Article
Anesthesiology
Pradeep Suri, Ian B. Stanaway, Yanfei Zhang, Maxim B. Freidin, Yakov A. Tsepilov, David S. Carrell, Frances M. K. Williams, Yurii S. Aulchenko, Hakon Hakonarson, Bahram Namjou, David R. Crosslin, Gail P. Jarvik, Ming Ta Lee
Summary: Identifying genetic risk factors for lumbar spine disorders through genome-wide association studies using electronic health record data may lead to the development of new treatments. The study identified two novel associations with lumbar spine disorders, including lumbosacral radicular syndrome and lumbar spinal stenosis. Replication in an independent sample confirmed the association with lumbar spinal stenosis.
Article
Medicine, General & Internal
Sangbong Ko, Hee-Chan Kim, Jaibum Kwon
Summary: This study aimed to investigate the effects of vitamin D supplementation on the improvement in symptoms, functional recovery of the spine, and changes in the quality of life in patients with spinal stenosis. The results showed that high-dose vitamin D injections can improve lower back pain, spine function, and quality of life in patients with lumbar spinal stenosis who do not require surgical treatment.
Article
Clinical Neurology
Freyr Gauti Sigmundsson, Anders Moller, Fredrik Stromqvist
Summary: This study investigated the outcomes of surgery for lumbar spinal stenosis in patients with mild preoperative leg pain levels. The results showed that leg pain increased, back pain decreased, and overall functional status improved at the 1-year follow-up. Approximately a third of patients achieved successful outcomes in terms of back pain, with a higher percentage reaching successful outcomes in terms of ODI and EQ-5D. The study findings can help surgeons in the shared decision-making process before surgery.
GLOBAL SPINE JOURNAL
(2021)
Article
Clinical Neurology
Raffael Peteler, Paul Schmitz, Martin Loher, Petra Jansen, Joachim Grifka, Achim Benditz
Summary: This study found sex-dependent differences in symptom-related disability in patients with lumbar spinal stenosis, with female patients showing higher scores in RMDQ and ODI, as well as significantly higher intermediate depression scores. The findings also suggest that variables such as age, pain chronicity, psychological symptoms, pain level, and paresis are influenced by patient sex.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Clinical Neurology
Yawara Eguchi, Yasuchika Aoki, Masaomi Yamashita, Kazuki Fujimoto, Takashi Sato, Koki Abe, Masashi Sato, Hajime Yamanaka, Toru Toyoguchi, Keisuke Shimizu, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Seiji Ohtori
Summary: This study compared the clinical effects of Neurotropin, limaprost alfadex, and a combination of both drugs for lumbar spinal stenosis with low back pain. The results showed that the combination of Neurotropin and limaprost had an additional effect on walking speed compared to single drug administration. Neurotropin may contribute to the improvement of low back pain, walking speed/stride length, and standing balance.
Article
Health Care Sciences & Services
Yinhao Liu, Lei Yuan, Yan Zeng, Jiajun Ni, Shi Yan
Summary: This study described the characteristics and differences in paraspinal muscle parameters between patients with degenerative lumbar scoliosis (DLS) and lumbar spinal stenosis (LSS), and investigated their correlation with health-related quality of life (HRQOL). The results showed that paraspinal muscle degeneration was more severe in the upper lumbar region of DLS patients compared to LSS patients, and only the multifidus (MF) muscle was associated with HRQOL in the LSS group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Orthopedics
Henni Myllykangas, Leena Ristolainen, Heikki Hurri, Jouni Lohikoski, Hannu Kautiainen, Ville Puisto, Heikki Osterman, Mikko Manninen
Summary: Obesity is associated with lower quality of life before lumbar spinal stenosis surgery, but all groups showed improved quality of life one year post-operation and stabilized at two years. Patients with obesity had significantly higher functional disability index preoperatively, with all groups showing improved disability index two years after surgery, although the differences were not statistically significant.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Clinical Neurology
Masaaki Kakiuchi, Eiji Wada, Takeo Harada, Ryoji Yamasaki, Wakaba Fukushima
Summary: The study aimed to confirm that decompression for lumbar spinal stenosis (LSS) relieves low back pain (LBP) as adequately as it relieves leg pain, and identified important predictors for inadequate LBP relief. Imaging parameters were not reliable predictors of inadequate LBP relief.
