Article
Multidisciplinary Sciences
Jeffrey R. Cooley, Tue S. Jensen, Per Kjaer, Angela Jacques, Jean Theroux, Jeffrey J. Hebert
Summary: This study examined the relationship between multifidus muscle morphology and degenerative spinal pathologies. It found associations between lower multifidus muscle cross-sectional area and various degenerative pathologies, indicating a potential dose-response relationship between the number of pathologies and multifidus morphology.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Yiming Li, Jaro Karppinen, Kathryn S. E. Cheah, Danny Chan, Pak C. Sham, Dino Samartzis
Summary: This study identified metabolomic biomarkers associated with Modic changes on lumbar spine MRI, particularly highlighting a potential causal relationship between decreased VLDL mean diameter and MC. The integration of metabolomics and genomics in imaging phenotypes offers new insights into personalized spine care for patients.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Modarress Julin, Jesperi Saukkonen, Petteri Oura, Juho-Antti Junno, Maisa Niemela, Juhani Maatta, Jaakko Niinimaki, Timo Jamsa, Raija Korpelainen, Jaro Karppinen
Summary: This population-based birth cohort study aimed to evaluate the relationship between vertebral dimensions and lumbar Modic changes (MC). The study found that vertebral height was positively associated with the presence of MC2, while vertebral cross-sectional area (CSA) was not associated with lumbar MC. Vertebral volume was positively associated with the presence of any MC, but the association did not persist when analyzing Type 1 (MC1) and Type 2 (MC2) separately. Further studies are needed to clarify the role of vertebral dimensions as independent risk factors for MC.
Article
Clinical Neurology
Hai Zhu, Zakir Hussain, Meng Zhang, Feng Ji, Haiqing Mao, Hanwen Li, Hao Chen
Summary: The study evaluated the effectiveness of PELD in managing LDH patients with Modic type II change. Results showed that PELD performed well in LDH patient management, but attention needs to be paid to continuous low back pain and the risk of recurrence in cases with Modic type II change.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Zhaohui Li, Xianda Gao, Wenyuan Ding, Ruoyu Li, Sidong Yang
Summary: This study aims to report a new distribution pattern of Modic changes (MCs) in patients with lumbar disc herniation (LDH) and investigate the prevalence, correlative factors, and clinical outcomes of asymmetric Modic changes (AMCs). AMCs were more common in LDH patients and were associated with leg pain and higher pain levels. Surgery can achieve satisfactory clinical improvement for both asymmetric and symmetric MCs.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Yoshimasa Mera, Masatoshi Teraguchi, Hiroshi Hashizume, Hiroyuki Oka, Shigeyuki Muraki, Toru Akune, Hiroshi Kawaguchi, Kozo Nakamura, Hidenobu Tamai, Sakae Tanaka, Munehito Yoshida, Noriko Yoshimura, Hiroshi Yamada
Summary: The study found that Type I Modic changes in the lumbar region are significantly associated with low back pain, suggesting that profiling Modic changes may help improve targeted treatment for LBP.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
G. Michael Mallow, David Zepeda, Timothy G. Kuzel, J. Nicolas Barajas, Khaled Aboushaala, Michael T. Nolte, Alejandro Espinoza-Orias, Chundo Oh, Matthew Colman, Monica Kogan, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: Contrary to traditional beliefs, this study found that Modic changes (MC) and their types can also occur in young pediatric patients. The presence of MCs was associated with degenerative disc/endplate abnormalities and structural spine phenotypes. Children with MCs had prolonged symptom duration.
EUROPEAN SPINE JOURNAL
(2022)
Article
Orthopedics
Jiandong Zhu, Hao Wu, Yilei Chen, Junhui Liu, Zhi Shan, Shunwu Fan, Fengdong Zhao
Summary: HU values in different types of Modic changes were higher compared to adjacent vertebral regions without changes. Higher HU values correlated positively with bone mineral density. A higher area ratio of Modic changes region was associated with more severe intervertebral disc degeneration.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Letter
Clinical Neurology
James E. Siegler, Steven Galetta
Summary: A study was conducted on patients with autosomal recessive limb-girdle muscular dystrophy type 12 (LGMDR12), and it was found that they did not have significant clinical worsening over a 2-year period. However, patients with LGMDR12 and intermediate-stage fatty replacement of muscle tissue experienced a significant worsening in Biodex Isometric Dynamometry, even after 1 year. This quantitative tool may be useful for monitoring clinical progression and response to targeted treatments.
Article
Orthopedics
Xiaoping Mu, Seong Woong Kim, Eberhard Uhl, Karsten Schoeller
Summary: The study found that lumbar surgeries, particularly non-fusion procedures, contribute to the development of new Modic changes (MCs) postoperatively. The first year after surgery appears to be the most active phase for the development of new MCs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Orthopedics
Kenneth T. Gao, Radhika Tibrewala, Madeline Hess, Upasana U. Bharadwaj, Gaurav Inamdar, Thomas M. Link, Cynthia T. Chin, Valentina Pedoia, Sharmila Majumdar
Summary: This retrospective imaging study aimed to develop an interpretable deep learning-based detection tool for voxel-wise mapping of Modic changes (MCs). The results showed that the model successfully identified changes in 85.7% of samples in the test set with high sensitivity and specificity, and significantly improved inter-rater reliability in the assessment of MCs.
Article
Orthopedics
Xiaoping Mu, Hansheng Deng, Xiaodong Wei, Jianxun Wei, Gianfilippo Caggiari
Summary: Higher BMI may be a risk factor for the development of severe MCs. MC1 and MC2 significantly contribute to lumbar instability. The extents of MCs lesion involvement are strongly associated with lumbar instability, but different lumbar levels involved by MCs have little effect on lumbar stability.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Z. Y. Feng, X. J. Hu, Q. Q. Zheng, M. C. Battie, Z. Chen, Y. Wang
Summary: The study revealed that cartilaginous endplate avulsion following lumbar disc herniation surgery is associated with residual back and leg pain, Modic changes, and endplate defects. Histologically, avulsed cartilaginous endplates show multiple defects, inflammatory responses, and nucleus invasion, potentially linked to NLRP3 inflammasome related inflammations.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Martijn Beukers, Guy C. M. Grinwis, Johannes C. M. Vernooij, Lisanne van Der Hoek, Anna R. Tellegen, Bjorn P. Meij, Stefanie Veraa, Dino Samartzis, Marianna A. Tryfonidou, Frances C. Bach
Summary: This study investigated whether dogs can be a valuable animal model to research Modic changes (MCs) by examining the prevalence, imaging, and histological characteristics of lumbar MCs in dogs. The results showed that dogs spontaneously develop MCs, but they may exhibit other pathological processes or more chronic bone marrow pathologies than humans with MCs. Therefore, more research is needed to determine the translatability of MCs encountered in dog low-back-pain patients in humans.
Article
Clinical Neurology
Baixing Wei, Han Wu
Summary: The study aimed to investigate the distribution of lumbar Modic changes (MC) in low back pain patients and its relationship with age, gender, segment, and lumbar degeneration diseases. A total of 500 patients who visited the outpatient clinic for lumbar spine MRI from 2019 to 2022 were randomly selected and analyzed. The study found that Modic changes were most common in the L4-5 and L5-S1 segments, with type II being the most frequent. Additionally, Modic changes were found to be associated with age, gender, and lumbar degeneration diseases.
JOURNAL OF PAIN RESEARCH
(2023)