Article
Medicine, General & Internal
Kyohei Sakaki, Kenichiro Sakai, Yoshiyasu Arai, Ichiro Torigoe, Masaki Tomori, Takashi Hirai, Hiroaki Onuma, Yutaka Kobayashi, Atsushi Okawa, Toshitaka Yoshii
Summary: This study investigated the postoperative dysphagia in cervical posterior longitudinal ligament ossification (C-OPLL) and cervical spondylotic myelopathy (CSM) to identify the risk factors of each disease and the incidence. The results showed that increased angle C2-7 was a risk factor for both diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Atsushi Kimura, Katsushi Takeshita, Toshitaka Yoshii, Satoru Egawa, Takashi Hirai, Kenichiro Sakai, Kazuo Kusano, Yukihiro Nakagawa, Kanichiro Wada, Keiichi Katsumi, Kengo Fujii, Takeo Furuya, Narihito Nagoshi, Tsukasa Kanchiku, Yukitaka Nagamoto, Yasushi Oshima, Hiroaki Nakashima, Kei Ando, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Shunji Matsunaga, Takashi Kaito, Kei Yamada, Sho Kobayashi, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Kota Watanabe, Shiro Imagama, Masao Koda, Yoshiharu Kawaguchi, Masaya Nakamura, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: The study found that patients with diabetes mellitus undergoing cervical spine surgery for OPLL had a higher incidence of postoperative complications, and lower scores in lower extremity function and quality of life at the 2-year follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shingo Morishita, Toshitaka Yoshii, Hiroyuki Inose, Takashi Hirai, Yu Matsukura, Takahisa Ogawa, Kiyohide Fushimi, Junya Katayanagi, Tetsuya Jinno, Atsushi Okawa
Summary: This study investigated the perioperative complication rates of patients with OPLL and CSM undergoing ADF. It found that OPLL had more perioperative complications, such as CSFL and SSI, compared to CSM. Medical costs were also higher in patients with complications in both OPLL and CSM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yasuaki Mizoguchi, Kiyokazu Akasaka, Kenta Suzuki, Fumihiko Kimura, Toby Hall, Satoshi Ogihara
Summary: This study validated the preoperative Japanese COMI-Neck in CSM and OPLL patients and identified specific QOL issues associated with each condition.
EUROPEAN SPINE JOURNAL
(2023)
Review
Clinical Neurology
Young Il Won, Chang-Hyun Lee, Woon Tak Yuh, Shin Won Kwon, Chi Heon Kim, Chun Kee Chung
Summary: Despite numerous studies, the exact cause of ossification of the posterior longitudinal ligament (OPLL) is still unclear. While previous genetic studies suggested variations in bone and collagen-related genes as the cause, recent research supports the involvement of inflammation-related genes. OPLL can be divided into genetic and idiopathic, with the former resembling the continuous type and the latter resembling the segmental type.
Article
Clinical Neurology
Shingo Morishita, Toshitaka Yoshii, Hiroyuki Inose, Takashi Hirai, Masato Yuasa, Yu Matsukura, Takahisa Ogawa, Kiyohide Fushimi, Junya Katayanagi, Tetsuya Jinno, Atsushi Okawa, Takeo Fujiwara
Summary: This retrospective cohort study aimed to investigate the perioperative complication rates and medical costs of degenerative cervical myelopathy (DCM) patients who underwent laminoplasty (LAMP). The study found that patients with ossification of the longitudinal ligament (OPLL) had higher rates of perioperative complications, including systemic and local complications, compared to patients with cervical spondylotic myelopathy (CSM) who underwent LAMP. Additionally, patients with OPLL had significantly higher hospitalization costs.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Lei Zhu, Yu Miao, Yan Mao, Kang-Kang Zuo
Summary: This study found that preoperative T1 slope and encroachment ratio were risk factors for C5 nerve palsy in patients undergoing cervical posterior open-door laminoplasty.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Lei Zhu, Yu Miao, Yan Mao, Kang-Kang Zuo
Summary: This study revealed that preoperative T1 slope and encroachment ratio were risk factors for C5 nerve palsy in patients who underwent cervical posterior open-door laminoplasty.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Yoshinori Ishikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Daisuke Kudo, Chiaki Sato, Yoichi Shimada
Summary: This case report presents successful treatment of coexisting cervical OLF and OPLL in a 70-year-old male patient. Surgical intervention led to significant improvement in symptoms and maintenance of cervical alignment. Surgeons should carefully evaluate the severity of adhesion, muscle damage, and necessity of posterior corrective surgery, as well as consider the patient's comorbidities and potential postoperative complications.
