Article
Orthopedics
Xun Wang, Yanze Lin, Wenchao Yao, Aiqi Zhang, Liqing Gao, Fabo Feng
Summary: This study conducted a bibliometric analysis of articles related to surgical site infection (SSI) in spine surgery to identify the research status and trends in this field. The research found an increasing number of studies on SSI in recent years, with a focus on the prevention of spinal SSI and the identification of risk factors.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Dermatology
Jiang Xie, Yuxuan Du, Zejiu Tan, Hao Tang
Summary: A meta-analysis was conducted to evaluate the relationship between malnutrition and surgical site infection (SSI) after spinal surgery. The results showed that malnutrition significantly increased the incidence of SSI. However, further high-quality studies with larger sample sizes are needed to validate these results.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Xinxin Zhang, Peng Liu, Jipeng You
Summary: This study used a meta-analysis to investigate risk factors for surgical site infection (SSI) following spinal surgery. The results showed that fusion approach, osteotomy, transfusion, a history of diabetes and surgery, hypertension, surgical location, osteoporosis, and the number of fusion levels were associated with SSI.
Article
Clinical Neurology
Alice Boishardy, Benjamin Bouyer, Louis Boissiere, Daniel Larrieu, Susana Nunez Pereira, David Kieser, Ferran Pellise, Ahmet Alanay, Frank Kleinstuck, Javier Pizones, Ibrahim Obeid
Summary: Surgical site infection (SSI) significantly increases the risk of pseudarthrosis after adult spinal deformity (ASD) surgery. Other risk factors include BMI, smoking, performance of Smith-Petersen osteotomy, number of vertebrae instrumented, and the caudal level of fusion.
Article
Medicine, General & Internal
Leon-Gordian Koepke, Annika Heuer, Martin Stangenberg, Marc Dreimann, Lutz Welker, Carsten Bokemeyer, Andre Strahl, Anne Marie Asemissen, Lennart Viezens
Summary: Our study demonstrates that cytological evaluation of spinal lesions suspected of malignancy can provide a quick and reliable diagnosis of the underlying disease in patients with new-onset malignant spinal lesions, facilitating appropriate treatment. Implementing this process as a routine clinical diagnostic can shorten the time to diagnosis and improve treatment outcomes for this vulnerable patient group.
Review
Medicine, General & Internal
Jessica L. Seidelman, Christopher R. Mantyh, Deverick J. Anderson
Summary: Surgical site infections occur in 0.5% to 3% of patients undergoing surgery and are associated with longer hospital stays. Measures such as avoiding razors, maintaining normothermia, using chlorhexidine gluconate plus alcohol-based skin preparation, decolonization with intranasal antistaphylococcal agents, controlling perioperative glucose concentrations, and using negative pressure wound therapy can reduce the rate of surgical site infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Kei Watanabe, Toru Yamaguchi, Satoshi Suzuki, Teppei Suzuki, Keita Nakayama, Satoru Demura, Yuki Taniguchi, Takuya Yamamoto, Ryo Sugawara, Tatsuya Sato, Kenta Fujiwara, Hideki Murakami, Tsutomu Akazawa, Kenichiro Kakutani, Toru Hirano, Haruhisa Yanagida, Kota Watanabe, Morio Matsumoto, Koki Uno, Toshiaki Kotani, Katsushi Takeshita, Tetsuya Ohara, Noriaki Kawakami
Summary: A retrospective multicenter study was conducted to determine the SSI rate, associated risk factors, and causative pathogens in pediatric patients with spinal deformity. The overall infection rate was low and the most common causative bacteria were methicillin-resistant staphylococci followed by gram-negative rods. Independent risk factors for SSI included scoliosis etiology, ASA class 3, and administration of antibiotic therapy twice daily.
Article
Clinical Neurology
Kei Watanabe, Toru Yamaguchi, Satoshi Suzuki, Teppei Suzuki, Keita Nakayama, Satoru Demura, Yuki Taniguchi, Takuya Yamamoto, Ryo Sugawara, Tatsuya Sato, Kenta Fujiwara, Hideki Murakami, Tsutomu Akazawa, Kenichiro Kakutani, Toru Hirano, Haruhisa Yanagida, Kota Watanabe, Morio Matsumoto, Koki Uno, Toshiaki Kotani, Katsushi Takeshita, Tetsuya Ohara, Noriaki Kawakami, Japan Spinal Deformity Inst Study Grp
Summary: The study revealed a low rate of surgical site infection in pediatric patients undergoing spinal deformity surgery, with the most common causative bacteria being methicillin-resistant staphylococci and gram-negative rods. Independent risk factors included scoliosis etiology, ASA class 3, and administration of antibiotic therapy twice daily.
