Review
Orthopedics
Jennifer Fayad, Peter Endre Eltes, Aron Lazary, Luca Cristofolini, Rita Stagni
Summary: The literature offers various stereophotogrammetric protocols for quantifying the multi-segmental motion of the thoracolumbar spine, but a standard guideline is lacking. From a clinical perspective, the application of these approaches is still limited. Further research is needed to define a precise motion analysis protocol and determine its clinical relevance.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biotechnology & Applied Microbiology
Mohammad Mehdi Alemi, Katelyn A. Burkhart, Andrew C. Lynch, Brett T. Allaire, Seyed Javad Mousavi, Chaofei Zhang, Mary L. Bouxsein, Dennis E. Anderson
Summary: The study evaluated the performance of different kinematic constraints for inverse kinematics analysis in spine motion. Results showed that adding more DOF to kinematic constraints did not notably improve performance, with 4-6DOF constraints producing similar levels of smoothness and physiologically reasonable joint ROMs. A kinematic constraint with 5DOF was found to produce smooth spine motions with relatively low marker error.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Clinical Neurology
Mazda Farshad, Frederic Cornaz, Jose Miguel Spirig, Reto Sutter, Nadja A. Farshad-Amacker, Jonas Widmer
Summary: The location and cranio-caudal extent of spondylophytes are crucial for their biomechanical effects, and a classification system can help in clinical decision-making. Non-bridging spondylophytes primarily act as tensile structures, while spondylophytes with osseous bridging contribute significantly in most loading conditions.
Article
Biophysics
Samuel Haupt, Frederic Cornaz, Anna L. Falkowski, Mazda Farshad, Jonas Widmer
Summary: In the flexed end-of-range position, the trunk is passively stabilized. This study investigates the effect of posterior surgical interventions on local and distant spinal regions.
JOURNAL OF BIOMECHANICS
(2023)
Article
Biotechnology & Applied Microbiology
Paul Mcmullin, Darian Emmett, Andrew Gibbons, Kelly Clingo, Preston Higbee, Andrew Sykes, David T. Fullwood, Ulrike H. Mitchell, Anton E. Bowden
Summary: This study utilized an optical motion capture system and a new marker set to non-invasively measure the dynamic, 3D in vivo segmental kinematics of the lower spine in a laboratory setting. The results were consistent with previous studies and identified motion coupling paradigms in the lumbar spinal segments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
William R. Reed, Carla R. Lima, Michael A. K. Liebschner, Christopher P. Hurt, Peng Li, Maruti R. Gudavalli
Summary: This study examined the effects of spinal manipulation on muscle pressure and applied forces in a animal model. The findings indicate that the viscoelastic properties of muscle and other soft tissues greatly diminish the forces and pressures applied during spinal manipulation, which could have clinical implications for the treatment of low back pain.
Article
Clinical Neurology
Marc Auerswald, Philipp Messer-Hannemann, Kay Sellenschloh, Jan Wahlefeld, Klaus Pueschel, Sven Hirschfeld Araujo, Michael M. Morlock, Arndt P. Schulz, Gerd Huber
Summary: This biomechanical study evaluated the effect of lag-screws on vertebral pincer fractures at the thoracolumbar junction. Results indicated promising outcomes, with increased bony contact in bolted specimens, potentially aiding in bony healing for these fractures.
GLOBAL SPINE JOURNAL
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Roberto Izzo, Sinan Al Qassab, Teresa Popolizio, Rosario Francesco Balzano, Marco Perri, Victor Cassar-Pullicino, Giuseppe Guglielmi
Summary: Spine trauma is a serious event with high morbidity and mortality, requiring advanced imaging techniques like multidetector computed tomography (MDCT) and MRI for accurate assessment of bone damage, soft tissue structures, and spinal cord injuries. Advanced MRI techniques, such as diffusion weighted imaging (DWI) and tractography, are increasingly being used to improve outcome prognostication in spinal injuries.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Environmental Sciences
Justyna Fercho, Michal Krakowiak, Rami Yuser, Tomasz Szmuda, Piotr Zielinski, Dariusz Szarek, Samuel D. Pettersson, Grzegorz Miekisiak
Summary: Despite the lack of clear evidence of proper spine stabilization during daily activities when wearing orthopedic braces, this study found that different types of braces provide varying levels of stability in the sagittal plane and rotational axis during basic tasks. The feedback pressure from the braces may stimulate paraspinal muscles, increasing trunk rigidity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Hui Lu, Qichuan Zhang, Fan Ding, Qimei Wu, Rong Liu
Summary: This study established and validated a three-dimensional finite element model of the thoracolumbal segments T12-L2. The results provide a practical reference for clinical work and are important for the establishment of a three-dimensional finite element model of the thoracolumbar junction.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Biology
Brittany Stott, Mark Driscoll
Summary: The geometric alignment of the spine affects stability, biomechanical loading, and pain. Variations in sagittal curvature can lead to different load distributions and range of motion. Finite element modeling reveals that excessive curvatures result in greater stress and reduced disc height, while straighter spines reduce stress. Considering patient-specific sagittal profiles in biomechanical analyses and treatments can provide valuable insights.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Justyna Fercho, Michal Krakowiak, Rami Yuser, Tomasz Szmuda, Piotr Zielinski, Dariusz Szarek, Grzegorz Miekisiak
Summary: This study aimed to determine the region with the greatest flexion in the cervical spine during smartphone use and explore the role of symmetry in maintaining this posture. The results showed that the C0-C1 joint was the area with the highest flexion. When using smartphones, there is an involuntary rotation of the cervical spine towards symmetry and a fast corrective movement towards the hand holding the device.
