Article
Engineering, Biomedical
Xiaoming Zhao, Hongyun Ma, Hao Han, Liuyang Zhang, Jing Tian, Bo Lei, Yingang Zhang
Summary: With the aging population, spinal degeneration seriously affects the quality of life for middle-aged and elderly patients. Injectable biomaterials have gained attention as a minimally invasive and precise repair option for irregular defects. However, the design and functional control of bioactive injectable biomaterials for efficient spinal degeneration treatment remains a challenge.
MATERIALS TODAY BIO
(2022)
Article
Surgery
Jiajun Huang, Weike Zeng, Ming Li, Ziying Cheng, Junshen Huang, Changchun Liang, Yuxi Li, Lin Huang
Summary: Percutaneous cement discoplasty (PCD) can enhance the stability of the lumbar spine in flexion-extension and lateral bending, providing effective treatment for low back pain. Fractures and sliding of bone cement after PCD may lead to nerve compression.
FRONTIERS IN SURGERY
(2022)
Article
Orthopedics
Xiaolong Chen, Dong Xue, Peng Cui, Ying Zhao, Shibao Lu
Summary: This study provides the first evidence that severe periodontitis is associated with a higher occurrence rate of disc structural failures and poor clinical outcomes in patients with cervical degenerative disorders.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Eduard Bezuglov, Artemii Lazarev, Arseniy Petrov, Alesia Brodskaia, Anastasiya Lyubushkina, Kamila Kubacheva, Evgeny Achkasov, Vladimir Nikolenko
Summary: Elite professional soccer players have a high prevalence of asymptomatic degenerative lumbar spinal changes, which are significantly associated with age. The most common pathologic condition was disc desiccation. Age was found to be associated with degenerative changes, while weight and body mass index did not show any association.
Review
Biochemistry & Molecular Biology
Brandon He, Kyle Sheldrick, Abhirup Das, Ashish Diwan
Summary: Degenerative cervical myelopathy (DCM) is a non-traumatic, chronic, and progressive disease, and current diagnostic and prognostic techniques have limitations. This article presents evidence on novel quantitative MRI (qMRI) techniques for assessing spinal cord integrity in DCM and suggests future research directions.
Article
Medicine, General & Internal
Nils Christian Lehnen, Robert Haase, Jennifer Faber, Theodor Ruber, Hartmut Vatter, Alexander Radbruch, Frederic Carsten Schmeel
Summary: The study evaluated the diagnostic performance of a convolutional neural network on lumbar spine MRI images, demonstrating high accuracy and consistency in automatically diagnosing various degenerative changes in the lumbar spine.
Review
Biochemistry & Molecular Biology
Jin-Woo Kim, Neunghan Jeon, Dong-Eun Shin, So-Young Lee, Myongwhan Kim, Dong Hun Han, Jae Yeon Shin, Soonchul Lee
Summary: The intervertebral disc is a complex joint structure with nucleus pulposus, annulus fibrosus, and cartilaginous endplate. Degeneration of the intervertebral disc involves cellular, compositional, and structural changes, with significant alterations in the extracellular matrix composition with age. The hypoxia-inducible factor HIF-1 alpha is crucial in regulating various processes of intervertebral disc degeneration and may serve as a diagnostic tool and therapeutic target for inhibiting this degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Mohamed Kamal Mesregah, Michael Repajic, Paul Mgbam, Zoe Fresquez, Jeffrey C. Wang, Zorica Buser
Summary: This study evaluated the trends and patterns of cervical degenerative disc disease in different age groups of symptomatic patients. The results showed that the number and severity of degenerated intervertebral discs increased significantly with age.
