Review
Clinical Neurology
Netanja Harlianto, Jonneke S. Kuperus, Firdaus A. A. Mohamed Hoesein, Pim A. de Jong, Jacob A. de Ru, F. Cumhur Oner, Jorrit-Jan Verlaan
Summary: This article provides an updated systematic review on the epidemiology and clinical knowledge of dysphagia and airway obstruction caused by cervical diffuse idiopathic skeletal hyperostosis (DISH). The study found a significant increase in published cases over the past decade. Surgical treatment was the most commonly chosen option and showed effective results with a low complication rate. However, there is still a lack of randomized studies or guidelines on treatment and prevention of recurrence.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacopo Ciaffi, Elena Borlandelli, Gaia Visani, Giancarlo Facchini, Marco Miceli, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Ursini
Summary: The purpose of this study was to provide updated information on the prevalence of DISH in Italy and describe the clinical and radiographic characteristics associated with the disorder. The results showed that the prevalence of DISH was higher in men and was significantly associated with factors such as age, BMI, diabetes, hypertension, and enthesopathies.
Article
Health Care Sciences & Services
Massimo Mesolella, Sarah Buono, Roberto D'Aniello, Annarita Ascione, Gaetano Motta, Salvatore Allosso
Summary: Forestier's disease is a systemic, degenerative metabolic condition characterized by the progressive ossification of the ligaments and entheses. This case report presents a 63-year-old man who had a painless mass in the pre-auricular region, gradually worsening dysphonia, severe dysphagia relating to solids, stiffness, and mild pain at the back of the neck. After further diagnostic tests, diffuse spondylarthrosis and beak-like osteophytes at C2-C5 were identified, causing esophageal compression. Intensive logopedic and postural rehabilitative treatment led to significant improvement in dysphagia symptoms, while medical therapy was limited to indomethacin to control osteophytic process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riku M. Vierunen, Ville V. Haapamaki, Mika P. Koivikko, Frank V. Bensch
Summary: This study retrospectively reviewed MRI findings of 70 patients with spinal ankylosis from DISH, revealing that 49% had spinal epidural hematoma and 4% had spinal subdural hematoma. It was found that spinal epidural hematoma can cause spinal cord impingement and progress to spinal cord injury.
EUROPEAN RADIOLOGY
(2023)
Review
Orthopedics
Torphong Bunmaprasert, Jakkrit Keeratiruangrong, Nantawit Sugandhavesa, K. Daniel Riew, Wongthawat Liawrungrueang
Summary: Surgical treatment for large bridging osteophytes of the anterior cervical spine from DISH, particularly for secondary dysphagia, has shown significant improvement in elderly patients. Different surgical techniques have been used, resulting in improved outcomes without recurrence, although concerns about cervical spine motion remain, especially with certain fusion techniques.
JOURNAL OF ORTHOPAEDIC SURGERY
(2021)
Article
Medicine, General & Internal
Hisanori Ikuma, Tomohiko Hirose, Dai Nakamura, Kazutaka Yamashita, Masataka Ueda, Kazuhiro Sasaki, Keisuke Kawasaki
Summary: This study conducted a cross-sectional survey on DISH patients and found that DISH is most prevalent at the thoracolumbar junction. Age and hyperostosis around the costovertebral joint were identified as related factors.
Article
Rheumatology
Reuven Mader, Nicola Pappone, Xenofon Baraliakos, Iris Eshed, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Amir Bieber, Irina Novofastovski, David Kiefer, Jorrit-Jan Verlaan, Pasquale Ambrosino, Dan Buskila, Jacome Bruges Armas, Muhammad Asim Khan
Summary: Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition with possible involvement of inflammation as a non-metabolic mechanism. Inflammation may play a role in promoting new bone formation in DISH, and further research is needed to better understand the mechanisms for early detection and management.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mikolaj Dabrowski, Lukasz Kubaszewski
Summary: DISH is characterized by calcification and ossification of cervical spine ligaments, potentially leading to dysphagia. It is more common in men with metabolic disorders and is often asymptomatic, with poorly understood etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Giorgio Lofrese, Alba Scerrati, Massimo Balsano, Roberto Bassani, Michele Cappuccio, Michele A. Cavallo, Fabio Cofano, Francesco Cultrera, Federico De Iure, Francesco Di Biase, Roberto Donati, Diego Garbossa, Marta Menegatti, Alessandro Olivi, Giorgio Palandri, Antonino Raco, Luca Ricciardi, Giannantonio Spena, Luigino Tosatto, Jacopo Visani, Massimiliano Visocchi, Gianluigi Zona, Pasquale De Bonis
Summary: A retrospective multicenter study was conducted to analyze the impact of preoperative settings and intraoperative techniques on the outcome of patients undergoing surgery for DISH involving the cervical spine. The use of a chisel was found to be more effective than a burr, and early decompression and bone removal involving multiple levels positively influenced clinical outcome. Early decompression was preferred, resulting in a high percentage of patients experiencing symptom disappearance within a week after surgery.
