Article
Clinical Neurology
M. Dobran, D. Aiudi, V. Liverotti, M. R. Fasinella, S. Lattanzi, C. Melchiorri, A. Iacoangeli, S. Campa, G. Polonara
Summary: The aim of this study was to evaluate the prognostic value of certain features documented on preoperative MRI in patients with acute cervical spinal cord injury. The length of the spinal cord lesion, the diameter of the canal at the level of spinal cord compression, and the presence of intramedullary hemorrhage were significantly associated with the SCIM questionnaire score at one year follow-up. Shorter spinal cord lesion, larger canal diameter at the level of spinal cord compression, and absence of intramedullary hemorrhage were predictors of better outcome.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Mehdy Dousty, Andrea Bandini, Parvin Eftekhar, David J. Fleet, Jose Zariffa
Summary: The study aimed to investigate the relationship between grasp types used at home and clinical scores. The results showed moderate to strong correlations between reliance on power grasp and clinical scores, while negative correlations were observed between the proportion of non-prehensile grasping and clinical scores. This study provides the first direct demonstration of the importance of hand grasp analysis in the home environment.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Mu-Lan Xu, Xiang-Bo Wu, Ying Liang, Ning Li, Xu Hu, Xiao-Dong Lin, Miao-Qiao Sun, Chun-Qiu Dai, Dan Niu, Yan-Rong Zhang, Hui Cao, Chen-Guang Zhao, Xiao-Long Sun, Hua Yuan
Summary: This study found that neuropathic pain is associated with functional recovery in spinal cord injury patients, potentially having a positive impact on their rehabilitation.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Rehabilitation
Amiram Catz, Malka Itzkovich, Keren Elkayam, Dianne Michaeli, Ilana Gelernter, Yoav Benjamini, Harvinder Singh Chhabra, Luigi Tesio, Einat Engel-Haber, Emiliana Bizzarini, Claudio Pilati, Giulio Del Popolo, Ilaria Baroncini, Nan Liu, Paulo Margalho, Thabata Pasquini Soeira, Bobeena Chandy, Mrinal Joshi, Jean-Francois Lemay, Dorothyann Curran, Annelie Schedin Leiulfsrud, Linda Sorensen, Fin Biering-Sorensen, Nur Kesiktas, Aheed Osman, Vadim Bluvshtein
Summary: This study aimed to evaluate the reliability and validity of the fourth version of the Spinal Cord Independence Measure (SCIM IV). The results showed good interrater reliability and high correlation with SCIM III. The validity, reliability, and responsiveness of SCIM IV were similar to SCIM III, indicating its potential value in clinical and research settings.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Geosciences, Multidisciplinary
Trevan Flynn, John Triantafilis, Andrei Rozanov, Freddie Ellis, Alberto Lazaro-Lopez, Andrew Watson, Cathy Clarke
Summary: Allocation of soil profiles to soil classes is influenced by surveyor's expertise. Numerical classifications assist in creating property-based clusters. Soil information downstream applications benefit from consistent soil classifications.
