Article
Clinical Neurology
Ian D. Coulter, Patricia M. Herman, Mallika Kommareddi, Eric L. Hurwitz, Paul G. Shekelle
Summary: The study found that chiropractors in the US tend to provide manipulation to very few patients with chronic low-back pain (CLBP) or chronic neck pain (CNP) for whom it is inappropriate. Most manipulation for patients with CLBP was appropriate, while for those with CNP it was mainly for cases where appropriateness was uncertain or equivocal. Patients with CLBP who had minor neurologic findings, sciatic nerve irritation, or no joint dysfunction were significantly less likely to receive manipulation.
Article
Health Care Sciences & Services
Eric J. Roseen, Kushang V. Patel, Rachel Ward, Xinyao de Grauw, Steven J. Atlas, Stephen Bartels, Julie J. Keysor, Jonathan F. Bean
Summary: While the use of chiropractic care or OT/PT for low back pain increased after the introduction of clinical guidelines in 2016, only about a third of US adults with low back pain reported using these services between 2016 and 2018, and disparities in use have not improved.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Clinical Neurology
Carolina Sitges, Olga Velasco-Roldan, Jaume Crespi, Nuria Garcia-Dopico, Joan Segur-Ferrer, Ana Maria Gonzalez-Roldan, Pedro Montoya
Summary: This study focused on exploring the acute effects of different physical exercise modalities on patients with nonspecific chronic low-back pain (NSCLBP), showing an increase in tactile sensitivity, pressure-pain thresholds, and lumbar flexibility, along with a decrease in pain sensitivity. However, further research is needed to fully understand the exercise-induced hypoalgesia effect in this population.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Orthopedics
Flavia Franciele dos Santos, Morgana Lopes Braga, Micaelen Mara Ferreira Barroso, Vinicius Cunha Oliveira, Murilo Xavier Oliveira
Summary: This study aims to evaluate the short-term and long-term effects of combining photobiomodulation therapy (PBMT) with an exercise protocol for individuals with persistent nonspecific low back pain. The research will assess whether adding PBMT to a physical therapist-supervised exercise program is more effective than exercise alone in treating chronic low back pain.
Article
Orthopedics
Vijay B. Vad, Antonio Madrazo-Ibarra, Deborah Estrin, John P. Pollak, Kaitlin M. Carroll, Deneen Vojta, Amoli Vad, Camilla Trapness
Summary: This study found that the Back Rx app can alleviate pain and improve functionality in patients with discogenic axial CLBP. Patients showed significant improvement in average VAS scores and functionality evaluations after using the app. The study also found that patients had a high overall satisfaction rate with the app.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Mitchell T. Gibbs, Jill A. Hayden, Aidan G. Cashin, Brishna Shah, Yannick L. Gilanyi, Andrew Natoli, Grant Holmes, Rachel Ogilvie, Amanda D. Hagstrom, James H. McAuley, Paul W. Marshall, Matthew D. Jones
Summary: This study aimed to estimate the proportion of exercise interventions tested in clinical trials for chronic low back pain (CLBP) that meet the World Health Organisation's (WHO) physical activity guidelines. A secondary analysis of the 2021 Cochrane review of exercise therapy for CLBP was performed, and the results showed that few interventions meet the WHO guidelines, indicating a lack of broader impact on health outcomes.
Article
Orthopedics
Lianne Wood, Ben Csiernik, Geronimo Bejarano, Gisela C. Miyamoto, Gemma Mansell, Jill A. Hayden, Martyn Lewis, Aidan G. Cashin
Summary: This study analyzed the data of 255 participants with chronic low back pain and found that reductions in pain catastrophising and kinesiophobia mediated the improvements in pain intensity and physical function with Pilates exercise.
JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Lise Hestbaek, Anne Mette Schmidt, Majbrit Andsbjerg Hald, Nanna Rolving
Summary: This study investigates the pre-referral history of low back pain patients referred to a spine clinic in a Danish hospital. It found that one third of the patients had not received an adequate course of treatment in primary care before referral. Unemployment and lack of health insurance were associated with a higher likelihood of not receiving appropriate treatment. Therefore, reevaluating the compensation structure for back pain patients is necessary to address health inequality in low back pain management.
Article
Biochemistry & Molecular Biology
Zhou Zhang, Chanjuan Zhang, Yuelong Li, Chuhuai Wang, Qiuhua Yu
Summary: Our study is the first to elucidate the alterations in the lipidomics and metabolomics of cNLBP physiotherapy-based treatment, expanding our knowledge of cNLBP physiotherapy-based treatment.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Biophysics
Fatih Karaarslan, Halim Yilmaz, Halil Ekrem Akkurt, Suleyman Gul, Sinan Kardes
Summary: Peloid therapy combined with home exercise may be superior to home exercise alone in improving pain and function in patients with chronic low back pain, suggesting a potential non-pharmacological treatment option for this patient population. Further randomized studies with longer follow-up and biochemical parameter assessments are needed to confirm and understand the mechanisms of action observed in this study.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2021)
Review
Orthopedics
Ji Ma, Teng Zhang, Yapeng He, Xin Li, Haoyang Chen, Qian Zhao
Summary: Aquatic physical therapy has been shown to benefit patients with chronic low back pain by reducing pain intensity, improving quality of life, and reducing disability. However, more high-quality studies are needed to verify these effects.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rheumatology
Shahul Hameed Pakkir Mohamed, Hamad S. Al Amer, Gopal Nambi
Summary: The study aimed to investigate the effectiveness of Kinesio taping (KT) and conventional physical therapy (CPT) for chronic low back pain (CLBP) patients. The results showed that the combined application of KT and CPT significantly reduced pain and improved functional disability and lumbar flexion range of motion after 2 and 6 weeks.
