Review
Orthopedics
Daniel Berman, Ari Holtzman, Zachary Sharfman, Nathaniel Tindel
Summary: The American College of Radiology has published appropriateness criteria to guide MRI usage, however, private health insurance companies in the United States have inconsistent guidelines for authorizing cervical MRI for neck pain. This study found notable discrepancies and lack of evidence-based literature to support the criteria requirements for prior authorization. Further scrutiny and investigation are warranted.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Orthopedics
Richard A. Wawrose, Forbes E. Howington, Clarissa M. LeVasseur, Clair N. Smith, Brandon K. Couch, Jeremy D. Shaw, William F. Donaldson, Joon Y. Lee, Charity G. Patterson, William J. Anderst, Kevin M. Bell
Summary: This study compared the kinematics of the spine under in vivo and in vitro loading conditions, finding that the in vitro model had a more anterior instant center of rotation and larger disc heights relative to in vivo. However, after adjusting for gender, the differences in disc height were not statistically significant.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Geological
Aylin Nouri, Ali Noorzad, Jean-Michel Pereira, Anh Minh Tang
Summary: A series of 1-g physical model tests were conducted to investigate the effects of cyclic thermal loading on the response of an energy pile subjected to inclined mechanical loading. The results showed that subjecting the pile to thermal cycles after inclined mechanical loading led to irreversible settlement and horizontal displacement at the pile head, which accumulated over the cycles. The accumulation of irreversible horizontal displacement during cyclic thermal loading was found to control the long-term performance of energy pile rather than the capacity.
Article
Biology
Maria Butylina, Katharina Wahl-Figlash, Michael Kothmayer, Katharina Gelles, Oliver Pusch, Peter Pietschmann
Summary: This study investigated the characteristics of intervertebral discs in healthy and deformed Nothobranchius furzeri. The results revealed age- and disease-related alterations in the vertebral discs of N. furzeri, suggesting its potential utility as a model for degenerative spine diseases.
Article
Materials Science, Characterization & Testing
X. Li, A. Heidari, S. M. Nourbakhsh, R. Mohammadi, D. Semiromi
Summary: This study investigates the strengthening of intervertebral discs using 3D printing technique, examines the mechanical properties and biological behavior of artificial discs, and analyzes the behavior of the artificial discs under different loads using Finite Element Method.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt J. Schwaiger, Charlotte Schneider, Sophia Kronthaler, Florian T. Gassert, Christof Boehm, Daniela Pfeiffer, Thomas Baum, Jan S. Kirschke, Dimitrios C. Karampinos, Marcus R. Makowski, Klaus Woertler, Markus Wurm, Alexandra S. Gersing
Summary: The study evaluated the performance of MRI in detecting vertebral fractures and degenerative bone changes, with T1SGRE showing better reliability in detecting vertebral fractures.
EUROPEAN RADIOLOGY
(2021)
Article
Food Science & Technology
Samaneh Tayebi-Moghaddam, Razieh Khatibi, Sevil Taklavi, Mona Hosseini-Isfahani, Hassan Rezaeinia
Summary: In this study, the sustained-release of clove essential oil (CEO) loaded into electrospun nanofibers of zein was used as a biopreservative to extend the shelf life of Iranian white cheese. Different loading levels of CEO affected the fiber structure and mechanical properties, while the gentle release of CEO effectively suppressed bacterial growth in the cheese.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Kemal Arda Guenay, Tze-Ling Chang, Nathaniel P. Skillin, Varsha V. Rao, Laura J. Macdougall, Alicia A. Cutler, Jason S. Silver, Tobin E. Brown, Chi Zhang, Chih-Chieh (Jay) Yu, Bradley B. Olwin, Edward S. Boyden, Kristi S. Anseth
Summary: This article presents a photopolymerized hydrogel formulation that allows for optical clearance and tunable expansion of cell cultures and tissue sections as well as cells embedded within hydrogels. The technology enables high-resolution optical imaging of cells embedded within degradable hydrogels.
Article
Pharmacology & Pharmacy
Xin Zhang, Shibin Shu, Zhenhua Feng, Yong Qiu, Hongda Bao, Zezhang Zhu
Summary: Stabilization of microtubules promotes the expression of COL2 in nucleus pulposus cells, alleviating disc degeneration. This study identifies microtubule as a promising therapeutic target for IDD and up-regulates COL2 synthesis via the Hippo-Yap pathway. Targeting microtubule acetylation may be an effective strategy for treating IDD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Sean Elphick, Duane A. Robinson, Sarath Perera, Jonathan C. Knott, Jason David, Gerrard Drury
Summary: Voltage rise caused by high levels of distributed generation poses challenges for electricity network service providers in terms of voltage regulation. This paper examines the impact of varying voltage levels on residential appliances through an evaluation of appliance performance at different voltage magnitudes. The results highlight the importance of good voltage regulation and provide appliance performance figures for future studies.
