Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xinmiao Zhou, Qingqing Ye, Jinlei Zheng, Lin Kuang, Jianhua Zhu, Hui Yan
Summary: This study found that IMP3 can regulate the functional properties of endothelial cells and accelerate re-endothelialization after arterial injury. IMP3 promotes endothelial cell proliferation and migration, while reducing apoptosis, by increasing stability of VEGF mRNA and activating the VEGF/PI3K/Akt signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Peichuang Li, Wanhao Cai, Xin Li, Kebing Wang, Lei Zhou, Tengda Shang, Xianmang Xu, Yuancong Zhao, Jin Wang
Summary: A novel tellurium-functionalized polycarbonate-polyurethane (PCU-TeTe) was designed and synthesized, showing excellent catalytic activity in nitric oxide release and significantly reducing the probability of thrombosis in blood environment.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Anees Ahmed Syed, Mohammed Shafiq, Mohammad Irshad Reza, Pragya Bharati, Athar Husain, Pragati Singh, Kashif Hanif, Jiaur R. Gayen
Summary: The chronic treatment of Cissus quadrangularis extract improved endothelium-dependent relaxation in spontaneously hypertensive rats by activating eNOS and inhibiting ROS production and inflammation, leading to antihypertensive effects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Multidisciplinary Sciences
Wenpeng Song, Yiming Yuan, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang, Ruili Guan
Summary: This study investigated the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. The results demonstrated that Icariside II can promote cell proliferation and nitric oxide release, and regulate the phosphorylation of eNOS through multiple signaling pathways.
Article
Nutrition & Dietetics
Qing Li, Yushi Du, Panyin Xiang, Guanyu Chen, Xiaoxian Qian, Shuangshuang Li, Yihui Mao, Wenhua Ling, Dongliang Wang
Summary: Brussels chicory, a typical vegetable in Mediterranean diets, has been found to stabilize advanced atherosclerotic plaques in the brachiocephalic artery of apoE-deficient mice. This study investigated the mechanism behind this effect and found that Brussels chicory improved oxidative stress, leading to the stabilization of aortic plaques and inhibition of monocyte adhesion.