Article
Infectious Diseases
Margaret A. Olsen, Jacob K. Greenberg, Kate Peacock, Katelin B. Nickel, Victoria J. Fraser, David K. Warren
Summary: This study aims to investigate the prevalence and factors associated with post-discharge prophylactic antibiotic use after spinal fusion, as well as its relationship with the risk of surgical site infection (SSI). Data from the MarketScan Commercial Database were analyzed, and it was found that post-discharge prophylactic antibiotic use was not associated with decreased SSI risk.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Clinical Neurology
Dustin R. Long, Chloe Bryson-Cahn, Ronald Pergamit, Celeste Tavolaro, Rajiv Saigal, Jeannie D. Chan, John B. Lynch
Summary: This retrospective hospital-registry study aimed to characterize the microbial epidemiology of surgical site infection in spinal fusion surgery and the burden of resistance to standard surgical antibiotic prophylaxis. The results revealed a gradient in the microbiology of infections along the spine, with the majority of infections showing resistance to the prophylactic antibiotics administered during surgery.
Article
Clinical Neurology
Hui Ying, Zhi-Wen Luo, Ai-Fen Peng, Qi-Kun Yang, Xin Wu, Xuan-Yin Chen, Shan-Hu Huang, Jia-Ming Liu, Zhi-Li Liu
Summary: This study aimed to investigate the incidences of postoperative acute surgical site infection (SSI) after lumbar spinal surgery. It found that Gram-negative bacteria, particularly Escherichia coli, were the most common pathogens in postoperative SSI cases, with patients with lumbar spinal stenosis having the highest incidence. The rate of postoperative SSI following lumbar spinal surgery showed fluctuations over the past 9 years, with changes in the types of infections observed.
EUROPEAN SPINE JOURNAL
(2022)
Article
Surgery
Xiaowen Liu, Yang Hou, Hongyang Shi, Tianyi Zhao, Haoyang Shi, Jiangang Shi, Guodong Shi
Summary: This study used meta-analysis to investigate the potential risk factors for non-superficial surgical site infection (SSI) following spinal surgery. The results showed that diabetes mellitus, obesity, using steroids, drainage time, and operative time were related to non-superficial SSI. Among these factors, operative time was found to be the most important risk factor.
Review
Medicine, General & Internal
Stuart Hastings, Paul S. Myles, Robert L. Medcalf
Summary: Surgical site infections (SSIs) are a common economic burden that increase patient morbidity and mortality. Although antibiotic prophylaxis is the primary prevention intervention, it may be less effective due to emerging antibiotic resistant organisms. Exploration of novel therapies, such as tranexamic acid, as adjunct to antibiotics is warranted to reduce SSIs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Masahiro Kuroiwa, Jordy Schol, Daisuke Sakai, Natsumi Horikita, Akihiko Hiyama, Hiroyuki Katoh, Yukihiro Yamamoto, Masato Sato, Masahiko Watanabe
Summary: This study aimed to identify prognostic indicators for successful treatment of spinal instrumentation surgical site infection (SSI). The results demonstrated that early selection of sensitive antimicrobial agents is critical, and infections caused by Staphylococcus aureus (S. Aureus) and methicillin-resistant Staphylococcus aureus (MRSA) are more challenging to treat.
Article
Surgery
Louay Baroun-Agob, Susan Liew, Belinda Gabbe
Summary: This study investigated the impact of surgical site infections (SSI) on patient outcomes in spinal trauma cohort and found that although SSI was associated with sepsis, readmission, revision surgery, and removal of implants, there were no differences in patient-reported outcomes between patients with and without SSI.
ANZ JOURNAL OF SURGERY
(2021)
Article
Clinical Neurology
Tsutomu Endo, Shiro Imagama, Satoshi Kato, Takashi Kaito, Hiroaki Sakai, Shiro Ikegawa, Yoshiharu Kawaguchi, Masahiro Kanayama, Yuichiro Hisada, Yoshinao Koike, Kei Ando, Kazuyoshi Kobayashi, Itaru Oda, Kazufumi Okada, Ryo Takagi, Norimasa Iwasaki, Masahiko Takahata
Summary: The study revealed that male early-onset OPLL patients had vitamin A deficiency associated with OPLL exacerbation, and lower levels of vitamin B6 compared to non-OPLL controls. Serum validation results showed lower levels of vitamins A and B6 in early-onset thoracic OPLL patients.
