Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Clinical Neurology
Yannick Rau, Arndt-Peter Schulz, Roland Thietje, Ludwig Matrisch, Jasper Frese, Sven Hirschfeld
Summary: This study provides recent data on the incidence of spinal cord injuries (SCI) in Germany and highlights the influence of age, gender, and type of lesion on incidence rates. The findings suggest potential directions for future research, particularly regarding the relative reduction in complete injuries among the elderly.
EUROPEAN SPINE JOURNAL
(2023)
Article
Critical Care Medicine
Ravindran Visagan, Florence R. A. Hogg, Mathew J. Gallagher, Siobhan Kearney, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun
Summary: This study examines the feasibility of monitoring tissue oxygen tension in patients with acute, severe traumatic spinal cord injuries. The results show that tissue oxygen tension is influenced by various factors, including intraspinal pressure, spinal cord perfusion pressure, tissue glucose levels, lactate/pyruvate ratio, and fever. In patients with motor-incomplete injuries, fluctuations in tissue oxygen tension correlate with fluctuations in limb motor score.
CRITICAL CARE MEDICINE
(2022)
Review
Cell Biology
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Summary: Ferroptosis, a novel type of programmed cell death, has been found to be associated with acute central nervous system (CNS) trauma. The processes that induce ferroptosis include iron overload, imbalanced glutathione metabolism, and lipid peroxidation. Understanding the mechanism of ferroptosis is important for studying the pathophysiological process of CNS trauma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pediatrics
Seyed Behnam Jazayeri, Samuel Berchi Kankam, Ali Golestani, Parnian Shobeiri, Morteza Gholami, Mohammad Amin Dabbagh Ohadi, Seyed Farzad Maroufi, Mohammad Reza Fattahi, Hamid Malekzadeh, Seyed Behzad Jazayeri, Zahra Ghodsi, Seyed Mohammad Ghodsi, Vafa Rahimi-Movaghar
Summary: This study aims to provide insight on the epidemiological characteristics of pediatric traumatic spinal cord injury (TSCI) worldwide. The study found that the incidence of pediatric TSCI in developed countries is 4.3 cases per million children aged 0-15. Boys comprised 67% of cases and the most prevalent level of injury was cervical. The frequency of SCI Without Obvious Radiological Abnormality (SCIWORA) among children 0-17 was 35%. The etiology of TSCI differed between developing and developed countries.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Nicole M. Vecin, David R. Gater
Summary: This manuscript reviews the risk of pressure injuries caused by spinal cord injury and discusses the multidisciplinary approach required to prevent and treat these injuries in the vulnerable population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Wei-Chih Lien, Wei-Ming Wang, Jung-Der Wang, Fuhmei Wang
Summary: This study found that the incidence of tetraplegia of traumatic SCI in Taiwan decreases with good economic performance, which may be resulted from the provision of public goods and services, possibly through improvements in the infrastructure of transportation and construction.