WORLD NEUROSURGERY
(2021)
Editorial Material
Clinical Neurology
Jia-Nan Zhang, Ding-Jun Hao
Summary: OPLL can result in symptoms such as hand clumsiness and impaired gait, as demonstrated in this case study. The patient presented with signs of spinal cord compression, and imaging showed seesaw-like OPLL, indicating laminoplasty and laminectomy may not be the most suitable treatment options.
WORLD NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Bing Wui Ng, Jin Aun Tan, Suffian Sabri, Azmi Baharuddin, Mohd Hisam Muhamad Ariffin
Summary: The study investigates the outcome of managing cervical ossification of the posterior longitudinal ligament (OPLL) using a treatment algorithm in a tertiary university hospital. A retrospective cross-sectional analysis was conducted on patients who underwent surgical treatment for cervical myelopathy secondary to OPLL from 2014 to 2020. The results demonstrate that the treatment algorithm used in the center can effectively guide the management of cervical OPLL and improve the patients' recovery rate and postoperative neck function.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Orthopedics
Bao Su, Jieliang Shen, Xiaoji Luo, Zhengxue Quan, Dianming Jiang, Xiaohua Peng, Ke Tang
Summary: The study revealed that one-stage posterior laminectomy and fusion surgery can achieve satisfactory clinical efficacy in improving neurological function and relieving radicular pain of the upper limbs for OPLL patients with radiculopathy symptoms.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Multidisciplinary Sciences
Woon Tak Yuh, Minjung Kim, Yunhee Choi, Junghoon Han, Junhoe Kim, Taeshin Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Moon Soo Park, Chi Heon Kim
Summary: This study compared the rate of additional surgery between anterior and posterior surgeries for degenerative cervical spinal disease. The results showed that there was no difference in the rates of additional surgery between anterior and posterior cervical surgeries.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Dong-Zhao Wu, Zhen-Fang Gu, De-Jing Meng, Shu-Bing Hou, Liang Ren, Xian-Ze Sun
Summary: This study aimed to investigate the surgical efficacy of crossing the cervicothoracic junction during posterior cervical laminectomy and fusion for the treatment of multilevel cervical ossification of the posterior longitudinal ligament (OPLL). The results showed that this method is safe and effective, improving both clinical symptoms and radiographic outcomes in patients.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Jun Jae Shin, Hyeongseok Jeon, Jong Joo Lee, Hyung Cheol Kim, Tae Woo Kim, Sung Bae An, Dong Ah Shin, Seong Yi, Keung-Nyun Kim, Do-Heum Yoon, Narihito Nagoshi, Kota Watanabe, Masaya Nakamura, Morio Matsumoto, Nan Li, Sai Ma, Da He, Wei Tian, Kenny Yat Hong Kwan, Kenneth Man Chee Cheung, K. Daniel Riew, Daniel J. Hoh, Yoon Ha
Summary: This retrospective multicenter study examined prognostic factors for neurological recovery in patients undergoing surgery for cervical ossification of the posterior longitudinal ligament (OPLL) based on their presenting mild, moderate, or severe myelopathy. Various patient and surgical factors were found to be correlated with the likelihood of neurological recovery, depending on the severity of presenting myelopathy.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Clinical Neurology
Dimitri Tkatschenko, Sonja Hansen, Julia Koch, Christopher Ames, Michael G. Fehlings, Sigurd Berven, Lali Sekhon, Christopher Shaffrey, Justin S. Smith, Robert Hart, Han Jo Kim, Jeffrey Wang, Yoon Ha, Kenny Kwan, Yong Hai, Marcelo Valacco, Asdrubal Falavigna, Nestor Taboada, Alfredo Guiroy, Juan Emmerich, Bernhard Meyer, Frank Kandziora, Claudius Thome, Markus Loibl, Wilco Peul, Alessandro Gasbarrini, Ibrahim Obeid, Martin Gehrchen, Andrej Trampuz, Peter Vajkoczy, Julia Onken
Summary: This study provides an international overview of the heterogeneity of surgical site infection prevention strategies in spine surgery. The results demonstrate a significant variation in pre-, peri-, and postoperative measures to prevent surgical site infection. There is a need for developing universal guidelines and testing areas of controversy in prospective clinical trials.