CLINICAL RHEUMATOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Ying Li, Lei Yan, Lingyu Hou, Xiaoya Zhang, Hanping Zhao, Chengkun Yan, Xianhuang Li, Yuanhe Li, Xiaoan Chen, Xiaorong Ding
Summary: This network meta-analysis found that compared with conventional rehabilitation and no intervention provided, tai chi, yoga, Pilates exercise, sling exercise, motor control exercise, and core or stabilization exercises significantly improved chronic low back pain (CLBP) in patients. Yoga and core or stabilization exercises were statistically significant in improving physical function in patients with CLBP.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Keisuke Shimizu, Kazuhide Inage, Mitsuo Morita, Ryota Kuroiwa, Hiroto Chikubu, Tadashi Hasegawa, Natsuko Nozaki-Taguchi, Sumihisa Orita, Yasuhiro Shiga, Yawara Eguchi, Kazuhiko Takabatake, Seiji Ohtori
Summary: The study aimed to evaluate the treatment effects of cognitive behavioral therapy (CBT), physical therapy (PT), and neurofeedback training (NFT) on chronic low back pain. The findings showed that early-chronic cases had better treatment outcomes, the NFT group had significantly increased alpha wave intensity after intervention, and the combination of CBT and NFT reduced low back pain.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Rui Wang, Dong Zhu, Lin Wang, Jing Liu, Jun Zou, Yang Sun, Yan Jiang, Hao-Yu Hu, Zhi-Wei Deng, Lin-Man Weng, Kang-Yong Zheng, Suparata Kiartivich, Xue-Qiang Wang
Summary: This study aims to compare the effectiveness of Tai Chi Quan and physical therapy in treating chronic low back pain, and explore the feasibility and outcomes of Tai Chi Quan for back pain. The study design includes a randomized controlled trial with a standardized protocol, large sample size, and comprehensive outcomes. The results of this study will provide valuable information for elderly people with low back pain and medical rehabilitation personnel.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, Karen H. Costenbader, Marvin J. Fritzler
Summary: In a longitudinal analysis of a large international incident SLE cohort, three ANA assays demonstrated high positivity rates and commutability. However, over a 5-year follow-up, there was a modest variation in ANA assay performance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C. Loft, Signe Bek Sorensen, Benedicte A. Lie, Mikael Brink, Lisbeth Arlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F. Gudbjartsson, Sigurjon A. Gudjonsson, Gisli H. Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Soren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H. Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G. Loft, Bjorn R. Ludviksson, Sigrun H. Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H. S. Moore, Heidi Munk, Kaspar R. Nielsen, Gudmundur L. Norddahl, Asmundur Oddsson, Thorunn A. Olafsdottir, Pall Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Horslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N. Silberberg, Hreinn Stefansson, Erik Sorensen, Inge J. Sorensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K. Kvien, Soren Brunak, Kristjan Steinsson, Vibeke Andersen, Ole A. Andreassen, Solbritt Rantapaa-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole Bv Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson
Summary: This study identified causal genes for rheumatoid arthritis (RA) and its subsets through a genome-wide association study. Most of these genes encode proteins related to interferon and IL-12/23 signaling, particularly in the JAK/STAT pathway. Variants in some of these genes were found to increase or decrease the risk of seropositive RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Medicine, Research & Experimental
Anders Kirkegaard Jensen, Katerina Chatzidionysiou, Christopher Kirkegaard Torp, Anne Sofie Sorensen, Helene Broch Tenstad, Valentin S. Schafer, Marie Kostine, Soren Jacobsen, Jan Leipe, Tue Wenzel Kragstrup
Summary: This literature review compares the pharmacological management of immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) and reactive arthritis (ReA). The studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GC), methotrexate (MTX), sulfasalazine (SSZ), and tumor necrosis factor alpha inhibition (TNFi) have shown effectiveness in both diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Rheumatology
Ann E. Clarke, John G. Hanly, Murray B. Urowitz, Yvan St. Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Vernon Farewell
Summary: The objective of this study was to estimate the costs associated with neuropsychiatric events in SLE. The study found that new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs. Indirect costs exceeded direct costs by 3.0 to 5.2 fold.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Renata Baronaite Hansen, Titilola Falasinnu, Mikkel Faurschou, Soren Jacobsen, Julia F. Simard
Summary: This study aimed to determine whether diabetes mellitus (DM) increases the risk of end-stage renal disease (ESRD) in patients with systemic lupus erythematosus (SLE). The findings show that SLE patients with DM have a 3 times higher risk of developing ESRD compared to SLE patients without DM.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Louise Pyndt Diederichsen, Line Vinderslev Iversen, Christoffer Tandrup Nielsen, Soren Jacobsen, Marie-Louise Hermansen, Nanna Witting, Rikke Cortes, Sine Sondergaard Korsholm, Markus Engebaek Krogager, Tina Friis
Summary: This study aimed to determine the prevalence and clinical associations of cN-1A autoantibodies in patients with connective tissue diseases. The results showed that cN-1A autoantibodies were predominantly found in patients with idiopathic inflammatory myopathies (IIM) and were associated with dysphagia in sporadic inclusion body myositis (sIBM) patients. Additionally, cN-1A positive non-IBM IIM patients had a milder disease course.