EUROPEAN SPINE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M. Laudier, Venetia Zachariou, James C. Iatridis
Summary: In this rat study, it was found that endplate injury leads to spinal cord sensitization, neuroinflammation, and pain-related behaviors. Additionally, increased macrophages were observed in the endplate and vertebrae, and there was a correlation between spinal cord sensitization, neuroinflammation, IVD degeneration, and macrophage presence. These findings suggest that therapies targeting neural pathologies, IVD degeneration, and chronic spinal inflammation are necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Elizabeth Gacek, Arin M. Ellingson, Victor H. Barocas
Summary: This study investigated the mechanical characteristics of the lumbar facet capsular ligament using cadaveric lumbar spines. The results showed that the ligament experiences nonzero strain under joint pressure and attachment constraints, with the highest stretching direction being from bone to bone. Releasing the ligament resulted in shrinkage, and the collagen in the ligament may remain uncrimped even when the spine is not loaded.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Biophysics
Aditya Vedantam, Balaji Harinathan, Yuvaraj Purushothaman, Stephen Scripp, Anjishnu Banerjee, Ali Warraich, Matthew D. Budde, Narayan Yoganandan
Summary: Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction in older adults, characterized by chronic cervical spinal cord compression. This study aimed to measure spinal cord stress/strain in DCM using patient-specific 3D finite element models (FEMs) and determine the primary determinant of spinal cord stress/strain.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guoliang Chen, Fuxin Wei, Liangyu Shi, Jiachun Li, Xianxiang Wang, Meng Wang, Huachuan Wu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu
Summary: French-door laminoplasty with intraoperative ultrasound (IOUS) can confirm sufficient decompression for the treatment of DCM, leading to higher likelihood of neurological recovery; inadequate spinal cord expansion after sufficient decompression may predict less satisfactory neurological recovery in DCM patients.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Masatsugu Tsukamoto, Tadatsugu Morimoto, Takaomi Kobayashi, Kazuki Muranaka, Tomohito Yoshihara, Kazumasa Maeda, Motoki Sonohata, Yuichi Kasai, Koji Otani, Masaaki Mawatari
Summary: This study evaluates the relationships between traction spur, Modic changes (MCs), and vacuum phenomenon (VP) and radiographic measurements in the lumbar spine. The results show a significant association between traction spur and translational motion, as well as between VP and vertical motion. These findings are important for identifying lumbar intervertebral instability.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Zdenek Kadanka, Zdenek Kadanka, Tomas Skutil, Eva Vlckova, Josef Bednarik
Summary: The study demonstrates that a standardized 10-m walk/run test can detect gait impairment in non-myelopathic degenerative cervical cord compression (NMDCC) patients, with correlations to severity of disability.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Jun Zhang, Tang-Fen Liu, Hua Shan, Zhong-Yuan Wan, Zhe Wang, Omar Viswanath, Antonella Paladini, Giustino Varrassi, Hai-Qiang Wang
Summary: Lumbar spinal stenosis (LSS) is a common disease in the elderly population, often requiring surgery. Minimally invasive spine surgery (MISS), including techniques like endoscopic spine surgery (ESS), is gaining popularity as a potential replacement for traditional open surgery in the treatment of LSS associated with degenerative spondylolisthesis (DS).
Article
Clinical Neurology
Atsushi Kimura, Teruaki Endo, Hirokazu Inoue, Katsushi Takeshita
EUROPEAN SPINE JOURNAL
(2016)
Article
Orthopedics
Hideaki Watanabe, Istuko Horiguchi, Shinya Hayasaka, Kayo Hagiwara, Ryo Sugawara, Hirokazu Inoue, Katsushi Takeshita, Eiji Marui, Ichiro Kikkawa
JOURNAL OF ORTHOPAEDIC SCIENCE
(2015)
Article
Orthopedics
Ryo Sugawara, Hideaki Watanabe, Kayo Hagiwara, Hirokazu Inoue, Katsushi Takeshita, Ichiro Kikkawa
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2016)
Article
Clinical Neurology
Atsushi Kimura, Atsushi Seichi, Katsushi Takeshita, Hirokazu Inoue, Tsuyoshi Kato, Toshitaka Yoshii, Takeo Furuya, Masao Koda, Kazuhiro Takeuchi, Shunji Matsunaga, Shoji Seki, Yoshimoto Ishikawa, Shiro Imagama, Masashi Yamazaki, Kanji Mori, Yosuke Kawasaki, Koji Fujita, Kenji Endo, Kimiaki Sato, Atsushi Okawa
Article
Orthopedics
Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii
BMC MUSCULOSKELETAL DISORDERS
(2019)
Article
Clinical Neurology
Hirokazu Inoue, Hideaki Watanabe, Hitoshi Okami, Yasuyuki Shiraishi, Atsushi Kimura, Katsushi Takeshita
EUROPEAN SPINE JOURNAL
(2020)
Letter
Clinical Neurology
Hirokazu Inoue, Hideaki Watanabe, Hitoshi Okami, Yasuyuki Shiraishi, Atsushi Kimura, Katsushi Takeshita
EUROPEAN SPINE JOURNAL
(2020)
Article
Medicine, General & Internal
Tsuyoshi Harakuni, Hiroki Iwai, Yasushi Oshima, Hirokazu Inoue, Tomoaki Kitagawa, Hirohiko Inanami, Hisashi Koga
MEDICINA-LITHUANIA
(2020)
Letter
Clinical Neurology
Hirokazu Inoue, Hideaki Watanabe, Hitoshi Okami, Yasuyuki Shiraishi, Atsushi Kimura, Katsushi Takeshita
EUROPEAN SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Hirokazu Inoue, Yukinori Hayashi, Hideaki Watanabe, Hideaki Sawamura, Yasuyuki Shiraishi, Ryo Sugawara, Atsushi Kimura, Masaaki Masubuchi, Katsushi Takeshita
Summary: This study examined the relationship between handgrip strength (HGS) and various measurements such as walking speed, muscle mass, daily activities, balance, phase angle, and body composition in elderly patients with thoracolumbar vertebral compression fracture (VCF). The study found that HGS was significantly correlated with walking speed, muscle mass, daily activities, balance, extracellular water (ECW) to total body water (TBW) ratio, and phase angle. The findings suggest that HGS is an important indicator of functional abilities, balance, and overall muscle strength in patients with thoracolumbar VCF.