IEEE TRANSACTIONS ON POWER DELIVERY
(2022)
Article
Veterinary Sciences
Erin C. Coscia, Nader S. Abutaleb, Bradley Hostetter, Mohamed N. Seleem, Gert J. Breur, Robyn R. McCain, Christa J. Crain, Ondrej Slaby, Manu N. Capoor, Andrew McDowell, Fahad S. Ahmed, Viju Vijayanpillai, Sanjeev K. Narayanan, Michael F. Coscia
Summary: This study demonstrated the feasibility of safely injecting Cutibacterium acnes into sheep intervertebral discs for in vivo research. While bacterial growth was successful in the first set of discs, no growth was detected in the discs from the second set after six months, indicating potential bacterial clearance. Further studies are needed to investigate the pathogenic potential of C. acnes within infected discs.
VETERINARY SCIENCES
(2021)
Article
Biochemical Research Methods
Magali Mercuri, David Fernandez Rivas
Summary: The diversity in skin characteristics and complexity in transport mechanisms limits the effectiveness of medical treatments; lack of fundamental knowledge on transport phenomena hampers the efficacy of bioengineering equipment and medical therapies; research on skin transport mechanisms and advanced transdermal delivery methods could pave the way for better therapies and new methods.
Article
Biotechnology & Applied Microbiology
Jie Li, Yilei Chen, Hao Wu, Zhi Shan, Dikai Bei, Kaifeng Gan, Junhui Liu, Xuyang Zhang, Binhui Chen, Jian Chen, Feng-Dong Zhao
Summary: The study aimed to investigate the effects of low- and high-virulence bacterial infection on cervical intervertebral discs (IVDs) and its association with degeneration. Using animal models and evaluating blood routine, histological staining, and gene expression, it was found that P. acnes infection can lead to IVD degeneration, while S. epidermidis infection manifests as septic discitis. The correlation between P. acnes infection and IVD degeneration found in clinical studies was confirmed.
Article
Astronomy & Astrophysics
Alison K. Young, Richard Alexander, Giovanni Rosotti, Christophe Pinte
Summary: Many circumstellar discs have misaligned central regions, causing shadows in scattered light observations. Small disc warps are difficult to detect but can be identified using CO emission characteristics. Radial profiles reveal the warp structure and the twist of the disc, which can be detected at moderate inclinations. However, the observed twist does not directly measure the warp structure due to its dependency on optical depth. The warp causes broad asymmetries in channel maps, distinct from features caused by embedded planets and gravitational instabilities.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Chemistry, Medicinal
Vara Prasada Rao Regu, Dhananjay Behera, Sai Prathyusha Sunkara, Vinit Gohel, Shyamalendu Tripathy, Ranjit Prasad Swain, Bharat Bhusan Subudhi
Summary: Metformin, a commonly used anti-diabetic medication, has anti-inflammatory properties. This study developed a gel formulation of metformin for topical ocular application, aiming to manage inflammation associated with diabetes. The optimized formulation showed sustained release and demonstrated potential as a safe alternative to steroids for managing ocular inflammation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Psychology, Clinical
Laurent Elkrief, Bochao Lin, Mattia Marchi, Mohammad H. Afzali, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jurjen Luykx, Marco P. Boks, Patricia J. Conrod
Summary: This study examines the relationship between cannabis use, genetic risk for schizophrenia, and psychotic-like experiences. The results suggest that cannabis use remains a risk factor for psychotic-like experiences, above and beyond genetic vulnerability for schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Lisa J. Pijnenburg, Anais Kaplun, Lieuwe de Haan, Magdalena Janecka, Lauren Smith, Abraham Reichenberg, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Eva Velthorst
Summary: This study suggests that autistic traits are associated with less frequent and lower quantity of alcohol use during adolescence. Adolescents with higher levels of autistic traits, including social impairment, detail orientation, and anxiety, were found to consume less alcohol and engage in less binge drinking.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Raka Maitra, Charlotte M. Horne, Owen O'Daly, Evangelos Papanastasiou, Christian Gaser, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne M. Winterer, Robert Whelan, Erin Burke Quinlan, Alex Ing, Gunter Schumann, Sukhi Shergill
Summary: The study found that Psychotic Like Experiences (PLEs) in adolescents are associated with changes in cortical gyrification, indicating abnormal neurodevelopment. Adolescents with higher PLEs had lower cortical gyrification in the fronto-temporal regions in the left hemisphere, and higher cortical gyrification in the right parietal cortex during late adolescence. The study also revealed that adolescents with high PLEs were 5.6 times more likely to develop psychosis by age 23.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Computer Science, Interdisciplinary Applications
J. Thewlis, D. Stevens, H. Power, D. Giddings, P. Gowland, M. Vloeberghs
