Article
Critical Care Medicine
Bizhan Aarabi, Noori Akhtar-Danesh, J. Marc Simard, Timothy Chryssikos, Kathirkamanathan Shanmuganathan, Joshua Olexa, Charles A. Sansur, Kenneth M. Crandall, Aaron P. Wessell, Gregory Cannarsa, Ashish Sharma, Cara D. Lomangino, Jason Boulter, Maureen Scarboro, Jeffrey Oliver, Abdul Kareem Ahmed, Nicole Wenger, Riccardo Serra, Phelan Shea, Gary T. Schwartzbauer
Summary: This retrospective study examined the impact of timing of decompression on the American Spinal Injury Association (ASIA) motor score following traumatic central cord syndrome (ATCCS) caused by spinal stenosis. The study found that the timing of decompression did not significantly affect the follow-up motor score, with only the admission motor score determining the outcome.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Mathias Moller Thygesen, Tim Damgaard Nielsen, Mads Rasmussen, Dariusz Orlowski, Michael Pedersen, Mikkel Mylius Rasmussen
Summary: Interventions on spinal cord perfusion pressure may have a positive correlation with neurological outcome in traumatic spinal cord injuries, but causality cannot be confirmed due to limited literature. Further well-designed studies are needed to address this issue.
EUROPEAN SPINE JOURNAL
(2021)
Article
Rehabilitation
Cristina Shea, Chloe Slocum, Richard Goldstein, Mary Joan Roach, Russell Griffin, Yuying Chen, Ross Zafonte
Summary: This study aimed to investigate whether initial emergency department physiological measures and trauma severity predict functional outcomes and neurologic recovery in traumatic spinal cord injury. The results showed that emergency department physiological parameters did not predict functional outcomes in this cohort.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Chengyue Ji, Yuluo Rong, Hongyu Jia, Ning Yan, Tiesheng Hou, Yao Li, Weihua Cai, Shunzhi Yu
Summary: Surgical decompression should be considered in patients with cervical SCI in the chronic stage and persistent spinal cord compression and/or gross cervical instability. Lower initial AMS, longer duration, injury above C4 level, higher age, and female gender are the five major relevant factors for functional recovery.
EUROPEAN SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Bo-Ram Na, Hyoung-Yeon Seo
Summary: The study investigated the effect of surgical decompression for severe adult spinal cord injury without major bone injury, finding that intramedullary lesion length (IMLL) and compression rate have the most powerful effect on neurological outcome. Additionally, 5 out of 11 patients showed improved neurological grade one year postoperatively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Clinical Neurology
John Eraifej, Colin Nnadi, Mario Ganau
Summary: Recent evidence suggests that early decompressive spinal surgery can improve neurological outcomes in acute spinal cord injury patients, highlighting the need for hospital systems to swiftly restructure to meet the demand for early and possibly ultra-early spinal decompression in the future.
EUROPEAN SPINE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Jiaqi Bi, Peiyu Sun, Erwei Feng, Jianxiong Shen, Chong Chen, Haining Tan, Zheng Li, Youxi Lin
Summary: This study demonstrated the synergistic therapeutic effects of melatonin and half-dose methylprednisolone for treating spinal cord injury. The combination of melatonin and half-dose methylprednisolone significantly reduced the dosage of methylprednisolone and limited its adverse reactions. The PI3K-AKT1 pathway was involved in the amelioration of acute SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Jose A. Canseco, Brian A. Karamian, Daniel R. Bowles, Michael P. Markowitz, Stephen L. DiMaria, Nicholas C. Semenza, Mark R. Leibensperger, Michael L. Smith, Alexander R. Vaccaro
Summary: The role of methylprednisolone in treating spinal cord pathologies such as acute spinal cord injury remains controversial, with some data supporting its benefits but also highlighting the risks of systemic adverse effects. Further research is needed to determine the effectiveness of steroids in treating patients with spinal cord pathology.
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Elsayed Metwally, Hatim A. Al-Abbadi, Mohamed A. Hashem, Yasmina K. Mahmoud, Eman A. Ahmed, Ahmed Maaty, Ibrahim E. Helal, Mahmoud F. Ahmed
Summary: The combination of methylprednisolone sodium succinate (MPSS) and a selective calpain inhibitor (PD150606) significantly reduces neuronal loss and microglial cell infiltration, improves locomotor score, and inhibits calpain-induced cleavage of p35, cdk5 activation, and tau phosphorylation in a dog spinal cord injury model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Chenghua Yuan, Jian Guan, Yueqi Du, Zeyu Fang, Xinyu Wang, Qingyu Yao, Can Zhang, Shanhang Jia, Zhenlei Liu, Kai Wang, Wanru Duan, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian
Summary: The study found that PTS tends to progress faster than CCJ-related syringomyelia. Except for the red blood cell count, peripheral blood inflammation markers (PBIMs) showed no value in distinguishing the two forms of syringomyelia. Spinal cord injury associated with PTS was more severe than that associated with CCJ.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Fred H. Geisler, Ali Moghaddamjou, Jamie R. F. Wilson, Michael G. Fehlings
Summary: The use of methylprednisolone (MP) to treat acute traumatic spinal cord injury (ATSCI) is controversial. Analysis of a new pooled ATSCI data set and an updated NASCIS2 data set revealed that MP did not enhance neurological recovery at 26 weeks. These findings need to be reviewed by clinical guideline groups.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Pharmacology & Pharmacy
W. -T. Chen, Y. -P. Zhou, G. -S. Zhang
Summary: Acute spinal cord injury (SCI) is a devastating disease that requires a multidisciplinary approach to treatment. Although the treatment of SCI has developed significantly, the use of steroids remains controversial due to limited clinical evidence. However, with the accumulation of evidence on the effectiveness of steroid treatment and the evidence of severe side effects, a gradual change in the treatment of SCI with steroids has become inevitable.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Yu Zhang, An-An Li, Shi-Ning Xiao, Nan-Shan Zhong, Wei-Lai Tong, Shi-Jiang Wang, Jia-Ming Liu, Zhi-Li Liu
Summary: This study conducted a bibliometric analysis of published literature on the treatment of spinal cord injury (SCI) using glucocorticoids. The research found that the use of methylprednisolone (MP) in treating SCI has increased over time, and emphasized the need for rigorous clinical trials to verify its therapeutic role and appropriate dosage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Bin Zhu, Guangjin Gu, Jie Ren, Xiaomeng Song, Junjin Li, Chunyan Wang, Wencan Zhang, Yanqing Huo, Haifeng Wang, Lin Jin, Shiqing Feng, Zhijian Wei
Summary: Spinal cord injury (SCI) leads to permanent loss of sensory and motor function, but effective clinical treatments are lacking. This study developed a non-invasive composite patch that releases exosomes and methylprednisolone to the injured spinal cord. The patch showed good biocompatibility, promoted macrophage polarization, reduced neuronal apoptosis, and inhibited inflammation in vitro and in vivo. These therapeutic effects are attributed to specific pathways. The composite patch offers a potential non-invasive treatment for SCI.
Article
Clinical Neurology
Tushar Narayan Rathod, Ashwin Hemant Sathe, Nandan Amrit Marathe, S. S. Mohanty, Prashant Kamble, Bhushan Hadole, Abhinandan Reddy Mallepally
Summary: This study reveals that there is potential for significant neurological improvement even after delayed surgery in patients with thoracolumbar SCI. Pre-operative LEMS score, cord signal changes, and presence of cord transection significantly influence unfavorable clinical outcomes at the end of 1-year post-surgery.
EUROPEAN SPINE JOURNAL
(2021)