Article
Cell & Tissue Engineering
Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury, Alan J. Burns
Summary: The combination treatment of enteric neural stem cells (ENSCs) with chondroitinase ABC (ChABC) showed superior regenerative effects in repairing spinal cord injury, suggesting a potential new strategy for treating SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Wupu Osimanjiang, JuliAnne E. Allgood, Rae L. Van Sandt, Daniel T. Burns, Jared S. Bushman
Summary: Spinal cord injury (SCI) is a devastating disorder with no clinically standardized treatment. Sex-dependent differences in sensory motor recovery, lesion size, and immune cell recruitment were observed post-SCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Ping Xu, Feng Zhang, Min-min Chang, Cheng Zhong, Cheng-Hong Sun, Hao-Ran Zhu, Jing-Chun Yao, Zhi-Zhong Li, Si-Tao Li, Wen-Cai Zhang, Guo-Dong Sun
Summary: This study demonstrates that γδ T cells are recruited to the site of spinal cord injury through CCL2/CCR2 signaling, exacerbating inflammatory response and worsening neurological impairment. This mechanism could be a potential therapeutic target for future SCI treatment.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Benoit Beliard, Chaimae Ahmanna, Elodie Tiran, Kadia Kante, Thomas Deffieux, Mickael Tanter, Fatiha Nothias, Sylvia Soares, Sophie Pezet
Summary: Acute spinal cord injury results in severe damage to the microvascular network. This study uses ultrafast Doppler imaging and ultrasound localization microscopy to analyze the structural and functional vascular alterations during chronic SCI. The results show hemodynamic alterations in the spinal cord and correlations between vascular dysfunction biomarkers and SCI severity. This imaging modality can be used to evaluate vascular function recovery and predict treatment outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Kui Shen, Xiaowei Li, Guanning Huang, Zhongwen Yuan, Bin Xie, Tianfeng Chen, Lizhen He
Summary: This study developed a targeted nanozyme loaded with Rapamycin (Rapa) and hollow mesoporous Prussian blue (HMPB), which can scavenge free radicals and reduce inflammation to relieve secondary damage in spinal cord injury (SCI). The nanozyme exhibited ROS scavenging capacity and multienzyme-like activity, and effectively alleviated neuronal damage and promoted motor function recovery in SCI mice.
Article
Clinical Neurology
Mathias Moller Thygesen, Torben Ellegaard Lund, Irene Klaerke Mikkelsen, Helge Kasch, Rikke Beese Dalby, Stig Eric Dyrskog, Michael Pedersen, Mikkel Mylius Rasmussen
Summary: This study aimed to establish a DKI protocol for acute SCI and found a significant correlation between decreasing mean kurtosis values at the injury site of the spinal cord and higher grade of disability in patients.
ACTA NEUROCHIRURGICA
(2022)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Wei Zeng, Yasuhiro Kamei, Shuji Shigenobu, Jin-Chuan Sheu, Huai-Jen Tsai
Summary: The newly discovered SCI stress-responsive regenerating cells (SrRCs) play a crucial role in neuronal regeneration after spinal cord injury, forming a bridge across the lesion and connecting with neighboring undamaged motor neurons. Among different subtypes of SrRCs, rostral-SrRCs exhibit higher neuronal differentiation capability and increased expression of caveolin 1 (cav1), which is responsible for axonal regrowth and overall regenerative capability in neuronal regeneration post-SCI.
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Rehabilitation
Leanna S. Lee, Sander L. Hitzig, Amanda Mayo, Michael Devlin, Steven Dilkas, Crystal MacKay
Summary: This study aimed to explore the barriers and facilitators to physical activity for individuals with lower limb amputation (LLA) from the perspectives of both individuals with LLA and health professionals. Through qualitative interviews and thematic analysis, six themes were identified, including support systems, availability of community resources, and the fit and function of prostheses. These findings provide a foundation for developing patient-centered interventions and physical activity programs to overcome the barriers to physical activity for individuals with LLA.
DISABILITY AND REHABILITATION
(2023)
Review
Gerontology
Kristina M. Kokorelias, Jessica E. Shiers-Hanley, Zoe Li, Sander L. Hitzig
Summary: This review assessed the outcomes of navigation programs for persons with dementia and their family caregivers. The findings indicate that system navigation programs can delay institutionalization and have benefits for caregiver outcomes. However, the results in other domains are less clear, which may be due to the varied approaches within system navigation models of care.