Article
Physiology
Robbert N. van Amstel, Richard T. Jaspers, Annelies L. Pool-Goudzwaard
Summary: Low back pain is associated with mobility impairments in the spine, pelvis, and hip. This study aimed to assess the effects of fascia tissue manipulation through lumbodorsal skin displacement (SKD) on the range of motion (ROM) in healthy subjects. The results showed that SKD had a significant effect on flexion and extension ROM, with the effect depending on the location and displacement direction. The intertester and intratester reliability of SKD were also found to be good.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Gabriella Fischer, Michael Alexander Wirth, Simone Balocco, Maurizio Calcagni
Summary: This study compared an inertial measurement unit-based system with an optoelectronic motion capture system for dart-throwing motion, showing challenges of comparing results of different kinematic motion capture systems for complex movements and highlighting the potential clinical application of inertial measurement units for dynamic and coupled wrist movements.
Article
Chemistry, Analytical
Haohan Song, Chaoqing Dong, Jicun Ren
Summary: This study introduced a new method for real-time and quantitative monitoring of autophagosomes and assessing autophagic flux based on fluorescence correlation spectroscopy (FCS). A parameter P-AP was proposed as an indicator to assess the basal autophagic activity and induced autophagic flux. This method shows high spatiotemporal resolution and very high sensitivity for autophagosomes in low EGFP-LC3B expressing cells and can be used in biological and medical studies, drug screening, and disease treatment.
Article
Otorhinolaryngology
C. Offergeld, M. Ketterer, M. Neudert, F. Hassepass, N. Weerda, B. Richter, L. Traser, C. Becker, N. Deeg, A. Knopf, T. Wesarg, A-K. Rauch, T. Jakob, F. Ferver, F. Lang, V. Vielsmeier, S. Hackenberg, M. Diensthuber, M. Praetorius, B. Hofauer, N. Mansour, S. Kuhn, T. Hildenbrand
Summary: The study revealed successful examples of transformation of classroom teaching to an exclusively virtual summer semester 2020 within university ENT clinics, but critical ratings from assistant professors and medical directors dominated regarding the current teaching situation. Urgent time-critical strategic advancement is needed.
Article
Otorhinolaryngology
Friederike Lang, Ben Everad, Andreas Knopf, Sebastian Kuhn, Christian Offergeld
Summary: This study evaluated the structure, functions, and usage of the ENT Learning Program developed by the University Hospital of Freiburg. Findings from questionnaire surveys and website visit data indicated that students widely used the program and perceived it as beneficial for exam preparation and motivation. The controlled study showed significantly better test outcomes in students who used the program.
LARYNGO-RHINO-OTOLOGIE
(2021)
Article
Surgery
Sebastian Kuhn, Florentine Huettl, Kim Deutsch, Elisa Kirchgaessner, Tobias Huber, Werner Kneist
Summary: This study evaluated a newly developed learning/teaching concept for the digital transformation of medicine, focusing on surgical teaching, through a series of courses involving virtual reality, augmented reality, and robotics, combined with semi-structured interviews and standardized evaluation questionnaires. Students considered expert discussion as an essential part of the course concept, and viewed it as a horizon-widening learning experience with high practical relevance. Quantitative student evaluation showed a positive development in knowledge, skills, and attitude.
ZENTRALBLATT FUR CHIRURGIE
(2021)
Article
Emergency Medicine
Iris Reiner, Manfred E. Beutel, Philipp Winter, Pol M. Rommens, Sebastian Kuhn
Summary: High distress and being involved in a car accident were identified as potential risk factors for the development of posttraumatic stress in trauma patients recruited from the resuscitation room.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Julia Greenfield, Philipp Appelmann, Felix Wunderlich, Dorothea Mehler, Pol Maria Rommens, Sebastian Kuhn
Summary: The study assessed the feasibility of using retrograde tibial nailing with double rather than triple-distal locking for far distal tibia fractures. It was found that the use of double locking preserved a significant amount of stiffness while maintaining stability in the fracture site.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Psychiatry
Severin Hennemann, Sebastian Kuhn, Michael Witthoeft, Stefanie M. Jungmann
Summary: This study tested the diagnostic performance of a widely available symptom checker in the context of formal diagnosis of mental disorders. The results showed that the tool could provide clinicians with a list of condition suggestions with moderate-to-good accuracy, but there were differences in diagnostic performance between disorder categories and low interrater reliability. Approximately 71% of participants preferred face-to-face diagnosis.