Article
Virology
Julie Knudsen, Nicole Hartwig Trier, Anette Holck Draborg, Christoffer Tandrup Nielsen, Soren Jacobsen, Peter Hojrup, Gunnar Houen
Summary: SLE and DIL are autoimmune diseases associated with EBV and CMV infections, but they differ in onset and clinical symptoms. This study found significantly elevated IgG titers to EBV and CMV antigens in serum samples from SLE and DIL patients, as well as reduced total IgG titers, which may be related to lymphocytopenia commonly seen in SLE.
Article
Microbiology
Rosa Maja Mohring Gynthersen, Mette Frimodt Hansen, Lukas Frans Ocias, Andreas Kjaer, Randi Fons Petersen, Sisse Rye Ostrowski, Lene Harritshoj, Soren Jacobsen, Ulrik Overgaard, Karen Angeliki Krogfelt, Anne-Mette Lebech, Helene Mens
Summary: The presence of N. mikurensis DNA was detected in immunocompromised patients in Denmark, highlighting the potential underdiagnosis of this bacterium in Danish patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, General & Internal
Simon Jonck, Malte Lund Adamsen, Pil Hojgaard, Iben Elmerdahl Rasmussen, Helga Ellingsgaard, Morten Asp Vonsild Lund, Peter Godsk Jorgensen, Soren Jacobsen, Lars Kober, Niels Vejlstrup, Lene Dreyer, Bente Klarlund Pedersen, Ronan M. G. Berg, Regitse Hojgaard Christensen
Summary: The chronic inflammatory state in rheumatoid arthritis (RA) increases the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role. Biological disease-modifying antirheumatic drugs (bDMARDs) may attenuate that risk. IL-6 is also a myokine, secreted from exercising skeletal muscles, where it exhibits anti-inflammatory effects that may mitigate the risk of CVD. We hypothesize that inhibiting IL-6 signaling will impair the cardiac and metabolic adaptations to exercise training compared to TNF inhibition in RA patients.
Article
Rheumatology
Yann Nguyen, Benoit Blanchet, Murray B. Urowitz, John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Joensen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Veronique Le Guern, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Jill Buyon, Nathalie Costedoat-Chalumeau
Summary: The study aimed to assess the association between severe nonadherence to hydroxychloroquine (HCQ), analyzed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates. Severe nonadherence was found to be independently associated with increased risk of SLE flares, early damage, and five-year mortality.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
R. Talarico, G. A. Ramirez, S. C. Barreira, C. Cardamone, P. Triggianese, S. Aguilera, J. Andersen, T. Avcin, K. Benistan, G. Bertsias, A. Bortoluzzi, C. Bouillot, I. Bulina, G. R. Burmester, S. Callens, P. E. Carreira, R. Cervera, M. Cutolo, L. Damian, E. Della Torre, R. Faria, J. E. Fonseca, I. Galetti, E. Hachulla, L. Iaccarino, S. Jacobsen, N. Khmelinskii, M. Limper, D. Marinello, A. Meyer, G. Moroncini, G. Nagy, M. Olesinska, C. Pamfil, M. Pileckyte, M. Pistello, S. Rednic, C. Richez, V. C. Romao, M. Schneider, S. Sciascia, C. A. Scire, G. Simonini, V. Smith, A. Sulli, C. Tani, S. W. Tas, A. Tincani, M. C. Vonk, M. Tektonidou, M. Mosca
Summary: Recent studies have shown that immunocompromised individuals may inadvertently contribute to the mutations of the virus that lead to new variants. This aspect should be carefully considered as immunocompromised individuals remain at risk of COVID-19 despite vaccination, experience more severe disease, and can be contagious for longer. The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET) addressed this issue by forming a multidisciplinary Task Force to develop guidelines for treating immunocompromised patients with COVID-19. The final principles and points-to-consider were agreed upon by the Task Force.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine A. Myhr, Amanda H. Zinglersen, Redi Pecini, Soren Jacobsen
Summary: This study aimed to investigate the prevalence and degree of myocardial fibrosis in SLE patients. The results showed that SLE patients displayed signs of myocardial fibrosis on CMR, which were associated with the presence of lupus anticoagulant (LAC).
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)