Article
Clinical Neurology
Nancy P. Thorogood, Vanessa K. Noonan, Xiaozhi Chen, Nader Fallah, Suzanne Humphreys, Nicolas Dea, Brian K. Kwon, Marcel F. Dvorak
Summary: This study estimated the incidence, prevalence, and trends of traumatic spinal cord injury (TSCI) in Canada using national-level health administrative data. The results showed an increasing number of TSCI cases and higher survival rates over the past 15 years, with a growing proportion among the elderly population. This study provides important insights for healthcare planning, prevention strategies, and future research.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
Ville Niemi-Nikkola, Eerika Koskinen, Eija Vaaral, Anna-Maija Kauppila, Mauri Kallinen, Aki Vainionpaa
Summary: This study evaluated the incidence and characteristics of acquired nontraumatic spinal cord injury in Finland. It found that NTSCI was more common in men, with degenerative causes being the most common etiology, and tetraplegia being less common. The study also pointed out the lack of previous research on NTSCI in Finland and the higher incidence rate compared to previous studies.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Bin Jiang, Dongling Sun, Haixin Sun, Xiaojuan Ru, Hongmei Liu, Siqi Ge, Jie Fu, Wenzhi Wang
Summary: This study investigated the epidemiological characteristics and prevalence, incidence, and external causes of traumatic spinal cord injury (TSCI) in China. The findings showed a high prevalence and incidence of TSCI in China, with falls and motor vehicle collisions being the two major causes of TSCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Blake M. Hauser, Samantha E. Hoffman, Saksham Gupta, Mark M. Zaki, Edward Xu, Melissa Chua, Joshua D. Bernstock, Ayaz Khawaja, Timothy R. Smith, Mark R. Proctor, Hasan A. Zaidi
Summary: This study conducted a retrospective cohort analysis of pediatric patients with traumatic spinal injuries (TSIs) to investigate the epidemiology and clinical predictors of venous thromboembolism (VTE). The results showed that VTE occurs in a low percentage of hospitalized pediatric patients with TSI. Injury severity, concomitant injuries, and obesity were identified as specific risk factors for VTE. Patients with VTE also required longer hospital stays and more rehabilitative care.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Physiology
Chun Yao, Xuemin Cao, Bin Yu
Summary: Traumatic spinal cord injury (SCI) leads to a series of complex pathological reactions, affecting the local microenvironment. Although endogenous angiogenesis is triggered, the new vessels often do not function normally. Many blood vessel interventions have been applied in SCI treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Clinical Neurology
Carly Weber-Levine, Brendan F. Judy, Andrew M. Hersh, Tolulope Awosika, Yohannes Tsehay, Timothy Kim, Alejandro Chara, Nicholas Theodore
Summary: This study reviewed the current evidence supporting SCPP as a stronger predictor of outcomes in traumatic spinal cord injury, while also indicating inconclusive evidence on the effectiveness of CSF drainage for reducing ISP.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Clinical Neurology
Lintao Xu, Jingyu Wang, Yueming Ding, Linlin Wang, Yong-Jian Zhu
Summary: Microglia undergo activation, proliferation, and changes in gene and protein expression and morphology after traumatic spinal cord injury (SCI), leading to both detrimental and beneficial effects. Understanding and regulating microglial activation status is crucial for reducing harmful effects, promoting repair, and developing effective therapies for SCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Brigida Molina-Gallego, Sagrario Gomez-Cantarino, Maria Idoia Ugarte-Gurrutxaga, Laura Molina-Gallego, Laura Mordillo-Mateos
Summary: Patients with chronic spinal cord injury showed significantly different cognitive profiles compared to those with subacute injury, and cognitive dysfunction may have significant implications on individuals' quality of life and societal integration even beyond the first stage of rehabilitation.
Article
Endocrinology & Metabolism
Petri Wiklund, Timo Tormakangas, Yi Shi, Na Wu, Aki Vainionpaa, Markku Alen, Sulin Cheng
Article
Clinical Neurology
Ville Niemi-Nikkola, Nelli Saijets, Henriikka Ylipoussu, Pietari Kinnunen, Juha Pesala, Pirkka Makela, Markku Alen, Mauri Kallinen, Aki Vainionpaa
Article
Clinical Neurology
Ville Niemi-Nikkola, Nelli Saijets, Henriikka Ylipoussu, Pietari Kinnunen, Juha Pesala, Pirkka Makela, Markku Alen, Mauri Kallinen, Aki Vainionpaa
Article
Biophysics
Riikka Ahola, Raija Korpelainen, Aki Vainionpaa, Timo Jamsa
JOURNAL OF BIOMECHANICS
(2010)
Article
Endocrinology & Metabolism
Kaijun Niu, Riikka Ahola, Hui Guo, Raija Korpelainen, Jin Uchimaru, Aki Vainionpaa, Kyoko Sato, Aiko Sakai, Sinikka Salo, Koshi Kishimoto, Eiji Itoi, Shoko Komatsu, Timo Jamsa, Ryoichi Nagatomi
JOURNAL OF BONE AND MINERAL METABOLISM
(2010)
Article
Rehabilitation
Elsa A. Campbell, Jouko Hynynen, Birgitta Burger, Aki Vainionpaa, Esa Ala-Ruona
Summary: This study aimed to investigate the effects of Vibroacoustic treatment and self-care intervention on patients with chronic pain. Results showed that practitioner-led sessions led to the greatest improvement, while self-care was beneficial for pain relief and relaxation.