JMIR MENTAL HEALTH
(2022)
Article
Education & Educational Research
Elizabete Neutel, Sebastian Kuhn, Peter Driscoll, Carl Gwinnutt, Zelia Moreira, Ana Veloso, Maria Conceicao Manso, Antonio Carneiro
Summary: This study aimed to assess the self-perceived impact of the European Trauma Course (ETC) on Reanima trainees' behavior and organizational change. A questionnaire based on Holton's evaluation model was used to evaluate the candidates' perceptions. The results showed that participation in the ETC led to behavioral changes in trauma care and had a significant impact on individuals' attitudes.
BMC MEDICAL EDUCATION
(2023)
Article
Health Care Sciences & Services
Igor Bibi, Daniel Schaffert, Mara Blauth, Christian Lull, Jan Alwin von Ahnen, Georg Gross, Wanja Alexander Weigandt, Johannes Knitza, Sebastian Kuhn, Johannes Benecke, Jan Leipe, Astrid Schmieder, Victor Olsavszky
Summary: This study used AutoML to analyze clinical research data of patients with chronic eczema or psoriasis who used a smartphone monitoring app. The study found correlations between important features and outcomes, highlighting the potential of smartphone and AutoML techniques in improving chronic disease management and patient care.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Lena Rettinger, Sebastian Kuhn
Summary: This study aimed to identify and map the perceived barriers to the use of video call-based telehealth interventions among allied health professionals and nurses. After conducting 56 studies in various countries, the barriers were categorized into 8 main categories and 23 subcategories. Common barriers included technology issues, practice issues, patient issues, environmental issues, attributions, interpersonal issues, policies and regulations, and administration issues.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Sebastian Griewing, Niklas Gremke, Uwe Wagner, Michael Lingenfelder, Sebastian Kuhn, Jelena Boekhoff
Summary: The recent availability of large language models (LLMs) has sparked interest in using artificial intelligence for medical purposes. This study compares the treatment recommendations of the LLM ChatGPT 3.5 with those of a tumor board for breast cancer. The results show that while there is some agreement between the LLM and the tumor board, there are also significant discrepancies, raising concerns about the reliability of publicly available LLMs for medical decision-making.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
Sophie von Rohr, Johannes Knitza, Manuel Grahammer, Marc Schmalzing, Sebastian Kuhn, Georg Schett, Andreas Ramming, Hannah Labinsky
Summary: The study aimed to investigate the use of student-led clinics and electronic patient-reported outcomes (ePROs) for the diagnosis and treatment of patients with axial spondyloarthritis (axSpA). The results showed that student-led clinics significantly accelerated patient appointments and NSAID therapy start, and completed the diagnostic workup for all patients. The electronic and paper-administered BASDAI questionnaires showed good correlation. Both student-led clinics and ePRO monitoring were well accepted by patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Education, Scientific Disciplines
Christoph Raphael Buhr, Harry Smith, Tilman Huppertz, Katharina Bahr-Hamm, Christoph Matthias, Andrew Blaikie, Tom Kelsey, Sebastian Kuhn, Jonas Eckrich
Summary: This study evaluated the performance of ChatGPT in answering clinical case-based questions in otorhinolaryngology (ORL) and compared it with the answers from ORL consultants. The study found that although ChatGPT provided longer answers, its medical adequacy and conciseness were significantly lower compared to the answers from ORL consultants.
JMIR MEDICAL EDUCATION
(2023)
Article
Rheumatology
Labinsky Hannah, Rohr von Sophie, Raimondo Maria Gabriella, Bohr Daniela, Morf Harriet, Horstmann Britta, Seese Felix, Proft Fabian, Muehlensiepen Felix, Boy Katharina, Kuhn Sebastian, Schmalzing Marc, Vuillerme Nicolas, Schett Georg, Ramming Andreas, Knitza Johannes
Summary: Patients with suspected axSpA can benefit from a stepwise asynchronous telemedicine-based diagnostic approach, which can potentially reduce the diagnostic delay and improve accuracy. Sufficient information, especially imaging results, is essential for correct diagnosis.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Dmytro Fedkov, Andrea Berghofen, Christel Weiss, Christine Peine, Felix Lang, Johannes Knitza, Sebastian Kuhn, Bernhard K. Kraemer, Jan Leipe
Summary: This study evaluated the efficacy and safety of a digital health application in patients with inflammatory arthritis. The results showed that using a personalized disease management program based on digital health significantly improved patient-reported outcomes and disease activity.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Markus Graef, Johannes Knitza, Jan Leipe, Martin Krusche, Martin Welcker, Sebastian Kuhn, Johanna Mucke, Axel J. Hueber, Johannes Hornig, Philipp Klemm, Stefan Kleinert, Peer Aries, Nicolas Vuillerme, David Simon, Arnd Kleyer, Georg Schett, Johanna Callhoff
Summary: This study compared the accuracy of an AI-based symptom checker (Ada) to physicians in diagnosing inflammatory rheumatic diseases (IRD). The study found that Ada had higher diagnostic accuracy compared to physicians when considering basic health and symptom-related medical history. These results highlight the potential of using symptom checkers early in the patient journey and the importance of complete patient information for accurate diagnosis.
RHEUMATOLOGY INTERNATIONAL
(2022)