Article
Medicine, General & Internal
Philipp Krauss, Stefan Motov, Maximilian Niklas Bonk, Andrea Prescher, Jasmin Scorzin, Mohammad Mehdi Hajiabadi, Dirk Michael Schulte, Bjoern Sommer, Marcel Seiz-Rosenhagen, Rezvan Ahmadi, Jaroslaw Maciaczyk, Jens Lehmberg, Ehab Shiban
Summary: This study compares high-frequency neuromodulation with spinal instrumentation surgery for the treatment of patients with PSPS2. The study aims to provide high-level evidence for the commonly used treatment options in this severely disabling condition by using comprehensive assessment measures such as ODI, VAS, SF-36, EuroQOL5D, and excluding certain patient conditions.
Article
Orthopedics
Katsutaka Yamada, Yoichi Aota, Tomoyuki Saito, Yutaka Inaba
Summary: This study aimed to reveal the correlation between leg pain at rest and spinal nerve edema in symptomatic foraminal stenosis. The clinical and MRI findings of 30 patients diagnosed with symptomatic foraminal stenosis were compared and analyzed. The results showed that the prevalence and VAS score of leg pain at rest were significantly higher in the presence of spinal nerve edema group.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Medicine, General & Internal
Brock K. Bakewell, Matthew Sherman, Kimberly Binsfeld, Asif M. Ilyas, Stephen A. Stache, Salon Sharma, David Stolzenberg, Ari Greis
Summary: This observational study found that treatment with hemp-derived CBD gel caps was associated with significant improvements in pain scores and quality-of-life measures for patients with lumbar spinal stenosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Baasanjav Uranbileg, Nobuko Ito, Makoto Kurano, Kuniyuki Kano, Kanji Uchida, Masahiko Sumitani, Junken Aoki, Yutaka Yatomi
Summary: The study indicated a potential link between elevated levels of LPC and LPA in cerebrospinal fluid and lumbar spinal canal stenosis. The use of an ATX inhibitor in a compression of DRG model showed promising results in alleviating pain symptoms and reducing populations of microglia and astrocytes in the spinal dorsal horn.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Sung Hyun Lee, Sung-Ha Hwang, Young-Kwan Moon, Hyun Min Bae, Dong Eon Moon
Summary: This retrospective study evaluated the clinical outcomes and safety of TFFP in 112 patients, showing that TFFP using the Foramoon device was effective in improving pain scores, ODI, and walking distance without serious adverse events.
Article
Clinical Neurology
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Sachika Matsuo, Tadashi Sumiya, Masafumi Nakagawa, Yoshio Yamamoto, Tomohiro Nakatani, Wakana Nagata, Yukihiro Nakagawa
Summary: The study aimed to identify factors associated with low back pain in patients with lumbar spinal stenosis. Significant associations were found between low back pain and diabetes, buttock and leg numbness, general health status, and erosive endplate defects in these patients.
Review
Surgery
Fei-Long Wei, Cheng-Pei Zhou, Rui Liu, Kai-Long Zhu, Ming-Rui Du, Hao-Ran Gao, Sheng-Da Wu, Li-Li Sun, Xiao-Dong Yan, Ya Liu, Ji-Xian Qian
Summary: The network meta-analysis and systematic review on interventions for lumbar spinal stenosis found that surgical interventions provided better pain relief but had higher complication rates, with endoscopic decompression being a less invasive surgical approach.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Clinical Neurology
Freyr Gauti Sigmundsson, Bo Jonsson, Bjorn Stromqvist
EUROPEAN SPINE JOURNAL
(2017)
Article
Clinical Neurology
Fredrik Stromqvist, Freyr Gauti Sigmundsson, Bjorn Stromqvist, Bo Jonsson, Magnus K. Karlsson
Article
Medicine, General & Internal
Freyr Gauti Sigmundsson, Fredrik Stromqvist, Bjarki Karlsson
Article
Clinical Neurology
Hjorleifur Skorri Thormodsson, Eleftherios Ntouniadakis, Marek Holy, Freyr Gauti Sigmundsson
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Freyr Gauti Sigmundsson, Anders Moller, Fredrik Stromqvist
Summary: This study investigated the outcomes of surgery for lumbar spinal stenosis in patients with mild preoperative leg pain levels. The results showed that leg pain increased, back pain decreased, and overall functional status improved at the 1-year follow-up. Approximately a third of patients achieved successful outcomes in terms of back pain, with a higher percentage reaching successful outcomes in terms of ODI and EQ-5D. The study findings can help surgeons in the shared decision-making process before surgery.