GLOBAL SPINE JOURNAL
(2022)
Article
Rheumatology
Ken Ueoka, Tamon Kabata, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Takuro Ueno, Junya Yoshitani, Yuki Yamamuro, Atsushi Taninaka, Satoshi Kato, Tetsutaro Yahata, Hiroyuki Tsuchiya
Summary: The prevalence of AWGS sarcopenia in patients awaiting total hip arthroplasty for osteoarthritis was 33.3%. The lower-HGS group exhibited significantly poorer physical function and JOA score than the normal-HGS group in both pre- and postoperative analyses. Postoperatively, the AWGS-sarcopenia group showed only poorer hand grip strength.
MODERN RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Takashi Hirai, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Yukihiro Nakagawa, Kanichiro Wada, Keiichi Katsumi, Kengo Fujii, Atsushi Kimura, Takeo Furuya, Narihito Nagoshi, Tsukasa Kanchiku, Yukitaka Nagamoto, Yasushi Oshima, Kei Ando, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Shunji Matsunaga, Takashi Kaito, Kei Yamada, Sho Kobayashi, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Shiro Imagama, Masao Koda, Yoshiharu Kawaguchi, Katsushi Takeshita, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: This study is the first large-scale, prospective, multicenter case series study to investigate factors influencing preoperative neurological status in patients with cervical ossification of the posterior longitudinal ligament (OPLL). The study found that age and signal intensity change on magnetic resonance imaging were significantly associated with Japanese Orthopedic Association (JOA) score in patients requiring surgery.
CLINICAL SPINE SURGERY
(2022)
Article
Oncology
Satoshi Kato, Satoru Demura, Hideki Murakami, Kazuya Shinmura, Noriaki Yokogawa, Ryohei Annen, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Norio Kawahara, Hiroyuki Tsuchiya
Summary: Metastasectomy is a reasonable treatment option for patients with isolated and removable spinal metastases, with better survival outcomes observed in patients with thyroid cancer.
Article
Orthopedics
Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Ko Hashimoto, Yoshito Onoda, Kenichiro Kakutani, Yuji Kakiuchi, Nobuyuki Suzuki, Kenji Kato, Yoshinori Terashima, Ryosuke Hirota, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Shoji Seki, Hitoshi Tonomura, Munehiro Sakata, Hiroshi Uei, Hirokatsu Sawada, Hiroyuki Tominaga, Hiroto Tokumoto, Takashi Kaito, Yoichi Iizuka, Eiji Takasawa, Yasushi Oshima, Hidetomi Terai, Koji Tamai, Bungo Otsuki, Masashi Miyazaki, Hideaki Nakajima, Kazuo Nakanishi, Kosuke Misaki, Gen Inoue, Katsuhito Kiyasu, Koji Akeda, Norihiko Takegami, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, Satoshi Kato
Summary: The 1-year mortality rate after spinal fusion surgery for cervical fracture in patients 65 years of age or older was 8%, and it was associated with a higher Charlson comorbidity index score, a more severe American Spinal Cord Injury Association impairment scale, and a longer surgical time. The rate of deterioration in walking capacity was 33%, and it was associated with a more severe American Spinal Cord Injury Association impairment scale, lower albumin and hemoglobin values, and a larger number of fused segments.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Ryohei Annen, Satoshi Kato, Satoru Demura, Shinji Miwa, Akira Yokka, Kazuya Shinmura, Noriaki Yokogawa, Noritaka Yonezawa, Motoya Kobayashi, Yuki Kurokawa, Toshifumi Gabata, Hiroyuki Tsuchiya
Summary: We investigated the abscopal effect after cryoablation on bone metastasis in a mouse model. The results showed that cryoablation alone had a significant immunoenhancing effect, which was further enhanced by combination treatment with PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Satoshi Kato, Satoru Demura, Kazuya Shinmura, Noriaki Yokogawa, Yuki Kurokawa, Ryohei Annen, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Hidenori Matsubara, Tamon Kabata, Hiroyuki Tsuchiya
Summary: This study prospectively investigated potential risk factors associated with future osteoporotic vertebral fracture (OVF) in middle-aged and older adult women. The results showed that abdominal trunk muscle weakness, low L-BMD, and the presence of old OVFs were significant risk factors for OVF occurrence in the future.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Motoya Kobayashi, Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Tsuchiya, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Junichi Yamane, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe
Summary: For older patients with decreased reserve function, traumatic cervical spine injuries often result in early mortality. This study aimed to identify prognostic factors for early mortality in this patient population. The analysis included 1512 patients aged >= 65 years who were hospitalized for treatment of traumatic cervical spine injuries. The results showed that older age, male sex, cervical spine fracture, complete motor paralysis, and chronic kidney disease were risk factors for early mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yohei Asano, Norio Yamamoto, Satoru Demura, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, Sei Morinaga, Takashi Sone, Miho Okuda, Isao Matsumoto, Seiji Yano, Hiroyuki Tsuchiya
Summary: This retrospective study investigated the therapeutic effects of immune checkpoint inhibitors (ICIs) and identified predictors of favorable response and prognosis in advanced non-small-cell lung cancer (NSCLC) patients with bone metastases. The study found a response rate of 30.9% and a median survival time of 9.3 months. Factors such as female sex, use of ICIs as first-line therapy, and pretreatment neutrophil-to-lymphocyte ratio (NLR) less than 2.1 were identified as predictors of therapeutic response, while concomitant use of a bone-modifying agent, Katagiri score <= 6 points, and NLR <2.1 were identified as predictors of good prognosis.
