Article
Radiology, Nuclear Medicine & Medical Imaging
Riku M. Vierunen, Ville V. Haapamaki, Mika P. Koivikko, Frank V. Bensch
Summary: This study retrospectively reviewed MRI findings of 70 patients with spinal ankylosis from DISH, revealing that 49% had spinal epidural hematoma and 4% had spinal subdural hematoma. It was found that spinal epidural hematoma can cause spinal cord impingement and progress to spinal cord injury.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Reuven Mader, Nicola Pappone, Xenofon Baraliakos, Iris Eshed, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Amir Bieber, Irina Novofastovski, David Kiefer, Jorrit-Jan Verlaan, Pasquale Ambrosino, Dan Buskila, Jacome Bruges Armas, Muhammad Asim Khan
Summary: Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition with possible involvement of inflammation as a non-metabolic mechanism. Inflammation may play a role in promoting new bone formation in DISH, and further research is needed to better understand the mechanisms for early detection and management.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Clinical Neurology
Scott McCarty, Jacob J. Bruckner, Jael E. Camacho, Julio J. Jauregui, Alexandra E. Thomson, Ivan Ye, Daniel L. Cavanaugh, Eugene Y. Koh, Steven C. Ludwig, Daniel E. Gelb
Summary: This study analyzed the outcomes and complications of patients with thoracic and lumbar fractures in the setting of ankylosing spinal disorders treated with minimally invasive surgery. The study found that DISH patients experienced more post-operative complications compared to AS and advanced spondylosis patients.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Nandish G. Shah, Abhishek Keraliya, Mitchel B. Harris, Christopher M. Bono, Bharti Khurana
Summary: A study comparing spine injuries in DISH and AS patients found a lower prevalence of posterior element injury in DISH patients compared to AS patients on CT or MRI. In patients with isolated vertebral body fractures without neurological deficits detected on CT, MRI revealed a significantly lower rate of posterior element injury in DISH patients compared to AS patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacopo Ciaffi, Elena Borlandelli, Gaia Visani, Giancarlo Facchini, Marco Miceli, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Ursini
Summary: The purpose of this study was to provide updated information on the prevalence of DISH in Italy and describe the clinical and radiographic characteristics associated with the disorder. The results showed that the prevalence of DISH was higher in men and was significantly associated with factors such as age, BMI, diabetes, hypertension, and enthesopathies.
Article
Clinical Neurology
Maximilian Schwendner, Martin Seule, Bernhard Meyer, Sandro M. Krieg
Summary: This study evaluated patient characteristics and procedures in patients with ankylosing spinal disorders (ASDs), finding that timely preoperative imaging and surgical treatment procedures are crucial for patient outcomes.
NEUROSURGICAL FOCUS
(2021)
Article
Health Care Sciences & Services
Massimo Mesolella, Sarah Buono, Roberto D'Aniello, Annarita Ascione, Gaetano Motta, Salvatore Allosso
Summary: Forestier's disease is a systemic, degenerative metabolic condition characterized by the progressive ossification of the ligaments and entheses. This case report presents a 63-year-old man who had a painless mass in the pre-auricular region, gradually worsening dysphonia, severe dysphagia relating to solids, stiffness, and mild pain at the back of the neck. After further diagnostic tests, diffuse spondylarthrosis and beak-like osteophytes at C2-C5 were identified, causing esophageal compression. Intensive logopedic and postural rehabilitative treatment led to significant improvement in dysphagia symptoms, while medical therapy was limited to indomethacin to control osteophytic process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Hisanori Ikuma, Tomohiko Hirose, Dai Nakamura, Kazutaka Yamashita, Masataka Ueda, Kazuhiro Sasaki, Keisuke Kawasaki
Summary: This study conducted a cross-sectional survey on DISH patients and found that DISH is most prevalent at the thoracolumbar junction. Age and hyperostosis around the costovertebral joint were identified as related factors.
Article
Clinical Neurology
Yuji Tsuchikawa, Naosuke Kamei, Kiyotaka Yamada, Toshio Nakamae, Nobuo Adachi, Yoshinori Fujimoto
Summary: The aim of the study was to determine the poor prognostic factors of balloon kyphoplasty for fractures of the distal vertebrae in ankylosing spines with diffuse idiopathic skeletal hyperostosis. The change in wedge angle was significantly associated with delayed bone healing, suggesting that balloon kyphoplasty alone should be avoided in patients with a difference of ≥10° in the wedge angle.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Medicine, General & Internal
Teresa Clavaguera, Patricia Reyner, Maria Buxo, Marta Valls, Eulalia Armengol, Xavier Juanola
Summary: This study examined different phenotypes of DISH patients based on clinicoradiological features, identifying peripheral, axial, and mixed patterns. The results indicated distinct clinical characteristics and disease progression among DISH patients, with the peripheral pattern standing out. Suggestions were made to include extravertebral manifestations in new classification criteria to cover the entire spectrum of the disease.