GLOBAL SPINE JOURNAL
(2023)
Editorial Material
Clinical Neurology
Michael G. Fehlings, Alexander A. Velumian
Review
Clinical Neurology
Zaid Salahem, Ali Moghaddamjou, Michael Fehlings
Summary: This scoping review explores the factors contributing to neurotrauma in indigenous populations and potential strategies to address this health care issue at a global level. The study identifies inadequate resources, social problems, and challenges within the health care system as the main factors contributing to neurotrauma burden in indigenous populations. Potential strategies include system-level changes, community-based initiatives, and culturally appropriate solutions.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Antigona Ulndreaj, Ariel Avila, James Hong, Cindy Zhou, Michael G. Fehlings, Pia M. Vidal
Summary: This study examined whether the natural progression of degenerative cervical myelopathy (DCM) is accompanied by hematological changes in the white blood cell composition. The results showed that T cells were decreased and monocytes were increased in the DCM group, suggesting that these changes occur before the development of neurobehavioral symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Alexander C. Disch, Stefano Boriani, Aron Lazary, Laurence D. Rhines, Alessandro Luzzati, Ziya L. Gokaslan, Charles G. Fisher, Michael G. Fehlings, Michelle J. Clarke, Dean Chou, Nicole M. Germscheid, Klaus-Dieter Schaser, Jeremy J. Reynolds
Summary: Compared to secondary lesions, primary spinal tumors are rare. The effect of different resection strategies on local recurrence and survival in patients with benign primary spinal tumors under the age of 25 was studied. The results showed no correlation between the grade of aggressiveness in resection and local recurrence rates in this younger patient cohort. The most common tumors in young patients were osteoblastomas, osteoid osteomas, and aneurysmal bone cysts.
Article
Oncology
Alexander C. Disch, Stefano Boriani, Alessandro Luzzati, Laurence D. Rhines, Charles G. Fisher, Aron Lazary, Ziya L. Gokaslan, Dean Chou, Michelle J. Clarke, Michael G. Fehlings, Klaus-Dieter Schaser, Nicole M. Germscheid, Jeremy J. Reynolds
Summary: Extradural primary malignant spinal tumors in young patients are rare. This study reports the clinical outcomes of young patients who underwent surgery for these tumors. The results show that surgery, combined with adjuvant therapy, can achieve better overall survival and low local recurrence rates.
Article
Clinical Neurology
Raymond Wong, Nader Hejrati, Michael G. G. Fehlings
Summary: This article discusses several key challenges that clinical investigators evaluating novel therapeutic strategies to treat traumatic spinal cord injury (SCI) may face, and proposes potential solutions, including patient recruitment, patient follow-up, heterogeneity of patients, complex pathophysiology of SCI, capturing treatment effects, high costs, implementation of guidelines, demographic shifts, and navigating regulatory bodies.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Review
Cell & Tissue Engineering
Katarzyna Pieczonka, Michael G. Fehlings
Summary: Spinal cord injury (SCI) has a significant impact on quality of life and finances. Neural stem/progenitor cell (NSPC) transplantation shows promise for spinal cord regeneration, but the integration of transplanted cells remains a challenge. This review proposes various techniques, including molecular cues and alternative methods, to guide the integration of grafted cells towards specific circuits. Future research in these areas may improve outcomes for SCI patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Katarzyna Pieczonka, Mohamad Khazaei, Michael G. G. Fehlings
Summary: In this study, the expression of Olig2 transcription factor was induced in tripotent neural progenitor cells (NPCs), leading to a significantly higher proportion of differentiated oligodendrocytes compared to NPCs. The induction of Olig2 was also associated with the upregulation of genes involved in oligodendrocyte development and function, and the downregulation of genes involved in other cell lineages. GO and GSEA analyses further confirmed the oligodendrocyte specification of the induced NPCs.