Article
Medicine, General & Internal
Masafumi Kawai, Satoru Demura, Satoshi Kato, Noriaki Yokogawa, Takaki Shimizu, Yuki Kurokawa, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Takaaki Uto, Hideki Murakami
Summary: Overall, total en bloc spondylectomy is an effective treatment for spinal tumors, but it carries a high risk of complications and the associated risk factors are not well understood. This study aimed to identify the risk factors for postoperative complications after total en bloc spondylectomy, including frailty and inflammatory biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yohei Yamada, Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Tsuchiya, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Junichi Yamane, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe
Summary: This study aimed to analyze the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. A total of 1512 elderly patients aged >= 65 years with traumatic cervical injuries were included, and 95 patients (6.3%) had dementia. The analysis showed that patients with dementia were older, predominantly female, had lower body mass index, higher frailty index, lower pre-injury activities of daily living, and more comorbidities compared to patients without dementia. Patients with dementia had poorer activities of daily living at 6 months and a higher incidence of dysphagia up to 6 months. Kaplan-Meier analysis also revealed a higher mortality rate in patients with dementia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Noriaki Yokogawa, Satoshi Kato, Takaki Shimizu, Yuki Kurokawa, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Masafumi Kawai, Takaaki Uto, Hideki Murakami, Norio Kawahara, Satoru Demura
Summary: This study investigated the clinical outcomes of total en bloc spondylectomy (TES) for spinal metastases previously treated with radiotherapy (RT). A total of 142 patients were enrolled and divided into two groups: those with and without a history of RT. Postoperative complications, local recurrence, and overall survival rates were evaluated. The group with an RT history had a significantly higher incidence of postoperative complications and a higher local recurrence rate compared to the group without an RT history. The overall postoperative survival tended to be lower in the group with an RT history, but the difference was not statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
S. Kato, S. Demura, N. Yokogawa, T. Shimizu, M. Kobayashi, Y. Yamada, H. Murakami, H. Tsuchiya
Summary: This study aimed to examine the long-term clinical outcomes of metastasectomy for spinal metastases of differentiated thyroid carcinomas (DTC). The results showed that metastasectomy for resectable DTC SMs yielded favorable results and had the potential to improve survival. Pre- and postoperative disability and operative site tumor recurrence were identified as risk factors for short postoperative survival.
BONE & JOINT JOURNAL
(2023)
Article
Orthopedics
T. Shimizu, S. Kato, S. Demura, K. Shinmura, N. Yokogawa, Y. Kurokawa, K. Yoshioka, H. Murakami, N. Kawahara, H. Tsuchiya
Summary: The aim of this study was to investigate the incidence and characteristics of instrumentation failure (IF) after total en bloc spondylectomy (TES) and analyze risk factors for IF. The medical records of 136 patients who underwent TES were reviewed retrospectively. It was found that IF is a common complication following TES, and factors such as cage subsidence and type of bone graft used are independent risk factors for IF.
BONE & JOINT JOURNAL
(2023)
Article
Rheumatology
Satoshi Kato, Satoru Demura, Tamon Kabata, Hidenori Matsubara, Yuki Kurokawa, Yoshitomo Kajino, Yoshiyuki Okamoto, Kazunari Kuroda, Hiroaki Kimura, Kazuya Shinmura, Noriaki Yokogawa, Takaki Shimizu, Kentaro Igarashi, Daisuke Inoue, Hiroyuki Tsuchiya
Summary: This study aimed to evaluate the condition and improvement of patients with locomotive syndrome (LS) after undergoing surgery for degenerative musculoskeletal diseases. The results showed that the new LS stage criteria are appropriate and the 25-Question Geriatric Locomotive Function Scale is a good option for evaluating patients requiring surgery. The study also found that the knee group had the worst results, while the foot and ankle groups had the best pre- and postoperative results.
MODERN RHEUMATOLOGY
(2022)