Article
Rehabilitation
Luigi Tesio, Stefano Scarano, Samah Hassan, Dinesh Kumbhare, Antonio Caronni
Summary: The article introduces latent variables, such as behaviors, attitudes, cognitive skills, and emotions, which cannot be observed directly in body parts. These variables are often targeted in physical and rehabilitation medicine interventions. Questionnaires are commonly used to measure these variables by listing representative behaviors as items. However, questionnaire scores are only a rough approximation to true measures and may have flaws. The article summarizes the flaws and highlights their consequences in outcome assessment.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Endocrinology & Metabolism
Kim Phung, Laura McAdam, Jinhui Ma, Hugh J. McMillan, Stefan Jackowski, Maya Scharke, Mary-Ann Matzinger, Nazih Shenouda, Khaldoun Koujok, Jacob L. Jaremko, Kevin Smit, Scott Walker, Colleen Hartigan, Nasrin Khan, Victor N. Konji, Lynn MacLeay, Marika Page, Elizabeth Sykes, Marie-Eve Robinson, Nathalie Alos, Elizabeth A. Cummings, Josephine Ho, Anne Marie Sbrocchi, Robert Stein, David Saleh, B. Catharine Craven, Utkarsh J. Dang, Kerry Siminoski, Frank Rauch, Leanne M. Ward
Summary: This study found that markers of systemic glucocorticoid exposure, such as shorter stature, greater bone age delay, and lower lumbar spine bone mineral density, were associated with spine fragility in patients with DMD.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Gerontology
Kristina M. Kokorelias, Hardeep Singh, Stephanie Posa, Sander L. Hitzig
Summary: This study explores the goals of older adults, caregivers, and healthcare providers during hospital-to-home transitions, and how patient navigation can support these goals. Common goals include having someone to rely on and easy access to services. Older adults seek independence, while caregivers and healthcare providers prioritize safety and skill development.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Article
Rehabilitation
Luigi Tesio, Antonio Caronni, Dinesh Kumbhare, Stefano Scarano
Summary: This article summarizes the characteristics of Rasch's theory and its application in measuring persons' properties. The theory provides a metrological model that transforms ordinal scores into linear measures, overcoming the limitations of traditional scoring methods. Rasch analysis allows for a more accurate and reliable measurement in the field of Medicine.
DISABILITY AND REHABILITATION
(2023)
Article
Rehabilitation
Luigi Tesio, Antonio Caronni, Anna Simone, Dinesh Kumbhare, Stefano Scarano
Summary: This paper discusses the developments and practical applications of Rasch's theory and statistical analysis in constructing questionnaires to measure individuals' traits. Rasch Analysis allows for the conversion of raw scores into measured scores with error estimates, satisfying essential measurement axioms. The use of this method can advance the scientific assessment of various aspects in different fields, including physical and rehabilitation medicine, as well as social and educational sciences.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Amiram Catz, Malka Itzkovich, Rotem Rozenblum, Keren Elkayam, Adi Kfir, Luigi Tesio, Harvinder Singh Chhabra, Dianne Michaeli, Gabi Zeilig, Einat Engel-Haber, Emiliana Bizzarini, Claudio Pilati, Salvatore Stigliano, Marcella Merafina, Giulio Del Popolo, Gabriele Righi, Jacopo Bonavita, Ilaria Baroncini, Nan Liu, Huayi Xing, Paulo Margalho, Ines Campos, Marcelo Riberto, Thabata Pasquini Soeira, Bobeena Chandy, George Tharion, Mrinal Joshi, Jean-Francois Lemay, Marie-Therese Laramee, Dorothyann Curran, Annelie Schedin Leiulfsrud, Linda Sorensen, Fin Biering-Sorensen, Henrik Hagen Poder, Nur Kesiktas, Lisa Burgess-Collins, Jayne Edwards, Aheed Osman, Vadim Bluvshtein
Summary: This study aims to validate the scores of the three subscales of SCIM IV using advanced statistical methods. Based on the assessment of 648 spinal cord lesion inpatients using SCIM IV and SCIM III, Rasch analysis confirms that the scores of each SCIM IV subscale are reliable and valid, supporting the use of SCIM IV in clinical practice and research.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Review
Multidisciplinary Sciences
Lauren Cadel, Stephanie R. Cimino, Glyneva Bradley-Ridout, Sander L. Hitzig, Tejal Patel, Chester H. Ho, Tanya L. Packer, Aisha K. Lofters, Shoshana Hahn-Goldberg, Lisa M. McCarthy, Sara J. T. Guilcher
Summary: The use of multiple medications is common post-stroke for secondary prevention and management of co-occurring chronic conditions. Optimizing medication self-management is important for this population. This scoping review aimed to identify and summarize interventions related to medication self-management for adults with stroke, with a focus on secondary stroke prevention and medication adherence.
