Article
Anesthesiology
Jeoung Kun Kim, Min Xing Wang, Min Cheol Chang
Summary: We developed and investigated the accuracy of a convolutional neural network (CNN) model for predicting therapeutic outcomes after transforaminal epidural steroid injections (TFESI) for controlling chronic lumbosacral radicular pain using T2-weighted sagittal lumbar spine magnetic resonance (MR) images as input data.
Article
Clinical Neurology
Fatma Fidan, Mehtap Balaban, Sukru Cem Hatipoglu, Enejd Veizi
Summary: This study evaluated the frequency of lumbosacral transitional vertebrae (LSTV) in patients with low back pain and lumbar disc herniation (LDH), and analyzed the correlation between LSTV presence and intervertebral disc degeneration. The results showed that LSTV was significantly associated with LDH, with a higher incidence in females and a greater impact on multiple intervertebral disc levels. Assessing the relationship between LSTV and intervertebral disc degeneration is important for understanding the pathogenesis of low back pain and LDH.
EUROPEAN SPINE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Luis Becker, Lukas Schoennagel, Tim Victor Mihalache, Henryk Haffer, Friederike Schoemig, Hendrik Schmidt, Matthias Pumberger
Summary: Patients with LSTV exhibit reduced range of motion in the transitional segment and significantly increased motion distribution to the cranial adjacent segment in flexion-extension radiographs. These findings may explain the higher rates of degeneration within the segment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cecilie Lerche Nordberg, Mikael Boesen, Gilles Ludger Fournier, Henning Bliddal, Philip Hansen, Bjarke Brandt Hansen
Summary: The study revealed dynamic behavior of lumbar disc herniations with morphological changes in the standing position, resulting in exacerbated nerve root compression.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiao-long Chen, Xiang-yu Li, Yu Wang, Shi-bao Lu
Summary: This study investigates the intra-rater and inter-rater agreement and reliability of different disc height measurement methods on MRI, and evaluates the relationship between these methods and Pfirrmann scores for intervertebral disc degeneration. It also examines the association between Pfirrmann scores and clinical outcomes.
Article
Medicine, General & Internal
Sangbong Ko, Jaebum Kwon
Summary: Patients who undergo lumbar discectomy may experience short-term improvement in low back pain (LBP), referred buttock pain (RBP), and lower leg radiating pain (LRP) within the first 3 months postoperatively. However, the improvement in LBP may plateau after 3 months and no further improvement is observed within the first year postoperatively.
Article
Orthopedics
A. P. Goode, R. J. Cleveland, V. B. Kraus, K. A. Taylor, S. Z. George, T. A. Schwartz, J. Renner, J. L. Huebner, J. M. Jordan, Y. M. Golightly
Summary: This study investigates the association between baseline biomarkers and longitudinal changes in disc space narrowing, vertebral osteophytes, and low back pain. The findings suggest that markers of inflammation and perceived pressure pain sensitivity are associated with the longitudinal worsening of low back pain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Clinical Neurology
Sunqi Nian, Na Li, Fanyi Kong, Sheng Lu, Jiayu Chen
Summary: A systematic review and meta-analysis found that preoperative Modic changes (MC) did not significantly impact low back pain and functional outcomes in patients with lumbar disc herniation (LDH) undergoing discectomy. However, LDH patients with preoperative Modic type 1 showed worse functional status at 2-year follow-up.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Zi-Xuan Wang, You-Gu Hu
Summary: This study found that MRI-visualized HIZ is a valuable method for screening lumbar IDD. Consecutive-slide HIZ is a more reliable indicator for discogenic back pain.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rafael Menezes-Reis, Carlos E. Garrido Salmon, Gustavo P. Bonugli, Debora Mazoroski, Leonor G. Savarese, Carlos Fernando P. S. Herrero, Helton L. A. Defino, Marcello Henrique Nogueira-Barbosa
Summary: The study found that a decrease in lumbar lordosis is associated with dehydration of the intervertebral disc nucleus pulposus, while low values of sacral slope, pelvic tilt, pelvic incidence, thoracic kyphosis, and spinosacral angle are related to a decrease in T2 relaxation times of the annulus fibrosus. Overall, spinopelvic parameters show a discrete association with lumbar disc composition and water content.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Multidisciplinary Sciences
Hua-Dong Zheng, Yue-Li Sun, De-Wei Kong, Meng-Chen Yin, Jiang Chen, Yong-Peng Lin, Xue-Feng Ma, Hong-Shen Wang, Guang-Jie Yuan, Min Yao, Xue-Jun Cui, Ying-Zhong Tian, Yong-Jun Wang
Summary: Low back pain has been a leading cause of disability worldwide. This study proposes a segmentation network and a quantitative method for evaluating lumbar intervertebral disc degeneration. The technique can accurately assess the severity of low back pain and provide more precise information.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Seong Son, Sang Gu Lee, Woo Kyung Kim, Yong Ahn, Jong Myung Jung
Summary: The study found that patients with discogenic low back pain had a significantly higher disc height discrepancy ratio compared to other patients. The disc height discrepancy ratio has diagnostic value in screening for discogenic low back pain.
Article
Clinical Neurology
Guntz Emmanuel, Pourveur Arnaud, Gouwy Jonathan, Renard Marie, Mocanu Iulia, Pather Sanjiva, Fils Jean-Francois, Vannieuwenhove Olivier
Summary: The study evaluated the accuracy of fusing CT and US images based on bony and surface landmarks, showing that these techniques allowed for precise localization and puncturing of lumbar neural foramina in phantom models.