GLOBAL SPINE JOURNAL
(2021)
Article
Orthopedics
Niyaz Hareni, Fredrik Stromqvist, Bjorn Stromqvist, Freyr Gauti Sigmundsson, Bjorn E. Rosengren, Magnus K. Karlsson
Article
Health Care Sciences & Services
Anders Joelson, Freyr Gauti Sigmundsson, Jan Karlsson
Summary: The study aimed to apply a single large longitudinal EQ-5D-3L dataset to multiple national EQ-5D-3L value sets and investigate differences in EQ-5D-3L index density functions and effect sizes before and after treatment. Analysis of procedures from patients surgically treated for lumbar spinal stenosis or lumbar disk herniation between 2007 and 2017 was conducted, revealing high variability in EQ-5D-3L index density functions and significant differences before and after treatment. However, effect sizes of 2-year change were found to be similar when the 9 value sets were applied, suggesting caution in aggregating international data and recommending against pooling different national EQ-5D-3L index data.
QUALITY OF LIFE RESEARCH
(2021)
Article
Clinical Neurology
Bertrand Debono, Thomas W. Wainwright, Michael Y. Wang, Freyr G. Sigmundsson, Michael M. H. Yang, Henriette Smid-Nanninga, Aurelien Bonnal, Jean -Charles Le Huec, William J. Fawcett, Olle Ljungqvist, Guillaume Lonjon, Hans D. de Boer
Summary: ERAS protocols have shown significant improvements in outcomes by optimizing patient care pathways, reducing complications, enhancing patient experience, and shortening hospital stays. A multidisciplinary consensus review on lumbar fusion surgery with ERAS program was conducted, resulting in 28 recommendations covering various aspects of preoperative, intraoperative, and postoperative care.
Article
Orthopedics
Anders Joelson, Fredrik Nerelius, Marek Holy, Freyr Gauti Sigmundsson
Summary: The study investigated reoperation rates after L4-5 fusion surgery and found that patients with degenerative spondylolisthesis had higher reoperation rates, especially at adjacent levels. There was no difference in patient-reported outcomes between fusion and decompression for reoperations at adjacent levels.
Article
Orthopedics
Anders Joelson, Freyr Gauti Sigmundsson, Jan Karlsson
Summary: The study found that using different national value sets in SF-6D index-based outcome analyses may lead to significant variability and differences in SF-6D index distributions. There were considerable differences in SF-6D index distribution shape before and after treatment when the same value set was used. The effect sizes of 2-year change were mostly similar when 9 different national value sets were applied to pre- and post-treatment data.
Article
Health Care Sciences & Services
Anders Joelson, Freyr Gauti Sigmundsson, Jan Karlsson
Summary: The SF-36 GH domain showed poor responsiveness to surgical treatment of spinal stenosis and disk herniation, while EQ VAS, EQ-5D index, and SF-6D demonstrated moderate to large responsiveness.
QUALITY OF LIFE RESEARCH
(2022)
Article
Medicine, Research & Experimental
Marek Holy, Anna MacDowall, Freyr Gauti Sigmundsson, Class Olerud
Summary: This study aims to evaluate the short- and long-term outcomes of anterior cervical decompression and fusion (ACDF) and posterior foraminotomy (PF) for cervical radiculopathy. The research seeks to compare the effectiveness of these two surgical treatments in order to determine the best option for patients with this condition.
Article
Clinical Neurology
Freyr Gauti Sigmundsson, Anders Joelson, Fredrik Stromqvist
Summary: The study found that patients without preoperative back pain had better pain relief after surgery, while 13% of patients without preoperative back pain developed clinically significant back pain one year after surgery.
EUROPEAN SPINE JOURNAL
(2022)
Review
Clinical Neurology
Signe F. Elmose, Gustav O. Andersen, Leah Yacat Carreon, Freyr G. Sigmundsson, Mikkel O. Andersen
Summary: This systematic review collected and grouped definitions of segmental instability in surgical studies of patients with lumbar spinal stenosis and/or lumbar degenerative spondylolisthesis. The study reported the frequencies of these definitions, compared imaging measurement thresholds for instability in patients with those reported in biomechanical studies and studies of spine healthy individuals, and included a reliability study. The results showed that segmental instability can radiologically be defined as > 3 mm dynamic sagittal translation in degenerative lumbar spine.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
F. G. Sigmundsson, A. Joelson, F. Stromqvist
Summary: This study analyzed the reasons and frequency of additional surgeries after lumbar disc prolapse surgery. The results showed that more than one-fifth of the patients required further surgery, with recurrent disc prolapse being the most common reason. The study also found that the outcome significantly deteriorated after the second additional operation.
BONE & JOINT JOURNAL
(2022)