MEDICINA-LITHUANIA
(2021)
Review
Orthopedics
Torphong Bunmaprasert, Jakkrit Keeratiruangrong, Nantawit Sugandhavesa, K. Daniel Riew, Wongthawat Liawrungrueang
Summary: Surgical treatment for large bridging osteophytes of the anterior cervical spine from DISH, particularly for secondary dysphagia, has shown significant improvement in elderly patients. Different surgical techniques have been used, resulting in improved outcomes without recurrence, although concerns about cervical spine motion remain, especially with certain fusion techniques.
JOURNAL OF ORTHOPAEDIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Mikolaj Dabrowski, Lukasz Kubaszewski
Summary: DISH is characterized by calcification and ossification of cervical spine ligaments, potentially leading to dysphagia. It is more common in men with metabolic disorders and is often asymptomatic, with poorly understood etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Anais Guiot, Charline Estublier, Marine Gaude, Pawel Szulc, Roland Chapurlat
Summary: DISH is associated with a higher risk of vertebral fracture in men, regardless of other risk factors. Assessment of intervertebral space dysfunction components may enhance vertebral fracture prediction in older men.
Article
Clinical Neurology
Eijiro Okada, Shinichi Ishihara, Koichiro Azuma, Takehiro Michikawa, Satoshi Suzuki, Osahiko Tsuji, Satoshi Nori, Narihito Nagoshi, Mitsuru Yagi, Michiyo Takayama, Takashi Tsuji, Nobuyuki Fujita, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
Summary: The study revealed a significant association between metabolic syndrome and DISH. Patients in the DISH group had older age, higher male prevalence, and higher BMI, with a greater frequency of metabolic syndrome. This suggests a potential relationship between metabolic syndrome and DISH.
Article
Rheumatology
Stefanie F. Pini, Emilio Pariente, Jose M. Olmos, Marta Martin-Millan, Raquel Pascua, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to assess the association between trabecular bone score (TBS) and diffuse idiopathic skeletal hyperostosis (DISH) in postmenopausal women. The results showed a significant association between DISH and TBS, with lower TBS values in DISH patients and a higher prevalence of osteoporosis and vertebral fractures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Engineering, Biomedical
Maurits G. L. Olthof, Diederik H. R. Kempen, James L. Herrick, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, Corlinda B. M. Ten Brink, Wouter J. A. Dhert, F. Cumhur Oner, Marianna A. Tryfonidou, Laura B. Creemers
ACTA BIOMATERIALIA
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Diederik H. R. Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A. Tryfonidou, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Clinical Neurology
Anita Krouwels, Jelena Popov-Celeketic, Saskia G. M. Plomp, Wouter J. A. Dhert, F. Cumhur Oner, Ruud A. Bank, Laura B. Creemers
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Xifeng Liu, Behdad Pouran, Bjorn P. Meij, Wouter J. A. Dhert, Michael J. Yaszemski, Lichun Lu, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Maaike V. J. Braham, Tilman Ahlfeld, A. Rahul Akkineni, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Anja Lode, Michael Gelinsky, Jacqueline Alblas
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, F. Cumhur Oner, Wouter J. A. Dhert, Marianna A. Tryfonidou, Laura B. Creemers
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Mahrokh Dadsetan, Wouter J. A. Dhert, Michael J. Yaszemski, Diederik H. R. Kempen, Lichun Lu
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Medicine, Research & Experimental
Vivian H. M. Mouser, Noel M. M. Dautzenberg, Riccardo Levato, Mattie H. P. van Rijen, Wouter J. A. Dhert, Jos Malda, Debby Gawlitta
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2018)
Article
Multidisciplinary Sciences
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Oner, J. Alblas
SCIENTIFIC REPORTS
(2018)
Review
Orthopedics
T. S. de Windt, S. L. Niemansburg, L. A. Vonk, J. M. van Delden, K. C. B. Roes, W. J. A. Dhert, D. B. F. Saris, A. L. Bredenoord
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Lichun Lu, Marianna A. Tryfonidou, Loek D. Loozen, Behdad Pouran, Michael J. Yaszemski, Bjorn P. Meij, Wouter J. A. Dhert, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2019)
Article
Engineering, Biomedical
Maaike V. J. Braham, Amelie S. P. Li Yim, Jara Garcia Mateos, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Jacqueline Alblas
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Multidisciplinary Sciences
Marijn Rutgers, Frances Bach, Lucienne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemers
Article
Cell & Tissue Engineering
L. D. Loozen, A. Vandersteen, A. H. M. Kragten, F. C. Oner, W. J. A. Dhert, M. C. Kruyt, J. Alblas
EUROPEAN CELLS & MATERIALS
(2018)