and epithelial changes. These effects may be related to abnormal serum estradiol levels and could potentially affect the processes of implantation and embryo maintenance in women with polycystic ovary syndrome.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Multidisciplinary Sciences
Louis P. Watanabe, Nicole C. Riddle
Summary: The study shows that climbing ability in Drosophila melanogaster varies after exercise treatment, with these changes being dependent on sex and genotype. Genes related to 'cell-cell signalling' are implicated in controlling climbing ability. Activity level and exercise-induced climbing ability change are not correlated, highlighting the difficulty in predicting individual responses to exercise.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Medical Laboratory Technology
Barbara Mayr, Edith E. Mueller, Christine Schaefer, Silke Droese, Martin Schoenfelder, Josef Niebauer
Summary: The study found that miRNA expression in CAD patients is responsive to maximal ergospirometry, with differences between genders. MiRNAs associated with glucose metabolism, oxidative stress, and angiogenesis show different responses to exercise and gender.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Claudia Morais Sequeira, Marcela Anjos Martins, Renata Alves, Ana Lucia Rosa Nascimento, Giuly Cristina Rodrigues Mello Botti, Vinicius Novaes Rocha, Cristiane Matsuura
Summary: The study demonstrated that aerobic exercise training could effectively prevent doxorubicin-induced cardiomyopathy and preserve cardiomyocyte ultrastructure, partially through activation of the physiological protein synthesis pathway and reduction of oxidative stress.
Article
Psychiatry
Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Fokko J. Bosker, Aviva Y. Cohn, Willem A. Nolen, Ursula B. Kaiser, Hadine Joffe, Brenda W. J. H. Penninx, Robert A. Schoevers
Summary: This study found that plasma androgens within the physiological range have limited effects on depressive disorders in women, with only a slightly higher level of free testosterone in women with current MDD compared to those who never had MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Urology & Nephrology
Cylia Dahmani, Patrick Caron, David Simonyan, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Levesque, Chantal Guillemette
Summary: Preoperative circulating levels of 11-oxygenated androgens are associated with metastasis-free survival in men with localized prostate cancer undergoing radical prostatectomy and are influenced by 5α-reductase inhibitor treatment.
JOURNAL OF UROLOGY
(2023)
Article
Multidisciplinary Sciences
Shuhiba Mohammad, Kelly Ann Hutchinson, Danilo Fernandes da Silva, Jayonta Bhattacharjee, Kurt McInnis, Dylan Burger, Kristi B. Adamo
Summary: The study characterized the circulating small extracellular vesicles (EVs) profile of pregnant and non-pregnant women after moderate-intensity exercise, showing that pregnant women had higher levels of small EVs at baseline and a significant increase post-exercise compared to non-pregnant women. Further research is needed to explore the functional roles of exercise-induced small EVs in pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Chloe Botsford, Angelique G. Brellenthin, Josh M. Cisler, Cecilia J. Hillard, Kelli F. Koltyn, Kevin M. Crombie
Summary: Recent research has explored the connection between blood-based biomarkers (such as endocannabinoids; eCBs: including N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) and mental health outcomes in psychiatric populations, especially posttraumatic stress disorder (PTSD). The findings suggest that there may be alterations in circulating eCBs and their response to stress in individuals with PTSD, and that moderate-intensity aerobic exercise can increase circulating eCBs in women with and without PTSD.
JOURNAL OF ANXIETY DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Le Garf, Brigitte Sibille, Isabelle Mothe-Satney, Cyril Eininger, Philippe Fauque, Joseph Murdaca, Giulia Chinetti, Jaap G. Neels, Anne-Sophie Rousseau
Summary: The decrease in regulatory T cells is associated with obesity, while dietary supplementation with ALA can improve immunometabolism in both mice and women, reducing fat tissue and enhancing oxidative capacity.