Article
Cell & Tissue Engineering
Katarzyna Pieczonka, Hiroaki Nakashima, Narihito Nagoshi, Kazuya Yokota, James Hong, Anna Badner, Jonathon C. T. Chio, Shinsuke Shibata, Mohamad Khazaei, Michael G. Fehlings
Summary: Traumatic spinal cord injury (SCI) causes the loss of neurons and glial cells. Current interventions for SCI lack regenerative solutions. Neural stem/progenitor cell (NPC) transplantation is a promising strategy for regeneration but inconsistent differentiation hinders functional recovery. This study generated oligodendrogenically biased NPCs (oNPCs) from human induced pluripotent stem cells (hiPSCs) and demonstrated their effectiveness in a rodent model of cervical SCI, showing enhanced tissue preservation, remyelination, and functional recovery without adverse effects. These findings highlight the therapeutic potential of oNPCs in cervical SCI and call for further investigation to optimize this approach.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Orthopedics
Nisaharan Srikandarajah, Mohammed Ali Alvi, Michael G. Fehlings
Summary: Traumatic spinal cord injury (SCI) is a serious disorder that leads to neurological impairment and disability, affecting the quality of life for patients. The pathophysiology involves primary and secondary phases, causing neurological damage. Current clinical management focuses on early decompressive surgery, optimizing arterial pressure, steroid therapy, and rehabilitation. Emerging therapies aim to repair the spinal cord through cell-based, gene, pharmacological, and neuromodulation approaches. Addressing both primary and secondary phases of SCI can enhance outcomes for patients.
JOURNAL OF ORTHOPAEDICS
(2023)
Review
Clinical Neurology
Ayesha Quddusi, Karlo M. M. Pedro, Mohammed Ali Alvi, Nader Hejrati, Michael G. G. Fehlings
Summary: Acute traumatic spinal cord injury (tSCI) is a severe event with global impact on morbidity and mortality. Early surgical intervention within 24 hours has been shown to improve prognosis and functional outcomes. This review explores the evidence, nuances, and challenges associated with timing of surgery, as well as the barriers to early surgical care for tSCI.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Nader Hejrati, Karlo Pedro, Mohammed Ali Alvi, Ayesha Quddusi, Michael G. Fehlings
Summary: Degenerative cervical myelopathy (DCM) includes age-related and genetically associated pathologies affecting the cervical spine. The RECODE-DCM consensus group has identified ten priority areas for translational research to improve the management and treatment of DCM. This article summarizes recent advancements in the field, including a refined definition, understanding of pathophysiology, assessment and diagnosis methods, treatment modalities, and genetic research opportunities.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Stephanie Voss, Andrea Adighibe, Emily Sanders, David Aaby, Rachel Kravitt, Gina Clark, Kelly Breen, Alexander Barry, Gail F. Forrest, Steve C. Kirshblum, Monica A. Perez, Sukhvinder Kalsi-Ryan, Masha Kocherginsky, William Zev Rymer, Milap S. Sandhu
Summary: GRASSP V1.0 is a 3-domain assessment for upper extremity function after tetraplegia, while the remote version rGRASSP was developed to meet the needs of telemedicine. This study evaluated the psychometric properties of rGRASSP, including concurrent validity and inter-rater reliability. The results showed that rGRASSP demonstrated strong concurrent validity and inter-rater reliability, making it a reliable remote assessment tool for upper extremity function in individuals with tetraplegia.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Public, Environmental & Occupational Health
Roger Wong, Margaret Anne Lovier
Summary: Older adults and people of colour are more vulnerable to COVID-19, and despite higher adherence to mitigation behaviours, minority older adults still have elevated odds of COVID-19. Research is needed to explore potential mechanisms for this disparity.
EPIDEMIOLOGY AND INFECTION
(2023)