EUROPEAN SPINE JOURNAL
(2021)
Article
Orthopedics
Patrick J. Owen, Mika Hangai, Koji Kaneoka, Timo Rantalainen, Daniel L. Belavy
Summary: The study found evidence that basketball and soccer may be associated with beneficial adaptations in the intervertebral discs in young athletes. The research also indicated that specific loading types may beneficially modulate lumbar IVD properties, similar to their impact on other tissues such as muscle and bone.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Rheumatology
Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z. Lim, Graeme Jones, Catherine L. Hill, Anita E. Wluka, Andrew Tonkin, Changhai Ding, Flavia M. Cicuttini
Summary: This study found evidence for the involvement of vascular pathology in the progression of knee osteoarthritis and suggested that targeting atherosclerosis could improve outcomes in knee osteoarthritis.
Article
Rheumatology
Zetao Liao, Jun Chang, Zhaohua Zhu, Weiyu Han, Tao Meng, Shuang Zheng, Liudan Tu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study examined the associations between dietary vitamin K intake and changes in knee symptoms and structures in patients with knee osteoarthritis (OA). The results showed that higher vitamin K intake was associated with a decrease in knee symptoms over 24 months. However, there was no overall association between vitamin K intake and changes in MRI features.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
S. J. J. Drummen, S. Balogun, A. Lahham, K. Bennell, R. S. Hinman, M. Callisaya, G. Cai, P. Otahal, T. Winzenberg, Z. Wang, B. Antony, I. P. Munugoda, J. Martel-Pelletier, J. P. Pelletier, F. Abram, G. Jones, D. Aitken
Summary: This study aimed to determine the feasibility of a randomized controlled trial (RCT) examining the effects of outdoor walking on knee osteoarthritis (KOA) clinical outcomes and MRI structural changes. The study found that a full-scale RCT is feasible based on acceptable adherence, retention, randomization, and safety, although recruitment challenges were identified. The significant symptomatic benefits demonstrate the clinical usefulness of a subsequent trial.
CLINICAL RHEUMATOLOGY
(2023)
Article
Orthopedics
S. M. Hussain, I. N. Ackerman, Y. Wang, D. R. English, A. E. Wluka, G. G. Giles, F. M. Cicuttini
Summary: The study aims to investigate the association between body mass index (BMI) trajectories from early adulthood to late midlife and the risk of total knee arthroplasty (TKA) for osteoarthritis. The results suggest that weight gain increases the risk of TKA, and weight reduction may play a significant role in preventing TKA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Rheumatology
Ambrish Singh, Alison Venn, Leigh Blizzard, Lyn March, Felix Eckstein, Graeme Jones, Wolfgang Wirth, Flavia Cicuttini, Changhai Ding, Benny Antony
Summary: This study aims to describe the associations between MRI markers and knee symptoms in young adults. The results showed that bone marrow lesions and cartilage defects were positively associated with knee symptoms, while cartilage volume and thickness were weakly and negatively associated with knee symptoms.
Review
Medicine, General & Internal
Nicholas Woodland, Antony Takla, Mahnuma Mahfuz Estee, Angus Franks, Mansi Bhurani, Susan Liew, Flavia M. Cicuttini, Yuanyuan Wang
Summary: This systematic review evaluated the patient-reported outcomes following total knee replacement in individuals aged 65 years and older. The study found that TKR can reduce pain, improve function, and increase the quality of life for older individuals. Patients generally reported overall satisfaction with the results of the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Ziyuan Shen, Yining Wang, Xing Xing, Graeme Jones, Guoqi Cai
Summary: Our findings from two independent cohorts consistently showed that smoking was not associated with knee cartilage loss in older adults.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Zhiqiang Wang, Graeme Jones, Leigh Blizzard, Dawn Aitken, Zhen Zhou, Mengmeng Wang, Saliu Balogun, Flavia Cicuttini, Benny Antony
Summary: This study aimed to describe the prevalence and correlates of the use of complementary and alternative medicines (CAMs) among community-dwelling older adults. The results showed that 35% of the participants reported CAM use, with vitamins/minerals being the most commonly used. CAM users were more likely to be female, be better educated, have more joints with osteoarthritis, and have healthier lifestyles.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Meeting Abstract
Medicine, General & Internal
Jacinta Cheng, Flavia Cicuttini, Graeme Jones, Helen Keen, Catherine Hill, Anita Wluka, Andrew Teichtahl, Benny Antony, Yuanyuan Wang
INTERNAL MEDICINE JOURNAL
(2023)
Article
Orthopedics
Hylton B. Menz, Polly Q. X. Lim, Sheree E. Hurn, Karen J. Mickle, Andrew K. Buldt, Matthew P. Cotchett, Edward Roddy, Anita E. Wluka, Bircan Erbas, Mehak Batra, Shannon E. Munteanu
Summary: This study aimed to evaluate the effectiveness of a nonsurgical intervention for reducing pain associated with hallux valgus and determine the feasibility of conducting a randomized trial. The results showed that the current intervention is not feasible, primarily due to low adherence and the impact of COVID-19.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Rheumatology
Mahnuma M. Estee, Yuanyuan Wang, Stephane Heritier, Donna M. Urquhart, Flavia M. Cicuttini, Mark A. Kotowicz, Sharon L. Brennan-Olsen, Julie A. Pasco, Anita E. Wluka
Summary: A study conducted on men over a 10-year period found that negative beliefs regarding back pain were associated with an increased likelihood of developing high-intensity pain and/or high disability.