Article
Geriatrics & Gerontology
Yuji Kanaya, Hirokazu Inoue, Hideaki Sawamura, Yuichi Hoshino, Katsushi Takeshita
Summary: This study aimed to assess the prevalence of sarcopenia in patients who underwent rehabilitation after hip fracture surgery and examine its association with physical and cognitive function outcomes. The results showed that the prevalence of sarcopenia was 59.8%. On admission and discharge, the sarcopenia group had significantly lower walking speed, MMSE score, FIM total score, and FIM motor score compared to the non-sarcopenia group. The study concluded that regardless of sarcopenia status, patients with hip fractures showed improved physical and cognitive function outcomes after postoperative rehabilitation.
GERIATRIC ORTHOPAEDIC SURGERY & REHABILITATION
(2023)
Article
Orthopedics
Hiroyuki Inose, Takashi Hirai, Toshitaka Yoshii, Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Asato Maekawa, Kenji Endo, Takuya Miyamoto, Takeo Furuya, Akira Nakamura, Kanji Mori, Shunsuke Kanbara, Shiro Imagama, Shoji Seki, Shunji Matsunaga, Kunihiko Takahashi, Atsushi Okawa
Summary: This study aimed to identify factors associated with preoperative and postoperative neck pain in patients with degenerative cervical myelopathy who underwent laminoplasty. The results showed that cervical lordosis in extension was significantly associated with neck pain, and preoperative cervical lordosis in extension and postoperative cervical lordosis in extension were independent predictors and contributors to postoperative neck pain.
JOURNAL OF ORTHOPAEDIC SURGERY
(2022)
Article
Surgery
Norihiro Isogai, Naobumi Hosogane, Haruki Funao, Kenya Nojiri, Satoshi Suzuki, Eijiro Okada, Seiji Ueda, Tomohiro Hikata, Yuta Shiono, Kota Watanabe, Kei Watanabe, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Hidetomi Terai, Koji Tamai, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Seiji Ohtori, Sumihisa Orita, Takeo Furuya, Toshitaka Yoshii, Shuta Ushio, Gen Inoue, Masayuki Miyagi, Wataru Saito, Shiro Imagama, Kei Ando, Daisuke Sakai, Tadashi Nukaga, Katsuhito Kiyasu, Atsushi Kimura, Hirokazu Inoue, Atsushi Nakano, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Kenichiro Kakutani, Takashi Yurube, Masashi Oshima, Hiroshi Uei, Yasuchika Aoki, Masahiko Takahata, Akira Iwata, Shoji Seki, Hideki Murakami, Katsuhito Yoshioka, Hirooki Endo, Michio Hongo, Kazuyoshi Nakanishi, Tetsuya Abe, Toshinori Tsukanishi, Ken Ishii
SPINE SURGERY AND RELATED RESEARCH
(2020)
Article
Clinical Neurology
Cheng Zeng, Jian Xiong, Jeffrey C. Wang, Hirokazu Inoue, Yanlin Tan, Haijun Tian, Bayan Aghdasi
GLOBAL SPINE JOURNAL
(2016)
Article
Clinical Neurology
Hirokazu Inoue, Scott R. Montgomery, Bayan Aghdasi, Tuncay Kaner, Yanlin Tan, Haijun Tian, Rodney Terrell, Jeffrey C. Wang, Michael D. Daubs
JOURNAL OF SPINAL DISORDERS & TECHNIQUES
(2015)