Article
Sport Sciences
Wafa Douzi, Olivier Dupuy, Maxence Tanneau, Geoffroy Boucard, Romain Bouzigon, Benoit Dugue
EUROPEAN JOURNAL OF SPORT SCIENCE
(2019)
Review
Environmental Sciences
Wafa Douzi, Olivier Dupuy, Dimitri Theurot, Juhani Smolander, Benoit Dugue
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Physiology
Julien Louis, Dimitri Theurot, Jean-Robert Filliard, Marielle Volondat, Benoit Dugue, Olivier Dupuy
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Sport Sciences
Wafa Douzi, Benoit Dugue, Dimitri Theurot, Ludwig Vinches, Stephane Halle, Olivier Dupuy
Summary: The study concluded that wearing a cooling vest during submaximal exercise in humid temperate conditions can improve perceptual and physiological responses, including decreased skin temperature, faster heart rate recovery, and increased cerebral tissue oxygenation.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dimitri Theurot, Benoit Dugue, Wafa Douzi, Paul Guitet, Julien Louis, Olivier Dupuy
Summary: This study found that a brief PBC exposure enhances cognitive inhibition performance on a Stroop task in males, mediated by increased parasympathetic cardiac control and cerebral oxygenation. However, the effects of PBC on cognitive function seem to differ in females, possibly due to different sensitivity to cold stimulation.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Jacopo Maria Fontana, Sibel Bozgeyik, Michele Gobbi, Paolo Pitera, Emanuele Maria Giusti, Benoit Dugue, Giovanni Lombardi, Paolo Capodaglio
Summary: This scoping review evaluates the therapeutic effects of Whole-Body Cryostimulation (WBC) in the treatment of obesity. The limited data suggest the efficacy of WBC as an adjunct treatment for obesity, but larger, high-quality studies are needed to reach definitive conclusions.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Douzi Wafa, De Bisschop Claire, Dugue Benoit
Summary: Sleep Apnea Syndrome (SAS) is a sleep-related breathing disorder with an increased risk of cardiovascular diseases. There is currently no effective treatment for all SAS symptoms. Cooling therapies may be an efficient strategy to reduce systemic inflammation, oxidative stress, and enhance sleep quality in SAS patients.
MEDICAL HYPOTHESES
(2022)
Article
Environmental Sciences
Jean-Baptiste Meslet, Benoit Dugue, Ugo Brisset, Alain Pianeta, Sophie Kubas
Summary: This study aimed to investigate the efficiency, feasibility, and safety of a hybrid cardiovascular rehabilitation program for low-risk acute coronary syndrome (ACS) patients. The results showed that the hybrid rehabilitation program was as beneficial and safe as the traditional program, at least in the short-term. Longitudinal follow-up is needed to examine the long-term impacts of this hybrid rehabilitation program.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Wafa Douzi, Delphine Bon, Sara Suikkanen, Paula Soukkio, Nadege Boildieu, Arja Nenonen, Markku Hupli, Katriina Kukkonen-Harjula, Benoit Dugue
Summary: This study used urine metabolomics to characterize older adults with hip fractures and predict patient outcomes. The findings showed that the levels of certain metabolites in the urine were associated with frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool for further understanding the characteristics of older adults.
Review
Biology
Maria Ntoumani, Benoit Dugue, Eric Rivas, Konstantina Gongaki
Summary: This scoping review examines human physiological and behavioral thermoregulation during whole-body water immersion, aiming to explore the feasibility of establishing a defined sensation scale for cold and hot water immersion. The findings highlight the impact of water immersion duration on human thermoneutral zone, thermal comfort zone, and thermal sensation. The study emphasizes the importance of thermal sensation as a health indicator to develop a behavioral thermal model for water immersion.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Physiology
Marcin Machnia, Wafa Douzi, Hela Jdidi, Elzbieta Miller, Benoit Dugue
Summary: The study found that daily WBC combined with physical exercise induced physiological adaptations and lowered sympathetic nervous activity in CIDP patients, indicating a reduced level of MS. These adaptations appear to depend on gender and age.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Review
Medicine, Research & Experimental
Fabien D. Legrand, Benoit Dugue, Joe Costello, Chris Bleakley, Elzbieta Miller, James R. Broatch, Guillaume Polidori, Anna Lubkowska, Julien Louis, Giovanni Lombardi, Francois Bieuzen, Paolo Capodaglio
Summary: Whole-body cryotherapy is a non-pharmacological treatment that influences inflammatory events and has various benefits, such as improved sleep quality, faster neuromuscular recovery, and chronic pain relief. It may also have positive effects on mental health and cognitive functions. There have been concerns about its safety, but these concerns are often based on misunderstandings regarding the differences between whole-body cryotherapy and partial-body cryotherapy. This article reviews the literature and concludes that the safety risks associated with whole-body cryotherapy are within acceptable limits and can be prevented by following existing recommendations and guidelines.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Sport Sciences
Romain Bouzigon, Olivier Dupuy, Ivo Tiemessen, Massimo De Nardi, Jean-Pierre Bernard, Thibaud Mihailovic, Dimitri Theurot, Elzbieta Dorota Miller, Giovanni Lombardi, Benoit Michel Dugue
Summary: Whole-body cryotherapy/cryostimulation is a new technique for recovery after exercise, with controversies and potential benefits that require customization based on specific conditions and individual characteristics.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)
Article
Biochemistry & Molecular Biology
Wafa Douzi, Xavier Guillot, Delphine Bon, Francois Seguin, Nadege Boildieu, Daniel Wendling, Nicolas Tordi, Olivier Dupuy, Benoit Dugue
Article
Mining & Mineral Processing
Chady Al Sayed, Ludwig Vinches, Olivier Dupuy, Wafa Douzi, Benoit Dugue, Stephane Halle
INTERNATIONAL JOURNAL OF MINING SCIENCE AND TECHNOLOGY
(2019)