Article
Health Care Sciences & Services
Sander L. Hitzig, Jorge Rios, Michael Devlin, Sara J. T. Guilcher, Crystal MacKay, Steven Dilkas, Michael W. Payne, Ricardo Viana, Ahmed Kayssi, Stephanie R. Cimino, Amanda L. Mayo
Summary: This study aimed to provide a descriptive account of health utility scores in community-dwelling adults with dysvascular lower extremity amputation. The study found that health utility scores were associated with SIGAM grade, age, months post-amputation, and severity of dysvascular conditions. Health utility scores were lower for participants in the high-impact groups for conditions such as diabetes mellitus, phantom limb pain, musculoskeletal pain, back pain, psychological distress, depression, vision problems, and other pain. These findings provide data for future economic evaluations and healthcare resource allocation.
QUALITY OF LIFE RESEARCH
(2023)
Article
Clinical Neurology
Arrani Senthinathan, B. Catherine Craven, Andrew M. Morris, Melanie Penner, Karen Tu, Susan B. Jaglal
Summary: This retrospective cohort study aimed to investigate antibiotic prescribing and urine culture testing patterns for urinary tract infections (UTIs) in a primary care Spinal Cord Injury (SCI) cohort. The study found that the average annual number of antibiotic prescriptions for UTIs was 1.9 for the SCI cohort, and urine cultures were conducted for 58.1% of antibiotic prescriptions. Physician characteristics, such as gender and training, were found to be associated with the choice of antibiotic and whether a urine culture was ordered. Patient characteristics did not show any association.
Article
Multidisciplinary Sciences
Valeria Feijo Martins, Luigi Tesio, Anna Simone, Andrea Kruger Goncalves, Leonardo A. Peyre-Tartaruga
Summary: This study investigates the physical and coordination determinants of walking speed decline in older women. The results show that the decline in walking speed is associated with balance and the ratio of step length to step cadence. The decrease in self-selected walking speed does not affect walking efficiency, while lowering the ratio of step length to step cadence at maximal speed prevents imbalance.
Review
Health Care Sciences & Services
Marina Wasilewski, Abirami Vijayakumar, Zara Szigeti, Sahana Sathakaran, Kuan-Wen Wang, Adam Saporta, Sander L. Hitzig
Summary: The objective of this scoping review was to summarize the literature on barriers and facilitators that influence the provision and uptake of inpatient cardiac rehabilitation. A total of 229 studies were included in the review. The importance rating of this article in English: 9 points.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Review
Public, Environmental & Occupational Health
Kristina M. M. Kokorelias, Jill I. I. Cameron, Nancy M. M. Salbach, Heather Colquhoun, Sarah E. P. Munce, Michelle L. A. Nelson, Julia Martyniuk, Carolyn Gray, Terence Tang, Sander L. L. Hitzig, M. Patrice Lindsay, Mark T. T. Bayley, Rosalie H. H. Wang, Navaldeep Kaur, Hardeep Singh
Summary: This study synthesized the literature on the experiences and needs of South Asian community members impacted by stroke and their family caregivers in high-income countries. The findings highlighted the impact of cultural factors, such as language barriers, on the experiences of South Asian stroke patients.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Health Care Sciences & Services
Marina B. Wasilewski, Zara Szigeti, Christine L. Sheppard, Jacqueline Minezes, Sander L. Hitzig, Amanda L. Mayo, Lawrence R. Robinson, Maria Lung, Robert Simpson
Summary: During the COVID-19 pandemic, discharge timelines were accelerated, and patients were moved across different care settings. This study aimed to understand the experiences of patients, caregivers, and healthcare providers in the COVID-19 care pathway.
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2023)