DISABILITY AND REHABILITATION
(2021)
Article
Rehabilitation
Ville Niemi-Nikkola, Eerika Koskinen, Eija Vaaral, Anna-Maija Kauppila, Mauri Kallinen, Aki Vainionpaa
Summary: This study evaluated the incidence and characteristics of acquired nontraumatic spinal cord injury in Finland. It found that NTSCI was more common in men, with degenerative causes being the most common etiology, and tetraplegia being less common. The study also pointed out the lack of previous research on NTSCI in Finland and the higher incidence rate compared to previous studies.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Susanna Tallqvist, Anna-Maija Kauppila, Aki Vainionpaa, Eerika Koskinen, Paula Bergman, Heidi Anttila, Harri Hamalainen, Anni Tackman, Mauri Kallinen, Jari Arokoski, Sinikka Hiekkala
Summary: The study aimed to explore the prevalence of comorbidities, secondary health conditions (SHCs), and multimorbidity in the Finnish population with spinal cord injury (SCI). The most common comorbidities were high blood pressure/hypertension (38%), back problems (28%), and high cholesterol (22%). The most common SHCs were joint and muscle pain (81%), muscle spasms (74%), chronic pain (71%), and bowel problems (71%).
Article
Clinical Neurology
Kirsi Majamaki, Susanna Tallqvist, Aki Vainionpaa, Eerika Koskinen, Anna-Maija Kauppila, Paula Bergman, Heidi Anttila, Harri Hamalainen, Anni Tackman, Mauri Kallinen, Jari Arokoski, Sinikka Hiekkala
Summary: This study analyzed data from the Finnish population with spinal cord injury to assess the impact of injury severity, age, and time since injury on functional independence. The results showed that higher levels of injury severity were associated with lower functional ability, and age and time since injury also negatively influenced functional independence.
Article
Clinical Neurology
Joonas Poutanen, Heidi Anttila, Susanna Tallqvist, Mauri Kallinen, Eerika Koskinen, Harri Hamalainen, Anna-Maija Kauppila, Anni Tackman, Aki Vainionpaa, Jari Arokoski, Sinikka Hiekkala
Summary: This study assesses the physical health of Finnish SCI population using PROMIS and compares it to the general US population. The results suggest a significant association between pain interference and physical function, highlighting the importance of pain management in improving physical function.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Rehabilitation
Kaarina Eskola, Eerika Koskinen, Heidi Anttila, Susanna Tallqvist, Paula Bergman, Mauri Kallinen, Harri Hamalainen, Anna-Maija Kauppila, Anni Tackman, Aki Vainionpaa, Jari Arokoski, Marketta Rajavaara, Sinikka Hiekkala
Summary: A low level of employment was found among Finnish spinal cord injury patients. Work participation was influenced by factors such as physical and social health, and individuals with paraplegia and younger age were more likely to participate in work.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Elina Johansson, Teemu M. Luoto, Aki Vainionpaa, Anna-Maija Kauppila, Mauri Kallinen, Eija Vaarala, Eerika Koskinen
Summary: A prospective cohort study conducted in two spinal cord injury centers in Finland over a 4-year period found that the mean annual incidence of traumatic spinal cord injury (TCSI) was 36.6 per million, with leading causes being falls and transport-related accidents. Among patients over 60 years old, injuries due to falls were more common in the neck region, while in patients under 60 years old, alcohol consumption was a common factor preceding injury in nearly half of the cases.
Article
Rehabilitation
Susanna Tallqvist, Heidi Anttila, Mauri Kallinen, Eerika Koskinen, Harri Hamalainen, Anna-Maija Kauppila, Anni Tackman, Aki Vainionpaa, Jari Arokoski, Sinikka Hiekkala
JOURNAL OF REHABILITATION MEDICINE
(2019)