GLOBAL SPINE JOURNAL
(2022)
Article
Rheumatology
Stefanie F. Pini, Emilio Pariente, Jose M. Olmos, Marta Martin-Millan, Raquel Pascua, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to assess the association between trabecular bone score (TBS) and diffuse idiopathic skeletal hyperostosis (DISH) in postmenopausal women. The results showed a significant association between DISH and TBS, with lower TBS values in DISH patients and a higher prevalence of osteoporosis and vertebral fractures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Emilio Pariente, Stefanie F. Pini, Jose M. Olmos, Patricia Fierro, Rosa Landeras, Carmen Ramos, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to investigate the potential relationship between early diffuse idiopathic skeletal hyperostosis (DISH) and chronic inflammation. The results showed that patients with early DISH had a higher prevalence of obesity, type 2 diabetes, and metabolic syndrome, and their lipid pattern was similar to that observed in chronic inflammatory diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Ho Yong Choi, Dae Jean Jo
Summary: This article reports two cases of DISH-related dysphagia treated with surgical removal of osteophytes using the bottleneck point as an anatomical landmark. The symptoms of the patients improved following osteophyte removal without recurrence.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, Legal
Alyssa C. Zamora, Sean D. Tallman
Summary: This study tested the accuracy of diffuse idiopathic skeletal hyperostosis (DISH) in making positive identifications through radiographic comparison. The results suggest that DISH may not be reliable for positive identifications, but could potentially be used to narrow down potential matches.
JOURNAL OF FORENSIC SCIENCES
(2022)
Article
Endocrinology & Metabolism
Angelo Fassio, Giovanni Adami, Luca Idolazzi, Alessandro Giollo, Ombretta Viapiana, Emma Bosco, Riccardo Negrelli, Elena Sani, Damiano Sandri, Alessandro Mantovani, Giovanni Targher, Maurizio Rossini, Davide Gatti
Summary: This study investigated the prevalence of DISH in post-menopausal women with Type 2 Diabetes Mellitus using DXA-VFA technology, identifying features of DISH in 20.8% of patients. Lower serum sclerostin levels were significantly associated with DISH presence, suggesting it as a key feature. The study also proposed DXA-VFA analysis as a viable diagnostic and prognostic tool for DISH screening in at-risk populations.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Norihiro Nishida, Fei Jiang, Junji Ohgi, Masahiro Fuchida, Rei Kitazumi, Yuto Yamamura, Rui Tome, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Xian Chen, Takashi Sakai
Summary: Patients with DISH are more prone to stress on vertebrae, and stresses on vertebrae and intervertebral discs differ depending on the morphology of ossification, even with similar loads. Examining ossification geometry may help surgeons determine the elevated position of stress in the thoracolumbar spine of patients with DISH, contributing to an understanding of the pathogenesis of pain.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Maurits G. L. Olthof, Diederik H. R. Kempen, James L. Herrick, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, Corlinda B. M. Ten Brink, Wouter J. A. Dhert, F. Cumhur Oner, Marianna A. Tryfonidou, Laura B. Creemers
ACTA BIOMATERIALIA
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Diederik H. R. Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A. Tryfonidou, Michael J. Yaszemski, Wouter J. A. Dhert, Lichun Lu
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Clinical Neurology
Anita Krouwels, Jelena Popov-Celeketic, Saskia G. M. Plomp, Wouter J. A. Dhert, F. Cumhur Oner, Ruud A. Bank, Laura B. Creemers
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Xifeng Liu, Behdad Pouran, Bjorn P. Meij, Wouter J. A. Dhert, Michael J. Yaszemski, Lichun Lu, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2018)
Article
Cell & Tissue Engineering
Maaike V. J. Braham, Tilman Ahlfeld, A. Rahul Akkineni, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Anja Lode, Michael Gelinsky, Jacqueline Alblas
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Anita Krouwels, Ferry P. W. Melchels, Mattie H. P. van Rijen, F. Cumhur Oner, Wouter J. A. Dhert, Marianna A. Tryfonidou, Laura B. Creemers
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Marianna A. Tryfonidou, Mahrokh Dadsetan, Wouter J. A. Dhert, Michael J. Yaszemski, Diederik H. R. Kempen, Lichun Lu
TISSUE ENGINEERING PART C-METHODS
(2018)
Review
Orthopedics
T. S. de Windt, S. L. Niemansburg, L. A. Vonk, J. M. van Delden, K. C. B. Roes, W. J. A. Dhert, D. B. F. Saris, A. L. Bredenoord
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Cell & Tissue Engineering
Maurits G. L. Olthof, Lichun Lu, Marianna A. Tryfonidou, Loek D. Loozen, Behdad Pouran, Michael J. Yaszemski, Bjorn P. Meij, Wouter J. A. Dhert, Jacqueline Alblas, Diederik H. R. Kempen
TISSUE ENGINEERING PART A
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ellen Boswijk, Karin J. C. Sanders, Evie P. M. Broeders, Marlies de Ligt, Guy H. E. J. Vijgen, Bas Havekes, Alma M. A. Mingels, Roel Wierts, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen, Felix M. Mottaghy, Joachim E. Wildberger, Jan Bucerius
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Engineering, Biomedical
Maaike V. J. Braham, Amelie S. P. Li Yim, Jara Garcia Mateos, Monique C. Minnema, Wouter J. A. Dhert, F. Cumhur Oner, Catherine Robin, Jacqueline Alblas
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Multidisciplinary Sciences
Marijn Rutgers, Frances Bach, Lucienne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemers
Article
Radiology, Nuclear Medicine & Medical Imaging
Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van Der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger, Jan Bucerius
Article
Cell & Tissue Engineering
L. D. Loozen, A. Vandersteen, A. H. M. Kragten, F. C. Oner, W. J. A. Dhert, M. C. Kruyt, J. Alblas
EUROPEAN CELLS & MATERIALS
(2018)