Article
Clinical Neurology
Seong Son, Sang Gu Lee, Woo Kyung Kim, Yong Ahn, Jong Myung Jung
Summary: The study found that patients with discogenic low back pain had a significantly higher disc height discrepancy ratio compared to other patients. The disc height discrepancy ratio has diagnostic value in screening for discogenic low back pain.
Article
Medicine, General & Internal
Frida Johansson, Zainab Sirat, Hanna Hebelka, Helena Brisby, Fredrik Nordstrom, Kerstin Lagerstrand
Summary: This study investigates the structural and mechanical behavior of intervertebral discs. A potential method for measuring the deformation of the discs under stress using MRI and image registration is presented. The results show that the largest deformation occurs in the lower lumbar spine, and there are regional differences in the behavior of individual discs. Regression analysis reveals that the degeneration grade and tilt angle are the main contributing factors to the deformation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
G. Michael Mallow, David Zepeda, Timothy G. Kuzel, J. Nicolas Barajas, Khaled Aboushaala, Michael T. Nolte, Alejandro Espinoza-Orias, Chundo Oh, Matthew Colman, Monica Kogan, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: Contrary to traditional beliefs, this study found that Modic changes (MC) and their types can also occur in young pediatric patients. The presence of MCs was associated with degenerative disc/endplate abnormalities and structural spine phenotypes. Children with MCs had prolonged symptom duration.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Mohamed Kamal Mesregah, Michael Repajic, Paul Mgbam, Zoe Fresquez, Jeffrey C. Wang, Zorica Buser
Summary: This study evaluated the trends and patterns of cervical degenerative disc disease in different age groups of symptomatic patients. The results showed that the number and severity of degenerated intervertebral discs increased significantly with age.
EUROPEAN SPINE JOURNAL
(2022)
Review
Immunology
Peng Feng, Ying Che, Chunyu Gao, Liguo Zhu, Jinghua Gao, Nam V. V. Vo
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain, and immune cells play a crucial role in modulating its progression by interacting with disc nucleus pulposus (NP) cells and extracellular matrix (ECM). This review comprehensively summarizes the interaction between macrophages and NP, highlighting the important role of immunology in disc degeneration.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Uruj Zehra, Muhammad Saad Ilyas, Rabia Latif, Sumera Imran, Ijaz Ahmad, Amer Aziz
Summary: This study found a significant association between preoperative adjacent disc degeneration (ADD) and vertebral endplate defects, Modic changes, high intensity zones (HIZ), and posterior bulges in patients with lumbar disc herniation. The findings suggest that levels with vertebral endplate defects and severe grade of disc herniation have a greater likelihood of developing ADD.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Xiao-long Chen, Xiang-yu Li, Yu Wang, Shi-bao Lu
Summary: This study investigates the intra-rater and inter-rater agreement and reliability of different disc height measurement methods on MRI, and evaluates the relationship between these methods and Pfirrmann scores for intervertebral disc degeneration. It also examines the association between Pfirrmann scores and clinical outcomes.
Article
Orthopedics
Samuel King, John Magnussen, James Elliott, Mark Jonathan Hancock
Summary: This study developed normalized quantitative measures of disc signal intensity (DSI) and disc height (DH) to rate the relative severity of lumbar disc degeneration (DD). The normalized measures showed stronger relationships with an experienced radiologist's subjective measures of DD severity compared to raw measures. The findings suggest that normalized quantitative measures are better at rating the severity of DD.
Article
Medicine, General & Internal
Sebastian Lippross, Paul Girmond, Katja A. Lueders, Friederike Austein, Lena Braunschweig, Stefan Lueders, Konstantinos Tsaknakis, Heiko M. Lorenz, Anna K. Hell
Summary: Magnetic resonance imaging showed that scoliotic children experienced a reduction in intervertebral disc volume and degeneration after long-term treatment with magnetically controlled growing rods. Compared to untreated children, those who underwent treatment showed more intervertebral disc degeneration.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao, Jing Liu, Zhonghai Li
Summary: Stem cell therapy for intervertebral disc degeneration is emerging as a potential treatment option, with evidence from in vitro, in vivo, and clinical trials showing its effectiveness in relieving pain and symptoms, reversing the degenerative cascade, delaying the aging process, and maintaining spinal function. Further research is needed to understand the mechanisms and effects of stem cells in IDD treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rikuto Yoshimizu, Junsuke Nakase, Katsuhito Yoshioka, Kengo Shimozaki, Kazuki Asai, Mitsuhiro Kimura, Katsuhiko Kitaoka, Hiroyuki Tsuchiya
Summary: This study found that lumbar degeneration was common in children and adolescent weightlifters after 5 years, with 33% of participants showing lumbar disc herniation findings. Long-term high frequency weightlifting training during growth periods may increase the risk of developing low back pain.
Article
Neurosciences
Manish Baldia, Sunithi Mani, Noel Walter, Sanjay Kumar, Alok Srivastava, Krishna Prabhu
Summary: The study found that injection of bone marrow-derived mesenchymal stem cells in a mouse disc degeneration model promoted disc regeneration, restored disc height, and increased collagen fiber content.
Article
Biotechnology & Applied Microbiology
Jean-Philippe Deneuville, Maksym Yushchenko, Tanguy Vendeuvre, Arnaud Germaneau, Maxime Billot, Manuel Roulaud, Mathieu Sarracanie, Najat Salameh, Philippe Rigoard
Summary: The study aims to analyze morphological and biomechanical changes of the intervertebral disc structure and stress distribution using a quantitative MRI protocol combined with ex vivo sagittal loading, potentially offering new opportunities for non-invasive disc exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Masaaki Machino, Hiroaki Nakashima, Keigo Ito, Kei Ando, Sadayuki Ito, Fumihiko Kato, Shiro Imagama
Summary: This study found that occupation and type of labor may have no effect on intervertebral disc degeneration (IDD) in the cervical spine, based on the results of cervical spine MRI scans in a cohort of healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)