Summary: This study introduces a four-dimensional local radial basis function interpolation method for reconstructing complex flow phenomena in medical image velocimetry datasets. The proposed method shows promising results in both experiments and applications, offering a potential tool for medical diagnoses and drug delivery.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhipeng Cao, Renata B. Cupertino, Jonatan Ottino-Gonzalez, Alistair Murphy, Devarshi Pancholi, Anthony Juliano, Bader Chaarani, Matthew Albaugh, Dekang Yuan, Nathan Schwab, James Stafford, Anna E. Goudriaan, Kent Hutchison, Chiang-Shan R. Li, Maartje Luijten, Martine Groefsema, Reza Momenan, Lianne Schmaal, Rajita Sinha, Ruth J. van Holst, Dick J. Veltman, Reinout W. Wiers, Bernice Porjesz, Tristram Lett, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Gunter Schumann, Robert Whelan, Ravi R. Bhatt, Alyssa Zhu, Patricia Conrod, Neda Jahanshad, Paul M. Thompson, Scott Mackey, Hugh Garavan
Summary: In this study, researchers identified a shared spatial pattern of cortical thickness (CT) in normative development and several psychiatric and neurological disorders. Further analysis revealed significant spatial correspondences between this pattern and widespread lower CT observed in psychiatric disorders, as well as the spatial pattern of normative maturation and aging. Transcriptional analysis also identified a set of genes closely related to this pattern, indicating disrupted neurodevelopment in the pathogenesis of psychiatric diseases emerging during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Alice Chavanne, Marie Laure Paillere Martinot, Jani Penttilae, Yvonne Grimmer, Patricia Conrod, Argyris Stringaris, Betteke van Noort, Corinna Isensee, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah S. Hohmann, Sabina Millenet, Juliane Froehner, Michael Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc Martinot, Eric Artiges
Summary: Recent studies have found MRI correlates of prospective anxiety symptoms in youth, but their predictive value is still uncertain. This study used machine-learning algorithms to predict clinical anxiety using MRI data and psychometric scores. The results showed that psychometric features were the main predictors for overall anxiety disorders, while MRI regional volumes were more valuable for predicting GAD. In conclusion, future clinical anxiety in non-anxious 14-year-old adolescents can be individually predicted using psychometric features, and including neuroanatomical data improves the prediction of GAD.
MOLECULAR PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Biochemistry & Molecular Biology
Upasana Gupta, Natish Kumar, Akash Lata, Preeti Singh, Ravi Kumar Arun
Summary: In this study, researchers have developed a spiral-shaped microfluidic device with a modified nanohybrid membrane for efficient filtration of urea. This device mimics the main features of the kidney and has the potential for organ-on-a-chips applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Monika Kumari, Verruchi Gupta, Natish Kumar, Ravi Kumar Arun
Summary: Efficient healthcare management relies on fast diagnostics tools, astute data analysis, and informatics analysis for prompt decision-making. Utilizing microfluidics in synergy with nanotechnology and biotechnology ensures rapid analyte detection at the point of care. Nanobiosensors, using nanotechnology for testing, enable rapid disease diagnosis, monitoring, and management. They detect biomolecules through bioreceptors and generate optical and electrical signals, aiding in early disease identification.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Meshari T. Alshammari, Ali S. Alyami, Victoria Wilkinson-Smith, Robin C. Spiller, Penny Gowland, Luca Marciani, Gordon W. Moran, Caroline L. Hoad
Summary: This study evaluated the reliability and variability of MRI tagging techniques for assessing colonic chyme mixing. The results showed that this technique can accurately assess the mixing of food in the colon and has high inter-rater agreement. Furthermore, the reliability of the technique did not significantly vary over time.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Transplantation
Venkata R. Latha Gullapudi, Eleanor F. Cox, Charlotte E. Buchanan, Bernard Canaud, Kelly White, Maarten W. Taal, Nicholas M. Selby, Susan T. Francis
Summary: A randomized trial was conducted to compare the effects of standard HD and thermocontrolled HD on structural, functional, and blood flow changes in the heart, brain, and kidneys. The results showed that HD adversely affects cardiac function, arterial blood flow, and kidney volume, but mild dialysate cooling does not change these effects.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Neurosciences
Radu Tanasescu, Olivier Mougin, I-Jun Chou, Ali Al-Radaideh, Oltita P. Jerca, Su-Yin Lim, Penny Gowland, Cris S. Constantinescu
Summary: Natalizumab can prevent the progression of microstructural tissue damage in patients with multiple sclerosis, as shown by high-field MRI.
Article
Chemistry, Physical
M. Kesava Reddy, P. Jaya Shalini, Nitin P. Lobo, Arun Roy, T. Narasimhaswamy
Summary: The overall molecular shape is crucial in determining the formation of liquid crystalline phases, as molecules rotate about their long axis. Molecular topology, which deals with the connectivity of atomic centers, plays an important role in the gross molecular shape. C-13 NMR is the most important technique for determining the molecular topology of mesogens in the liquid crystalline phase. In this study, we used C-13-H-1 dipolar couplings from 2D NMR to find the topology of three different mesogens. The dipolar couplings were found to be sensitive to the core unit topology, allowing us to establish the molecular topology based on the protonated carbons of the constituent phenyl rings.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Physics, Fluids & Plasmas
Dipak Patra, Arun Roy
Summary: The spontaneous breaking of chiral symmetry in banana-shaped molecules is attributed to the excluded volume interactions between them.